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Diagnosis and treatment of an inborn error of bile acid synthesis type 4:A case report

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World Journal of Clinical Cases 2021年第26期9卷 7923-7929页

作者： Shou-Hao Wang Tian-Chen Hui zhe-wen zhou Cheng-An Xu wen-Hao Wu Qing-Qing Wu Wei zheng Qiao-Qiao Yin Hong-Ying Pan zhejiang Provincial People’s Hospital Qingdao UniversityHangzhou 310014Zhejiang ProvinceChina Department of Infectious Diseases Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Inborn error of bile acid synthesis type 4 is a peroxisomal disease with impaired bile acid synthesis caused by a-methylacyl-CoA racemase(AMACR)gene *** disease is usually found in children with mild to severe liver disease,cholestasis and poor fat-soluble vitamin *** present,there is no report of inborn errors of bile acid synthesis type 4 in adults with liver disease and poor fat-soluble vitamin *** SUMMARY A 71-year-old man was hospitalized in our department for recurrent liver *** clinical manifestations were chronic liver disease and yellow skin and *** transaminase,bilirubin and bile acid were abnormally increased;and fat-soluble vitamins *** cirrhosis and ascites were diagnosed by computed *** patient had poor coagulation function and ascites and did not undergo liver *** testing showed AMACR gene missense *** patient was diagnosed with inborn error of bile acid synthesis type *** was treated with ursodeoxycholic acid,liver protection and vitamin supplementation,and jaundice of the skin and sclera was *** indicators of liver function and the quality of life were significantly *** When adults have recurrent liver function abnormalities,physicians should be alert to genetic diseases and provide timely treatment.

关键词： Bile acid synthesis A-methylacyl-CoA racemase gene Gene mutation Inborn error of metabolism Ursodeoxycholic acid Case report

Pneumocystis jirovecii and Legionella pneumophila coinfection in a patient with diffuse large B-cell lymphoma:A case report

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World Journal of Clinical Cases 2021年第28期9卷 8595-8601页

作者： wen-Hao Wu Tian-Chen Hui Qing-Qing Wu Cheng-An Xu zhe-wen zhou Shou-Hao Wang Wei zheng Qiao-Qiao Yin Xi Li Hong-Ying Pan Department of Infectious Diseases Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Medical College Qingdao UniversityQingdao 266071Shandong ProvinceChina Centre of Laboratory Medicine Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a common non-Hodgkin's lymphoma.R-CHOP is a protocol for long-term chemotherapy for DLBCL *** chemotherapy can lead to low immunity and increase the risk of opportunistic pathogen infections in immunocompromised *** SUMMARY We report a case of coinfection with Pneumocystis jirovecii(***)and Legionella pneumophila(***)in a patient with *** patient was a 40-year-old female who was diagnosed with DLBCL and was admitted due to pulmonary *** and *** were detected in her bronchoalveolar lavage fluid by hexamine silver staining,isothermal amplification and metagenomic *** To the best of our knowledge,this is the first case of *** and *** coinfection found in a DLBCL *** should be aware of the risk of complicated infection in patients undergoing long-term chemotherapy.

关键词： Legionella pneumophila Pneumocystis jirovecii Next-generation sequencing Diffuse large B-cell lymphoma Case report

Distributed dynamic task allocation for unmanned aerial vehicle swarm systems:A networked evolutionary game-theoretic approach

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Chinese Journal of Aeronautics 2024年第6期37卷 182-204页

作者： zhe ZHANG Ju JIANG Haiyan XU wen-An ZHANG College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China

Task allocation is a key aspect of Unmanned Aerial Vehicle(UAV)swarm collaborative *** an continuous increase of UAVs’scale and the complexity and uncertainty of tasks,existing methods have poor performance in computing efficiency,robustness,and realtime allocation,and there is a lack of theoretical analysis on the convergence and optimality of the *** paper presents a novel intelligent framework for distributed decision-making based on the evolutionary game theory to address task allocation for a UAV swarm system in uncertain scenarios.A task allocation model is designed with the local utility of an individual and the global utility of the ***,the paper analytically derives a potential function in the networked evolutionary potential game and proves that the optimal solution of the task allocation problem is a pure strategy Nash equilibrium of a finite strategy ***,a PayOff-based Time-Variant Log-linear Learning Algorithm(POTVLLA)is proposed,which includes a novel learning strategy based on payoffs for an individual and a time-dependent Boltzmann *** former aims to reduce the system’s computational burden and enhance the individual’s effectiveness,while the latter can ensure that the POTVLLA converges to the optimal Nash equilibrium with a probability of *** simulation results show that the approach is optimal,robust,scalable,and fast adaptable to environmental changes,even in some realistic situations where some UAVs or tasks are likely to be lost and increased,further validating the effectiveness and superiority of the proposed framework and algorithm.

关键词： Task allocation Unmanned Aerial Vehicles(UAV) Game theory Log-linear learning Distributed optimization algorithm

Effect of nano-carbon black content on wetting phenomenon of molten steel and alumina-carbon ceramic filter substrates

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Journal of Iron and Steel Research International 2024年第8期31卷 1900-1913页

作者： Jin-wen Song wen Yan zhe Chen Ying Liu Shao-song Hong The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina National-provincial Joint Engineering Research Center of High Temperature Materials and Lining Technology Wuhan University of Science and TechnologyWuhan 430081HubeiChina Jiangsu Sheng Nai New Materials Co. Ltd.Taizhou 225503JiangsuChina

The effect of nano-carbon black content(O,8 and 12 wt.%)on the wettability of molten steel on Al_(2)O_(3)-C substrates was investigated by the sessile drop wetting method at 1500℃ under argon *** the beginning of the wetting experiment,the contact angle decreased with the increase in nano-carbon black *** the wetting experiment progressed,FeAl_(2)0_(4) layer and sheet Al_(2)O_(3) layer were found at the interface between the molten steel and the Al_(2)O_(3)-C substrates with O and 8 wt.% nano-carbon black content,and the contact angle deceased with *** the content of nano-carbon black was 12 wt.%,a large number of nano-Al_(2)O_(3) whiskers were observed,which made the contact angle between the molten steel and Al_(2)O_(3)-C substrate become *** on the scanning electron microscope and energy dispersive spectrometry results,the formation mechanism of FeAl2O4 layer and Al_(2)O_(3) layer and the interfacial reaction mechanism were proposed.

关键词： Contact angle Nano-carbon black Al_(2)O_(3)-C substrate Molten steel Interfacial reaction

Index-free triangle-based graph local clustering

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Frontiers of Computer Science 2024年第3期18卷 143-153页

作者： zhe YUAN zhewei WEI Fangrui LV Ji-Rong wen The Country and Area Studies Academy Beijing Foreign Studies UniversityBeijing 100089China Gaoling School of Artificial Intelligence Renmin University of ChinaBeijing 100872China

Motif-based graph local clustering(MGLC)is a popular method for graph mining tasks due to its various ***,the traditional two-phase approach of precomputing motif weights before performing local clustering loses locality and is impractical for large *** some attempts have been made to address the efficiency bottleneck,there is still no applicable algorithm for large scale graphs with billions of *** this paper,we propose a purely local and index-free method called Index-free Triangle-based Graph Local Clustering(TGLC^(*))to solve the MGLC problem w.r.t.a ***^(*)directly estimates the Personalized PageRank(PPR)vector using random walks with the desired triangleweighted distribution and proposes the clustering result using a standard sweep *** demonstrate TGLC^(*)’s scalability through theoretical analysis and its practical benefits through a novel visualization ***^(*)is the first algorithm to solve the MGLC problem without precomputing the motif *** experiments on seven real-world large-scale datasets show that TGLC^(*)is applicable and scalable for large graphs.

关键词： graph local clustering triangle motif index-free sampling method visualization

Lnc524369 promotes hepatocellular carcinoma progression and predicts poor survival by activating YWHAZ-RAF1 signaling

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 253-264页

作者： Wei zheng Guo-Liang Shen Ke-Yang Xu Qiao-Qiao Yin Tian-Chen Hui zhe-wen zhou Cheng-An Xu Shou-Hao Wang wen-Hao Wu Ling-Fei Shi Hong-Ying Pan Department of Clinical Medicine Medical College of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Infectious Diseases Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Hepatobiliary&Pancreatic Surgery and Minimally Invasive Surgery Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina School of Chinese Medicine Hongkong Baptist universityHong Kong 999777China Department of Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Second Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Medical Department of Qingdao University Qingdao UniversityQingdao 266071ShandongChina Diagnosis and Treatment Center of Osteoporosis Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHang Zhou 310014Zhejiang ProvinceChina

BACKGROUND Liver cancer is one of the most highly malignant cancers,characterized by easy metastasis and chemoradiotherapy *** evidence indicates that long noncoding RNAs(LncRNAs),including Lnc524369,are highly involved in the initiation,progression,radioresistance,and chemoresistance of hepatocellular carcinoma(HCC).However,the function of Lnc524369 remains *** To explore the function of Lnc524369 in *** To investigate the effect of Lnc524369,tissue from 41 HCC patients were analyzed using CCK8,migration,and invasion ***524369 and YWHAZ(also named 14-3-3ζ)mRNA were detected by qPCR,and YWHAZ and RAF1 proteins were detected by western blot in liver cancer cell lines and human HCC *** Cancer Cell Line Encyclopedia(CCLE)databases,STRING database,Human Protein Atlas database,and the TCGA database were used for bioinformatic *** Lnc524369 was significantly upregulated in the nucleus of liver cancer cells and human HCC *** of Lnc524369 was associated with the proliferation,migration,and invasion of liver cancer *** and RAF1 proteins and YWHAZ mRNA were overexpressed in liver cancer,which could be attenuated by overexpression of ***524369 and its downstream target YWHAZ and RAF1 proteins were negatively associated with overall survival *** Lnc524369 might be a promising target of HCC as it can enhance liver cancer progression and decrease the overall survival time of HCC by activating the YWHAZ/RAF1 pathway.

关键词： Long noncoding RNAs Lnc524369 Hepatocellular carcinoma YWHAZ RAF1

Porous nanofibrous dressing enables mesenchymal stem cell spheroid formation and delivery to promote diabetic wound healing

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Chinese Journal of Chemical Engineering 2024年第4期68卷 156-164页

作者： Kexin Zhang wenmin Zhang Heng An zhe Huang Yanzhen wen Xiangyu Jiao Yongqiang wen College of Chemical Engineering and Technology Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research InstituteSchool of Chemistry&Biological EngineeringUniversity of Science&Technology BeijingBeijing 100083China

Delayed and nonhealing of diabetic wounds imposes substantial economic burdens and physical pain on *** stem cells(MSCs)promote diabetic wound *** when MSCs aggregate into multicellular spheroids,their therapeutic effect is ***,traditional culture platforms are inadequate for the efficient preparation and delivery of MSC spheroids,resulting in inefficiencies and inconveniences in MSC spheroid *** this study,a three-dimensional porous nanofibrous dressing(NFD)is prepared using a combination of electrospinning and homogeneous *** thermal crosslinking,the NFD not only achieves satisfactory elasticity but also maintains notable *** the design of its structure and chemical composition,the NFD allows MSCs to spontaneously form MSC spheroids with controllable sizes,serving as MSC spheroid delivery systems for diabetic wound *** importantly,MSC spheroids cultured on the NFD exhibit improved secretion of vascular endothelial growth factor,basic fibroblast growth factor,and hepatocyte growth factor,thereby accelerating diabetic wound *** NFD provides a competitive strategy for MSC spheroid formation and delivery to promote diabetic wound healing.

关键词： Electrospinning Homogenization Biomedical engineering Nanomaterials Stem cell spheroids Diabetic wound healing

Biological sources, paleoenvironment, and organic matter enrichment in source rocks of the Ordovician Majiagou Formation, Ordos Basin, China:Evidence from biomarkers,microfossils, and inorganic geochemical analyses

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Journal of Palaeogeography 2024年第1期13卷 92-115页

作者： Jing-Jing Cao wen-zhe Gang Shang-Ru Yang State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Bejing)Beijing 102249China College of Geosciences China University of Petroleum(Bejing)Beijing 102249China Oil and Gas Technology Research Institute PetroChina Changqing Oifield CompanyXi'an 710018Shaanxi ProvinceChina

Carbonate deposits in the Ordovivian Majiagou Formation are significant source rocks for natural gas generation in the Ordos Basin, northwestern China. Previous studies mainly focused on the organic matter enrichment mechanism of shales rather than carbonate rocks. The biological sources and paleoenvironment of carbonate source rocks, and the main controlling factors of organic matter enrichment in the carbonate source rocks were studied in this paper in combination with evidence from biomarkers, microfossils and inorganic geochemistry analysis. The results show that four types of microfacies were identified in the Majiagou Formation, respectively as: mud flat microfacies, mud-dolomite flat microfacies, dolomite flat microfacies, and open marine microfacies. The biological sources of organic matter are chiefly planktonic algae, followed by bacteria. The mud flat and mud-dolomite flat contain a high abundance of terrigenous detrital inputs, as indicated by the high content of Al_(2)O_(3), TiO_(2), Th, and Zr. The low Sr/Cu and high Rb/Sr values reveal warm and humid paleoclimate conditions in the mud flat and mud-dolomite flat, whereas the dolomite flat and open marine were likely formed in hot and arid paleoclimate conditions. The mud flat and mud-dolomite flat deposits were characterized by high paleoproductivity of the Majiagou Formation. Low Sr/Ba values were found in the mud flat samples, indicating fresh to brackish water condition, whereas samples of other facies have a relatively high degree of salinity. Based on U_(auth), Mo_(auth), Cr_(auth), Co_(auth), δCe, and δEu values, the mud flat microfacies was formed in a suboxic and anoxic environment, whereas the mud-dolomite flat, dolomite flat and open marine microfacies were within dysoxic to oxic conditions. A model of organic matter enrichment in the Majiagou Formation is thus established. The level of terrigenous detrital inputs is the principal factor of organic matter enrichment in the Majiagou Formation,

关键词： Biological source Microfacies Trace elements Organic matter Majiagou Formation Ordos Basin

Pressure-induced color change arising from transformation between intra-and inter-band transitions in LuH_(2±x)N_(y)

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 161-166页

作者： zhe Liu Yingjie Zhang Shenyang Huang Xue Ming Qing Li Chenghao Pan Yaomin Dai Xiaoxiang zhou Xiyu Zhu Hugen Yan Hai-Hu wen Center for Superconducting Physics and Materials National Laboratory of Solid State Microstructures and Department of PhysicsNational Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China State Key Laboratory of Surface Physics Key Laboratory of Micro and Nano-Photonic Structures of the Ministry of EducationDepartment of PhysicsFudan UniversityShanghai 200433China

The pressure-induced color change in the nitrogen-doped lutetium hydride has triggered extensive discussions about the underlying physics and potential ***,we study the optical response of LuH_(2±x)N_(y)in a broad frequency range at ambient pressure and its evolution with pressure in the visible spectral *** broad-band optical spectra at ambient pressure reveal a Drude component associated with intra-band electronic transitions and two Lorentz components(L1 and L2)arising from inter-band electronic *** application of pressure causes a spectral weight transfer from L1 to the Drude component,leading to a blue shift of the plasma edge in the reflectivity spectrum alongside a reduction of the high-frequency *** results suggest that the pressure-induced color change in LuH_(2±x)N_(y)is closely related to the transformation between intra-and inter-band electronic transitions,providing new insights into the mechanism of the pressure-induced color change in LuH_(2±x)N_(y).

关键词： nitrogen-doped lutetium hydride optical spectroscopy high-pressure technique color change