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Active constituents and mechanisms of Respiratory Detox Shot, a traditional Chinese medicine prescription, for COVID-19 control and prevention: Network-molecular docking-LC–MS^E analysis

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Journal of Integrative Medicine 2020年第3期18卷 229-241页

作者： Zi-jia Zhang wen-yong wu Jin-jun Hou Lin-lin Zhang Fei-fei Li Lei Gao Xing-dong wu Jing-ying Shi Rong Zhang Hua-li Long Min Lei Wan-ying wu De-an Guo Kai-xian Chen Lewis A.Hofmann Zhong-hua Ci Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China World Health Science Organization LeesburgVA 20176USA

Objective: Lung-toxin Dispelling Formula No. 1, referred to as Respiratory Detox Shot(RDS), was developed based on a classical prescription of traditional Chinese medicine(TCM) and the theoretical understanding of herbal properties within TCM. Therapeutic benefits of using RDS for both disease control and prevention, in the effort to contain the coronavirus disease 2019(COVID-19), have been shown. However,the biochemically active constituents of RDS and their mechanisms of action are still unclear. The goal of the present study is to clarify the material foundation and action mechanism of ***: To conduct an analysis of RDS, an integrative analytical platform was constructed, including target prediction, protein–protein interaction(PPI) network, and cluster analysis;further, the hub genes involved in the disease-related pathways were identified, and the their corresponding compounds were used for in vitro validation of molecular docking predictions. The presence of these validated compounds was also measured in samples of the RDS formula to quantify the abundance of the biochemically active constituents. In our network pharmacological study, a total of 26 bioinformatic programs and databases were used, and six networks, covering the entire Zang-fu viscera, were constructed to comprehensively analyze the intricate connections among the compounds-targets-disease pathways-meridians of ***: For all 1071 known chemical constituents of the nine ingredients in RDS, identified from established TCM databases, 157 passed drug-likeness screening and led to 339 predicted targets in the constituent–target network. Forty-two hub genes with core regulatory effects were extracted from the PPI network, and 134 compounds and 29 crucial disease pathways were implicated in the target–constitu ent–disease network. Twelve disease pathways attributed to the Lung–Large Intestine meridians, with six and five attributed to the Kidney–Urinary Bladder and Stomach–Spleen meridian

关键词： Lung-toxin Dispelling Formula No.1 COVID-19 3C-like protease Network pharmacology Molecular docking Meridian tropism

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医用驻波电子直线加速器的微波系统

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高能物理与核物理 2007年第7期31卷 683-685页

作者：温勇武温旭刘建欣熊猫集团南京210014 南京威达天宇医疗器械有限公司南京210017

讨论医用驻波电子直线加速器的微波系统的信号传输、反射以及相位特性等,同时给出了加速器输出剂量率与微波相位关系的实验曲线．

关键词：直线加速器微波系统相位

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圆波导介质加载锁式铁氧体变极化器的实验研究

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电子学报 1999年第10期27卷 143-144页

作者：车文荃沙侃温勇武温俊鼎南京理工大学通信工程系南京210094

在实验基础上，本文给出圆波导锁式铁氧体变极化器的介质加载的研究结果．实验表明，在铁氧体环内适当加载介质，可明显提高器件的相移，而对插入损耗特性影响甚微．这一发现对改进器件性能。

关键词：变极化器圆波导介质加载

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Outcomes of using Firebird rapamycin eluting stents in routine coronary intervention practice: one-year results from the pilot study of Firebird in China registry

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Chinese Medical Journal 2006年第7期119卷 609-611页

作者： LIU Hai-bo XU Bo GAO Run-lin YANG Yue-jin YAO Min QIN Xue-wen wu yong-jian YUAN Jin-qing MA Wei-hua QIAO Shu-bin CHEN Ji-lin Cardiovascular Institute and Fuwai Hospital Chinese Academy ofMedical Sciences Peking Union Medical College Beijing 100037China

Recent clinical trials with rapamycin-eluting stents ,have shown very low restenosis ***, the higher penetration of drug eluting stent （DES） in China is being limited by the high costs of these imported devices, especially when considering multiple stenting. Firebird （Microport Co. Ltd., China） is a rapamycin （Huadong Pharmaceutical, China） polymer-based eluting stent with reasonable cost. The objective of this study was to evaluate the safety and efficacy of using Firebird stents in routine interventional practice.

关键词： stents clinical trial percutanous coronary intervention

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温胆汤合三子养亲汤加减治疗痰湿蕴肺咳嗽的临床研究

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云南中医中药杂志 2017年第3期38卷 24-26页

作者：温勇伍小涌南宁市第三人民医院广西南宁530003

目的观察温胆汤合三子养亲汤加减治疗痰湿蕴肺咳嗽的临床疗效。方法采用随机对照的研究方法,将痰湿蕴肺咳嗽患者93例随机分为治疗组(47例)和对照组(46例),治疗组采用温胆汤合三子养亲汤加减治疗,对照组采用西药治疗。两组均治疗7天,分... 详细信息

目的观察温胆汤合三子养亲汤加减治疗痰湿蕴肺咳嗽的临床疗效。方法采用随机对照的研究方法,将痰湿蕴肺咳嗽患者93例随机分为治疗组(47例)和对照组(46例),治疗组采用温胆汤合三子养亲汤加减治疗,对照组采用西药治疗。两组均治疗7天,分别在治疗前及治疗后收集相关数据,对咳嗽程度、咳嗽时间、咳痰量、复发率及临床疗效进行统计,比较两种疗法的差异。结果治疗组总有效率为85.11%,对照组总有效率为65.22%,差异有统计学意义(P<0.05);治疗组治疗后明显减轻患者咳嗽程度,减少咳嗽时间和咳痰量,降低复发率(P<0.05)。其中减轻咳嗽程度,减少咳痰量,降低复发率等疗效方面优于对照组(P<0.05)。结论温胆汤合三子养亲汤加减治疗痰湿蕴肺咳嗽疗效肯定,值得临床应用推广。

关键词：温胆汤三子养亲汤咳嗽痰湿蕴肺型

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饲料价格、加工价格、猪肉价格波动关系实证分析

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价格月刊 2017年第3期 47-52页

作者：陈哲蕊田文勇吴秀敏四川农业大学管理学院四川成都611130 铜仁学院经济管理学院贵州铜仁554300 四川农业大学商学院四川都江堰611830

采用2011年8月~2016年6月间我国饲料价格(以玉米、豆粕价格为代表)、加工价格与猪肉价格的月度数据,运用脉冲响应函数等方法分析三者之间的关系。结果表明:猪肉产业链中上游饲料价格波动是造成猪肉价格波动的主要因素,猪肉价格波动反作... 详细信息

采用2011年8月~2016年6月间我国饲料价格(以玉米、豆粕价格为代表)、加工价格与猪肉价格的月度数据,运用脉冲响应函数等方法分析三者之间的关系。结果表明:猪肉产业链中上游饲料价格波动是造成猪肉价格波动的主要因素,猪肉价格波动反作用于玉米价格;上游饲料价格波动与中游加工价格波动影响单向通畅;下游猪肉价格波动是引起中游加工价格变化的主要因素。基于结论提出保证玉米、豆粕的持续供应,加强屠宰加工与流通环节的管理,引导从业者理性决策,建立猪肉一体化生产体系等建议。

关键词：饲料价格加工价格猪肉价格波动关系

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Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang Linlin wu Wei Sun Hongliang Zhang Jianhua Chen yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

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永磁低速同步电动机应用技术概况

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微特电机 2001年第3期29卷 32-35页

作者：张文勇邬显光苏州电讯电机厂苏州215002

介绍了永磁低速同步电动机的基本工作原理、主要特点和典型的应用场合。

关键词：永磁低速同步电动机定子转子铁芯

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小型永磁直流无刷轴流风机概况

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微特电机 2001年第5期29卷 27-28,31页

作者：张文勇邬显光苏州电讯电机厂苏州215002

介绍了小型永磁直流无刷轴流风机的主要技术性能、技术发展趋势和在不同领域的使用情况 ,并论述了其近期国内外市场动态。

关键词：小型永磁直流无刷轴流风机市场发展趋势

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Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： wen Jin LIU Zhanzhi wu Zhengwei PAN Yu ZHANG Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

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