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微量元素对AlCu4.5合金力学性能的影响

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特种铸造及有色合金 2003年第1期23卷 16-18页

作者：董晟全周敬恩严文梁艳峰李建平杨通西安交通大学西安工业学院

高强度铸造Al Cu合金具有良好的室温和高温强度 ,但它的热裂倾向性一直是制约其发展的瓶颈。通过对合金的收缩应变和热裂抗力及准固态力学行为进行测试 ,研究了微量合金元素 (Ni,Si ,Ce ,La ,Ti,Zr ,Mn)对AlCu4.5合金准固态力学性能的... 详细信息

高强度铸造Al Cu合金具有良好的室温和高温强度 ,但它的热裂倾向性一直是制约其发展的瓶颈。通过对合金的收缩应变和热裂抗力及准固态力学行为进行测试 ,研究了微量合金元素 (Ni,Si ,Ce ,La ,Ti,Zr ,Mn)对AlCu4.5合金准固态力学性能的影响。结果表明 ,Si,Ce ,La ,Ti,Zr合金元素能使AlCu4.5的热裂倾向性降低 ;加入质量分数为 2 %的Si会使合金的再辉现象非常严重 ,导致合金不可能有很高的强度而很快断裂 ;与其他AlCu4.5Si合金相比 ,AlCu4.5Si3合金具有很强的补缩能力 ,断裂应力值最高 ;La的加入能缩小二次枝晶间距 ,明显提高合金的抗热裂性能。

关键词：微量元素力学性能热裂铸造AlCu4.5合金准固态抗热裂性铝合金

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu wendanqi liang wenbo Ji Jianhua Zhuang yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Assessing healthcare workers’knowledge and confidence in the diagnosis,management and prevention of Monkeypox

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World Journal of Clinical Cases 2025年第1期13卷 38-47页

作者： Epipode Ntawuyamara Thierry Ingabire Innocent yandemye Polycarpe Ndayikeza Bina Bhandari yan-Hua liang Department of Dermatology Cosmetology and VenereologyShenzhen Hospital of Southern Medical UniversityShenzhen 518101Guangdong ProvinceChina Department of Dermatology and Venereology Kamenge Teaching HospitalUniversity of BurundiBujumbura 1020Burundi Department of Infectious Diseases Kamenge Teaching HospitalUniversity of BurundiBujumbura 1020Burundi General Directorate of Healthcare Supply Modern and Traditional MedicineNutrition and RegistrationMinistry of Public Health and Fight Against HIV/AIDSBujumbura 1055Burundi Department of Epidemiology National Institute of Public HealthBujumbura 350Burundi General Directorate of Planification Ministry of Public Health and Fight Against HIV/AIDSBujumbura 1055Burundi

BACKGROUND Monkeypox(Mpox),is a disease of global public health concern,as it does not affect only countries in western and central *** To assess Burundi healthcare workers(HCWs)s’level of knowledge and confidence in the diagnosis and management of *** We conducted a cross-sectional study via an online survey designed mainly from the World Health Organization course distributed among Burundi HCWs from June-July *** questionnaire comprises 8 socioprofessional-related questions,22 questions about Mpox disease knowledge,and 3 questions to assess confidence in Mpox diagnosis and *** data were analyzed via SPSS software version 25.0.A P value<0.05 was considered to indicate statistical *** The study sample comprised 471 HCWs who were mainly medical doctors(63.9%)and nurses(30.1%).None of the 22 questions concerning Mpox knowledge had at least 50%correct responses.A very low number of HCWs(17.4%)knew that Mpox has a *** confidence level to diagnose(21.20%),treat(18.00%)or prevent(23.30%)Mpox was low among *** confidence level in the diagnosis of Mpox was associated with the HCWs’age(P value=0.009),sex(P value<0.001),work experience(P value=0.002),and residence(P value<0.001).The confidence level to treat Mpox was significantly associated with the HCWs’age(P value=0.050),sex(P value<0.001),education(P value=0.033)and occupation(P value=0.005).The confidence level to prevent Mpox was associated with the HCWs’education(P value<0.001),work experience(P value=0.002),residence(P value<0.001)and type of work institution(P value=0.003).CONCLUSION This study revealed that HCWs have the lowest level of knowledge regarding Mpox and a lack of confidence in the ability to diagnose,treat or prevent *** is an urgent need to organize continuing medical education programs on Mpox epidemiology and preparedness for Burundi *** encourage future researchers to assess potential hesitancy toward Mpox vaccination and its asso

关键词： Monkeypox Public health emergency of international concern Healthcare workers Epidemic Preparedness Knowledge Confidence

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： Zhong-liang Gong Hong-Jie Zhang yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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布鲁氏菌病M5、S2疫苗免疫血清半抗原-琼脂扩散试验方法检测评价

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中国人兽共患病学报 2023年第8期39卷 766-771页

作者：刘丽娅剡文亮张子荣宋洁郑莹马晓菁叶锋谷文喜易新萍李岩新疆畜牧科学院兽医研究所新疆动物疫病研究重点实验室乌鲁木齐830011 新疆生产建设兵团畜牧兽医工作总站乌鲁木齐830021 新疆生产建设兵团第六师畜牧兽医工作站五家渠831304 新疆天润乳业股份有限公司乌鲁木齐830000

目的应用NH-AGID方法对布鲁氏菌M5、S2疫苗株免疫血清进行检测,评价该方法适用性。方法选取3~5月龄羔羊74只,随机分为3组。分别以S2株1.0×1010 CFU、5.0×109 CFU灌服和皮下注射接种羔羊各25只,M5株以1.0×10^(9) CFU皮下注射接种羔羊2... 详细信息

目的应用NH-AGID方法对布鲁氏菌M5、S2疫苗株免疫血清进行检测,评价该方法适用性。方法选取3~5月龄羔羊74只,随机分为3组。分别以S2株1.0×1010 CFU、5.0×109 CFU灌服和皮下注射接种羔羊各25只,M5株以1.0×10^(9) CFU皮下注射接种羔羊24只。免疫后7 d~150 d采集羊全血,分离血清,经RBT初筛和SAT确诊免疫抗体阳性血清。评估NH-AGID方法对M5和S2株疫苗免疫抗体与感染抗体的鉴别诊断特异性。结果NH-AGID方法对M5株疫苗免疫阳性血清的LPS抗体检出率为100%,NH抗体检出率8.3%~29.2%,鉴别诊断特异性为82.8%。对S2株疫苗口服组免疫阳性血清的LPS抗体检出率为31.2%~66.7%,NH抗体检出率为0%;皮下注射组免疫阳性血清的LPS抗体检出率为45.4%~100%,NH抗体检出率为4.5%~20%。对S2株疫苗免疫血清的鉴别诊断特异性为96.5%。结论NH-AGID方法不完全适用于羊用布鲁氏菌疫苗M5株和S2株的鉴别诊断,该方法的鉴别诊断特异性与疫苗毒力、免疫剂量和途径等因素相关,应进一步研究明确该方法的适用范围及条件,以期合理应用于布病防控诊断工作中。

关键词：布鲁氏菌病半抗原-琼脂扩散试验 M5株 S2株鉴别诊断

应用Gray—Brown法研究MOS电容辐射感生界面态密度

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微电子学与计算机 1989年第12期6卷 1-4页

作者：高文钰严荣良范隆余学峰中国科学院新疆物理研究所

本工作建立了能准确测量MOS电容禁带两端界面态密度分布和平均界面态密度的Gray-Brown法(简称G-B法),并同高低频C-V法进行了比较,结合Stretch Out(简称S-O)法研究了不同工艺MOS电容的辐照感生界面态特性。结果表明,禁带上端界面态密度... 详细信息

本工作建立了能准确测量MOS电容禁带两端界面态密度分布和平均界面态密度的Gray-Brown法(简称G-B法),并同高低频C-V法进行了比较,结合Stretch Out(简称S-O)法研究了不同工艺MOS电容的辐照感生界面态特性。结果表明,禁带上端界面态密度分布较均匀,最大值与最小值相差不到两倍;禁带上端的平均界面态密度不大于禁带中央附近的三倍;辐照引起禁带中央附近界面态和禁带两端界面态的增长快慢与MOS器件制备工艺有关。

关键词： MOS器件电容辐射 Gray-Brown法

重组链激酶溶栓治疗在急性心肌梗死患者中的应用效果

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实用心脑肺血管病杂志 2017年第7期25卷 100-102页

作者：杨成班少扬颜文亮广西百色市人民医院急诊科 533000

目的分析重组链激酶溶栓治疗在急性心肌梗死(AMI)患者中的应用效果。方法选取2014年2月—2016年3月百色市人民医院收治的AMI患者50例,根据治疗方法分为对照组和观察组,每组25例。对照组患者给予阿司匹林治疗,观察组患者在对照组基础上... 详细信息

目的分析重组链激酶溶栓治疗在急性心肌梗死(AMI)患者中的应用效果。方法选取2014年2月—2016年3月百色市人民医院收治的AMI患者50例,根据治疗方法分为对照组和观察组,每组25例。对照组患者给予阿司匹林治疗,观察组患者在对照组基础上给予重组链激酶治疗。比较两组患者治疗前及治疗后2 h、6 h、24 h凝血纤溶指标[纤维蛋白原(Fg)、D-二聚体、组织型纤溶酶原激活物(t-PA)、组织型纤溶酶原激活物抑制物(PAI)]及冠状动脉再通率,并记录两组患者治疗期间不良反应/并发症发生情况。结果时间与方法在Fg、D-二聚体、t-PA、PAI上存在交互作用(P<0.05);时间在Fg、D-二聚体、t-PA、PAI上主效应显著(P<0.05);方法在Fg、D-二聚体、t-PA、PAI上主效应显著(P<0.05);治疗后2 h、6 h、24 h观察组患者Fg、PAI低于对照组,D-二聚体、t-PA高于对照组(P<0.05)。观察组患者冠状动脉再通率高于对照组(P<0.05)。两组患者治疗期间均未出现严重不良反应/并发症。结论重组链激酶溶栓治疗能有效改善AMI患者凝血纤溶指标,提高冠状动脉再通率,且安全性较高。

关键词：心肌梗死重组链激酶治疗结果

亚麻籽蛋白质、亚麻酸和木酚素含量近红外预测模型建立与应用

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中国油料作物学报 2021年第2期43卷 353-360页

作者：叶佳丽江海霞郭栋良闫文亮杨亮杰黄丽丽陈大伟李恭泽谢丽琼新疆大学生物科学与技术学院新疆乌鲁木齐830046

为优化油用亚麻营养品质检测方法,提高育种效率,利用无损近红外光谱分析法定量分析亚麻籽粒蛋白质、亚麻酸和木酚素含量,初步探讨蛋白质、亚麻酸和木酚素含量相关性。以具有代表性的200份亚麻籽为研究对象,采集近红外光谱,使用偏最小二... 详细信息

为优化油用亚麻营养品质检测方法,提高育种效率,利用无损近红外光谱分析法定量分析亚麻籽粒蛋白质、亚麻酸和木酚素含量,初步探讨蛋白质、亚麻酸和木酚素含量相关性。以具有代表性的200份亚麻籽为研究对象,采集近红外光谱,使用偏最小二乘法和净分析信号光谱预处理建立了蛋白质、亚麻酸和木酚素含量近红外模型。结果表明:亚麻籽蛋白质、亚麻酸和木酚素含量建模标准偏差分别为0.7526、0.5943和0.1483;建模相关系数分别为0.9784、0.9969和0.9943;预测平均偏差分别为-0.2441、1.2271和0.0521;预测标准偏差分别为2.7896、8.2459和1.0163;外部检验相关系数分别为0.9207、0.8885和0.9659;200份亚麻种质蛋白质、亚麻酸和木酚素含量符合正态性检验;相同环境木酚素与亚麻酸含量均呈现正相关、木酚素与蛋白质含量均呈现负相关、亚麻酸与蛋白质含量呈现负相关。使用模型,从863份亚麻种质资源库中筛选出亚麻酸70%以上种质12份,蛋白质含量低于10%以下种质8个,木酚素含量高于10%种质11份。本研究将为亚麻重要品质性状改良提供技术和材料。

关键词：亚麻籽蛋白质亚麻酸木酚素近红外模型

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杜仲转录组微卫星特征分析

经济林研究 2016年第4期34卷 47-51页

作者：申响保闫文德梁小翠孙志强中南林业科技大学林学院河南郑州450003 中南林业科技大学南方林业生态应用技术国家工程实验室湖南长沙410004 国家林业局泡桐研究开发中心河南郑州450003

为给杜仲SSR分子标记的选择提供参考依据,利用MISA软件对杜仲转录组序列进行了微卫星查找,共获得重复单元长度为1~6碱基的29 067个微卫星序列。分析这些微卫星序列后发现,在杜仲转录组中,长度为二核苷酸的微卫星重复单元最为丰富,占43.... 详细信息

为给杜仲SSR分子标记的选择提供参考依据,利用MISA软件对杜仲转录组序列进行了微卫星查找,共获得重复单元长度为1~6碱基的29 067个微卫星序列。分析这些微卫星序列后发现,在杜仲转录组中,长度为二核苷酸的微卫星重复单元最为丰富,占43.7%;在单碱基重复和二碱基重复这两种类型中,最主要的优势重复单元分别是A/T和AG/CT;在三碱基、四碱基、五碱基重复类型中,（AAN）n、（ANAT）n、（AANAN）n分别为其对应的优势重复单元。杜仲转录组中,微卫星的频率随着微卫星总长度的增加而降低。

关键词：杜仲转录组微卫星