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Polyethylene glycol crosslinked decellularized single liver lobe scaffolds with vascular endothelial growth factor promotes angiogenesis in vivo

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 622-631页

作者： Jian-Se Zhang Zhi-Bin Wang Zhi-Zhen Lai jing-wen yang wen-jing Song Yu-Bing Wei Jin Mei Jian-Guang Wang Anatomy Department School of Basic Medical SciencesWenzhou Medical UniversityWenzhou 325000China Institute of Bioscaffold Transplantation and Immunology Wenzhou Medical UniversityWenzhou 325000China Institute of Hypoxic Medicine School of Basic Medical SciencesWenzhou Medical UniversityWenzhou 325000China Intensive Care Unit Tongde Hospital of Zhejiang ProvinceHangzhou 310012China Department of Geriatric Medicine The First Affiliated HospitalWenzhou Medical UniversityWenzhou 325000China Department of Microbiology and Immunology Wenzhou Medical UniversityWenzhou 325000China Medical Research Center Ningbo City First HospitalNingbo 315000China Department of Biochemistry School of Basic Medical SciencesWenzhou Medical UniversityWenzhou 325000China

Background: Improving the mechanical properties and angiogenesis of acellular scaffolds before transplantation is an important challenge facing the development of acellular liver grafts. The present study aimed to evaluate the cytotoxicity and angiogenesis of polyethylene glycol(PEG) crosslinked decellularized single liver lobe scaffolds(DLSs), and establish its suitability as a graft for long-term liver tissue engineering. Methods: Using mercaptoacrylate produced by the Michael addition reaction, DLSs were first modified using N-succinimidyl S-acetylthioacetate(SATA), followed by cross-linking with PEG as well as vascular endothelial growth factor(VEGF). The optimal concentration of agents and time of the individual steps were identified in this procedure through biomechanical testing and morphological analysis. Subsequently, human umbilical vein endothelial cells(HUVECs) were seeded on the PEG crosslinked scaffolds to detect the proliferation and viability of cells. The scaffolds were then transplanted into the subcutaneous tissue of Sprague-Dawley rats to evaluate angiogenesis. In addition, the average number of blood vessels was evaluated in the grafts with or without PEG at days 7, 14, and 21 after implantation. Results: The PEG crosslinked DLS maintained their three-dimensional structure and were more translucent after decellularization than native DLS, which presented a denser and more porous network structure. The results for Young’s modulus proved that the mechanical properties of 0.5 PEG crosslinked DLS were the best and close to that of native livers. The PEG-VEGF-DLS could better promote cell proliferation and differentiation of HUVECs compared with the groups without PEG cross-linking. Importantly, the average density of blood vessels was higher in the PEG-VEGF-DLS than that in other groups at days 7, 14, and 21 after implantation in vivo. Conclusions: The PEG crosslinked DLS with VEGF could improve the biomechanical properties of native DLS, and most i

关键词： Decellularization Single liver lobe Polyethylene glycol Angiogenesis Liver tissue engineering

Theoretical Analysis on Optical Limiting Properties of Newly Synthesized Graphene Oxide-Porphyrin Composites

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Chinese Journal of Chemical Physics 2015年第3期28卷 257-262,I0001页

作者： Yu-jin Zhang wen-jing yang Jian-zhong Fan Yu-zhi Song Chuan-kui Wang College of Physics and Electronics Shandong Normal University Jinan 250014 China

Optical limiting （OL） properties and two-photon absorption （TPA） of a series of covalently linked graphene oxide-porphyrin composite materials have been investigated by numerically solving the rate equations and field intensity equation with an iterative predictor-corrector finite-difference time-domain technique in nanosecond time domain. Our results show that graphene oxide-porphyrin composites exhibit enhanced OL behavior and possess larger TPA cross section compared with individual porphyrins. Interestingly~ unlike the previous result that porphyrin with heavier central metal shows better nonlinear abilities than that with- out metal substitute, graphene oxide-metal free porphyrin composite has stronger nonlinear absorption properties compared with graphene oxide-metal porphyrin composite. The com- putational results are in reasonable agreement with the experimental ones. Special attention has been paid to the influence of thickness of the medium and pulse width on TPA cross sections, which presents that larger TPA cross sections are obtained as the medium is thicker or the pulse duration is wider.

关键词： Optical limiting Two-photon absorption Graphene oxide Porphyrin

Preparation of 2D square-like Bi2S3-BiOCl heterostructures with enhanced visible light-driven photocatalytic performance for dye pollutant degradation

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Water Science and Engineering 2017年第4期10卷 334-339页

作者： jing-jing Xu jing-wen yang Pu Zhang Quan Yuan Yan-hong Zhu Yu Wang Miao-miao Wu Zheng-mei Wang Min-dong Chen Collaborative Innovation Center of Atmospheric Environment and Equipment Technology School of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China Jiangsu Engineering Technology Research Center of Environmental Cleaning Materials Nanjing University of Information Science and TechnologyNanjing 210044China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Nanjing University of Information Science and TechnologyNanjing 210044China

A series of Bi2 S3-BiOCI composites with two-dimensional(2 D) square-like structures were prepared via a two-step anion exchange route.X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), and diffuse reflectance spectra(DRS)were used to investigate the properties of the as-prepared Bi_2 S_3-BiOCI heterostructures. The coupling of BiOCl and Bi_2 S_3 induced enhanced photoabsorption efficiency and bandgap narrowing. A reactive brilliant red X-3 B dye was used as a contaminant to test the photocatalytic activity of the obtained Bi_2 S_3-BiOCl samples under visible light irradiation. The sample Bi_2 S_3-BiOCl with a mass ratio of 8:4 exhibited the highest photodegradation efficiency, which was six times higher than that of pure BiOCl. In addition, a mechanism for the enhancement of photocatalytic activity is proposed.

关键词： Photocatalysis Bi2S3 BiOCl Visible light Heterostructure

Clinical Features of Oxaliplatin-induced Hypersensitivity Reactions in Chinese Patients: A Retrospective Multicenter Analysis

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Current Medical Science 2021年第4期41卷 827-831页

作者： Min LI Chen JIANG jing-wen yang Zao-qin YU Wei LI Li ZHAO Qiu-yan SONG Cheng-liang ZHANG Dong LIU Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Center for Adverse Drug Reaction Monitoring Wuhan 430030China People's Hospital ofYuxi City Yuxi 653100China

Objective The characteristics of oxaliplatin-induced hypersensitivity reactions(HSRs)in Chinese patients were investigated to provide a reference for patients treated with *** The study reviewed the records of patients who developed oxaliplatin-induced HSRs in 17 hospitals from May 2016 to May *** collected and analyzed the basic information,history of oxaliplatin administration and premedication treatments,chemotherapy cycles,HSR symptoms,and the management and outcomes of these *** Oxaliplatin-induced HSRs were recorded in 137 patients who had been treated with oxaliplatin-containing *** different chemotherapy regimens were *** median infusion cycle when oxaliplatin-induced HSRs occurred was 7,and HSRs occurred during or shortly after oxaliplatin *** of the patients experienced grade 1 or grade 2 HSRs with mild symptoms of pruritis(49.64%),flushing(46.72%),chest discomfort(26.28%),and urticaria(25.55%).The majority of the patients completely recovered from HSRs following treatment with antihistamines and *** patients completed chemotherapy with oxaliplatin after the symptoms resolved with proper *** The results indicate that oxaliplatin-induced HSRs remain an important issue in safely and successfully fulfilling oxaliplatin-containing *** studies are needed to analyze the risk factors and establish prophylaxis for such reactions.

关键词： oxaliplatin hypersensitivity reaction retrospective study multicenter

Geochemistry of Trace and Rare Earth Elements in Red Soils from the Dongting Lake Area and Its Environmental Significance

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Pedosphere 2009年第5期19卷 615-622页

作者： MAO Long-Jiang MO Duo-wen yang jing-Hong SHI Chen-Xi College of Atmospheric Science Nanjing University of Information Science & Technology Nanjing 210044 (China) College of Urban and Environmental Sciences Peking University Beijing 100871 (China) Department of Earth Sciences Nanjing University Nanjing 210093 (China)

Trace element(TE) and rare earth element(REE) contents in red soils from the Dongting Lake area of China were determined to understanding the provenance and weathering characteristics of the red *** results showed similar REE distribution patterns among red soils from the Dongting Lake area,Xiashu loess from Zhenjiang,loess and Pliocene red soil from the Loess *** patterns implied a similar provenance from dust-storms,except for red soil R5 which formed by bedrock weathering and had significant light REE(LREE) enrichment and heavy REE(HREE) depletion due to longer weathering periods and higher intensity of *** element,especially the Rb/Sr and Li/Ba ratios,and REE,especially the LREE/HREE ratio and δEu could trace weathering *** Rb/Sr,Li/Ba,and LREE/HREE ratios and negative Eu anomalies were present in the red soils from the Dongting Lake *** weathering intensity was in the decreasing order of R5 in the Dongting Lake area > red soils from the Dongting Lake area(including reticulate red soil,weak reticulate red soil,and homogeneous red soil formed by dust storms) > Xiashu loess from Zhenjiang > loess-paleosol and Pliocene red soil from the Loess *** in the TE and REE contents of soil could be effectively used to study the provenance and the weathering intensity.

关键词： Hunan Province provenance sedimentary processes weathering intensity

Influence of Acupuncture on Autonomic Balance in Adult Tinnitus Patients:An Exploratory Study

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Current Medical Science 2019年第6期39卷 947-953页

作者： Jian-feng TU Mirim Kim jing-wen yang Qian-qian LI Gerhard Litscher Lu WANG Guang-xia SHI Daniela Litscher Cun-zhi LIU School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijing 100010China Research Unit for Complementary and Integrative Laser Medicine Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine and TCM Research Center GrazMedical University of GrazGraz 8036Austria

Acupuncture is an alternative therapy for tinnitus in clinical *** mechanism by which acupuncture can alleviate tinnitus is still *** nervous system was reported to be responsible for *** aim of this study was to explore the effect of acupuncture on autonomic balance in adult tinnitus *** patients were randomly assigned into either the deep acupuncture(DA)group or the shallow acupuncture(SA)*** patient received 6 acupuncture sessions(a-f phase)over three *** of heart rate variability and Tinnitus Handicap Inventory(THI)were obtained at baseline and after the sixth acupuncture session in all *** results showed that the low frequency/high frequency(LF/HF)pattern was increased at b-f phase until the sixth acupuncture session when compared with that at the first acupuncture session in DA ***,it continuously increased at b-f phase in SA group even at the sixth acupuncture session,which was not significantly different from that at the first acupuncture *** decrease in THI in DA group was greater than that in SA group after 3-week treatment(P=0.043).Our preliminary study suggests three-week deep acupuncture can improve tinnitus symptoms in adult tinnitus patients,which may be related to the regulation of autonomic nervous system balance.

关键词： tinnitus acupuncture heart rate variability autonomic nervous system

Effectiveness and safety of endoscopic submucosal dissection for intraepithelial neoplasia of the esophagogastric junction

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Chinese Medical Journal 2014年第3期127卷 417-422页

作者： wen jing Linghu Enqiang yang Yunsheng Liu Qingsen yang jing Wang Shufang Wang Xiangdong Du Hong Meng Jiangyun Wang Hongbin Lu Zhongsheng Department of Gastroenterology Chinese Peoples Liberation Army Genera Hospital Beijing 100853 China

Background Endoscopic submucosal dissection of the esophagogastric junction is the most difficult gastric and esophageal dissection *** reports of endoscopic submucosal dissection for Siewert type ii carcinoma of the esophagogastric junction have compared the outcomes of endoscopic submucosal dissection for all three Siewert types of *** study aimed to evaluate the efficacy and safety of endoscopic submucosal dissection for intraepithelial neoplasia of the esophagogastric *** From October 2008 to June 2013,73 patients underwent endoscopic submucosal dissection for intraepithelial neoplasia of the esophagogastric *** patients were prospectively evaluated regarding the executability of the technique,short-term results of the procedure,en bloc resection rate,curative resection rate,complications and additional treatment after endoscopic submucosal dissection,and follow-up *** Sixty-eight of the 73 patients （93.2％） underwent en bloc resection; the mean maximum specimen diameter was 33.7 ***-seven of 61 patients （93.4％） who underwent curative resection were successfully followed-up for 1.0 to 56.0 months （average,24.1 months）.Local recurrence developed in one patient with high-grade intraepithelial *** patients underwent noncurative resection,including lateral resection margin residues in three,vertical resection margin residues in one,signet ring cell carcinoma or undifferentiated adenocarcinoma in four,lymphatic or vessel invasion in one,vertical residual margin residues combined with signet ring cell carcinoma in one,and undifferentiated adenocarcinoma with lymphatic or vessel invasion in *** the noncurative resection group,one patient was lost to follow-up,seven underwent additional surgery,and the remaining four were periodically followed up; none had local recurrence or distant *** only complication was delayed bleeding in three patients,which was successfully controlled by c

关键词： endoscopic submucosal dissection intraepithelial neoplasia esophagogastric junction

Influence of multi-pass friction stir processing on microstructure and mechanical properties of 7B04-O Al alloy

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Transactions of Nonferrous Metals Society of China 2017年第4期27卷 789-796页

作者： Yu CHEN Hua DING Zhi-hui CAI wen-jing yang School of Materials Science and Engineering Northeastern University Shenyang 110819 China

Three-pass friction stir processing(FSP)with different moving distances of the stirring tool between the two successivepasses,50%diameter of the pin(traditional way)and50%diameter of the shoulder(novel way),was conducted on7B04-O Al *** result shows that an improvement in the mechanical properties of the processed zone is accomplished due to grain and secondphase particles *** hardness of the multi-pass FSP(M-FSP)sample is about HV40higher than that of the base *** the tensile strength of the M-FSP specimens is also significantly increased to about1.4times that of the base ***,theweak region of the processed zone is mainly dependent on the moving distance,where it is the previous pass stir zone in thetraditional way and the transitional zone in the novel *** the rotational speed narrows the weak region in the novel way,while it does not in the traditional way.

关键词： friction stir processing multi-pass grain refinement aluminum alloy

A network-based predictive gene expression signature for recurrence risks in stage Ⅱ colorectal cancer

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A network-based predictive gene expression signature for rec...