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Predictive value of angiopoietin-like protein 8 in metabolic dysfunction-associated fatty liver disease and its progression:A case-control study

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World Journal of Diabetes 2024年第3期15卷 418-428页

作者： Lu-Lu Gan Can Xia Xuan Zhu Yue Gao wen-Chang Wu Qi Li Ling Li zhe Dai Yi-Min Yan Medical College Wuhan University of Science and TechnologyWuhan 430071Hubei ProvinceChina Department of Endocrinology Xiaogan Hospital Affiliated with Wuhan University of Science and TechnologyThe Central Hospital of XiaoganXiaogan 432000Hubei ProvinceChina Department of Endocrinology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND The prevalence of metabolic dysfunction-associated fatty liver disease(MAFLD)is rapidly increasing,currently affecting approximately 25%of the global *** fibrosis represents a crucial stage in the development of MAFLD,with advanced liver fibrosis elevating the risks of cirrhosis and hepatocellular *** serum markers are less effective in diagnosing liver fibrosis compared to more complex ***,imaging techniques like transient elastography face limitations in clinical application due to equipment and technical ***,it is imperative to identify a straightforward yet effective method for assessing MAFLD-associated liver *** To investigate the predictive value of angiopoietin-like protein 8(ANGPTL8)in MAFLD and its *** We analyzed 160 patients who underwent abdominal ultrasonography in the Endocrinology Department,Xiaogan Central Hospital affiliated to Wuhan University of Science and Technology,during September 2021-July *** abdominal ultrasonography and MAFLD diagnostic criteria,among the 160 patients,80 patients(50%)were diagnosed with *** MAFLD group was divided into the liver fibrosis group(n=23)and non-liver fibrosis group(n=57)by using a cut-off fibrosis-4 index≥*** regression was used to analyze the risk of MAFLD and the risk factors for its *** operating characteristic curves were used to evaluate the predictive value of serum ANGPTL8 in MAFLD and its *** Compared with non-MAFLD patients,MAFLD patients had higher serum ANGPTL8 and triglyceride-glucose(TyG)index(both P<0.05).Serum ANGPTL8(r=0.576,P<0.001)and TyG index(r=0.473,P<0.001)were positively correlated with *** ANGPTL8 was a risk factor for MAFLD[odds ratio(OR):1.123,95%confidence interval(CI):1.066-1.184,P<0.001).Serum ANGPTL8 and ANGPTL8+TyG index predicted MAFLD[area under the curve(AUC):0.832 and 0.886,respectively;both P<0.05].Compared with MAFL

关键词： Angiopoietin-like protein 8 Metabolic dysfunction-associated fatty liver disease Fibrosis-4 index Liver fibrosis

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Tuberous sclerosis complex combined with primary lymphedema:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2642-2648页

作者： Xing-Peng Li Xiao-Li Sun Xin Liu zhe wen Li-Hua Jiang Yan Fu Yun-Long Yue Ren-Gui Wang Department of Radiology Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of Lymph Surgery Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of Nuclear Medicine Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China Department of MRI Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijing 100038China

BACKGROUND Tuberous sclerosis complex(TSC)and primary lymphedema(PLE)are both rare diseases,and it is even rarer for both to occur in the same *** this work,we have provided a detailed description of a patient's clinical presentation,imaging findings,and *** a retrospective analysis was conducted on 14 published relevant case *** SUMMARY A 16-year-old male came to our hospital for treatment due to right lower limb *** swelling is already present from *** patient’s memory had been progressively *** had occurred 1 year prior at an unknown *** patient was diagnosed with TSC combined with PLE through multimodal imaging examination:Computed tomography,magnetic resonance imaging,and *** patient underwent *** swelling of the patient's right lower limb significantly improved after *** did not *** taking antiepileptic drugs and *** TSC with PLE is a rare and systemic *** can detect lesions of this disease,which are important for diagnosis and treatment.

关键词： Tuberous sclerosis complex Lymphedema Sirolimus Multimodal imaging examination Case report

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Selective synthesis of heteroleptic PdAB-cages: modulating size-preference of supramolecular hosts via endo-functionalization

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Science China Chemistry 2024年

作者： wen-Tao Dai Ting-Ting Liu Qixia Bai zhe Zhang Pingshan Wang Wei Lu Qi Zhang Key Laboratory of Green Chemistry and Technology of Ministry of Education College of Chemistry Sichuan University Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of Education Guangzhou University

The size complementarity between a host and a guest is a critical prerequisite for selective molecular recognition. Numerous artificial host systems have been designed to achieve size-selective recognition and chemical transformations. However, the inherent challenge lies in the fixed selectivity governed by a size-exclusion mechanism dictated by the host’s *** the selectivity necessitates structural modifications of hosts. Examples of host systems with modifiable sizeselectivity are rare. In this study, we present an approach to modulating guest-selectivity via endo-functionalization of supramolecular cavities. Heteroleptic Pd2A3B-cages are constructed with a Pd2A3precursor or directly from palladium ions and relevant ligands. Furthermore, the simultaneous and selective formation of multiple hetero-cages was achieved by simply mixing PdIIand the free ligands in a one-pot reaction. The fidelity of the assembly process relies on cooperative steric control at the periphery and within the cavity of the hetero-cages, respectively. The central steric group also functions as the endohedral moiety. Variations of the endohedral groups facilitate facile and modular derivatization of the microenvironment within the cages, enabling the fine-tuning of guest binding affinities as evidenced by titration experiments. This strategy offers a new solution for the development of customized host structures.

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Absence of ultrasonic-vibration-induced plasticity in metallic glacial glasses

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Rare Metals 2024年第7期43卷 3422-3429页

作者： zhe Chen Shuai Ren Jian Zhu Jie Shen Xin Li He-Ting Zhang Hong-Ji Lin Sajad Sohrabi wen-Qing Ruan zhen-Xuan Zhang Xiong Liang Jiang Ma Jun Shen Shenzhen Key Laboratory of High Performance Nontraditional Manufacturing College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060China Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Mechanical Electrical and Information EngineeringShandong UniversityWeihai 264209China

Metallic glasses (MGs) have been found to exhibit unexpected ultrasonic-vibration-induced plasticity (UVIP),which provides a promising way to realize room temperature processing and molding of ***,whether all MGs poss... 详细信息

关键词： glasses metallic plasticity

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Effect of trace boron on grain refinement of commercially pure aluminum by Al-5Ti-1B

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Transactions of Nonferrous Metals Society of China 2022年第4期32卷 1061-1069页

作者： Fei XIAO Ming-xu WU Yi-xiao WANG wen-zhe zhou Shu-bin WANG Dong-hong WANG Guo-liang ZHU Michael JIANG Da SHU Jia-wei MI Bao-de SUN Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming and State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Engineering Research Center of Light Alloy Net Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shenzhen Almate Inc. Shenzhen 518102China School of Engineering and Computer Science University of HullHullHU67RXUK

The effect of boron content on grain refinement of commercially pure aluminum by Al-5Ti-1B was quantitatively *** the boron content is less than 0.03 wt.%,the refining performance of Al-5Ti-1B gradually is weakened as the boron content increases,which is attributed to the reaction of boron with the Al_(3)Ti interlayer on TiB_(2)and the consumption of solute *** the contrary,when the boron content exceeds 0.03 wt.%,the refining performance of Al-5Ti-1B gradually recovers with increasing boron content,which is related to the formation of primary AlB_(2)particles that provide additional nucleant substrates.

关键词： aluminum alloy casting Al-5Ti-1B grain refinement boron treatment nucleation

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Persistence of charge density wave against variation of band structures in V_(x)Ti_(1−x)Se_(2)(x=0–0.1)

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Nano Research 2024年第3期17卷 2129-2135页

作者： Zhanfeng Liu Tongrui Li wen Zhu Hongwei Shou Mukhtar Lawan Adam Qilong Cui Yuliang Li Sheng Wang Yunbo Wu Hongen Zhu Yi Liu Shuangming Chen Xiaojun Wu Shengtao Cui Li Song zhe Sun National Synchrotron Radiation Laboratory CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230029China CAS Key Laboratory of Strongly-coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China School of Chemistry and Materials Sciences CAS Key Laboratory of Materials for Energy Conversionand CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230026China School zhejiang Institute of Photonelectronics Jinhua 321004China

Charge density wave(CDW)is a phenomenon that occurs in materials,accompanied by changes in their intrinsic electronic *** study of CDW and its modulation in materials holds tremendous significance in materials research,as it provides a unique approach to controlling the electronic properties of ***_(2) is a typical layered material with a CDW phase at low *** V substitution for Ti in TiSe_(2),we tuned the carrier concentration in V_(x)Ti_(1-x)Se_(2) to study how its electronic structures ***-resolved photoemission spectroscopy(ARPES)shows that the band-folding effect is sustained with the doping level up to 10%,indicating the persistence of the CDW phase,even though the band structure is strikingly different from that of the parent compound TiSe_(2).Though CDW can induce the band fold effect with a driving force from the perspective of electronic systems,our studies suggest that this behavior could be maintained by lattice distortion of the CDW phase,even if band structures deviate from the electron-driven CDW *** work provides a constraint for understanding the CDW mechanism in TiSe_(2),and highlights the role of lattice distortion in the band-folding effect.

关键词： charge density wave band structure lattice distortion

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Esophageal cancer screening,early detection and treatment:Current insights and future directions

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1180-1191页

作者： Hong-Tao Qu Qing Li Liang Hao Yan-Jing Ni wen-Yu Luan zhe Yang Xiao-Dong Chen Tong-Tong Zhang Yan-Dong Miao Fang Zhang Department of Emergency Yantai Mountain HospitalYantai 264000Shandong ProvinceChina Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2nd Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival *** to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 *** 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and *** cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local ***,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United *** role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of *** effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated *** variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer *** areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive *** techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal *** screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer.

关键词： Esophageal cancer Screening Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection

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种业公司目标市场需求调研与战略制定分析

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分子植物育种 2024年第1期22卷 318-322页

作者：温哲内蒙古开放大学呼和浩特010011

本研究以种子产业为研究对象,探讨了种业公司如何通过需求调研和战略制定,来更好地满足目标市场的需求。本研究对全球种子市场进行了概述,分析了其主要特点和需求,深入探讨了种业公司在选择目标市场时需要考虑的主要因素,以及进行需求... 详细信息

本研究以种子产业为研究对象,探讨了种业公司如何通过需求调研和战略制定,来更好地满足目标市场的需求。本研究对全球种子市场进行了概述,分析了其主要特点和需求,深入探讨了种业公司在选择目标市场时需要考虑的主要因素,以及进行需求调研和战略制定的主要方法。通过分析,本研究发现需求调研和战略制定在种业公司满足目标市场需求和提升竞争力中起到了关键作用。最后,本研究对未来的研究提出了建议,包括扩大研究范围,深入探讨消费者行为模式,关注新兴市场和技术,以及注重可持续发展等,以期能为种业公司更好地满足目标市场需求并制定有效的市场策略提供理论支持和实践指导,这对于种业公司的发展具有重要的参考价值。

关键词：种业公司目标市场需求调研战略制定全球种子市场

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纳米线电卡效应的表面应力与固溶改性相场模拟

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物理学报 2024年第10期73卷 50-58页

作者：邹幸朱哲方文啸湘潭大学材料科学与工程学院湘潭411100 中山大学集成电路学院深圳518107

以铁电纳米线为填料的复合薄膜表现出了满足固态制冷需求的高绝热温变,其平行分布填充的纳米线因和传统垂直分布的取向不同,被认为是获得大电卡效应的关键因素,然而其大电卡效应的内在机理尚不十分明确.因此本文以PbTiO_(3)纳米线为研... 详细信息

以铁电纳米线为填料的复合薄膜表现出了满足固态制冷需求的高绝热温变,其平行分布填充的纳米线因和传统垂直分布的取向不同,被认为是获得大电卡效应的关键因素,然而其大电卡效应的内在机理尚不十分明确.因此本文以PbTiO_(3)纳米线为研究对象,建立平行分布纳米线模型,通过相场模拟研究表面应力和固溶改性对其电卡效应的影响.结果表明,表面应力和固溶改性能够分别调控纳米线相变温度并获取大的绝热温变,并最终实现了在600 kV/cm电场下,0-300℃的宽温度区间获得大于6 K绝热温变的效果.同时结合三维畴结构的演变,揭示了诱发不同畴翻转类型是平行分布纳米线结构获得大电卡效应的内在机理.通过本研究为基于平行分布铁电纳米线电卡效应的固态制冷技术发展提供了有益的理论指导.

关键词：电卡效应纳米线表面应力固溶改性

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论康德的道德人类学:方案、方法与方向

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湖北大学学报（哲学社会科学版） 2024年第3期51卷 22-29页

作者：潘文哲昆明理工大学马克思主义学院云南昆明650000

道德人类学是康德实践哲学的重要部分,然而其在体系方面的必要性和在内容方面的丰富性尚待进一步挖掘。从总体方案上看,道德人类学构成实践哲学的应用环节,是道德形而上学的方法论:它一方面为道德形而上学的形式性原则提供必要的质料性... 详细信息

道德人类学是康德实践哲学的重要部分,然而其在体系方面的必要性和在内容方面的丰富性尚待进一步挖掘。从总体方案上看,道德人类学构成实践哲学的应用环节,是道德形而上学的方法论:它一方面为道德形而上学的形式性原则提供必要的质料性条件,使先验道德法则能够在人性中得到贯彻,构成现实的道德经验;另一方面有助于实践理性克服干扰,与诸能力相互配合,作出准确的道德判断。从具体方法上看,道德人类学在先验哲学的框架下提供了基于“同时是义务的目的”的属人义务推导方法、基于良知的内在道德评价方法、基于情感的促进道德判断的主观方法,这些内容构成一种相对完备的道德判断力理论,从而在层次上丰富了实践哲学。基于道德人类学的定位与内容的独特性,康德为后世“人类学化”哲学研究和“道德化”人类学研究提供了可供探索的开放性路径。

关键词：康德道德人类学道德判断力良知道德情感

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