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Neural stem cells derived from sporadic Alzheimer disease iPSCs exhibit excessive cell apoptosis and premature neuronal differentiation

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中国药理学与毒理学杂志 2018年第4期32卷 335-336页

作者： lin ZHANG Ning JIANG wen-xia ZHOU Yong-xiang ZHANG Institute of Pharmacology and Toxicology Beijing 100850 China State Key Laboratory ofToxicology and Medical Countermeasures Beijing 100850 China School of Life Science and Biopharmaceutical Sciences Shenyang Pharmaceutical University Shenya

OBJECTIVE To establish an in vitro cell model based on patient-specific human neural stem cells to study the pathomechanism of sporadic AD as well as screen candidate *** The peripheral blood cells from sporadic AD patients and cognitive normal controls were *** into inducedpluripotent stem cells(iPSCs),which were further induced into neural stem cells and *** cell growth curve during the differentiation process was recorded by the IncuCyte ZOOM,and neural stem cells and neurons were identified by *** apoptosis of neural stem cells and neurons was detected by Click-iT~Plus TUNEL *** Neural stem cells derived from AD patients and cognitive normal controls can express neural stem cell markers ***,Sox1,Sox2 and *** assay results showed that the number of TUNEL-positive cells in *** stem cells derived from AD patients was significantly higher than that of cognitive normal controls(P<0.01).When neural stem cells were differentiated into neurons,the percentage of MAP2 positive cells in the neural stem cell-derived culture dish of AD patients was significantly higher than the *** normal controls at day 16 of neuronal differentiation(P<0.01);the TUNEL assay showed that the number of TUNEL-positive cells in AD-derived neurons was significantly greater than that in cognitive normal controls(P<0.01) at day 16 of neuronal *** Our study revealed that AD-iPSC-derived neural stem cells exhibit premature neuronal differentiation and increased neural apoptosis,which might be relevant to the neuronal loss of AD,thus may provide valuable new tools to screen candidate drugs for the disease and to discover the mechanisms underlying AD pathogenesis.

关键词：神经干细胞神经元临床分析治疗方法

A balanced mechanism between plant growth and stress response

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Advanced Agrochem

Advanced Agrochem 2023年第2期2卷 105-106页

作者： Zi-Bo lin Yan-xiang Zhao wen-Chao Yang National Key Laboratory of Green Pesticide Central China Normal UniversityWuhan430079PR China Department of Applied Biology and Chemical Technology State Key Laboratory of ChirosciencesThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

We intended to highlight the interesting findings that three leucine-rich repeat receptor kinases function as receptors for sulfated plant peptide hormones,which could mediate switching between plant growth and stress ***,we proposed the potential of developing chemical regulators for promoting plant growth when they are suffering from environmental stresses.

关键词： Plant growth Stress tolerance Mechanism Chemical modulator

Deciphering H^(+)/Zn^(2+) co-intercalation mechanism of MOF-derived2D MnO/C cathode for long cycle life aqueous zinc-ion batteries

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Rare Metals 2022年第11期41卷 3729-3739页

作者： Zheng-xiang Zhu Zhang-wen lin Zhong-Wei Sun Pei-Xin Zhang Chang-Ping Li Rui Dong Hong-Wei Mi College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen518060China Guangdong Engineering Technology Research Centre for Distributed and Intelligent Small Solar Energy Storage Shenzhen Hello Tech Energy Co.Ltd.Shenzhen518100China Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan523808China Shenzhen Wesmart Sensor Technology Co. Ltd.Shenzhen518118China

Poor conductivity,sluggish ion diffusion kinetics and short cycle life hinder the further development of manganese oxide in aqueous zinc-ion batteries(AZIBs).Exploring a cathode with high capacity and long cycle life is critical to the commercial development of ***,a two-dimensional(2D) MnO/C composite derived from metal organic framework(MOF) was *** 2D MnO/C cathode exhibits a remarkably cyclic stability with the capacity retention of 90.6% after 900 cycles at 0.5 A·g^(-1) and maintains a high capacity of 120.2 mAh·g^(-1)after 4500 cycles at 1.0 A·g^(-1).It is demonstrated that MnO is converted into Mn_(3)O_(4) through electrochemical activation strategy and shows a Zn^(2+)and H^(+)co-intercalation *** general,this work provides a new path for the development of high-performance AZIBs cathode with controllable morphology.

关键词： Aqueous zinc-ion battery MnO/C Morphology design H^(+)/Zn^(2+)co-insertion

The role of liver sinusoidal endothelial cells in liver remodeling after injury

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 22-27页

作者： Zhi-wen Li lin Wang Department of Hepatobiliary Surgery Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China

Liver transplantation is the optimal treatment for patients with end-stage liver disease,metabolic liver diseases,and hepatic malignancies that are not amenable to *** ischemia-reperfusion injury(IRI)is the main problem in liver transplantation and liver resection,leading to parenchymal cell injury and organ *** damage of liver sinusoidal endothelial cells(LSECs)is a critical event in *** work as an important regulating factor of liver regeneration after partial *** review primarily describes the mechanisms of LSECs injury in IRI and explores the roles of LSECs in liver regeneration,and briefly introduces the protective strategies targeting LSECs damaged in IRI.

关键词： Liver sinusoidal endothelial cells Liver transplantation Ischemia-reperfusion injury Liver regeneration

linear Integral Analysis of Bar Rough Rolling by Strain Rate Vector

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Journal of Iron and Steel Research International 2010年第3期17卷 28-33页

作者： DENG Wei ZHAO De-wen QIN Xiao-mei GAO Xiu-hua DU lin-xiu LIU xiang-hua State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

A new linear integral method for bar hot rolling on roughing train was obtained. First, for plastic deformation energy rate, equivalent strain rate about Kobayashi＇s three-dimensional velocity field was expressed by two-dimensional strain rate vector; then, the two-dimensional strain rate vector was inverted into inner product and was integrated term by term. During those processes, boundary equation and mean value theorem were introduced; for friction and shear energy dissipation rate, definite integral was applied to the solution process. Sequentially, the total upper bound power was minimized, and the analytical expressions of rolling torque, separating force, and stress state factor were obtained. The calculated results by these expressions were compared with those of experimental values. The results show that the new linear integral method is available for bar rough rolling analysis and the calculated results by this method are a little higher than those of experimental ones. However, the maximum error between them is less than 10%.

关键词： bar rough rolling linear integration strain rate vector roll separating force

Suppression of self-sustained oscillations of incompressible flow over aperture-cavities and its mechanisms

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Journal of Hydrodynamics 2022年第5期34卷 876-892页

作者： wen-wen Zhang Rong-wu Xu lin He Jia Duan Institute of Vibration and Sound Naval University of EngineeringWuhan430033China National Key Laboratory on Ship Vibration and Noise Naval University of EngineeringWuhan430033China

Experiments and large-eddy simulations(LESs)are conducted to study the effectiveness and the underlying physical mechanisms of a passive control technique for suppressing the self-sustained oscillations of incompressible flow over *** control technique is implemented by installing a wedge block above the chamfered *** experiments are carried out in a low-speed water tunnel with the freestream velocity ranging from 0.4 m/s to 4.4 m/s,while the large-eddy simulations are carried out corresponding to the experiment at a velocity of 4.0 m/*** wall pressure fluctuations measured along the cavity floor show that a significant suppression of the self-sustained oscillations of the shear layers can be achieved by the control ***,the suppression performance is improved as the freestream velocity increases,not limited to the design point of the control *** analysis of numerical simulation results focuses on three aspects,the vorticity fields,the velocity fields and the pressure fields,and the physical effects of the control device on the incompressible aperture-cavity flow are *** mechanisms of suppressing the cavity oscillations are identified from the numerical results,which are the destruction of the large vortex structures by the high frequency vortical excitations,the inhabitation of the intracavity recirculation feedback by introducing the lower shunt flow,and the attenuation of the trailing-edge impingement by thickening the shear layer.

关键词： Cavity oscillations flow control flow-induced noise numerical simulations hydrodynamic noise

Structure, Infrared Radiation Properties and Mssbauer Spectroscopic Investigations of Co_(0.6)Zn_(0.4)Ni_xFe_(2-x)O_4 Ceramics

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Journal of Materials Science & Technology 2010年第8期26卷 687-692页

作者： Ying Zhang Jun lin Dijiang wen Inorganic Materials Department College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China

Ferrite compound Co0.6Zn0.4NixFe2-xO4 was synthesized by solid state reaction. The structure and performance of Co0.6Zn0.4NixFe2-xO4 compounds were studied by Moessbauer spectroscopy, X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS） and infrared radiant tester. Moessbauer spectroscopy and XPS analysis show the valence states and distribution of cations in Co0.6Zn0.4NixFe2-xO4. Zn2＋ has invariably shown preference for the tetrahedral sites, and Ni2＋ has the preference for the octahedral sites. The occupancy of Fe3＋ linearly increases on the tetrahedral sites, and sharply decreases on the octahedral sites with increasing x, owing to its gradual replacement by Ni2＋ on the octahedral sites. It indicates that due to the occupation of octahedral sites by the majority of Ni2＋, Fe3＋ decreasingly migrated from the octahedral sites to the tetrahedral sites and substituted Co3＋ sites, which made the number of Co3＋ in the tetrahedral sites decreasing. According to the measurement results of XRD and the infrared radiant tester analysis, the lattice parameter and infrared radiance have shown a nonlinear variation, exhibiting the infrared average radiance of 0.92 in the 8-14μm waveband, and the results demonstrate that these Co-Zn-Ni spinel ferrites have potential for application in a wide range of infrared heating and drying materials.

关键词： Infrared radiance Moessbauer spectroscopy NiO Spinel ferrites

Resuscitative endovascular balloon occlusion of the aorta in the treatment of severe hemorrhagic shock caused by upper gastrointestinal bleeding

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World Journal of Emergency Medicine 2023年第3期14卷 247-249页

作者： Yu-lin Li Jun-yang Wang wen Han Tao Sun Kang Lyu Shan-xiang Xu Department of Emergency Medicine the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

Hemorrhagic shock is a life-threatening disease often encountered in emergency departments(EDs).Hemorrhagic shock caused by extensive bleeding from multiple sites is often associated with high mortality and *** recent years,resuscitative endovascular balloon occlusion of the aorta(REBOA)has been widely used in traumatic hemorrhagic shock and is considered to be an effective resuscitation measure.[1]Some studies reported that REBOA was also effective for non-traumatic hemorrhage.[2,3]In this study,we report a case of hemorrhagic shock caused by acute upper gastrointestinal bleeding that was successfully treated and received REBOA to obtain a transition *** report may provide feasible options for emergency physicians,gastroenterologists,or surgeons to more actively treat refractory gastrointestinal bleeding.

关键词： balloon hemorrhagic gastrointestinal

Sources for Heat-Stable Resistance to Southern Root-Knot Nematode (Meloidogyne incognita) in Solanum lycopersicum

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Agricultural Sciences in China 2009年第6期8卷 697-702页

作者： WU wen-wen SHEN Huo-lin YANG wen-cai Department of Vegetable Science College of Agronomy and Biotechnology China Agricultural University Beijing 100193 P.R.China

Southern root-knot nematode （Meloidogyne incognita） is a major problem in vegetable production in China due to the expansion of plastic tunnel and solar greenhouse. Using resistant cultivars is an effective approach to control the disease. Nine genes, Mi-1 to Mi-9, have been reported and only Mi-1 has been successfully used in tomato breeding. However, Mi-1 is inactive at a temperature above 28~C. In order to identify sources for heat-stable resistance to southern root-knot nematode, 53 genotypes of tomato （Solarium spp.） were inoculated with an isolate of M. incognita in the growth chamber at 28 or 32℃ for initial screening. 28 lines had less than 25 galls and were considered as resistant candidates. The top 60% （16 in total） of resistant candidates obtained from each temperature were subject to re-evaluation at 32~C using the same nematode isolate. Three lines ZN17, ZN 48, and LA0385 showed heat-stable resistance with an average of 10 galls or less per plant. LA0385 is a wild species, while ZNI7 and ZN48 are elite breeding lines. These lines were grown in a greenhouse for two seasons, and also showed high resistance with less than 10 galls per plant. Thus they were considered as good sources for breeding resistance to southern root-knot nematode in tomato.

关键词： heat-stable resistance Meloidogyne incognita tomato