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Chronic pulmonary mucormycosis caused by rhizopus microsporus mimics lung carcinoma in an immunocompetent adult:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3295-3303页

作者： Xing-Zi Guo liang-Hui Gong wen-Xiang Wang De-Song yang Bai-Hua Zhang Ze-Tao Zhou Xiao-Hui Yu Department of Gynecologic Oncology Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410031Hunan ProvinceChina The Second Department of Thoracic Surgery Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410031Hunan ProvinceChina GZMU-GIBH School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436Guangdong ProvinceChina Department of Pathology Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410031Hunan ProvinceChina

BACKGROUND Pulmonary mucormycosis is a rare but life-threatening invasive fungal infection that mostly affects immunocompromised *** disease usually develops acutely and progresses rapidly,often leading to a poor clinical *** pulmonary mucormycosis is highly unusual in immunocompetent *** SUMMARY A 43-year-old man,who was a house improvement worker with a long history of occupational dust exposure,presented with an irritating cough that had lasted for two *** patient was previously in good health,without dysglycemia or any known *** computed tomography revealed a mass in the left lower lobe,measuring approximately 6 cm in diameter,which was suspected to be primary lung carcinoma complicated with obstructive ***-assisted left lower lobectomy was performed,and metagenomic next-generation sequencing detection,along with special pathological staining of surgical specimens,suggested Rhizopus microsporus ***,the patient’s respiratory symptoms were relieved,and no signs of recurrence were found during the six-month *** This article reports a rare case of chronic pulmonary mucormycosis caused by Rhizopus microsporus in a middle-aged male without dysglycemia or *** patient’s surgical outcome was excellent,reaffirming that surgery remains the cornerstone of pulmonary mucormycosis treatment.

关键词： Rhizopus microsporus Pulmonary mucormycosis Immunocompetent patient Surgical resection Case report

基于压电纳米发电机的柔性传感与能量存储器件

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物理学报 2020年第17期69卷 43-60页

作者：申茂良张岩电子科技大学物理学院成都610054 中国科学院北京纳米能源与系统研究所北京100083 中国科学院大学纳米科学与技术学院北京100049

柔性电子与柔性传感器件未来将广泛应用在物联网、可穿戴、可植入系统中,例如人体健康监控、触觉感知人造感官以及智能机器人电子皮肤等.柔性压电纳米发电机的能量转换特性,使其不仅可以作为供能器件,而且可以作为传感器件提供传感信号... 详细信息

柔性电子与柔性传感器件未来将广泛应用在物联网、可穿戴、可植入系统中,例如人体健康监控、触觉感知人造感官以及智能机器人电子皮肤等.柔性压电纳米发电机的能量转换特性,使其不仅可以作为供能器件,而且可以作为传感器件提供传感信号,可以解决柔性电子与自驱动技术中存在供能与性能的限制.纳米发电机利用调控界面与表面的极化电场可以获得高性能传感与能量存储,提供自驱动特性,同时具有与目前电子技术相媲美的高性能.本文综述了柔性压电纳米发电机在柔性传感与能量存储领域的最新研究进展.

关键词：柔性压电纳米发电机自驱动传感自充电能源包

Encoding and display technologies for combinatorial libraries in drug discovery:The coming of age from biology to therapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3362-3384页

作者： Yu Fan Ruibing Feng Xinya Zhang Zhen-liang Wang Feng Xiong Shuihua Zhang Zhang-Feng Zhong Hua Yu Qing-wen Zhang Zhang Zhang Yitao Wang Guodong Li Macao Centre for Research and Development in Chinese Medicine State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development Ministry of Education(MoE)of People’s Republic of ChinaCollege of PharmacyJinan UniversityGuangzhou 510632China Zhuhai UM Science and Technology Research Institute Zhuhai 519031China Department of Pharmacy Guangzhou Red Cross HospitalFaculty of Medical ScienceJinan UniversityGuangzhou 510632China Geriatric Medicine First People’s Hospital of XinXiang and the Fifth Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453100China Shenzhen Innovation Center for Small Molecule Drug Discovery Co. Ltd.Shenzhen 518000China

Drug discovery is a sophisticated process that incorporates scientific innovations and cuttingedge *** to traditional bioactivity-based screening methods,encoding and display technologies for combinatorial libraries have recently advanced from proof-of-principle experiments to promising tools for pharmaceutical hit discovery due to their high screening efficiency,throughput,and resource *** review systematically summarizes the development history,typology,and prospective applications of encoding and displayed technologies,including phage display,ribosomal display,mRNA display,yeast cell display,one-bead one-compound,DNA-encoded,peptide nucleic acidencoded,and new peptide-encoded technologies,and examples of preclinical and clinical *** discuss the progress of novel targeted therapeutic agents,covering a spectrum from small-molecule inhibitors and nonpeptidic macrocycles to linear,monocyclic,and bicyclic peptides,in addition to *** also address the pending challenges and future prospects of drug discovery,including the size of screening libraries,advantages and disadvantages of the technology,clinical translational potential,and market *** review is intended to establish a comprehensive high-throughput drug discovery strategy for scientific researchers and clinical drug developers.

关键词： Drug screening Phage display DNA-encoded chemical libraries Peptide-encoded chemical libraries Clinical drugs

Association of interleukin-18 gene polymorphisms with Takayasu arteritis in a Chinese Han population

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Chinese Medical Journal 2020年第19期133卷 2315-2320页

作者： Dan wen Xian-liang Zhou Xin Du Jian-Zeng Dong Chang-Sheng Ma Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Center for Cardiovascular DiseasesBeijing Advanced Innovation Center for Big Data-Based Precision Medicine for Cardiovascular DiseasesBeijing 100029China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100037China.

Background:Interleukin-18(IL18)gene polymorphisms are related to many inflammatory and autoimmune ***,a correlation analysis between IL18-607C/A and-137G/C gene polymorphisms and Takayasu arteritis(TA)is ***:This study enrolled 200 patients with TA as the case group and 334 region-,age-,and sex-matched healthy subjects as the control *** genotyped alleles and genotypes at positions-607 and-137 of the IL18 gene and analyzed the distribution ***-Whitney U test,t test,Chi-squared test and Hardy-Weinberg equilibrium were ***:After adjusting for risk factors,the adjusted odds ratios and 95%confidence intervals at position-607C/A were 0.533,0.391 to 0.880(P=0.010);0.266,0.586 to 1.002(P=0.051);and 0.122,0.552 to 1.420(P=0.613)under the dominant,additive,and recessive models,*** the-137G/C polymorphism,the adjusted odds ratios and 95%confidence intervals were 1.571,1.068 to 2.311(P=0.022);1.467,1.086 to 1.980(P=0.012);and 1.815,0.901 to 3.656(P=0.095)under the dominant,additive,and recessive models,***,regardless of the model used,we found no statistical difference in distribution frequency between the active and quiescent states of TA for the-607C/A(P=0.355,0.631,and 0.705,respectively)and-137G/C polymorphisms(P=0.205,0.385,and 0.208,respectively).Conclusions:The IL18-607C/A gene polymorphism may decrease the risk of TA,and thus is a protective factor,whereas-137G/C may increase the risk of TA,and thus is a risk ***,neither polymorphism was related to activity(active ***)of TA.

关键词： Gene polymorphism Interleukin-18 Takayasu arteritis

The Additive Hazard Mixing Models

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Acta Mathematicae Applicatae Sinica 2012年第1期28卷 139-148页

作者： Ping LI Xiao-liang LING College of Sciences Hebei University of Science and TechnologyShijiazhuang 050018China

This paper is concerned with the aging and dependence properties in the additive hazard mixing models including some stochastic comparisons. Further, some useful bounds of reliability functions in additive hazard mixi... 详细信息

关键词： additive hazard mixing models dependence property stochastic comparison

Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

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Virologica Sinica 2024年第4期39卷 705-707页

作者： Jie-Mei Yu Ze-Yin liang Yuan-Hui Fu Xiang-Lei Peng yan-Peng Zheng Yu-Jun Dong Jin-Sheng He College of Life Sciences and Bioengineering Beijing Jiaotong UniversityBeijing100044China Department of Hematology Peking University First HospitalBeijing100034China

Dear Editor,Patients undergoing allogeneic hematopoietic stem cell transplantation(HSCT)often experience a significant reduction in immune function due to factors such as severe lymphopenia,immunosuppressive treatment,and the development of graft-versus-host disease,rendering them more susceptible to severe infections(Sahin et al.,2016).Traditional diagnostic approaches are limited in sensitivity,speed,and assay targets,thus failing short of meeting the diagnostic demands(Qu et al.,2022).However,next-generation sequencing(NGS)has greatly improved the accuracy and efficiency of diagnosing various diseases(Schuler et al.,2022),and has been widely utilized for pathogen detection in samples from HSCT patients(Armstrong et al.,2019;Peng et al.,2021).In this study,we employed viral metagenomics analysis using high-throughput sequencing on fecal and tissue samples from a patient with HSCT experiencing severe lingual papillomatosis.

关键词： al. papilloma rendering

Improvement in the weldability of molybdenum alloy by pre-welding solid carburising

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Journal of Materials Science & Technology 2021年第21期80卷 1-12页

作者： liang-liang Zhang Lin-Jie Zhang Jian Long Xiang-Dong Ding Jun Sun Yuan-Jun Sun State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China

Molybdenum(Mo), with its high chemical stability and resistance to neutron irradiation, has wide application prospects in the nuclear industry;however, the embrittlement of welded Mo joints limits its further application. In this study, the brittleness of the welded joints of Mo alloy was reduced and their strength was enhanced by adding carbon to the fusion zone(FZ) during laser welding. In the FZ of the Mo joints, carbon mainly existed as Mo_(2)C, and some free C atoms, and MoC and MoOxC yphases were also present. The distribution of Mo_(2)C directly influenced the bonding strength of the grain *** Mo_(2)C was dispersedly distributed as particles or discontinuous lines at the grain boundaries of Mo,it improved the resistance of the grain boundaries to the propagation of cracks and thereby increasing their strength. However, the Mo_(2)C phases distributed in a reticular pattern at the grain boundaries of Mo provided channels that enabled cracks to rapidly propagate, thereby reducing the resistance of the grain boundaries to crack propagation and weakening their strength. The emergence of the MoOxC yphase reduced the weakening effect of free oxygen atoms on the strength of grain boundaries of Mo.

关键词： Molybdenum Carbon Mo_(2)C Laser beam welding Pre-welding solid carburising

A multi-layered Ti3C2/Li2S composite as cathode material for advanced lithium-sulfur batteries

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Journal of Energy Chemistry 2019年第12期28卷 176-181页

作者： Xin liang Jufeng Yun Kun Xu Hongfa Xiang Yong Wang Yi Sun yan Yu School of Materials Science and Engineering Anhui Provincial Key Laboratory of Advanced Functional Materials and DevicesHefei University of TechnologyHefei 230009AnhuiChina CAS Key Laboratory of Materials for Energy Conversions Department of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026AnhuiChina

Lithium-sulfur(Li-S)batteries with lithium sulfide(Li2S)as cathode have attracted great attention recently,because of high specific capacity(1166 mA h g^-1)of Li2S and potential safety of using Li metal-free ***2S cathode has lower volume expansion and higher thermal stability than the traditional sulfur ***,the problems of"shuttle effect"and poor electrical conductivity of the cathode material still need to be *** this work,multi-layered Ti3C2/Li2S(ML-Ti3C2/Li2S)composite has been prepared and applied as a cathode in advanced Li-S *** unique multi-layer sheet structure of Ti3 C2 provides space for the storage of Li2S,and its good conductivity greatly enhances the usage ratio of Li2 S and improves the conductivity of the whole Li2S *** with commonly used graphene,ML-Ti3C2 can trap polysulfides effectively by chemical adsorption and also activate the reaction of Li2S to polysulfides by forming Ti-S *** a result,during the cycling of the batteries with ML-Ti3C2/Li2S cathodes,the activation voltage barrier of the first cycle has decreased to 2.8 V,and the"shuttle effect"has been suppressed *** cycling and rate performances of the ML-Ti3C2/Li2S cathodes have been significantly improved compared to that of graphene/Li2 S *** maintain a capacity of 450 mAh g^-1 at 0.2 C after 100 cycles,and deliver attractive rate performances of 750,630,540,470 and 360 mAh g^-1 at 0.1 C,0.2 C,0.5 C,1 C,and 2 C,respectively.

关键词： Multi-layered Ti3C2 Li2S Lithium-sulfur batteries Activation voltage barrier Shuttle effect

Rapid, continuous projection multi-photon 3D printing enabled by spatiotemporal focusing of femtosecond pulses

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Light(Science & Applications) 2021年第10期10卷 1987-1997页

作者： Paul Somers Zihao liang Jason E.Johnson Bryan W.Boudouris liang Pan Xianfan Xu School of Mechanical Engineering and Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Charles D.Davidson School of Chemical Engineering Purdue UniversityWest LafayetteINUSA Department of Chemistry Purdue UniversityWest LafayetteINUSA

There is demand for scaling up 3D printing throughput,especially for the multi-photon 3D printing process that provides sub-micrometer structuring capabilities required in diverse *** this work,high-speed projection multiphoton printing is combined with spatiotemporal focusing for fabrication of 3D structures in a rapid,layer-by-layer,and continuous *** focusing confines printing to thin layers,thereby achieving print thicknesses on the micron and sub-micron *** projection of dynamically varying patterns with no pause between patterns,a continuous fabrication process is established.A numerical model for computing spatiotemporal focusing and imaging is also presented which is verified by optical imaging and printing *** 3D structures with smooth features are fabricated,with millimeter scale printing realized at a rate above 10−3 mm3 s−*** method is further scalable,indicating its potential to make fabrications of 3D structures with micro/nanoscale features in a practical time scale a reality.

关键词： projection continuous thereby