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KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2959-2976页

作者： Chaofan peng peng Yang Dongsheng Zhang Chi Jin wen peng Tuo Wang Qingyang Sun Zhihao Chen Yifei Feng Yueming Sun Department of General Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Colorectal Institute of Nanjing Medical University Nanjing 210029China The First School of Clinical Medicine Nanjing Medical UniversityNanjing 210029China Jiangsu Province Engineering Research Center of Colorectal Cancer Precision Medicine and Translational Medicine Nanjing 210029China

Excessive fructose diet is closely associated with colorectal cancer(CRC)***,fructose’s specific function and precise mechanism in colorectal cancer liver metastasis(CRLM)is rarely ***,this study reported that the fructose absorbed by primary colorectal cancer could accelerate CRLM,and the expression of KHK-A,not KHK-C,in liver metastasis was higher than in paired primary ***,KHK-A facilitated fructose-dependent CRLM in vitro and in vivo by phosphorylating PKM2 at ***2 phosphorylated by KHK-A inhibited its tetramer formation and pyruvic acid kinase activity but promoted the nuclear accumulation of *** and aerobic glycolysis activated by nuclear PKM2 enhance CRC cells’migration ability and anoikis resistance during CRLM ***-46 treatment,targeting the phosphorylation of PKM2,inhibited the pro-metastatic effect of ***,c-myc activated by nuclear PKM2 promotes alternative splicing of KHK-A,forming a positive feedback loop.

关键词： CRC CRLM Fructose KHK-A PKM2

Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441

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Research 2024年第1期2023卷 181-197页

作者： wen-Juan Lin wen-Pu Shi Wan-Yi Ge Liang-Liang Chen Wei-Hong Guo peng Shang Da-Chuan Yin Key Laboratory for Space Bioscience and Biotechnology School of Life SciencesNorthwestern Polytechnical University127 Youyixi RoadXi'an 710072ShaanxiPR China

The biological effects of magnetic fields(MFs)have been a controversial ***,in recent years,there has been increasing evidence that MFs do affect biological ***,the physical mechanism remains ***,we show that MFs(16 T)reduce apoptosis in cell lines by inhibiting liquid–liquid phase separation(LLPS)of Tau-441,suggesting that the MF effect on LLPS may be one of the mechanisms for understanding the“mysterious”magnetobiological *** LLPS of Tau-441 occurred in the cytoplasm after induction with *** phase-separated droplets of Tau-441 recruited hexokinase(HK),resulting in a decrease in the amount of free HK in the *** cells,HK and Bax compete to bind to the voltage-dependent anion channel(VDAC I)on the mitochondrial membrane.A decrease in the number of free HK molecules increased the chance of Bax binding to VDAC I,leading to increased Bax-mediated *** the presence of a static MF,LLPS was marked inhibited and HK recruitment was reduced,resulting in an increased probability of HK binding to VDAC I and a decreased probability of Bax binding to VDAC I,thus reducing Bax-mediated *** findings revealed a new physical mechanism for understanding magnetobiological effects from the perspective of *** addition,these results show the potential applications of physical environments,such as MFs in this study,in the treatment of LLPS-related diseases.

关键词： inhibited Apoptosis finding

Cation-Dipole Interaction-Induced Coacervate Underwater Adhesives in Natural Seawater

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Chinese Journal of Polymer Science 2024年第7期42卷 984-991,I0009页

作者： Xu-Fei Liu Chong-Rui Zhang Hua-wen peng Qiang Zhao Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China

Significant progress has been made in wet adhesives for low salinity water,but exploration of general ionic adhesives for natural seawater is less developed because the high salinity could weaken interfacial bonding and shields electrostatic interactions,resulting in adhesion ***,the design of adhesives for natural seawater represents challenges less ***,a cationic polyelectrolyte(PECHIA)containing imidazolacetonitrile unit was explored to prepare adhesives enabled by natural *** combining the ion shielding effect with the“cation-dipole”interactions between PECHIA chains,aqueous solution of the PECHIA underwent coacervation and self-crosslinking in natural seawater,allowing for underwater adhesion to various substrates in *** instantaneous lap-shear and tensile adhesion strengths are 47 and 119 kPa,respectively,while the cured adhesive shows~739 k Pa tensile adhesion in natural *** design of PECHIA enables wet adhesives viable for applications in the diversified scenarios of natural seawater.

关键词： Coacervate Underwater adhesives Seawater Cation-dipole interaction

Elastohydrodynamic Lubrication Interface Stiffness and Damping Considering Asperity Lateral Contact

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Acta Mechanica Solida Sinica 2024年第1期37卷 109-123页

作者： Zhiqiang Gao Yu Zhang Xian Wei Yanfang Zhu Lixia peng Weiping Fu wen Wang School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China School of Intelligent Manufacturing Panzhihua UniversityPanzhihua 617000China Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Light Chemical TechnologyYibin 644002China School of Mechanical Engineering Anyang Institute of TechnologyAnyang 455099China

Elastohydrodynamic lubrication(EHL)point contact occurs between two rough surfaces at the mesoscopic level,while the interaction of rough surfaces involves contact between asperities at the microscale *** most cases,the contact between asperities within an interface takes the form of lateral contact rather than peak *** devoid of contact asperities are filled with lubricating ***,conventional models often oversimplify lateral contact forms as interactions between asperities and a smooth,rigid *** simplifications fail to accurately represent the true contact conditions and can lead to inaccuracies in the analysis of EHL’s contact *** address this issue,we have developed a novel EHL interface model comprising two rough *** model allows us to explore the influence of asperity height,contact angle,and contact azimuth angle on EHL interface performance.

关键词： EHL interface Asperity lateral contact Contact stiffness Damping

Abnormal grain growth induced byδ→γphase transformation in Fe-based shape memory alloys

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Journal of Materials Science & Technology 2024年第5期172卷 196-201页

作者： Huabei peng Liqiu Yong Gaixia Wang Jiazhen Yan Bing Xu Yuhua wen School of Mechanical Engineering Sichuan UniversityChengdu 610065China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610041China

Grain boundaries,including low-angle,high-angle,and coinci-dence boundaries,are intrinsic interfaces in polycrystalline *** heat-treatment at sufficiently high temperatures,grain boundary migration occurs because the grain boundaries are ther-modynamically ***,grain growth occurs due to a decrease in grain boundary area after heat-treatment[1].In general,there are two types of grain growth:normal grain growth,where grains grow uniformly,and abnormal grain growth,where one or a few grains selectively grow and engulf surround-ing smaller grains,leading to the formation of large grains,some-times several millimeters or greater in size[2].The classical tech-nique to achieve abnormal grain growth is the strain-annealing method,which involves subjecting the material to a small strain followed by annealing[3,4].This method has been reported to ob-tain single-crystal wires or plates[1].Additionally,abnormal grain growth can be achieved by plastic straining at high temperatures,resulting in the fabrication of large grains or single crystals[5].However,the above methods are not applicable to components with complicated shapes due to the inevitable deformation ***,Omori et *** a simply method of abnor-mal grain growth to fabricate ultra-large grains,even single crys-tals,in Cu-Al-Mn[1],Fe-Mn-Al-Ni[2],and Fe-Mn-Al-Ni-Cr[6]*** method involves applying cyclic heat treatment between a high temperature BCC single-phase region and a low tempera-ture BCC+FCC two-phase region[1,2,6-12].Note that the cyclic heat treatment resulted in the formation of BCC sub-grain struc-tures responsible for abnormal grain growth[1,2,6-12].In addition,Yang et *** that abnormal grain growth occurred at above 900℃,and large-grains,even single crystals,were obtained only through annealing cast Cu-based polycrystalline alloys contained coherent nano-particles[13,14].Notably,the cyclic heat treatment and annealing cast alloys are deform

关键词： grain alloys deformation

Ni-Catalyzed Enantioselective Difunctionalization of Alkynes to Azepine Derivatives Bearing a Quaternary Center and an Unprotected Imine

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Chinese Journal of Chemistry 2024年第8期42卷 873-878页

作者： Jian Long Zhiwu Lu Xiao-Lin Li peng Xue wen-Bo Liu Engineering Research Center of Organosilicon Compounds&Materials(Ministry of Education)and College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei430072 China

Comprehensive Summary,The azepine ring is a prominent structural scaffold in biologically significant molecules. In this study, we present a Ni(II)-catalyzed asymmetric difunctionalization of alkynes, involving intermolecular regioselective arylation and intramolecular nitrile addition, enabling the synthesis of enantioenriched azepine derivatives. This reaction simultaneously installs an all-carbon quaternary stereocenter and introduces an unprotected imine functionality, showing great promise for subsequent transformations. The reaction exhibits good tolerance toward various functional groups, resulting in high yields and enantioselectivities. The synthetic utility of this methodology is further demonstrated through gram-scale synthesis and product derivatization. This research offers an efficient approach to the synthesis of seven-membered nitrogen heterocycles.

关键词： Nickel Asymmetric catalysis N-Heterocycles Alkyne functionalization Quaternary centers

High-chromium vanadium-titanium magnetite all-pellet integrated burden optimization and softening-melting behavior based on flux pellets

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 498-507页

作者： Bojian Chen Tao Jiang Jing wen Guangdong Yang Tangxia Yu Fengxiang Zhu peng Hu School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China Liaoning Key Laboratory for Metallurgical Sensor and Technology Shenyang 110819China State key laboratory of vanadium and titanium resources comprehensive utilization Panzhihua 617000China

High-chromium vanadium-titanium magnetite(HVTM)is a crucial polymetallic-associated resource to be *** allpellet operation is a blast furnace trend that aims to reduce carbon dioxide emissions in the *** referencing the production data of vanadium-titanium magnetite blast furnaces,this study explored the softening-melting behavior of high-chromium vanadium-titanium magnetite and obtained the optimal integrated burden based on flux *** results show that the burden with a composition of 70wt%flux pellets and 30wt%acid pellets exhibits the best softening-melting *** comparison to that of the single burden,the softening-melting characteristic temperature of this burden composition was *** melting interval first increased from 307 to 362℃and then decreased to 282℃.The maximum pressure drop(ΔPmax)decreased from 26.76 to 19.01 *** permeability index(S)dropped from 4643.5 to 2446.8 kPa·℃.The softening-melting properties of the integrated burden were apparently *** acid pellets played a role in withstanding load during the softening *** flux pellets in the integrated burden exhibited a higher slag melting point,which increased the melting temperature during the melting *** slag homogeneity and the TiC produced by over-reduction led to the gas permeability deterioration of the single *** segregation of the flux and acid pellets in the HVTM proportion and basicity mainly led to the better softening-melting properties of the integrated burden.

关键词： high-chromium vanadium-titanium magnetite softening-melting properties all pellets integrated burden flux pellets

A new insight into LPSO phase transformation and mechanical properties uniformity of large-scale Mg-Gd-Y-Zn-Zr alloy prepared by multi-pass friction stir processing

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Journal of Magnesium and Alloys 2024年第5期12卷 2041-2056页

作者： Xiaohu Guan wen Wang Ting Zhang Pai peng Qiang Liu peng Han Ke Qiao Jun Cai Liqiang Wang Kuaishe Wang School of Metallurgical Engineering National and Local Joint Engineering Research Center for Functional Materials ProcessingXi’an University of Architecture and TechnologyNo.13 Yanta RoadXi’anShaanxi 710055China Xi’an Rare Metal Materials Institute Co.Ltd Xi’an 710016China State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityNo.800 Dongchuan RoadShanghai 200240China

A large-scale fine-grained Mg-Gd-Y-Zn-Zr alloy plate with high strength and ductility was successfully prepared by multi-pass friction stir processing(MFSP)technology in this *** structure of grains and long period stacking ordered(LPSO)phase were characterized,and the mechanical properties uniformity was ***,a quantitative relationship between the microstructure and tensile yield strength was *** results showed that the grains in the processed zone(PZ)and interfacial zone(IZ)were refined from 50μm to 3μm and 4μm,respectively,and numerous original LPSO phases were *** IZ,some block-shaped 18R LPSO phases were transformed into needle-like 14H LPSO phases due to stacking faults and the short-range diffusion of solute *** severe shear deformation in the form of kinetic energy caused profuse stacking fault to be generated and move rapidly,greatly increasing the transformation rate of LPSO *** MFSP,the ultimate tensile strength,yield strength and elongation to failure of the large-scale plate were 367 MPa,305 MPa and 18.0% *** refinement and LPSO phase strengthening were the major strengthening mechanisms for the MFSP *** particularly,the strength of IZ was comparable to that of PZ because the strength contribution of the 14H LPSO phase offsets the lack of grain refinement strengthening in *** result opposes the widely accepted notion that IZ is a weak region in MFSP-prepared large-scale fine-grained plate.

关键词： Friction stir processing Multi-pass Mg-Gd-Y-Zn-Zr alloy LPSO phase transformation Mechanical properties

Westerlies Affecting the Seasonal Variation of Water Vapor Transport over the Tibetan Plateau Induced by Tropical Cyclones in the Bay of Bengal

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Advances in Atmospheric Sciences 2024年第5期41卷 881-893页

作者： Xiaoli ZHOU wen ZHOU Dongxiao WANG Qiang XIE Lei YANG Qihua peng Key Laboratory of Polar Atmosphere-ocean-ice System for Weather and Climate Ministry of Education&Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric SciencesFudan UniversityShanghai 200438China School of Marine Sciences Sun Yat-Sen UniversityZhuhai 519082China Institute of Deep-sea Science and Engineering Chinese Academic SciencesSanya 572000China State Key Laboratory of Tropical Oceanography South China Sea Institute of OceanologyChinese Academic ScienceGuangzhou 510301China Scripps Institution of Oceanography University of CaliforniaSan DiegoLa JollaCalifornia 92093USA

This study investigates the activity of tropical cyclones(TCs)in the Bay of Bengal(BOB)from 1979 to 2018 to discover the mechanism affecting the contribution rate to the meridional moisture budget anomaly(MMBA)over the southern boundary of the Tibetan Plateau(SBTP).May and October–December are the bimodal phases of BOB TC frequency,which decreases month by month from October to December and is relatively low in ***,the contribution rate to the MMBA is the highest in *** seasonal variation in the meridional position of the westerlies is the key factor affecting the contribution *** relatively southern(northern)position of the westerlies in November and December(May)results in a lower(higher)contribution rate to the *** mechanism is confirmed by the momentum *** water vapor enters the westerlies near the trough line,the resultant meridional acceleration is directed *** follows that the farther north the trough is,and the farther north the water vapor can be *** water vapor enters the westerlies from the area near the ridge line,for Type-T(Type-R)TCs,water vapor enters the westerlies downstream of the trough(ridge).Consequently,the direction of the resultant meridional acceleration is directed south and the resultant zonal acceleration is directed east(west),which is not conducive to the northward transport of water *** is especially the case if the trough or ridge is relatively south,as the water vapor may not cross the SBTP.

关键词： tropical cyclone Tibetan Plateau Bay of Bengal moisture budget weste