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Monolithic integration of embedded Ⅲ-Ⅴ lasers on SOI

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Light(Science & Applications) 2023年第5期12卷 743-753页

作者： wen-qi wei An He Bo Yang Zi-Hao Wang Jing-Zhi Huang Dong Han Ming Ming Xuhan Guo Yikai Su Jian-Jun Zhang Ting Wang Institute of Physics Chinese Academy of SciencesBeijingChina Songshan Lake Materials Laboratory DongguanGuangdongChina State Key Laboratory of Advanced Optical Communication Systems and NetworksDepartment of Electronic EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Physical Sciences University of Chinese Academy of SciencesBeijingChina

Silicon photonic integration has gained great success in many application fields owing to the excellent optical device properties and complementary metal-oxide semiconductor(CMOS)*** monolithic integration of Ⅲ-Ⅴ lasers and silicon photonic components on single silicon wafer is recognized as a long-standing obstacle for ultradense photonic integration,which can provide considerable economical,energy-efficient and foundry-scalable onchip light sources,that has not been reported ***,we demonstrate embedded InAs/GaAs quantum dot(QD)lasers directly grown on trenched silicon-on-insulator(SOI)substrate,enabling monolithic integration with buttcoupled silicon *** utilizing the patterned grating structures inside pre-defined SOI trenches and unique epitaxial method via hybrid molecular beam epitaxy(MBE),high-performance embedded InAs QD lasers with monolithically out-coupled silicon waveguide are achieved on such *** resolving the epitaxy and fabrication challenges in such monolithic integrated architecture,embedded Ⅲ-Ⅴ lasers on SOI with continuous-wave lasing up to 85°C are *** maximum output power of 6.8mW can be measured from the end tip of the butt-coupled silicon waveguides,with estimated coupling efficiency of approximately-6.7 *** results presented here provide a scalable and low-cost epitaxial method for the realization of on-chip light sources directly coupling to the silicon photonic components for future high-density photonic integration.

关键词： SOI trench waveguide

Hepatocytes targeting of cationic liposomes modified with soybean sterylglucoside and polyethylene glycol

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World Journal of Gastroenterology 2005年第32期11卷 4947-4952页

作者： Xian-Rong qi wen-wei Yan Jing Shi Department of Pharmaceutics School of Pharmaceutical Sciences Peking University Beijing 100083 China

AIM： In this study, a hepatocyte-specific targeting technology was developed by modifying cationic liposomes with soybean sterylglucoside （SG） and polyethylene glycol （PEG）（C/SG/ PEG-liposomes）. METHODS： The liposomal transfection efficiencies in HepG2 2.2.15 cells were estimated with the use of fluorescein sodium （FS） as a model drug, by flow cytometry. The antisense activity of C/SG/PEG-liposomes entrapped antisense oligonucleotides （ODN） was determined as HBsAg and HBeAg in HepG2 2.2.15 cells by ELISA. The liposome uptake by liver and liver cells in mice was carried out after intravenous injection of 3H-labeled liposomes. RESULTS： C/SG-liposomes entrapped FS were effectively transfected into HepG2 2.2.15 cells in vitro. C/SG/PEG-Iiposomes entrapped ODN, reduced the secretion of both HBsAg and HBeAg in HepG2 2.2.15 cells when compared to free ODN. After in vivo injection of ^3H-labeled C/SG/PEG-liposomes, higher radiation accumulation was observed in the hepatocytes than non-parenchymal cells of the liver. CONCLUSION： C/SG/PEG-liposomes mediated gene transfer to the liver is an effective gene-delivery method for hepatocytes-specific targeting, which appears to have a potential for gene therapy of HBV infections.

关键词： Hepatocytes targeting Cationic liposomes Soybean sterylglucoside

Bufferless Epitaxial Growth of GaAs on Step-Free Ge(001)Mesa

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Chinese Physics Letters 2021年第6期38卷 67-71页

作者： Ding-Ming Huang Jie-Yin Zhang Jian-Huan Wang wen-qi wei Zi-Hao Wang Ting Wang Jian-Jun Zhang Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

GaAs/Ge heterostructures have been employed in various semiconductor devices such as solar cells,high-performance CMOS transistors,andⅢ-Ⅴ/Ⅳheterogeneous optoelectronic *** performance of these devices is directly dependent on the material quality of the GaAs/Ge heterostructure,while the material quality of the epitaxial GaAs layer on the Ge is limited by issues such as the antiphase domain(APD),and stacking-fault pyramids(SFP).We investigate the epitaxial growth of high-quality GaAs on a Ge(001)mesa array,via molecular beam *** a systematic study of the Ge terrace via an in situ scanning tunneling microscope,an atomically step-free terrace on the Ge mesa measuring up to 5×5μm^(2) is obtained,under optimized growth *** step-free terrace has a single-phase c(4×2)surface *** deposition of a high-quality GaAs layer with no APD and SFP is then achieved on this step-free Ge ***-resolution transmission electron microscopy and electron channel contrast image characterizations reveal the defect-free growth of the GaAs layer on the step-free Ge ***,InAs quantum dots on this GaAs/Ge mesa reveal photoluminescent intensity comparable to that achieved on a GaAs substrate,which further confirms the high quality of the GaAs layer on Ge.

关键词： GaAs/Ge optoelectronic tunneling

1,3-Dinitro-2-chloro-5-trifluorotoluene and its bridged derivatives Ⅰ.An investigation on the displacement reactions of bidentate nucleophiles towards aromatic rings

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Chinese Journal of Chemistry 1991年第4期9卷 343-350页

作者： JI,Jing-Shun CHEN,Mei-Jin WANG,qi-wen SHENG,wei Shanghai Institute of Organic Chemistry,Academia Sinica,Shanghai 200032

The reactions of 1,3-dinitro-2-chloro-5-trifluorotoluene(DNCTT)(1)and its bridged com- pounds with bidentate nucleophiles have been *** or secondary diamines and diethylene glycol react with 1 and its bridged derivatives by replacing the substituent grouppara to CF_3, whereas ethanedithiol reacts either by replacing the substituent group para to CF_3 or by displacing both groups and a nitro *** results have been rationalized in terms of electronic effects and nucleophilicity of the nucleophiles.

关键词： An investigation on the displacement reactions of bidentate nucleophiles towards aromatic rings Dinitro-2-chloro-5-trifluorotoluene and its bridged derivatives

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu wei Huang Jiayi wen Xin Xiong Ting Xu qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

Multi-wavelength injection locked semiconductor comb laser

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Photonics Research 2022年第8期10卷 1840-1847页

作者： JIA-JIAN CHEN wen-qi wei JIA-LE qiN BO YANG JING-ZHI HUANG ZI-HAO WANG TING WANG CHANG-YUAN YU JIAN-JUN ZHANG Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China Department of Electronic and Information Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China

Quantum dot lasers on silicon have gained significant interest over the past decade due to their great potential as an on-chip silicon photonic light source. Here, we demonstrate multi-wavelength injection locking of In As/Ga As quantum dot Fabry–Perot(FP) lasers both on Ga As and silicon substrates by optical self-injection via an external cavity. The number of locked laser modes can be adjusted from a single peak to multiple peaks by tuning wavelength dependent phase and mode spacing of back-injected light through a Lyot filter. The multi-wavelength injection locked laser modes exhibit average optical linewidth of ~20 k Hz, which are narrowed by approximately three orders of magnitude from their free-running condition. Furthermore, multi-wavelength self-injection locking via an external cavity exhibits flat-top optical spectral properties with approximately 30 stably locked channels under stable operation over time, where the frequency detuning is less than 700 MHz within 40 min. Particularly,FP lasers by direct epitaxial growth on silicon substrates are self-injection locked as a flat-top comb source with tunable free spectral range from approximately 25 to 700 GHz. The reported results emphasize the great potential of multi-wavelength injection locked lasers as tunable on-chip multi-wavelength light sources.

关键词： tuning laser tunable

Ultra-broadband flat-top quantum dot comb lasers

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Photonics Research 2022年第5期10卷 1308-1316页

作者： JING-ZHI HUANG ZI-TAO JI JIA-JIAN CHEN wen-qi wei JIA-LE qiN ZI-HAO WANG ZHI-YUAN LI TING WANG XI XIAO JIAN-JUN ZHANG Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronic Engineering University of Chinese Academy of SciencesBeijing 100049China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China Songshan Lake Materials Laboratory Dongguan 523808China National Information Optoelectronics Innovation Center China Information and Communication Technologies Group Corporation(CICT)Wuhan 430074China

A quantum dot(QD)mode-locked laser as an active comb generator takes advantage of its small footprint,low power consumption,large optical bandwidth,and high-temperature stability,which is an ideal multi-wavelength source for applications such as datacom,optical interconnects,and *** this work,we report a fourth-order colliding pulse mode-locked laser(CPML)based on InAs/GaAs QD gain structure,which can generate ultrastable optical frequency combs in the O-band with 100 GHz spacing at operation temperature up to 100℃.A record-high flat-top optical comb is achieved with 3 dB optical bandwidth of 11.5 nm(20 comb lines)at 25℃.The average optical linewidth of comb lines is measured as 440 ***-channel non-return-to-zero modulation rates of 70 Gbit/s and four-level pulse amplitude modulation of 40 GBaud/s are also *** further extend the comb bandwidth,an array of QD-CPMLs driven at separate temperatures is proposed to achieve 36 nm optical bandwidth(containing 60 comb lines with 100 GHz mode spacing),capable of a total transmission capacity of 4.8 Tbit/*** demonstrated results show the feasibility of using the QD-CPML as a desirable broadband comb source to build future large-bandwidth and power-efficient optical interconnects.

关键词： quantum spacing mode

随机共因失效条件下的多阶段任务成功概率评估研究

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兵工学报 2017年第4期38卷 766-775页

作者：曹文斌胡起伟苏续军赵建民军械工程学院装备指挥与管理系河北石家庄050003 军械工程学院火炮工程系河北石家庄050003

共因失效广泛存在于装备作战任务过程中,合理地对共因失效事件进行建模,对于准确评估装备任务成功概率,具有十分重要的意义。针对现有的多阶段任务成功概率评估模型中没有考虑的一类随机共因失效问题,采用隐式二元决策图法,建立了当共... 详细信息

共因失效广泛存在于装备作战任务过程中,合理地对共因失效事件进行建模,对于准确评估装备任务成功概率,具有十分重要的意义。针对现有的多阶段任务成功概率评估模型中没有考虑的一类随机共因失效问题,采用隐式二元决策图法,建立了当共因失效事件的产生服从随机分布时的多阶段任务成功概率评估解析模型,并以某型火箭炮装备为实际案例对模型进行了验证。研究结果表明:所建立的数学模型可以解决随机共因失效条件下的多阶段任务成功概率评估问题,为评估装备多阶段任务成功概率提供了模型支撑;合理地任务剖面分析与建模有助于准确评估装备任务成功概率。

关键词：系统评估与可行性分析多阶段任务成功概率随机共因失效二元决策图

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou wei Chen Aidong wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics