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Amelanotic primary cervical malignant melanoma:A case report and review of literature

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World Journal of Clinical Oncology 2024年第7期15卷 953-960页

作者： Jin-Lin Duan Jing Yang Yong-Long Zhang wen-tao huang Department of Pathology The Affiliated Tongren HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200332China Laboratory of Targeted Therapy and Precision Medicine Department of Clinical LaboratoryShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Primary malignant melanoma of the cervix(PMMC)is an extremely rare disease that originates from primary cervical malignant melanoma and frequently re-presents a challenge in disease diagnosis due to unclarified clinical and histo-logical presentations,particularly those without *** SUMMARY Here,we report a case of amelanotic PMMC,with a history of breast cancer and thyroid *** patient was finally diagnosed by immunohistochemical staining and staged as IB2 based on the International Federation of Gynecology and Obstetrics with reference to National Comprehensive Cancer Network guide-lines and was treated with radical hysterectomy,bilateral salpingo-oophorectomy and pelvic *** then received combination therapy consisting of immunotherapy with tislelizumab and radiofrequency *** has remained free of disease for more than 1 *** The differential diagnosis process reenforced the notion that immunohisto-chemical staining is the most reliable approach for amelanotic PMMC *** to the lack of established therapeutic guidelines,empirical information from limited available studies does not provide the rationale for treatment-decision *** integrating'omics'technologies and patient-derived xenografts or mini-patient-derived xenograft models this will help to identify selective thera-peutic window(s)and screen the appropriate therapeutics for targeted therapies,immune checkpoint blockade or combination therapy strategies effectively and precisely that will ultimately improve patient survival.

关键词： Primary cervical malignant melanoma MelanA Immunotherapy Patient management Case report

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三维微分系统中心流形上的等时中心

数学学报（中文版） 2024年第5期67卷 995-1008页

作者：黄文韬王勤龙杜超雄广西应用数学中心(GXNU)广西师范大学数学与统计学院桂林541006 广西应用数学中心(GUET)桂林电子科技大学数学与计算科学学院桂林541004 长沙师范学院数学学院长沙410100

本文给出了研究一类三维多项式微分系统中心流形上等时中心的直接方法.首先,定义了三维系统的等时常数,并给出了求等时常数的递推公式,由此,不经中心流形而直接计算等时常数确定等时性的必要条件.在应用部分,解决了两类具体系统的等时... 详细信息

本文给出了研究一类三维多项式微分系统中心流形上等时中心的直接方法.首先,定义了三维系统的等时常数,并给出了求等时常数的递推公式,由此,不经中心流形而直接计算等时常数确定等时性的必要条件.在应用部分,解决了两类具体系统的等时中心问题.该方法是平面微分系统刘一戎奇点量计算形式级数方法的推广与发展.其算法是线性的,十分便于计算机代数系统来实现.

关键词：三维系统等时中心中心流形等时常数

Multiple Bifurcations of Critical Period for a Quartic Kolmogorov Model

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Acta Mathematicae Applicatae Sinica 2021年第4期37卷 673-681页

作者： Chao-xiong DU wen-tao huang School of Mathematics Changsha Normal UniversityChangsha410100China School of Mathematics and Statistics Guangxi Normal UniversityGuilin541001China

Our work is concerned with the bifurcation of critical period for a quartic Kolmogorov *** computing the periodic constants carefully,we show that point(1,1)can be a weak center of fourth order,and the weak centers condition is ***,point(1,1)can bifurcate 4 critical periods under a certain *** terms of multiple bifurcation of critical periodic problem for Kolmogorov model,studied results are less seen,our work is good and interesting.

关键词： singular values weak center periodic constants bifurcation of critical period

Multiple Limit Cycles Bifurcation From the Degenerate Singularity for a Class of Three-dimensional Systems

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 73-80页

作者： Qin-long WANG wen-tao huang Yi-rong LIU School of Science Hezhou UniversityHezhou542800China Mathematics School of Central South University Changsha 410075China

In this paper,bifurcation of small amplitude limit cycles from the degenerate equilibrium of a three-dimensional system is ***,the method to calculate the focal values at nilpotent critical point on center manifold is *** an example is studied,by computing the quasi-Lyapunov constants,the existence of at least 4 limit cycles on the center manifold is *** terms of degenerate singularity in high-dimensional systems,our work is new.

关键词： Quasi-Lyapunov constant degenerate singularity limit cycles bifurcation three-dimensional system

Weak Centers and Local Bifurcations of Critical Periods at Infinity for a Class of Rational Systems

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Acta Mathematicae Applicatae Sinica 2013年第2期29卷 377-390页

作者： wen-tao huang Valery G.ROMANOVSKI WEI-NIAN ZHANG School of Mathematics and Computing Science Guilin University of Electronic Technology Center for Applied Mathematics and Theoretical Physics University of Maribor School of Mathematics Sichuan University

We describe an approach to studying the center problem and local bifurcations of critical periods at infinity for a class of differential systems. We then solve the problem and investigate the bifurcations for a class... 详细信息

关键词： weak center isochronicity bifurcation of critical periods

Single-centre study comparing standard apical dissection with a modified technique to facilitate vesico-urethral anastomosis during laparoscopic radical prostatectomy

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Asian Journal of Andrology 2011年第3期13卷 494-498,515页

作者： Xin Gao Xiao-Yong Pu Jie Si-Tu wen-tao huang Department of Urology the Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China

A modified apical dissection of the prostate to improve the efficiency of vesico-urethral anastomosis （VUA） in laparoscopic radical prostatectomy （LRP） was reported. A total of 42 patients were randomly selected and enrolled in this study. A standard LRP was performed in 21 patients （group 1）, whereas a novel, modified apical dissection of the prostate in LRP was performed in another 21 patients （group 2）. Surgical data, total operative time, VUA time, extravasation rate, catheterisation time, occurrence of anastomotic strictures, and the early and late continence rates were analysed statistically. No differences in clinical or pathological characteristics were determined between the two groups. The total operative time, VUA time, blood loss and catheterisation time were lower in group 2, which received the novel, modified technique compared with group 1, which received the standard technique to dissect the apex of the prostate （P〈0.01 for each variable）. Regarding the extravasation rate and the occurrence of anastomotic strictures, no significant differences were found between the two groups （P〉0.0.05 for each）. After catheter removal, a statistically significant difference in the continence rates was present at 3 and 30 days post operation in the two groups （P〈0.01, respectively）. At 90 days post operation, the difference, although still present, was no longer statistically significant （P〉0.05）. The novel, modified apical dissection of the prostate facilitates the VUA and significantly improves the efficacy of the procedure and early restoration of continence.

关键词： continence laparoscopic technique radical prostatectomy vesico-urethral anastomosis

ALKBH5 suppresses autophagic flux via N6-methyladenosine demethylation of ZKSCAN3 mRNA in acute pancreatitis

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World Journal of Gastroenterology 2024年第12期30卷 1764-1776页

作者： tao Zhang Shuai Zhu Geng-wen huang Department of General Surgery Xiangya HospitalCentral South UniversityChangsha 410005HunanChina. National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410005HunanChina.

BACKGROUND Increasing evidence has demonstrated that N6-methyladenosine(m6A)RNA modification plays an essential role in a wide range of pathological *** autophagy is a critical hallmark of acute pancreatitis(AP).AIM To explore the role of the m6A modification of ZKSCAN3 in the regulation of autophagy in *** The AP mouse cell model was established by cerulein-treated mouse pancreatic acinar cells(MPC-83),and the results were confirmed by the levels of amylase and inflammatory *** activity was evaluated by specific identification of the autophagy-related microstructure and the expression of autophagy-related ***3 and ALKBH5 were knocked down to study the function in AP.A m6A RNA binding protein immunoprecipitation assay was used to study how the m6A modification of ZKSCAN3 mRNA is regulated by *** The increased expression of amylase and inflammatory factors in the supernatant and the accumulation of autophagic vacuoles verified that the AP mouse cell model was *** downregulation of LAMP2 and upregulation of LC3-II/I and SQSTM1 demonstrated that autophagy was impaired in *** expression of ZKSCAN3 was upregulated in *** of ZKSCAN3 increased the expression of LAMP2 and decreased the expression of the inflammatory factors,LC3-II/I and ***,ALKBH5 was upregulated in *** of ALKBH5 downregulated ZKSCAN3 expression and restored decreased autophagic flux in ***,the bioinformatic analysis revealed 23 potential m6A modification sites on ZKSCAN3 *** m6A modification of ZKSCAN3 mRNA was significantly decreased in *** of ALKBH5 increased the modification of ZKSCAN3 mRNA,which confirmed that ALKBH5 upregulated ZKSCAN3 expression in a m6A-dependent *** ALKBH5 inhibits autophagic flux through m6A demethylation of ZKSCAN3 mRNA in AP,thereby aggravating the severity of the disease.

关键词： Acute pancreatitis Autophagy ZKSCAN3 N6-methyladenosine ALKBH5

A strategy to achieve efficient green-emission dual-mode luminescence of Yb^(3+),Er^(3+) doped NaBiF_(4)

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Rare Metals 2021年第8期40卷 2040-2048页

作者： Jin-Hui Xie Jue Wang Gui-Hua Qiu Xi-Bing Li wen-tao huang Rui-Rong Zhang Tong Lin Li-Xi Wang Qi-Tu Zhang College of Materials Science and Engineering Nanjing Tech UniversityNanjing210009China Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites Nanjing210009China Shandong Institute of Non-metallic Material Jinan250031China

A series of hexagonal phase NaBiF_(4):x Yb^(3+),y Er^(3+) were successfully synthesized by solvothermal *** morphology,phase structure,up-conversion luminescence and down-conversion luminescence properties of Yb^(3+) and Er^(3+) doping concentration and the energy transfer mechanism were *** shows that the doping of Yb^(3+) and Er^(3+) does not cause the phase transition of NaBiF_(4),but influences its *** the NaBiF_(4):Yb^(3+),Er^(3+),Yb^(3+) can transfer energy with Er^(3+),enhancing up-conversion green *** Yb^(3+) doping concentration increasing,the up-conversion red-green ratio will increase while the down-conversion intensity of the green emission decreases and that of the red emission *** the potential application of Na BiF4:x Yb^(3+),y Er^(3+) phosphors in optical illumination,the thermal stability was carried out.

关键词： NaBiF_(4) Dual-mode luminescence Energy transfer High temperature fluorescence

Sampling-efficient path planning and improved actor-critic-based obstacle avoidance for autonomous robots

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Science China(Information Sciences) 2024年第5期67卷 197-214页

作者： Yefeng YANG tao huang Tianqi WANG wenyu YANG Han CHEN Boyang LI Chih-yung wen Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic University Center for Control Theory and Guidance Technology Harbin Institute of Technology School of Engineering The University of Newcastle Research Center for Unmanned Autonomous Systems The Hong Kong Polytechnic University

Autonomous robots have garnered extensive utilization in diverse fields. Among the critical concerns for autonomous systems, path planning holds paramount importance. Notwithstanding considerable efforts in its development over the years, path planning for autonomous systems continues to grapple with challenges related to low planning efficiency and inadequate obstacle avoidance response in a timely *** study proposes a novel and systematic solution to the path planning problem within intricate office buildings. The solution consists of a global planner and a local planner. To handle the global planning aspect, an adaptive clustering-based dynamic programming rapidly exploring random tree(ACDP-RRT) algorithm is proposed. ACDP-RRT effectively identifies obstacles on the map by leveraging geometric *** obstacles are then represented as a collection of sequentially arranged convex polygons, optimizing the sampling region and significantly enhancing sampling efficiency. For local planning, a network decoupling actor-critic(ND-AC) algorithm is employed. The proposed ND-AC simplifies the local planner design process by integrating planning and control loops into a neural network(NN) trained via an end-to-end model-free deep reinforcement learning(DRL) framework. Moreover, the adoption of network decoupling(ND) techniques leads to an improved obstacle avoidance success rate when compared to conventional actor-critic(AC)-based methods. Extensive simulations and experiments are conducted to demonstrate the effectiveness and robustness of the proposed approach.

关键词： rapidly exploring random tree (RRT) adaptive clustering network decoupling actor critic (AC) path planning