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Prospective study found that peripheral lymph node sampling reduced the false-negative rate of sentinel lymph node biopsy for breast cancer

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Chinese Journal of Cancer 2016年第6期35卷 63-68页

作者： Chao Han Ben Yang wen-shu zuo Yan-Song Liu Gang Zheng Li Yang Mei-Zhu Zheng School of Medicine and Life Sciences University of Jinan-Shandong Academy of Medical SciencesJinan 250022ShangdongPRChina Department of Surgery Shandong Breast Center of Prevention and TreatmentShandong Cancer Hospital Affiliated to Shandong UniversityShandong Academy of Medical Sciences440 Jiyan RoadJinan 250117ShangdongPRChina

Background:Although sentinel lymph node biopsy(SLNB) can accurately predict the status of axillary lymph node(ALN) metastasis,the high false?negative rate(FNR) of SLNB is still the main obstacle for the treatment of patients who receive SLNB instead of ALN dissection(ALND).The purpose of this study was to evaluate the clinical significance of SLNB combined with peripheral lymph node(PLN) sampling for reducing the FNR for breast cancer and to discuss the effect of "skip metastasis" on the FNR of ***:At Shandong Cancer Hospital Affiliated to Shandong University between March 1,2012 and June 30,2015,the sentinel lymph nodes(SLNs) of 596 patients with breast cancer were examined using radiocolloids with blue dye ***,the SLNs were removed;then,the area surrounding the original SLNs was selected,and the visible lymph nodes in a field of 3–5 cm in diameter around the center(i.e.,PLNs) were removed,avoiding damage to the structure of the ***,ALND was *** SLNs,PLNs,and remaining ALNs underwent pathologic examination,and the relationship between them was ***:The identification rate of SLNs in the 596 patients was 95.1%(567/596);the metastasis rate of ALNs was 33.7%(191/567);the FNR of pure SLNB was 9.9%(19/191);and after the SLNs and PLNs were eliminated,the FNR was 4.2%(8/191),which was significantly decreased compared with the FNR before removal of PLNs(P Aected number(N) of SLNs,the patients were divided into four groups of N = 0.028).ccording to the det= 1,2,3,and ≥4;the FNR in these groups was 19.6,9.8,7.3,and 2.3%,*** the patients with removal of PLNs was significantly decreased compared with that before remo≤2 or val of P≤3 detected SLNs,the FNR afterLNs(N 3:12.2% vs.4.7%,P ≤ 2:14.0% vs.4.7%,P = 0.019;N ≤ nt(P = 0.021),whereas for patients with ≥4 detected SLNs,the decrease in FNR was not statistically significa= 1.000).In the entire cohorts,the "skip metastasis" rate was 2.5%(15/596);the FNR caused by "s

关键词： Breast cancer Sentinel lymph node biopsy Peripheral lymph node False-negative rate Skip metastasis

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Patient satisfaction and follow-up adherence to glaucoma case management clinic in China

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 73-81页

作者： Hao Lin Hu-Jie Lu wen-Zhe Zhou shu-shu zuo Yan-Yan Chen Shao-Dan Zhang National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina School of Ophthalmology and Optometry Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To assess glaucoma patient satisfaction and follow-up adherence in case management and identify associated predictors to improve healthcare quality and patient ***:In this cross-sectional study,a total of 119 patients completed a Patient Satisfaction Questionnaire-18 and a sociodemographic *** data was obtained from the case management ***-up adherence was defined as completing each follow-up within±30d of the scheduled time set by ophthalmologists during the study ***:Average satisfaction scored 78.65±7,with an average of 4.39±0.58 across the seven *** negatively correlated with satisfaction(P=0.008),whilst patients with follow-up duration of 2 or more years reported higher satisfaction(P=0.045).Multivariate logistics regression analysis revealed that longer follow-up durations were associated with lower follow-up adherence(OR=0.97,95%CI,0.95-1.00,P=0.044).Additionally,patients with suspected glaucoma(OR=2.72,95%CI,1.03-7.20,P=0.044)and those with an annual income over 100000 Chinese yuan demonstrated higher adherence(OR=5.57,95%CI,1.00-30.89,P=0.049).CONCLUSION:The case management model proves effective for glaucoma patients,with positive adherence *** implementation of this model can be optimized in the future based on the identified factors and extended to glaucoma patients in more hospitals.

关键词： glaucoma patient satisfaction follow-up adherence case management

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Large eddy simulation of boundary layer combustion of hydrogen and hydrocarbon fuel films in a modeled scramjet combustor

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Chinese Journal of Aeronautics 2024年第7期37卷 109-133页

作者： Jianfei WEI Silong ZHANG Jingying zuo Xin LI Jiang QIN wen BAO School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China

Supersonic fuel film cooling is a promising way to simultaneously reduce the severe wall heat and friction load of the internal passage in a scramjet engine when operating at hypersonic *** eddy simulations were performed to investigate the cooling and wall friction characteristics of hydrogen and hydrocarbon films under inert and reactive *** results show that the essential difference of the turbulent state in the mixing layer contributes to the totally different behaviors of the cooling and wall friction reduction performances of the two fuel *** turbulent transport processes between the hydrogen film and the mainstream are much weaker as compared to the case of hydrocarbon film,making inert hydrogen rather superior in cooling and friction reduction ***,the increase of wall temperature for hydrogen film under the inert case is mainly driven by the loss of hydrogen with high heat capacity instead of by direct heat ***,the film cooling performance severely deteriorates when the hydrogen film burns due to presence of severe heat release sources near the *** the other hand,combustion of hydrocarbon film in the boundary layer can remarkably improve its originally barely-satisfactory cooling and friction reduction performance to the level comparable to that of hydrogen film,due to the suppression of turbulent transport processes in the mixing layer and presence of heat absorption sources near the ***,the hydrogen film is more advantageous in friction reduction,while the hydrocarbon film is more suitable for cooling.

关键词： Supersonic film cooling Hydrogen Hydrocarbon Boundary layer combustion Large eddy simulation

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Exploring a new path of green and efficient utilization of sinter return fine to produce composite pellets

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Journal of Iron and Steel Research International 2024年第7期31卷 1610-1622页

作者： Yan-biao Chen wen-guo Liu Hao Guo Jing-song Wang Qing-guo Xue Hai-bin zuo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China MCC Capital Engineering and Research Incorporation Limited Beijing 100176China

Efficient utilization of sinter return fine is an important measure to reduce cost,increase efficiency,save energy and reduce emission.A new path of green and efficient utilization of return fine was proposed to produce composite *** metallurgical properties of composite pellets under the condition of hydrogen-rich blast furnace were *** experimental results indicate that the coated concentrate was consolidated for the composite pellets through normal Fe_(2)O_(3) *** the surface of core return fine,the liquid phase formed due to its low-melting point,assimilated the adjacent concentrate,and then consolidated with the temperature *** with regular pellets,the com-pressive strength and reduction swelling index of composite pellets were decreased,but the reducibility index and softening-melting properties were *** addition,the reduction degradation index of composite pellets was sig-nificantly higher than that of ***,adding composite pellets was conducive to indirect reduction in blast furnace,reducing fuel ratio and improving production *** to the effect of the roasting system on the metallurgical properties,the roasting temperature and time were determined as 1250℃and 30 min,*** composite pellets can be produced under the traditional pelletizing process.

关键词： Sinter Return fine Composite pellet Roasting system Metallurgical property Hydrogen-rich blast furnace

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Robustness Assessment of Wind Power Generation Considering Rigorous Security Constraints for Power System: A Hybrid RLO-IGDT Approach

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 518-529页

作者： Lianyong zuo Shengshi Wang Yong Sun Shichang Cui Jiakun Fang Xiaomeng Ai Baoju Li Chengliang Hao Jinyu wen State Key Laboratory of Advanced Electromagnetic Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430073China State Grid Jilin Electric Power Company Changchun 130021China

Fossil fuel depletion and environmental pollution problems promote development of renewable energy(RE)*** increasing penetration of RE,operation security and economy of power systems(PS)are greatly impacted by fluctuation and intermittence of renewable *** this paper,information gap decision theory(IGDT)is adapted to handle uncertainty of wind power *** on conventional IGDT method,linear regulation strategy(LRS)and robust linear optimization(RLO)method are integrated to reformulate the model for rigorously considering security *** a robustness assessment method based on hybrid RLO-IGDT approach is proposed for analyzing robustness and economic performance of ***,a risk-averse linearization method is adapted to convert the proposed assessment model into a mixed integer linear programming(MILP)problem for convenient optimization without robustness ***,results of case studies validate superiority of proposed method in guaranteeing operation security rigorously and effectiveness in assessment of RSR for PS without *** Terms-Hybrid RLO-IGDT approach,information gap decision theory(IGDT),operation security,robustness assessment,robustness security region(RSR).

关键词： IGDT approach information gap decision theory(IGDT) operation security robustness assessment robustness security region(RSR)

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Improving mathematical model of burden distribution and correcting chute angle to cope with fluctuation of stock line

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Journal of Iron and Steel Research International 2024年第2期31卷 342-356页

作者： Jian-sheng Chen wen-guo Liu Hao Guo Wang Ding Qing-guo Xue Jing-song Wang Hai-bin zuo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China MCC Capital Engineering&Research Incorporation Limited Beijing100176China Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina

Accurate evaluations of the burden distribution are of critical importance to stabilize the operation of blast *** mathematical model and discrete element method(DEM)are two attractive methods for predicting burden *** on DEM,the initial velocities of the pellet,sinter,and coke were calculated,and the velocity attenuations of the above three particles between the burden and the chute were *** initial velocity and velocity attenuation were applied to a mathematical model for improving the ***,based on the improved model,a scheme for rectifying the chute angles was proposed to address the fluctuation of the stock line and maintain a stable burden *** validity of the scheme was confirmed via a stable burden distribution under different stock *** mathematical model has been successfully applied to evaluate the online burden distribution and cope with the fluctuation of the stock line.

关键词： Burden distribution Mathematical model Discrete element method Velocity attenuation Stock line fluctuation

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AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 43-51页

作者： Qing-Qi Zhang Qian Chen Pan Cao Chun-Xia Shi Lu-Yi Zhang Lu-wen Wang zuo-Jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060China

Background:Acute liver failure(ALF)is an unpredictable and life-threatening critical *** pathological characteristic of ALF is massive necrosis of hepatocytes and lots of inflammatory cells infiltration which may lead to multiple organ ***:Animals were divided into 3 groups,normal,thioacetamide(TAA,ALF model)and TAA+*** L02 cells were divided into 5 groups,normal,TAA,TAA+mitofusin 2(MFN2)-siRNA,TAA+AGK2,and TAA+AGK2+MFN2-siRNA *** liver histology was evaluated with hematoxylin and eosin staining,inositol-requiring enzyme 1(IRE1),activating transcription factor 6β(ATF6β),protein kinase R(PKR)-like endoplasmic reticulum kinase(PERK)and phosphorylated-PERK(p-PERK).C/EBP homologous protein(CHOP),reactive oxygen species(ROS),MFN2 and glutathione peroxidase 4(GPX4)were measured with Western blotting,and cell viability and liver chemistry were also *** endoplasmic reticulum membranes(MAMs)were measured by ***:The liver tissue in the ALF group had massive inflammatory cell infiltration and hepatocytes necrosis,which were reduced by AGK2 *** comparison to the normal group,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+in the TAA-induced ALF model group were significantly increased,which were decreased by AGK2 *** levels of MFN2 and GPX4 were decreased in TAA-induced mice compared with the normal group,which were enhanced by AGK2 *** with the TAA-induced L02 cell,apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+were further increased and levels of MFN2 and GPX4 were decreased in the MFN2-siRNA ***2 pre-treatment decreased the apoptosis rate and levels of IRE1,ATF6β,p-PERK,CHOP,ROS and Fe2+and enhanced the protein expression of MFN2 and GPX4 in MFN2-siRNA treated L02 *** observation showed that level of MAMs was promoted in the AGK2 pre-treatment group when compared with the TAA-induced gr

关键词： SIRT2 inhibitor AGK2 Acute liver failure MFN2 Ferroptosis

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Amplification effect of intra-seasonal variability of soil moisture on heat extremes over Eurasia

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Advances in Climate Change Research 2024年第1期15卷 1-8页

作者： Yi-Nuo WANG Zhi-Yan zuo Liang QIAO Kai-wen ZHANG Mei-Yu CHANG Dong XIAO Zou-Xing LIN Huan WANG Department of Atmospheric and Oceanic Sciences Institute of Atmospheric SciencesFudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Key Laboratory of Cites Mitigation and Adaptation to Climate Change in Shanghai China Meteorological AdministrationShanghai 200030China Collaborative Innovation Centeron Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 211800China Shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Shanghai 200123China College of Geography and Resources Science Sichuan Normal UniversityChengdu 610101China National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary Shanghai 202183China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China

Drying soil has been conducive to a high frequency of extreme high-temperature events over many regions worldwide in recent ***,changes in the intraseasonal variability of soil moisture can also influence the likelihood of extremely high *** previous investigators have examined the association between extremely high temperatures and large-scale atmospheric circulation variability,the role of land-atmosphere coupling dominated by soil moisture variability in extremely high temperatures,particularly over the Eurasian continent,is not well *** this study,on the basis of the Land Surface,Snow,and Soil Moisture Model Intercomparison Project,we found that land-atmosphere feedback amplified the variability of soil moisture in most regions of Eurasia during summer from 1980 to *** amplification of soil moisture variability is closely correlated with more intensive intraseasonal variability of surface air temperature and more frequent occurrences of extreme high-temperature events,particularly in Europe,Siberia,Northeast Asia,and the Indochina *** correlation implies that increasing the intraseasonal variability of soil moisture results in a high likelihood of heat extremes during summer in most parts of Eurasia except Asian desert *** the intraseasonal timescale,the land-atmosphere coupling increases the variability of surface sensible heat flux and net long-wave radiation heating the atmosphere by intensifying the soil moisture variability,thus amplifying the variability of surface air temperature and enhancing the extreme high-temperature *** finding demonstrates the importance of changes in intraseasonal soil moisture variability for the increasing likelihood of heat extremes in summer.

关键词： Soil moisture Intraseasonal variability Land-atmosphere coupling Heat extremes

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Harpoon-shaped topological photonic crystal for on-chip beam splitter

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 91-98页

作者： Zhiwei Guan Ruixue Dou Chuangxin Xie Tianyimei zuo Liyu Huang Keyin wen Chaofeng Wang Huapeng Ye Junmin Liu Ze Dong Dianyuan Fan shuqing Chen Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060China College of Physics and Engineering Technology Minzu Normal University of XingyiXingyi 562400China Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China College of New Materials and New Energies Shenzhen Technology UniversityShenzhen 518118China School of information and Electronics Beijing Institute of TechnologyBeijing 100081China

The advancement of integrated optical communication networks necessitates the deployment of on-chip beam splitters for efficient signal interconnections at network ***,the pursuit of micron-scale beam splitting with large corners and reducing the device footprint to boost connection flexibility often results in phase *** mismatches,which stem from radiation modes and backward scattering,pose significant obstacles in creating highly integrated and interference-resistant *** address this,we introduce a solution based on the topological valley-contrasting state generated by photonic crystals with opposing valley Chern numbers,manifested in a harpoon-shaped structure designed to steer the splitting *** approach enables adiabatic mode field evolution over large corners,capitalizing on the robust phase modulation capabilities and topological protection provided by the subwavelength-scale valley-contrasting *** demonstration reveals that beam splitters with large corners of 60°,90°,and 120°exhibit insertion loss fluctuations below 2.7 dB while maintaining a minimal footprint of 8.8μm×8.8μ*** a practical demonstration,these devices facilitate three-channel signal connections,successfully transmitting quadrature phase shift keying signals at 3.66 Tbit/s with bit error rates below the forward error correction threshold,demonstrating performance comparable to that in defects *** harnessing the unidirectional excitation feature,we anticipate significant enhancements in the capabilities of signal distribution and connection networks through a daisy chain configuration.

关键词： channel interconnection on-chip beam splitter topological valley-contrasting state

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Mating behaviors in ovoviviparous black rockfish(Sebastes schlegelii):molecular function of prostaglandin E2 as both a hormone and pheromone

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Marine Life Science & Technology 2024年第1期6卷 15-30页

作者： Likang Lyu Yijia Yao Songyang Xie Xiaojie Wang Haishen wen Yun Li Jianshuang Li Chenpeng zuo Shaojing Yan Jingyi Dong Xin Qi Key Laboratory of Mariculture(Ocean University of China) Ministry of EducationOcean University of ChinaQingdao 266003China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China

Prostaglandins(PGs)are profound hormones in teleost sexual behavior,especially in *** act as pheromones that affect the olfactory sensory neurons of males,inducing the initiation of a series of mating ***,the molecular mechanism by which PGs trigger mating behavior in ovoviviparous teleosts is still *** the present study,we employed the ovoviviparous black rockfish(Sebastes schlegelii),an economically important marine species whose reproductive production is limited by incomplete fertilization,as a model *** results showed that when the dose of PGE2 was higher than 10 nmol/L,a significant(P<0.05)increase in mating behaviors was ***-fluorescence in situ hybridization indicated that PGE2 could fire specific neurons in different brain regions and receptor cells in the olfactory *** combining with specific neurons in the central nervous system(CNS),a series of genes related to reproduction are *** intracerebroventricular administration of PGE_(2) significantly increased lhb levels(P<0.05)in both ***,steroidogenesis in gonads was also affected,inducing an increase(P<0.05)in E_(2) levels in males and T levels in ***_(2) levels were also increased significantly(P<0.05)in both *** present study revealed that PGE2 can activate mating behavior in black rockfish in both hormone and pheromone pathways,leading to variations in sex steroid levels and activation of reproductive *** results provide not only novel insight into the onset of mating behaviors in ovoviviparous teleosts but also solutions for the incomplete fertilization caused by natural mating in cage aquaculture.

关键词： Black rockfish Mating behavior Ovoviviparity Prostaglandin E2

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