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Trichloroethylene Induces Biphasic Concentration-dependent Changes in Cell Proliferation and the Expression of SET-Associated Proteins in Human Hepatic L-02 Cells

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Biomedical and Environmental Sciences 2013年第7期26卷 618-621页

作者： HONG wen Xu YE Jin Bo CHEN Mou Tong YAN Yan ZHOU Gui Feng YANG Xi Fei YANG Liang REN Xiao Hu HUANG Hai Yan ZHOU Li HUANG Xin Feng zhuang Zhi Xiong LIU Jian Jun Key Laboratory of Modern Toxicology of Shenzhen Medical Key Laboratory of Guangdong Province Medical Key Laboratory of Health Toxicology of Shenzhen Shenzhen Center for Disease Control and Prevention Medical College Hunan Normal University Shenzhen Nanshan Center for Disease Control and Prevention

Trichloroethylene （TCE） is a major pollutant that affects both occupational and general environments. The liver is an important target organ of TCEE. Substantial efforts and remarkable progress into understanding TCE cytotoxicity have been made in cultured liver cells. However, the molecular mechanisms by which TCE induces hepatotoxicity are not well understood. SET （also known as protein phosphatase 2A inhibitor, 12PP2A, or template-activating factor-I, TAF-D is a nuclear protein that regulates histone modification, gene transcription, DNA replication, nucleosome assembly,

关键词： SET As TCE Trichloroethylene Induces Biphasic Concentration-dependent Changes in Cell Proliferation and the Expression of SET-Associated Proteins in Human Hepatic L-02 Cells

The Mechanism of CagA and VacA in Gastric Cancer under the Tumor Microenvironment and Vitro Factors

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Journal of Nutritional Oncology 2020年第2期5卷 59-70页

作者： Zhu Jiang Dai Hui wen Fang Jing Qiu Zhang Qi Wu Jia Ming Xu Han Jian Zhu Jin Gao zhuang zhuang Liu Dong Tang Dao Rong Wang Clinical Medical college Yangzhou UniversityYangzhou 225001JiangsuChina Department of General Surgery Institute of General SurgeryClinical Medical CollegeYangzhou UniversityYangzhou 225001JiangsuChina

Gastric cancer is closely related to the stomach microbiota,especially Helicobacter *** reports and clinical studies have shown that microbial behavior in the stomach may lead to pathological changes in the gastrointestinal tract of the host,which ultimately leads to the production and development of gastric *** review outlines the major pathogenic processes of Helicobacter pylori in the stomach,specifically focusing on Cag A,Vac A,inflammatory pathways and oxidative *** addition,we describe the effects of some non-Helicobacter pylori factors,such as other microbiota,alcohol,and tobacco,on the carcinogenesis induced by Helicobacter *** effects of family history are also taken into *** hope that understanding the stomach microbiota will make it possible to more easily prevent,detect and treat gastric cancer.

关键词： Microbiota Gastric cancer Helicobacter pylori CagA VacA Inflammatory pathway

Down-regulation of GY6 gene resulted in improved yield traits in indica rice

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Down-regulation of GY6 gene resulted in improved yield trait...

Spatial-Temporal Differentiation of Sustainable Development in Cities and Counties of Hainan Province

2014年中国作物学会学术年会

作者： Ma Huan ying Jiezheng Fan Yeyang Zhu Yujun Huang Derun zhuang Jieyun Chinese National Center for Rice Improvement/State Key Laboratory of Rice Biology China National Rice Research Institute College of life science Hebei Normal University

GY6 is a pleotropic gene conditioning heading date,number of grains per panicle,plant height and grain *** we report that decreased expression of GY6 caused by RNA interference(RNAi)technology could improve yield traits in *** vector was constructed with a double T-DNA binary vector ’p1102’ and transformed into a well-known indica cytoplasm male sterile restorer line ’Minghui86’mediated by *** expression of GY6 gene was validated by real-time polymerase chain reaction(PCR).Southern blot analysis of the transgenic rice was performed to confirm the presence and copy number of the GY6 RNAi *** asymmetric interlaced PCR was employed to determine the insertion sites of GY6 RNAi structure on rice *** with the wild type ’Minghui86’,heading date of the transgenic lines was significantly delayed for 13-17 days in T1 *** homozygous transgenic lines,TGY61,TGY62,TGY63,and the wild type were selected for a randomized compete design with three replications in the field in Zhejiang *** of rice inflorescence development with a stereomicroscope indicated that down-regulation of GY6 gene significantly prolonged the basic vegetative growth period of the transgenic lines,but showed a little effect on the regulation of the duration of panicle *** with the wild type,the transgenic lines,TGY61,TGY62 and TGY63 increased grain yield per plant by 6.5-6.9g.

关键词： rice(Oryza sativa) GY6 heading date yield traits gene regulation

来源： cnki会议评论

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Journal of Landscape Research 2018年第1期10卷 7-15页

作者： zhuang Haiyan School of Art Sanya University

A total of 18 cities and counties in Hainan from 2012 to 2015 were selected as the basic research units to construct an index system for evaluating the ability of sustainable development that includes four guidelines of economic development capacity, population development capacity, social support capacity, and resource utilization and environmental protection capacity. The improved entropy method was used to determine the weight, the Technique for Order of Preference by Similarity to Ideal Solution(TDPSIS) was used to calculate the capacity for sustainable development of the cities and counties and sort these cities and counties, and Arcgis10.2 was used to draw the provincewide distribution of the four guidelines. Thereupon, the author reached following conclusions: there was no big regional difference in the sustainable development capacity of cities and counties in Hainan, and they were basically in a general state of intermediate stage in the past four years; Haikou City and Sanya City, as the key cities, had a higher ability of sustainable development and had shown a remarkable capacity to drive the sustainable development of surrounding areas; according to the development level, the four guidelines were in the following order: resource utilization and environmental protection capacity, population development capacity, social support capacity, and economic development capacity.

关键词： Sustainable development Index system Evaluation Cities and counties Hainan

Novel Finite Difference Discretization of Interface Boundary Conditions for Stablized Explicit-Implicit Domain Decomposition Methods

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Journal of Applied Mathematics and Physics 2014年第6期2卷 397-404页

作者： Yu zhuang Computer Science Department Texas Tech University Lubbock Texas USA

Stabilized explicit-implicit domain decomposition is a group of methods for solving time-dependent partial difference equations of the parabolic type on parallel computers. They are efficient, stable, and highly parallel, but suffer from a restriction that the interface boundaries must not intersect inside the domain. Various techniques have been proposed to handle this restriction. In this paper, we present finite difference schemes for discretizing the equation spatially, which is of high simplicity, easy to implement, attains second-order spatial accuracy, and allows interface boundaries to intersect inside the domain.

关键词： Domain Decomposition Parallel Computing Unsteady Convection-Diffusion Equation Finite Difference

Forms vs. Contents： A Perspective View to the Evaluation of Learner＇s Errors in Written Discourse

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Sino-US English Teaching 2006年第2期3卷 44-51页

作者： Xin zhuang Zhejiang Gongshang University

This paper analyses the experiment carried out by Peter S. Green and Karlheinz Hecht about criteria towards error-analysis in writing. In order to define what a good writing is, it further investigates the relation between accuracy and communicative effectiveness by examining the difference between Chinese teachers and English teachers＇ rating two university students＇ written works to find out the EFL learners＇ dilemma. By comparing the evaluation in written works from both non-native teachers and native teachers, it emphasizes the importance of composition teachers＇ role in providing feedback to their students, and proper suggestions have been given out to solve the problems of motivation in EFL learners.

关键词： Writing motivation language accuracy communicative fluency error-correction

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大型船闸泵送混凝土自生体积变形规律研究

山西建筑 2024年第19期50卷 103-107页

作者：李晨曦庄维张伟钟胜魏海东安徽水安建设集团股份有限公司安徽合肥230000 三峡大学水利与环境学院湖北宜昌443002

为了研究大型船闸泵送混凝土自生体积变形变化规律,首先在船闸现场埋设了无应力计筒进行现场监测试验,并通过采集到的混凝土温度-应变实测资料,分析了早龄期泵送混凝土温度-应变变化规律;然后建立了混凝土无应力计测值统计模型表达式,... 详细信息

为了研究大型船闸泵送混凝土自生体积变形变化规律,首先在船闸现场埋设了无应力计筒进行现场监测试验,并通过采集到的混凝土温度-应变实测资料,分析了早龄期泵送混凝土温度-应变变化规律;然后建立了混凝土无应力计测值统计模型表达式,将统计模型系数估计转换为参数反演的数学优化模型,采用仿生算法反演分离出自生体积变形分量,进而分析了早龄期泵送混凝土自生体积变形变化规律。结果表明:混凝土应变随温度变化规律明显,混凝土温度上升,体积膨胀,温度下降,体积收缩,混凝土热膨胀系数均值为6.77×10^(-6)/℃;泵送混凝土自生体积变形为单调收缩型,12 d龄期时收缩值约为-46.09με。

关键词：泵送混凝土现场试验无应力计统计模型自生体积变形

Chromosome-scale assembly of the Kandelia obovata genome

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Horticulture Research 2020年第1期7卷 1823-1834页

作者： Min-Jie Hu Wei-Hong Sun wen-Chieh Tsai Shuang Xiang Xing-Kai Lai De-Qiang Chen Xue-Die Liu Yi-Fan Wang Yi-Xun Le Si-Ming Chen Di-Yang Zhang Xia Yu wen-Qi Hu zhuang Zhou Yan-Qiong Chen Shuang-Quan Zou Zhong-Jian Liu Key Laboratory of Humid Sub-tropical Eco-Geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350007China Fujian Colleges and Universities Engineering Research Institute of Conservation and Utilization of Natural Bioresources College of ForestryFujian Agriculture and Forestry UniversityFuzhou 350002China Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization at the College of Landscape Architecture Fujian Agriculture and Forestry UniversityFuzhou 350002China Institute of Tropical Plant Sciences and Microbiology National Cheng Kung UniversityTainan 701China Administration of the Quanzhou Bay Estuary Wetland Nature Reserve Quanzhou 362000China Ocean College Minjiang UniversityFuzhou 350002China Henry Fok College of Biology and Agriculture Shaoguan UniversityShaoguan 512005China

The mangrove Kandelia obovata(Rhizophoraceae)is an important coastal shelterbelt and landscape tree distributed in tropical and subtropical areas across East Asia and Southeast ***,a chromosome-level reference genome of *** based on PacBio,Illumina,and Hi-C data is *** high-quality assembled genome size is 177.99 Mb,with a contig N50 value of 5.74 Mb.A large number of contracted gene families and a small number of expanded gene families,as well as a small number of repeated sequences,may account for the small *** *** found that *** experienced two whole-genome polyploidization events:one whole-genome duplication shared with other Rhizophoreae and one shared with most eudicots(γevent).We confidently annotated 19,138 protein-coding genes in *** and identified the MADS-box gene class and the RPW8 gene class,which might be related to flowering and resistance to powdery mildew in *** and Rhizophora apiculata,*** reference *** genome described here will be very useful for further molecular elucidation of various traits,the breeding of this coastal shelterbelt species,and evolutionary studies with related taxa.

关键词： breeding coastal landscape

Proteomic Analysis of Proteins in the Salivary Glands of the Fed and Unfed Female Tick Rhipicephalus haemaphysaloides

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Agricultural Sciences in China 2009年第1期8卷 121-127页

作者： XIANG Fei-yu ZHANG Jian-wu ZHOU Yong-zhi LI zhuang GONG Hai-yan ZHOU Jin-lin Key Lab of Animal Parasitology of Ministry of Agriculture of China~Shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences Shanghai 200232 P.R.China Shanghai lnsititute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai 200032 P.R.China

Identification of differentially expressed salivary gland proteins between the fed and unfed female Rhipicephalus haemaphysaloides may obtain valuable functional molecules. In this study, comparative two-dimensional gel electrophoresis （2-DE） and mass spectrometry were used to separate and identify differentially expressed salivary gland proteins between the fed and unfed female R. haemaphysaloides. The soluble proteins from the salivary glands of fed and unfed female R. haemaphysaloides were separated by a sequential extraction method followed by 2-DE and 2-DE images. Image analysis of the gels revealed 1 096 ± 87 protein spots from the fed female ticks and 991 ±64 protein spots from the unfed female ticks. Among those protein spots, about 724 ±34 were present both in the fed and unfed female ticks. Fourteen spots from the fed ticks and six spots from the unfed ticks were selected for peptide mass fingerprinting （PMF） and sequencing assay by mass spectrometry （MS）. Bioinformatic analysis showed that a majority of the differentially expressed proteins were involved in signal transduction, metabolism, and transcriptional regulation. These differentially expressed proteins might be antigen candidates for the development of vaccines against the tick.

关键词： Rhipicephalus haemaphysaloides salivary g/and differentially expressed proteins two-dimensional gel electrophoresis mass spectrometry