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World Journal of Clinical Cases 2018年第10期6卷 322-334页

作者： Ning duan yang-Heng Zhang wen-Mei Wang Xiang Wang Department of Oral Medicine Nanjing Stomatological Hospital Medical School of Nanjing University Department of Periodontology Nanjing Stomatological Hospital Medical School of Nanjing University

Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome(LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. The important differential diagnoses of mucocutaneous and nail pigmentation are provided. An accurate diagnosis is crucial to design a reasonable medical strategy, including management options, malignant transformation surveillance, and psychological support. It is important that clinicians conduct long-term follow-up and surveillance due to the potential risks of malignant transformation and local severe complications in some conditions.

关键词： Laugier-Hunziker syndrome Dermoscopy Pathology Pigmentation Differential diagnosis Peutz-Jeghers syndrome Neurofibromatosis type 1 Carney complex Melanonychia

Endogenous neurogenesis in adult mammals after spinal cord injury

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Science China(Life Sciences) 2016年第12期59卷 1313-1318页

作者： Hongmei duan Wei Song wen Zhao Yudan Gao Zhaoyang yang Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China School of Rehabilitation Medinice China Rehabilitation Research CentreCapital Medical UniversityBeijing 100069China

During the whole life cycle of mammals, new neurons are constantly regenerated in the subgranular zone of the dentate gyms and in the subventricular zone of the lateral ventricles. Thanks to emerging methodologies, great progress has been made in the characterization of spinal cord endogenous neural stem cells （ependymal cells） and identification of their role in adult spinal cord development. As recently evidenced, both the intrinsic and extrinsic molecular mechanisms of ependymal cells control the sequential steps of the adult spinal cord neurogenesis. This review introduces the concept of adult endogenous neurogenesis, the reaction of ependymal cells after adult spinal cord injury （SCI）, the heterogeneity and markers of ependymal cells, the factors that regulate ependymal cells, and the niches that impact the activation or differentiation of ependymal ceils.

关键词： adult endogenous neurogenesis neural stem cells ependymal cells spinal cord injury adult mammals regeneration

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Suppression of self-sustained oscillations of incompressible flow over aperture-cavities and its mechanisms

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Journal of Hydrodynamics 2022年第5期34卷 876-892页

作者： wen-wen Zhang Rong-wu Xu Lin He Jia duan Institute of Vibration and Sound Naval University of EngineeringWuhan430033China National Key Laboratory on Ship Vibration and Noise Naval University of EngineeringWuhan430033China

Experiments and large-eddy simulations(LESs)are conducted to study the effectiveness and the underlying physical mechanisms of a passive control technique for suppressing the self-sustained oscillations of incompressible flow over *** control technique is implemented by installing a wedge block above the chamfered *** experiments are carried out in a low-speed water tunnel with the freestream velocity ranging from 0.4 m/s to 4.4 m/s,while the large-eddy simulations are carried out corresponding to the experiment at a velocity of 4.0 m/*** wall pressure fluctuations measured along the cavity floor show that a significant suppression of the self-sustained oscillations of the shear layers can be achieved by the control ***,the suppression performance is improved as the freestream velocity increases,not limited to the design point of the control *** analysis of numerical simulation results focuses on three aspects,the vorticity fields,the velocity fields and the pressure fields,and the physical effects of the control device on the incompressible aperture-cavity flow are *** mechanisms of suppressing the cavity oscillations are identified from the numerical results,which are the destruction of the large vortex structures by the high frequency vortical excitations,the inhabitation of the intracavity recirculation feedback by introducing the lower shunt flow,and the attenuation of the trailing-edge impingement by thickening the shear layer.

关键词： Cavity oscillations flow control flow-induced noise numerical simulations hydrodynamic noise

NUMERICAL SIMULATION OF SLOSHING IN RECTANGULAR TANK WITH VOF BASED ON UNSTRUCTURED GRIDS

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Journal of Hydrodynamics 2010年第6期22卷 856-864页

作者： MING Ping-jian duan wen-yang College of Power and Energy Engineering Harbin Engineering University Harbin 150001 China College of Shipbuilding Engineering Harbin Engineering University Harbin 150001 China

A new method for sloshing simulation in a sway tank is present, in which the two phase interface is treated as a physical discontinuity, which can be captured by a well-designed high order scheme. Based on Normalized Variable Diagram （NVD）, a high order discretization scheme with unstructured grids is realized, together with a numerical method for free surface flow with a fixed grid. This method is implemented in an in-house code General Transport Equation Analyzer （ GTEA ） which is an unstructured grids finite volume solver. The present method is first validated by available analytical solutions. A simulation for a 2-D rectangular tank at different excitation frequencies of the sway is carried out. A comparison with experimental data in literature and results obtained by commercial software CFX shows that the sloshing load on the monitor points agrees well with the experimental data, with the same grids, and the present method gives better results on the secondary peak. It is shown that the present method can simulate the free surface overturning and breakup phenomena.

关键词： sloshing numerical simulation unstructured grid Volume Of Fluid (VOF)

豆壳过氧化物酶的序列联配、二级结构预测及疏水性分析

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纤维素科学与技术 2001年第1期9卷 8-16页

作者：刘稳李杨段新源齐飞高培基方靖山东大学微生物技术国家重点实验室济南250100

利用生物大分子数据库和软件技术对豆壳过氧化物酶 (Soybeanhullperoxidase ,SHP ,EC 1 .1 1 .1 .7)进行了序列联配、二级结构预测及疏水性分析 ,通过与其它来源过氧化物酶的比较研究 ,分析了结构保守性与功能域的关系 ,从分子水平探讨... 详细信息

利用生物大分子数据库和软件技术对豆壳过氧化物酶 (Soybeanhullperoxidase ,SHP ,EC 1 .1 1 .1 .7)进行了序列联配、二级结构预测及疏水性分析 ,通过与其它来源过氧化物酶的比较研究 ,分析了结构保守性与功能域的关系 ,从分子水平探讨了过氧化物酶活性位点结构特征。

关键词：豆壳过氧化物酶序列联配二级结构疏水性结构域

Differences in floral traits and flower visitation rates in mating systems in Prunella vulgaris(Lamiaceae)

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Journal of Plant Ecology 2022年第1期15卷 39-56页

作者： Tial C.Ling Lin-Lin Wang Yong-Ping yang Yuan-wen duan CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Institute of Tibetan Plateau Research at Kunming Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina University of the Chinese Academy of Sciences Beijing 100049China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglun 666303China

Floral traits and the number of visitors are expected to change with different mating *** tested this hypothesis by comparing flowers of Prunella vulgaris(Lamiaceae)with inserted and exserted styles across a strongly exserted style biased,an exserted style biased,and a strongly inserted style biased subalpine *** examined flowering phenology,floral morphology,flower visitation rate,capacity for autonomous selfpollination and visitor contribution to seed production for each style type and in each *** also examined inbreeding depression(ID)by comparing the relative performance of progeny from self-and *** style plants had larger and more open flowers,increased pollen production,higher amounts of nectar rewards and higher visitation and outcrossing rates than inserted style *** on the population level,the visitation rates were higher in the exserted style-biased populations than in the inserted style-biased *** style plants provided a stronger reproductive assurance(RA)through autonomous selfing than exserted style *** and outcrossing rates did not differ among populations,showing low visitation rates may be sufficient for adequate seed production in *** inserted style plants had a lower ID level than exserted style plants,the ID of both was less than 0.5,suggesting that an ID should not counteract the evolution of selfing in this *** style plants provide RA through autonomous selfing,and exserted style plants ensure outcrossing through pollinator services,supporting a stable mixed mating system in this subalpine plant.

关键词： autonomous selfing floral traits inbreeding depression visitors Prunella vulgaris reproductive assurance

Impacts of Future Changes in Heavy Precipitation and Extreme Drought on the Economy over South China and Indochina

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Advances in Atmospheric Sciences 2024年第6期41卷 1184-1200,I0022-I0034页

作者： Bin TANG wenting HU Anmin duan Yimin LIU wen BAO Yue XIN Xianyi yang State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 101408China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361005China Chinese Academy of Sciences the CAS Institutes of Science and DevelopmentBeijing 101408China School of Public Policy and Management University of Chinese Academy of SciencesBeijing 101408China

Heavy precipitation and extreme drought have caused severe economic losses over South China and Indochina(INCSC)in recent *** the areas with large gross domestic product(GDP)in the INCSC region are distributed along the coastline and greatly affected by global warming,understanding the possible economic impacts induced by future changes in the maximum consecutive 5-day precipitation(RX5day)and the maximum consecutive dry days(CDD)is critical for adaptation planning in this *** on the latest data released by phase 6 of the Coupled Model Intercomparison Project(CMIP6),future projections of precipitation extremes with bias correction and their impacts on GDP over the INCSC region under the fossil-fueled development Shared Socioeconomic Pathway(SSP5-8.5)are *** indicate that RX5day will intensify robustly throughout the INCSC region,while CDD will lengthen in most regions under global *** changes in climate consistently dominate the effect on GDP over the INCSC region,rather than the change of *** only considering the effect of climate change on GDP,the changes in precipitation extremes bring a larger impact on the economy in the future to the provinces of Hunan,Jiangxi,Fujian,Guangdong,and Hainan in South China,as well as the Malay Peninsula and southern Cambodia in ***,timely regional adaptation strategies are urgent for these ***,from the sub-regional average viewpoint,over two thirds of CMIP6 models agree that maintaining a lower global warming level will reduce the economic impacts from heavy precipitation over the INCSC region.

关键词： CMIP6 heavy precipitation extreme drought South China Indochina economic impact

Metal ion-binding properties of wild-type and mutant D37K of ciliate Euplotes octocarinatus centrin

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Chinese Science Bulletin 2010年第27期55卷 3118-3122页

作者： LIU wen duan Lian ZHAO YaQin LIANG AiHua yang BinSheng Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University Taiyuan 030006 China Institute of Biotechnology Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University Taiyuan 030006 China

Ciliate Euplotes octocarinatus centrin (EoCen) is an EF-hand calcium-binding protein closely related to the prototypical calcium sensor protein *** first amino acid of the Ca2+-binding loops found in the EF-hand calcium-binding proteins is a highly conserved aspartic acid *** D37K mutant was produced to elucidate the metal binding role of the first aspartic acid of the EF-loop I of ***-sensitized Tb3+fluorescence results indicated that the metal binding ability of loop I was lost due to the D37K *** on fluorescence titration curves of Lu2-D37K,the conditional binding constants of the EoCen loop II were quantitatively found to be KII=(1.61±0.04)×105 L mol-1 and KII=(3.52±0.08)×102 L mol-1 with Tb3+ and Ca2+,*** 2-p-toluidinylnaphthalene-6-sulfonate as a hydrophobic probe,exposure of the hydrophobic surface upon metal binding was found to be significantly reduced for the metal ion-saturated EoCen D37K mutant.

关键词： centrin 金属离子突变型纤毛虫结合特性游仆虫野生型钙结合蛋白

Design and preparation of highly crystalline K-intercalated W@PCN:an efficient material for aniline elimination

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Rare Metals 2024年第3期43卷 1337-1342页

作者： Hao-Fei Li Kai-wen Yu Xiao-Bi Jing Lei duan Yi-yang Zhang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225002China School of Mechanical Engineering Yangzhou UniversityYangzhou225127China School of Material Science and Engineering Huazhong University of Science and TechnologyWuhan430071China School of Chemical Engineering and Materials Changzhou Institute of TechnologyChangzhou213032China Department of Basic Courses Army Engineering University of PLANanjing211101China

In this paper,we designed and prepared the polymeric carbon nitride-supported tungsten(W@PCN)*** were employed as the catalysts for photocatalytic oxidation of aniline in *** the process,H_(2)O_(2)was initially generated via the PCN-catalyzed *** by supported tungsten,aniline was oxidized by the in situ generated H_(2)O_(2)to obtain less toxicpoly aniline.

关键词： materials aniline crystalline