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Application of hybrid operating rooms for treating spinal dural arteriovenous fistula

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World Journal of Clinical Cases 2020年第6期8卷 1056-1064页

作者： Nai Zhang wen-qiang xin Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND A hybrid operating room(hybrid-OR)is a surgical space that combines a conventional operating room with advanced medical imaging *** To explore and summarize the technical features and effectiveness of the application of a hybrid-OR in dealing with spinal dural arteriovenous fistulas(SDAVFs).METHODS Eleven patients with SDAVFs were treated with the use of a hybrid-OR at the Department of Neurosurgery of our hospital between January 2015 and December *** dual-marker localization technique was used in the hybrid-OR to locate the SDAVFs and skin incision,and the interoperative digital subtraction angiography(DSA)technique was used before and after microsurgical ligation of the fistulae in the hybrid-OR to verify the accuracy of *** patients were followed for an average of 2 years after the operation,and the preoperative American Spinal Cord Injury Association(ASIA)score and postoperative ASIA score at 6 mo after the operation were *** The location and skin incision of the SDAVFs were accurately obtained by using the dual-marker localization technique in the hybrid-OR in all patients,and there were no cases that required expansion of the range of the bone window in order to expose the *** error obliteration occurred and was identified in two patients by using the intraoperative DSA technique;therefore,the findings provided by the intraoperative DSA system significantly changed the surgical procedure in these two *** the assistance of the hybrid-OR,the feeding artery was correctly ligated in all cases,and the intraoperative error obliteration rate decreased from 18.2%(2/11)to 0%.All 11 patients were followed for an average of 2 *** ASIA score at 6 mo after the operation was significantly improved compared with the preoperative ASIA score,and there were no patients with late recurrence during the *** Compared with intra-arterial embolization for the treatment of SDAVFs,hyb

关键词： Spinal dural arteriovenous fistula Hybrid operating room Dual-marker localization technique Interoperative DSA technique Retrospective study

Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia

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World Journal of Stem Cells 2021年第8期13卷 1030-1048页

作者： wen-qiang xin Wei Wei Yong-Li Pan Bao-Long Cui xin-Yu Yang Mathias Bähr Thorsten R Doeppner Department of Neurology University Medical Center GöttingenGöttingen 37075Germany Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China

Inflammation plays an important role in the pathological process of ischemic stroke,and systemic inflammation affects patient *** resident immune cells in the brain,microglia are significantly involved in immune defense and tissue repair under various pathological conditions,including cerebral *** the differentiation of M1 and M2 microglia is certainly oversimplified,changing the activation state of microglia appears to be an intriguing therapeutic strategy for cerebral *** evidence indicates that both mesenchymal stem cells(MSCs)and MSC-derived extracellular vesicles(EVs)regulate inflammation and modify tissue repair under preclinical stroke ***,the precise mechanisms of these signaling pathways,especially in the context of the mutual interaction between MSCs or MSC-derived EVs and resident microglia,have not been sufficiently ***,this review summarizes the state-ofthe-art knowledge on MSC-and MSC-EV-mediated regulation of microglial activity under ischemic stroke conditions with respect to various signaling pathways,including cytokines,neurotrophic factors,transcription factors,and microRNAs.

关键词： Extracellular vesicles Mesenchymal stem cells Microglial activation M2 polarization Ischemic stroke

Majocchi’s granuloma caused by Trichophyton rubrum after facial injection with hyaluronic acid:A case report

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World Journal of Clinical Cases 2020年第17期8卷 3853-3858页

作者： Jie Liu wen-qiang xin Lan-Ting Liu Chao-Feng Chen Lin Wu Xiao-Ping Hu Department of Dermatology Skin Research Institute of Peking University Shenzhen HospitalPeking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina Department of Neurosurgery Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Facial cosmetic procedures become popular for people with a desire to have a younger appearance,and cosmetic technology has developed rapidly over the past several ***,increasing complications related to cosmetic injections have been reported,and infection is one of the most serious problems and can cause anxiety and facial *** here report a case of Majocchi’s granuloma(MG)caused by Trichophyton rubrum after facial injection of hyaluronic *** SUMMARY A 37-year-old woman presented to our hospital with a history of red papules,nodules,and abscesses on her left zygomatic arch for 2 *** had received a cosmetic injection of hyaluronic acid on the left side of her face prior to the appearance of the *** caused by Trichophyton rubrum after facial injection of hyaluronic acid was diagnosed based on morphology and molecular biological *** vitro antifungal susceptibility testing was conducted according to the Clinical and Laboratory Standards Institute M38-A2 *** inhibitory concentrations were used to evaluate the antifungal *** antifungal agents and their minimal inhibitory concentrations for the strain were terbinafine(<0.5μg/mL),itraconazole(0.06μg/mL),amphotericin B(0.25μg/mL),fluconazole(32μg/mL),voriconazole(0.125μg/mL),posaconazole(0.125μg/mL),and isavuconazole(0.06μg/mL).We initially administered 250 mg/d oral terbinafine for 2 mo,but the patient still had painful papules,nodules and abscesses on her ***,we adjusted the treatment to itraconazole 400 mg/d for 8 wk based on the in vitro antifungal susceptibility testing *** skin lesions improved significantly,and there was no recurrence during *** This case revealed that facial injection of hyaluronic acid may cause serious *** susceptibility testing should be considered in the treatment of MG caused by Trichophyton rubrum.

关键词： Trichophyton rubrum Facial injection Hyaluronic acid Case report

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang wen-Jie Shi Yu-xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

不同性别急诊非创伤性胸痛患者的临床特点及病因分析

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中国全科医学 2016年第29期19卷 3607-3610页

作者：文新强郑冰唐映利兵器工业521医院急诊科陕西省西安市710065

目的探讨不同性别急诊非创伤性胸痛患者的临床特点及病因。方法选择2013年6月—2015年7月兵器工业521医院接诊的以急性非创伤性胸痛为主诉就诊的患者384例,将其按照性别分为男性组（n=206）和女性组（n=178）,比较两组患者基本资料、胸... 详细信息

目的探讨不同性别急诊非创伤性胸痛患者的临床特点及病因。方法选择2013年6月—2015年7月兵器工业521医院接诊的以急性非创伤性胸痛为主诉就诊的患者384例,将其按照性别分为男性组（n=206）和女性组（n=178）,比较两组患者基本资料、胸痛特点（包括疼痛诱因、疼痛部位、疼痛性质、疼痛持续时间、有无放射痛或并发症等）、胸痛病因（包括心源性、肺源性、主动脉夹层、胃肠源性、带状疱疹、原因不明确等）、心电图、超声心动图等临床资料。结果两组患者高血压病史、糖尿病病史、高血脂病史比较,差异均无统计学意义（P〉0.05）;两组患者年龄、吸烟史、饮酒史比较,差异均有统计学意义（P〈0.05）。两组患者疼痛部位、有无放射痛比较,差异均无统计学意义（P〉0.05）;两组患者疼痛诱因、疼痛性质、疼痛持续时间、有无并发症比较,差异均有统计学意义（P〈0.05）。男性组中胸痛病因分别为心源性84例（40.78%）、肺源性62例（30.10%）、主动脉夹层9例（4.37%）、胃肠源性37例（17.96%）、带状疱疹3例（1.46%）、原因不明确11例（5.33%）;女性组中胸痛病因分别为心源性61例（34.27%）、肺源性53例（29.78%）、主动脉夹层7例（3.93%）、胃肠源性20例（11.24%）、带状疱疹4例（2.25%）、原因不明确33例（18.53%）。两组患者胸痛病因构成比较,差异有统计学意义（χ2=27.228,P〈0.05）。两组患者心电图ST-T改变、超声心动图中左心室舒张功能降低、左心室射血功能降低、室壁运动异常发生率比较,差异均无统计学意义（P〉0.05）。男性患者18~30岁胸痛病因主要是胃肠源性（66.67%）,31~50岁、51~70岁、71~82岁胸痛病因主要是心源性（分别为37.10%、50.67%、53.85%）。女性患者18~30岁胸痛病因主要是胃肠源性（29.41%）,31~50岁胸痛病因主要是原因不明确（31.33%）,51~70岁、71~82岁胸痛病因主要是心源性（分别为45.10%、51.85%）。结论男、女性急诊非创伤性胸痛病因均以心源性胸痛为主,男性患者年龄大者所占比例较女性高,且多有吸烟史和饮酒史,此类患者在临床诊治过程中应根据疾病特点及时准确治疗。

关键词：胸痛急诊处理病因分析临床特点

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi wen xin Xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

三维能量多普勒超声检测黄体血流对高龄女性妊娠的作用

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西安交通大学学报（医学版） 2018年第4期39卷 567-572页

作者：王丽文新强张文轲吕淑兰杨筱凤李芬白娥西安交通大学第一附属医院妇产科陕西西安710061 兵器工业521医院陕西西安710065 青岛大学附属医院妇产科山东青岛266555

目的探索三维能量多普勒超声检测黄体血流对高龄女性妊娠的作用。方法选择2016年1月至2017年7月在西安交通大学第一附属医院就诊的排卵正常高龄女性464例为研究组,选择同期计划妊娠0.05),排卵后第1天黄体血流分级亦无统计学差异(P>0.05)... 详细信息

目的探索三维能量多普勒超声检测黄体血流对高龄女性妊娠的作用。方法选择2016年1月至2017年7月在西安交通大学第一附属医院就诊的排卵正常高龄女性464例为研究组,选择同期计划妊娠0.05),排卵后第1天黄体血流分级亦无统计学差异(P>0.05),但研究组排卵后第7~9天黄体血流分级较对照组显著降低(P0.05),研究组排卵后第7~9天黄体血管形成指数(VI)、血流指数(FI)、血管形成-血流指数(VFI)均显著低于对照组(P<0.05)。研究组生化妊娠率和临床妊娠率分别为16.38%、9.05%,显著低于对照组的23.17%、19.04%(P<0.05)。研究组生化妊娠流产率为7.33%,显著高于对照组的4.13%(P<0.05)。两组患者中生化妊娠流产组黄体V、VI、FI、VFI均显著低于临床妊娠组(P<0.05)。结论高龄女性胚胎着床窗口期黄体血供减少,可能与子宫内膜容受性和妊娠率降低有关。无论高龄与否,生化妊娠流产者易出现黄体血供减少,进而导致妊娠失败。

关键词：三维能量多普勒超声黄体血流血管参数高龄女性妊娠

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu wen-qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids