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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze li wen-li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Technology of fiber-optic temperature sensing and its application in ＆ temperature measuring of gob area

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Journal of Coal Science & Engineering(China) 2011年第2期17卷 171-175页

作者： liU Jing-wen huang li-ming Department of Business Management Heibei Normal University of Science and Technology Qinhuangdao 066004 China

Based on advantages of technology of distributive fiber-optic temperature sensing and specific to its applications in monitoring mine conflagration, the corresponding Processes such as connection arrangement, signal transmission and monitoring were illustrated. As applied in Sitai Coal Mine of Datong Coal Mine Group Co., this method is effective and accurate and could provide reliable gist for monitoring spontaneous combustion in gob area of mines.

关键词： distributive optical fiber gob area temperature sensing fire source detection

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Application experience and research progress of different emerging technologies in plastic surgery

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World Journal of Clinical Cases 2023年第18期11卷 4258-4266页

作者： Bin Yang ling Yang wen-li huang Qing-Zhu Zhou Jia He Xian Zhao Plastic and Cosmetic Department The Affiliated Calmette Hospital of Kunming Medical UniversityThe First People’s Hospital of KunmingCalmette Hospital KunmingKunming 650224Yunnan ProvinceChina Radiology Department The Third Affiliated Hospital of Kunming Medical University(Yunnan Cancer HospitalYunnan Cancer Center)Kunming 650118Yunnan ProvinceChina

In the diagnosis and treatment of plastic surgery,there are structural processing problems,such as positioning,moving,and reconstructing complex threedimensional *** operate according to their own experience,and the inability to accurately locate these structures is an important problem in plastic *** digital technologies such as virtual reality,augmented reality,and three-dimensional printing are widely used in the medical field,particularly in plastic *** article reviews the development of these three technical concepts,introduces the technical elements and specific applications required in plastic surgery,summarizes the application status of the three technologies in plastic surgery,and summarizes prospects for future development.

关键词： Virtual reality Augmented reality Three-dimensional printing Plastic surgery Progress

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Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy

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Chinese Medical Journal 2019年第21期132卷 2628-2635页

作者： Zhi-Sheng Wu wen-li huang Shu-Jie Gong Department of Neurology The First Affiliated Hospital of QuanzhouFujian Medical UniversityQuanzhouFujian 362000China.

Background:Epilepsy is a chronic and severe neurological *** and tensin homolog deleted on chromosome ten(PTEN)-deficient mice exhibit learning and memory deficits and spontaneous *** aim of this study was to investigate the role of PTEN in brain oxidative damage and neuroinflammation in a rat model of ***:An adenovirus(Ad)-PTEN vector was constructed,and status epilepticus(SE)was induced in 41 model rats using lithium ***-six SE rats were then allocated into the Ad-PTEN,Ad-LacZ,and SE groups,those were administered intracerebroventricular injections of Ad-PTEN,Ad-enhanced green fluorescent protein,and phosphate buffer saline,*** normal group was comprised of healthy Sprague-Dawley *** staining was conducted to evaluate neuronal damage,and immunohistochemistry was conducted to observe the morphology of cells in the hippocampal CA1 region and the distribution of ionized calcium-binding adaptor molecule 1(Iba1)and ED1(rat homologue of human CD68).Levels of apoptosis-related proteins,inflammatory-related factors,and oxidative stress-related markers(reactive oxygen species[ROS],glutathione[GSH],superoxide dismutase[SOD],and malondialdehyde[MDA])were *** between multiple groups were conducted using oneway analysis of variance(ANOVA),and pairwise comparisons after ANOVA were conducted using the Tukey multiple comparisons ***:After SE induction,PTEN expression in the rat brain exhibited a four-fold decrease(P=0.000)and the expression of both Iba1 and ED1 ***,significant neuronal loss,oxidative damage,and neuroinflammation were observed in the SE rat *** intracerebroventricular injection of Ad-PTEN,PTEN expression exhibited a three-fold increase(P=0.003),and the expression of both Iba1 and ED1 ***,neurons were restored and neuronal apoptosis was ***,ROS and MDA levels decreased,GSH level and SOD activity

关键词： Epilepsy Status epilepticus Brain injuries Oxidative stress Neurons Inflammation

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随机波动率与投资中的q理论

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数学学报（中文版） 2018年第3期61卷 469-476页

作者：黄文礼浙江财经大学中国金融研究院

本文将随机波动率引入托宾q模型，讨论生产率冲击的波动率大小对公司价值与投资决策的影响．研究发现，公司托宾q值会受到生产率冲击波动率的显著影响，波动率的增大会降低托宾q值，且该影响会随着波动率的增大而加剧．此外，波动率对托... 详细信息

本文将随机波动率引入托宾q模型，讨论生产率冲击的波动率大小对公司价值与投资决策的影响．研究发现，公司托宾q值会受到生产率冲击波动率的显著影响，波动率的增大会降低托宾q值，且该影响会随着波动率的增大而加剧．此外，波动率对托宾q值的影响也会传导到公司的投资决策上来，托宾q降低会使得投资额减小，该影响同样会随波动率的增大而加剧．本文还考虑了波动率对公司在用资产与成长机会价值的影响，更为合理地刻画了公司生产过程中生产率冲击的波动率为随机的假设现实情况，所得结论对公司估值及投资决策均有一定的参考价值．

关键词：随机波动率随机控制托宾q理论

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SOliD-PHASE SYNTHESIS OF 4,5-DISUBSTITUTED 1,2,3-TRIAZOLES

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Chinese Chemical Letters 1991年第10期2卷 773-774页

作者： Chen Xi li wen Qiang huang Yu LU Bing lin HE Institute of Polymer Chemistry, Nankai University, Tianjin, 300071

4-Aryl-5-ethoxycarbonyl-1-H-1,2,3-triazoles have been prepared by treatment of ethyl polystyrylsulfonylacetate with substituted benzaldehydes and then sodium azide.

关键词： OC IR NH KBr SOliD-PHASE SYNTHESIS OF 4,5-DISUBSTITUTED 1,2,3-TRIAZOLES Ph

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Identification and Gene Mapping of Completely Dominant Earliness in Rice

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Agricultural Sciences in China 2002年第1期1卷 11-18页

作者： DENG Xiao-jian, ZHOU Kai-da, li Ren-duan, CHUN Ze li Ping, WANG wen-ming, ZHAI wen-xue and ZHU li-huang( Rice Research Institute, Sichuan Agricultural University, wenjiang 611130 Institute of Genetics, Chinese Academy of Sciences, Beijing 100101) Rice Research Institute Sichuan Agricultural University Wenjiang 611130 Institute of Genetics Chinese Academy of Sciences Beijing 100101 Rice Research Institute Sichuan Agricultural University Wenjiang 611130 Institute of Genetics Chinese Academy of Sciences Beijing 100101

The completely dominant earliness was identified in a genie male-sterile and early maturing indica line 6442S-7. F1 progenies from 6442S-7 crossed with thirteen various types of medium- or late-maturing varieties, shared the same heading date as 6442S-7. The segregation of heading date in the F2 and B1F1 populations showed that the earliness of 6442S-7 is mainly controlled by two dominant major genes. The local linkage map of one dominant earliness gene harbored in 6442S-7 was constructed with F2 population and four kinds of molecular marker techniques. The results showed that the gene was located between a RFLP marker C515 and a RAPD marker OPI 11.557 on the terminal region of short arm of rice chromosome 3, 10.9cM and 1.5cM from C515 and OPI11.557, respectively. The genetic distances from the target gene to two SSR markers, RM22 and RM231, and one AFLP marker, PT671, were 3.0, 6.7 and 12.4 cM, respectively. This gene, being identified and mapped first, is designated tentatively as Ef-cd(t). As a new genetic resource of completely dominant earliness, 6442S-7 has splendid future in rice improvement.

关键词： Oryza saliva L. Growth duration Earliness Dominant earliness gene Gene mapping

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新媒体如何影响群体性事件?——中介机制与实证检验

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北京师范大学学报（社会科学版） 2016年第6期 109-119页

作者：尉建文黄莉北京师范大学中国社会管理研究院/社会学院北京100875 中央财经大学社会学系北京100081

在新媒体时代,如何正确认识新媒体对群体性事件影响的机制,深入探究群体性事件发生的特征,这对于确保社会和谐稳定、促进社会经济健康有序发展具有重要意义。新媒体对群体事件存在显著推动作用,新媒体信息获取越便捷,新媒体的信任程度越... 详细信息

在新媒体时代,如何正确认识新媒体对群体性事件影响的机制,深入探究群体性事件发生的特征,这对于确保社会和谐稳定、促进社会经济健康有序发展具有重要意义。新媒体对群体事件存在显著推动作用,新媒体信息获取越便捷,新媒体的信任程度越高,个体对群体性事件的参与程度越高。社会态度是新媒体影响个体群体性事件参与的重要中介因素。新媒体的信任程度越高,个体的社会态度越倾向于负向消极,群体性事件的参与程度越高。新媒体信息获取的便捷性,在一定程度上存在中介效应,但其影响机制还有待更多经验研究的进一步验证。资源动员能力同样具有一定中介效应,但其稳定性仍需进一步检验,围观效应的中介效应则不显著。信息来源无论是传统媒体,还是新媒体,对于个体群体性事件参与程度的影响不存在显著差异。在新媒体时代,如何增强民众对政府媒体的信任,从而改变民众的社会态度是增强群体性事件治理的重要方向。

关键词：新媒体群体性事件影响机制

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Horticulture Research 2020年第1期7卷 745-755页

作者： Bo Sun Min Jiang Hao Zheng Yue Jian wen-li huang Qiao Yuan Ai-Hong Zheng Qing Chen Yun-Ting Zhang Yuan-Xiu lin YanWang Xiao-Rong Wang Qiao-Mei Wang Fen Zhang Hao-Ru Tang College of Horticulture Sichuan Agricultural University611130 ChengduChina Institute of Pomology and Olericulture Sichuan Agricultural University611130 ChengduChina Key Laboratory of Horticultural Plant Growth Development and Quality ImprovementMinistry of AgricultureDepartment of HorticultureZhejiang University310058 HangzhouChina

The carotenoid isomerase gene(BoaCRTISO)of Chinese kale was targeted and edited using the CRISPR/Cas9 system in the present *** results showed a high mutation rate(81.25%),and 13 crtiso mutants were *** two types of mutations,insertions and replacements,were *** the total and individual carotenoid and chlorophyll concentrations of the biallelic and homozygous mutants were reduced,and the total levels declined by 11.89–36.33%.The color of the biallelic and homozygous mutants changed from green to yellow,likely reflecting a reduction in the color-masking effect of chlorophyll on *** expression levels of most carotenoid and chlorophyll biosynthesis-related genes,including CRTISO,were notably lower in the mutants than in the WT *** addition,the functional differences between members of this gene family were *** summary,these findings indicate that CRISPR/Cas9 is a promising technique for the quality improvement of Chinese kale and other Brassica vegetables.

关键词： CRT insertion yellow

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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