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Activation of the Akt/mTOR signaling pathway:a potential response to long-term neuronal loss in the hippocampus after sepsis

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Neural Regeneration Research 2017年第11期12卷 1832-1842页

作者： Jia-nan Guo Lin-yu Tian wen-yu liu lie Mu Dong Zhou Department of Neurology West China HospitalSichuan UniversityChengduSichuan ProvinceChina

Survivors of sepsis may suffer chronic cognitive impairment as a long-term sequela. However, the precise mechanisms of cognitive dys- function after sepsis are not well understood. We employed the cecal ligation-and-puncture-induced septic mouse model. We observed elevated phosphorylation of Akt, mammalian target of rapamycin （roTOR） and p70S6K on days 14 and 60, progressive neuronal loss in the cornu ammonis 1 region, and abnormal neuronal morphology in the hippocampus in the sepsis mouse model, These findings indicate that changes in neuronal morphology and number in the hippocampus after sepsis were associated with strong activation of the Akt/mTOR sig- naling pathway, and may reflect a ＂self-rescuing＂ feedback response to neuronal loss after sepsis.

关键词： nerve regeneration sepsis cognitive impairment Akt mTOR p 7OS6K hippocampus neurons phosphorylation neural hypertrophy neural regeneration

Kinetics and Mechanism of Iridium(Ⅲ)-Catalyzed Oxidation of Ethanol Amine by Cerium(Ⅳ) in Sulfuric Acid Media

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Chemical Research in Chinese Universities 2007年第3期23卷 333-338页

作者： ZHAI Yong-qing liu Hong-mei YANG Lin YANG Guo-zhong SONG wen-yu liu yu-kai College of Chemistry and Environmental Science Hebei University Baoding 071002 P. R. China

In this study, the kinetics and mechanism of the iridium（ Ⅲ ） -catalyzed oxidation of ethanol amine（EAN） by cerium（Ⅳ） in a sulfuric acid medium was investigated using titrimetric technique of redox in a temperature range of 298--313 K. It was found that the reaction is of first order with respect to Ce（ Ⅳ ） and It（ Ⅲ ）, and a positive fractional order with respect to EAN. It was also found that the pseudo-first-order （ [EAN ] 〉〉 [ Ce （ Ⅳ） ] ） rate constant koba decreases with the increase of [ H^＋ ] and [ HSO^-4 ]. Under the protection of nitrogen gas, the reaction system can initiate the polymerization of acrylonitrile, indicating the generation of free radicals. On the basis of the experimental results, a suitable mechanism was proposed. From the dependence of koba on the concentration of hydrogen sulfate, Ce（SO4）2 was found to be the kinetically active species. The rate constants of the rote-determining step together with the activation parameters were evaluated.

关键词： Iridium(Ⅲ) ion Cerium(Ⅳ) ion Ethanol amine Catalytic oxidization Kinetics and mechanism

Dual versus single antiplatelet therapy for patients with long-term oral anticoagulation undergoing coronary intervention： a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2017年第12期14卷 725-736页

作者： Jing-Jing WU Chan ZOU wen-yu liu Guo-Ping YANG Center of Clinical Pharmacology the Third Xiangya Hospital Central South University Changsha Hunan China College of Pharmacy Central South University Changsha Hunan China

Objective The main aim of this meta-analysis is to compare the efficacy and safety of dual versus single antiplatelet therapy for pa- tients taking oral anticoagulation （OAC） after coronary intervention. Background The optimal regimen remains controversial for patients taking OAC after coronary intervention. Methods PubMed, Embase and Cochrane Central Register of Controlled Trials were searched for eligible studies including data of triple therapy （TT） versus OAC plus single antiplatelet therapy for patients requiring OAC after coronary intervention. The primary outcome was major adverse cardiac and cerebrovascular event （MACCE）. The safety outcome was major bleeding. Results Fourteen studies with 32,825 patients were included. Among prospective studies, patients with TT had a trend toward a higher risk of major bleeding [odds ratios （OR）： 1.56, 95% confidence interval （CI）： 0.98-2.49, P = 0.06] and a markedly higher risk of all-cause death （OR; 2.11, 95% CI： 1.10-4.06 P = 0.02） compared with OAC plus clopidogrel. Meanwhile, TT was associated with decreased risks of MACCE （OR： 0.63, 95% CI： 051-0.77 P 〈 0.0001）, all-cause death （OR： 0.45, 95% CI： 0.20-0.97, P = 0.04）, and stroke/transient ischemic attack （TIA）/peripheral embolism （PE）（OR= 0.29, 95% CI： 0.09~3.96, P = 0.04） compared with OAC plus aspirin. Conclusions For pa- tients requiring OAC after coronary intervention, OAC plus clopidogrel may bring more clinical net benefit than TT, whereas OAC plus aspirin should be the last choice. More large-size randomized control trials are needed to confirm these findings.

关键词： Coronary intervention Dual therapy Efficacy Oral anticoagulation Safety Triple therapy

YOLOP:You Only Look Once for Panoptic Driving Perception

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Machine Intelligence Research 2022年第6期19卷 550-562页

作者： Dong Wu Man-wen Liao Wei-Tian Zhang Xing-Gang Wang Xiang Bai wen-Qing Cheng wen-yu liu Hubei Key Laboratory of Smart Internet Technology School of Electronic Information and CommunicationsHuazhong University of Science and TechnologyWuhan 430074China School of Electronic Information and Communication Huazhong University of Science and TechnologyWuhan 430074China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China

A panoptic driving perception system is an essential part of autonomous driving.A high-precision and real-time perception system can assist the vehicle in making reasonable decisions while *** present a panoptic driving perception network(you only look once for panoptic(YOLOP))to perform traffic object detection,drivable area segmentation,and lane detection *** is composed of one encoder for feature extraction and three decoders to handle the specific *** model performs extremely well on the challenging BDD100K dataset,achieving state-of-the-art on all three tasks in terms of accuracy and ***,we verify the effectiveness of our multi-task learning model for joint training via ablative *** our best knowledge,this is the first work that can process these three visual perception tasks simultaneously in real-time on an embedded device Jetson TX2(23 FPS),and maintain excellent *** facilitate further research,the source codes and pre-trained models are released at https://***/hustvl/YOLOP.

关键词： Driving perception multitask learning traffic object detection drivable area segmentation lane detection

Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters

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Chinese Chemical Letters 2021年第9期32卷 2765-2768页

作者： Wei Huang Ming-Liang Han yu-wen liu Hui Xu Hui-Xiong Dai School of Pharmacy Nanchang UniversityNanchang 330006China b Chinese Academy of Sciences Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Institute for Advanced Study Shenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

We report herein a palladium-catalyzed diarylative dearomatization of indole by employing thioester and arylboronic acid as the aryl *** reaction involved a decarbonylation/migratory insertion/terminal Suzuki coupling *** bearing various functional groups are well tolerated in the reaction,affording the diarylated indoline skeletons in moderate to good yields.

关键词： Thioester Decarbonylation Dearomatization Indolines skeleton Diarylation

Toxic epidermal necrolysis induced by ritodrine in pregnancy:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1381-1387页

作者： wen-yu liu Jia-Rong Zhang Xian-Ming Xu Tian-Yi Ye Department of Obstetrics and Gynecology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201600China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Preterm birth accounts for about 12%of all pregnancies worldwide and is the leading cause of neonatal morbidity and *** order to avoid premature birth and prolong gestational age,tocolytics are the first and the best *** is the most commonly used tocolytic ***,side effects such as pulmonary edema,hypokalemia,and hyperglycemia are *** we report a rare but serious side effect–toxic epidermal necrolysis(TEN)–caused by *** SUMMARY A woman(31 years,gravida 4,para 2)was hospitalized because of premature contractions at 27+6 wk of gestation.A skin rash with pruritus appeared at 32+3 wk of gestation after administration of ritodrine,indomethacin,and dexamethasone,and it spread throughout the whole body in 3 d,particularly the four *** 11 d’treatment,she was diagnosed with *** emergency cesarean section was performed immediately to deliver the baby and intensive symptomatic treatment was promptly commenced after *** recovered from the severe condition without any sequelae except for slight pigmentation after symptomatic *** When a skin rash appears during the administration of ritodrine,we are supposed to consider the risk of TEN.

关键词： Preterm birth Ritodrine Side effect Tocolytics Toxic epidermal necrolysis Case report

Filamin A Gene Associated Periventricular Nodular eterotopia and Epilepsy in a Cohort of Chinese Patients

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Chinese Medical Journal 2017年第20期130卷 2506-2507页

作者： wen-yu liu Dong Zhou Department of Neurology West China Hospital Sichuan University Chengdu Sichuan 610041 China

Periventricular nodular heterotopia （PNH） is a cortical malformation commonly found in epilepsy patients caused by the failure of neurons to *** with PNH present with various clinical manifestations and genetic mutations. Despite their remarkable structural malformations, PNH patients generally have no neurological deficits or cognitive disabilities. However, particularly in patients with abnormal cortical development, the systematic abnormalities can also be severely delayed.

关键词： Filamin A: Periventricular Nodular Heterotopia Phenotype Social Support

Psychometric validation of the Chinese version of the dry eye-related quality-of-life score questionnaire

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1614-1620页

作者： yu-wen liu Shu-Jia Guo Jia-Ni Li yu-Ting Zhang Wei-Jie Ouyang yu-Qian Wang Cai-Hong Huang Yi Liao Jiaoyue Hu Zuguo liu Xiamen University Affiliated Xiamen Eye Center Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceFujian Engineering and Research Center of Eye Regenerative MedicineEye Institute of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361005Fujian ProvinceChina Department of Ophthalmology the First Affiliated Hospital of University of South ChinaHengyang 421001Hunan ProvinceChina

AIM:To psychometrically validate the Chinese version of the dry eye-related quality-of-life score questionnaire(DEQSCHN)among Chinese patients with dry ***:This study involved 231 participants,including 191 with dry eye disease(DED)comprising the dry eye disease group,and 40 healthy participants forming the control *** were required to complete the DEQS-CHN,and Chinese dry eye questionnaire and undergo clinical tests including the fluorescein breakup time(FBUT),corneal fluorescein staining(CFS),and Schirmer I *** assess the internal consistency and retest reliability,Cronbach’sαand the intraclass correlation coefficient(ICC)were *** validity was assessed by item-level content validity index(ICV)and an average scale-level content validity index(S-CVI/Ave).Construct validity was assessed by confirmatory factor *** concurrent validity was assessed by calculating correlations between DEQS-CHN and Chinese dry eye *** validity was evaluated through nonparametric tests,with receiver operating characteristic(ROC)curve serving as conclusive indicators of the questionnaire’s distinguishing ***:The Cronbach’sαcoefficients for frequency and degree of ocular symptoms,impact on daily life,and summary score were 0.736,0.704,0.811,0.818,0.861,and 0.860,respectively,and the ICC were 0.611,0.677,0.715,0.769,0.711,and 0.779,*** I-CVI scores ranged from 0.833 to 1.000,with an S-CVI/Ave of *** factor analysis results exhibited a wellfitting model consistent with the original questionnaire[χ^(2)/df=2.653,incremental fit index(IFI)=0.924,comparative fit index(CFI)=0.924,Tucker-Lewis index(TLI)=0.909,and root mean square error of approximation(RMSEA)=0.065].There was a moderate positive correlation between the DEQS-CHN and the Chinese dry eye questionnaire(r^(2)=0.588).The dry eye group demonstrated significantly higher scores compared to the control group,and the area under

关键词： dry eye quality-of-life questionnaire

Study of tip vortex cavitation inception and vortex singing

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Journal of Hydrodynamics 2019年第6期31卷 1170-1177页

作者： Xiao-xing Peng Ling-xin Zhang Ben-long Wang Liang-hao Xu Ming-tai Song Yan-tao Cao yu-wen liu Fang-wen Hong Kai Yan National Key Laboratory on Ship Vibration and Noise China Ship Scientific Research CenterWuxi 214082China Department of Mechanics Zhejiang UniversityHangzhou 310027China Department of Engineering Mechanics Shanghai Jiao Tong UniversityShanghai 200240China

Tip vortex cavitation(TVC)is an important cavitation phenomenon in marine *** formation and evolution of tip vortex cavitation are hot topics consistently both in engineering application and mechanism *** this paper some recent studies on tip vortex cavitation inception and the noise of tip vortex cavitation evolution are *** effects of both flow field and water qualities on tip vortex cavitation inception are considered by experiments and numerical *** results show that besides the average minimum pressure in the vortex core the turbulence fluctuation and water qualities including air content and nuclei distribution have great influence on tip vortex cavitation *** on the idea of first nucleus cavitating in tip vortex core new prediction formula for tip vortex cavitation inception is *** synchronous technique of high speed video observation and noise measurement are adopted to study the development of tip vortex cavitation.S-type total noise characteristics are obtained when cavitation number from low to *** singing is found in the case where the tip vortex cavitation just before leaves the tip *** excited mechanism of vortex singing is proposed by analyzing the wave propagation on the interface of vortex cavity.

关键词： Tip vortex cavitation flow field water quality cavitation inception noise