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Ultra-lightweight CNN design based on neural architecture search and knowledge distillation: A novel method to build the automatic recognition model of space target ISAR images

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Defence Technology（防务技术） 2022年第6期18卷 1073-1095页

作者： Hong Yang Ya-sheng Zhang Can-bin Yin wen-zhe ding Space Engineering University Beijing101416China Beijing Institute of Tracking and Telecommunications Technology China

In this paper,a novel method of ultra-lightweight convolution neural network(CNN)design based on neural architecture search(NAS)and knowledge distillation(KD)is *** can realize the automatic construction of the space target inverse synthetic aperture radar(ISAR)image recognition model with ultra-lightweight and high *** method introduces the NAS method into the radar image recognition for the first time,which solves the time-consuming and labor-consuming problems in the artificial design of the space target ISAR image automatic recognition model(STIIARM).On this basis,the NAS model’s knowledge is transferred to the student model with lower computational complexity by the flow of the solution procedure(FSP)distillation ***,the decline of recognition accuracy caused by the direct compression of model structural parameters can be effectively avoided,and the ultralightweight STIIARM can be *** the method,the Inverted Linear Bottleneck(ILB)and Inverted Residual Block(IRB)are firstly taken as each block’s basic structure in *** the expansion ratio,output filter size,number of IRBs,and convolution kernel size are set as the search parameters to construct a hierarchical decomposition search ***,the recognition accuracy and computational complexity are taken as the objective function and constraint conditions,respectively,and the global optimization model of the CNN architecture search is ***,the simulated annealing(SA)algorithm is used as the search strategy to search out the lightweight and high accuracy STIIARM *** that,based on the three principles of similar block structure,the same corresponding channel number,and the minimum computational complexity,the more lightweight student model is designed,and the FSP matrix pairing between the NAS model and student model is ***,by minimizing the loss between the FSP matrix pairs of the NAS model and student model,the student model’s weight adjust

关键词： Space target ISAR image Neural architecture search Knowledge distillation Lightweight model

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong wen Minna Liu Yi ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou zhe-Yi Han Jun Xiao Jian-Feng Ma wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao ding Yuan-Yuan Fang wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics

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Ultra-lightweight CNN design based on neural architecture search and knowledge distillation:A novel method to build the automatic recognition model of space target ISAR images

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Defence Technology 2022年第6期

作者： Hong Yang Ya-sheng Zhang Can-bin Yin wen-zhe ding

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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-wen ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第02期 325-334页

作者： Xinguang Zhu Chenxi ding zhe Sui Hong Su Xu Guo School of Civil and Resources Engineering University of Science and Technology Beijing Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of Sciences School of Mechanics and Civil Engineering China University of Mining and Technology (Beijing) School of Chemical and Blasting Engineering Anhui University of Science and Technology

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock fragmentation. It involves analyses of the evolution patterns of blasting stress, characteristics of crack distribution, and rock fracture features in the specimens. First, blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock mass. The experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock mass. Subsequently, the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum–discontinuum element method(CDEM) and the Landau explosion source model, with varying thicknesses of bottom cushion layers. The numerical simulation results indicate that with increasing cushion thickness, the absorption of energy generated by the explosion becomes more pronounced, resulting in fewer cracks in the bottom rock mass. This illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

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A DYNAMIC ALLOCATION MODEL FOR MEDICAL RESOURCES IN THE CONTROL OF INFLUENZA DIFFUSION

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Journal of Systems Science and Systems Engineering 2015年第3期24卷 276-292页

作者： Ming Liu zhe Zhang ding Zhang Department of Management Science and Engineering Nanjing University of Science and Technology School of Business State University of New York

In this paper, we develop a unique time-varying forecasting model for dynamic demand of medical resources based on a susceptible-exposed-infected-recovered （SEIR） influenza diffusion model. In this forecasting mechanism, medical resources allocated in the early period will take effect in subduing the spread of influenza and thus impact the demand in the later period. We adopt a discrete time-space network to describe the medical resources allocation process following a hypothetical influenza outbreak in a region. The entire medical resources allocation process is constructed as a multi-stage integer programming problem. At each stage, we solve a cost minimization sub-problem subject to the time-varying demand. The corresponding optimal allocation result is then used as an input to the control process of influenza spread, which in turn determines the demand for the next stage. In addition, we present a comparison between the proposed model and an empirical model. Our results could help decision makers prepare for a pandemic, including how to allocate limited resources dynamically.

关键词： Time-varying demand medical resources influenza diffusion time-space network

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A Note on Critical p-adic L-functions

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Acta Mathematica Sinica,English Series 2021年第1期37卷 121-141页

作者： Yi wen ding Bejing International Center for Mathematical Research Peking UniversityBeijing 100871P.R.China

We study the adjunction property of the Jacquet–Emerton functor in certain neighborhoods of critical points in the *** an application,we construct two-variable p-adic L-functions around critical points via Emerton’s... 详细信息

关键词： p-adic L-function eigencurve critical p-stabilization Jacquet–Emerton functor

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Ultrafast magnetization enhancement and spin current injection in magnetic multilayers by exciting the nonmagnetic metal

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Science China(Physics,Mechanics & Astronomy) 2023年第12期66卷 158-168页

作者： wen-Tian Lu zhe Yuan Xiaohong Xu Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China

A systematic investigation of spin injection behavior in Au/FM(FM=Fe and Ni)multilayers is performed using the superdiffusive spin transport *** exciting the nonmagnetic layer,the laser-induced hot electrons may transfer spin angular momentum into the adjacent ferromagnetic(FM)metals resulting in ultrafast demagnetization or *** find that these experimental phenomena sensitively depend on the particular interface reflectivity of hot electrons and may reconcile the different observations in the *** by the ultrafast spin currents carried by the hot electrons,we propose the multilayer structures to generate highly spin-polarized currents for the development of future ultrafast spintronics *** spin polarization of the electric currents carried by the hot electrons can be significantly enhanced by the joint effects of bulk and interfacial spin ***,the intensity of the generated spin current can be optimized by varying the number of repeated stacking units and the thickness of each metallic layer.

关键词： spintronics ultrafast magnetodynamics spin polarization transport magnetic multilayer

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