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Deep learning-based lung sound analysis for intelligent stethoscope

Military Medical Research 2024年第4期11卷 567-588页

作者： Dong-Min Huang Jia Huang Kun Qiao Nan-Shan Zhong Hong-Zhou Lu wen-jin wang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina The Third People’s Hospital of Shenzhen Shenzhen 518112GuangdongChina Guangzhou Institute of Respiratory Health China State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory Diseasethe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China

Auscultation is crucial for the diagnosis of respiratory system ***,traditional stethoscopes have inherent limitations,such as inter-listener variability and subjectivity,and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in *** emergence of digital stethoscopes has overcome these limitations by allowing physicians to store and share respiratory sounds for consultation and *** this basis,machine learning,particularly deep learning,enables the fully-automatic analysis of lung sounds that may pave the way for intelligent *** review thus aims to provide a comprehensive overview of deep learning algorithms used for lung sound analysis to emphasize the significance of artificial intelligence(AI)in this *** focus on each component of deep learning-based lung sound analysis systems,including the task categories,public datasets,denoising methods,and,most importantly,existing deep learning methods,i.e.,the state-of-the-art approaches to convert lung sounds into two-dimensional(2D)spectrograms and use convolutional neural networks for the end-to-end recognition of respiratory diseases or abnormal lung ***,this review highlights current challenges in this field,including the variety of devices,noise sensitivity,and poor interpretability of deep *** address the poor reproducibility and variety of deep learning in this field,this review also provides a scalable and flexible open-source framework that aims to standardize the algorithmic workflow and provide a solid basis for replication and future extension:https://***/contactless-healthcare/Deep-Learning-for-Lung-Sound-Analysis.

关键词： Deep learning Lung sound analysis Respiratory sounds

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THE EFFECT OF SILICA MORPHOLOGY ON PROPERTIES OF PVA/SILICA NANO-COMPOSITES

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Chinese Journal of Polymer Science 2013年第11期31卷 1546-1553页

作者： Lei Bi jin-wen wang 陈枫傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

Two kinds of poly（vinyl alcohol）（PVA）-silica composites were prepared with different methods. One composite was prepared by directly mixing PVA with 80 nm silica nano-particles which were made from tetraethoxysilane （TEOS）. The another was obtained by the mixing PVA and hydrolyzed TEOS in the presence of acid-catalyst. The properties of the two PVA/silica hybrids were characterized by means of scanning electron microscopy （SEM）, UV-Visible spectroscopy, solubility tests, limiting oxygen index （LOI） test, tensile test and dynamical mechanical analysis （DMA）, respectively. The results indicate that PVA-TEOS composites （PT for short） display more transparency than PVA-silica nano-particles hybrids （PS for short）. At the same time, The PT composites presented more excellent performance than PS in water resistance, fire resistance and mechanical properties. Moreover, the Tg of PT increased with increasing TEOS content, while that of PS decreased.

关键词： Silica Poly(vinyl alcohol) TEOS Network Nano-composite.

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Solvent- and catalyst-free synthesis of dihydropyrimidinthiones in one-pot under focused microwave irradiation conditions

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Chinese Chemical Letters 2008年第10期19卷 1183-1185页

作者： Hong wen Zhan jin Xian wang Xi Tian wang Institufe of Chemistry Department of Chemistry Northwest Normal University 967 Arming Road （E.） Lanzhou 730070 China

Fifteen dihydropyrimidinthiones have been synthesized by microwave-assisted Biginelli reactions without any solvent or catalyst. The advantages of this novel protocol include the excellent yield, operational simplicit... 详细信息

关键词： Focused microwave-assisted Catalyst- and solvent-free Synthesis Dihydropyrimidinthiones

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Facial reanimation with interposition nerve graft or masseter nerve transfer:a comparative retrospective study

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Neural Regeneration Research 2022年第5期17卷 1125-1130页

作者： wen-jin wang Wei-Dong Zhu Mathias Tremp Gang Chen Zhao-Yan wang Hao Wu Wei wang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Head and Neck Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases ShanghaiChina Ear Institute Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Plastic ReconstructiveAesthetic and HandsurgeryUniversity Hospital BaselBaselSwitzerland

Both interposition nerve grafts and masseter nerve transfers have been successfully used for facial reanimation after irreversible injuries to the cranial portion of the facial ***,no comparative study of these two procedures has yet been *** this two-site,twoarm,retrospective case review study,32 patients were *** these,17 patients(eight men and nine women,mean age 42.1 years)underwent interposition nerve graft after tumor extirpation or trauma between 2003 and 2006 in the Ear Institute,School of Medicine,Shanghai Jiao Tong University,China,and 15 patients(six men and nine women,mean age 40.6 years)underwent masseter-to-facial nerve transfer after tumor extirpation or trauma between November 2010 and February 2016 in Shanghai Ninth People's Hospital,*** patients achieved House-Brackmann III recovery after masseter nerve repair than interposition nerve graft repair(15/15 vs.12/17).The mean oral commissure excursion ratio was also higher in patients who underwent masseter nerve transfer than in patients subjected to an interposition nerve *** findings suggest that masseter nerve transfer results in strong oral commissure excursion,avoiding obvious synkinesis,while an interposition nerve graft provides better resting *** study was approved by the Institutional Ethics Committee,Shanghai Ninth People's Hospital,China(approval ***9 H-2019-T332-1)on December 12,2019.

关键词： facial palsy facial reanimation facial symmetry House-Brackmann score interposition masseter nerve nerve graft oral commissure excursion resting symmetry synkinesis

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Risk of cardiac rupture after acute myocardial infarction is related to a risk of hemorrhage

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 736-742页

作者： Geng QIAN Hong-bin LIU jin-wen wang Chen WU Yun-dai CHEN Department of Cardiology Chinese People’s Liberation Army General Hospital

Although cardiac rupture (CR) is a fatal mechanical complication of acute myocardial infarction (AMI), to date no predictive model for CR has been described. CR has common pathological characteristics with major bleeding. We aimed to investigate the relationship between the risk factors of major bleeding and CR. A total of 10 202 consecutive AMI patients were recruited, and mechanical complications occurred in 72 patients. AMI patients without CR were chosen as control group. Clinical characteristics including bleeding-related factors were compared between the groups. The incidences of free wall rupture (FWR), ventricular septal rupture (VSR), and papillary muscle rupture (PMR) were 0.39%, 0.21%, and 0.09%, respectively, and the hospital mortalities were 92.5%, 45.5%, and 10.0%, respectively. Female proportion and average age were significantly higher in the groups of FWR and VSR than in the control group (P<0.01); higher white blood cell count and lower hemoglobin were found in all CR groups (P<0.01). Compared to the control group, patients with CR were more likely to receive an administration of thrombolysis [26.39% vs. 13.19%, P<0.05], and were less likely to be treated with primary percutaneous coronary intervention (PCI) [41.67% vs. 81.60%, P<0.05]. The major bleeding scores (integer scores) of FWR, VSR, and PMR were (17.70±7.24), (21.91±8.33), and (18.60±7.88), respectively, and were significantly higher than that of the control group (11.72±7.71) (P<0.05). A regression analysis identified age, increased heart rate, anemia, higher white blood cell count, and thrombolysis as independent risk factors of CR, most of which were major bleeding-related factors. The patients with CR have a significantly higher risk of hemorrhage compared to the group without CR. Risk of CR after AMI is related to the risk of hemorrhage.

关键词： Acute myocardial infarction (AMI) Risk factor Hemorrhage

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Single-atom Ag-loaded carbon nitride photocatalysts for efficient degradation of acetaminophen:The role of Ag-atom and O_(2)

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Journal of Environmental Sciences 2024年第5期139卷 12-22页

作者： Yi Yuan wen-Long wang Zhi-Wei wang jin wang Qian-Yuan Wu Key Laboratory of Microorganism Application and Risk Control of Shenzhen Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyInstitute of Environment and EcologyShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenzhen Environmental Science and New Energy Technology Engineering Laboratory Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China

Carbon nitride has been extensively used as a visible-light photocatalyst,but it has the disadvantages of a low specific surface area,rapid electron-hole recombination,and relatively low light *** this study,single-atom Ag was successfully anchored on ultrathin carbon nitride(UTCN)via thermal polymerization,the catalyst obtained is called *** Ag hardly changed the carbon nitride's layered and porous physical *** exhibited efficient visible-light photocatalytic performances in the degradation of various recalcitrant pollutants,eliminations of 85% were achieved by visible-light irradiation for *** with Ag improved the photocatalytic performance of UTCN by narrowing the forbidden band gap from 2.49 to 2.36 e V and suppressing electron-hole pair *** addition,Ag doping facilitated O_(2) adsorption on UTCN by decreasing the adsorption energy from -0.2 to -2.22 e V and favored the formation of O_(2)^(·-).Electron spin resonance and radical-quenching experiments showed that O_(2)^(·-)was the major reactive species in the degradation of Acetaminophen(paracetamol,APAP).

关键词： Ag single atom Carbon nitride Photocatalysis Visible light Adsorption energy Reactive species

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An insulinoma with clinical and electroencephalographic features resembling complex partial seizures

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第6期9卷 496-499页

作者： Shuang wang Hai-tao HU Shu-qun wen Zhong-jin wang Bao-rong ZHANG Mei-ping DING Department of Neurology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

We described a female patient with insulinoma who experienced recurrent episodes of automatism, confusion and convulsion. Furthermore, her electroencephalography （EEG） findings resembled the pattern in complex partial seizures with secondary generalization. The interictal EEG showed spikes and sharp waves, as well as focal slowing over the left temporal lobe, and the ictal EEG revealed generalized spikes and sharp waves associated with diffused slowing. She was initially misdiagnosed as pharmacoresistant epilepsy. After the insulinoma was found and surgically removed, her EEG turned normal and she was seizure-free during the 4-year follow-up. This report highlights the need for careful reassessment of all seizures refractory to medication, even for the oatients associated with eoileotiform discharges on EEG.

关键词： Insulinoma Hypoglycemia Electroencephalography (EEG) Seizure

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Trace determination of cobalt ion by using malic acid-malonic acid double substrate oscillating chemical system

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Chinese Chemical Letters 2008年第9期19卷 1103-1107页

作者： Jie wang Wu Yang Jie Ren Miao Guo Xiao Dong Chen wen Bin wang jin Zhang Gao College of Chemistry ＆ Chemical Engineering Northwest Normal University Lanzhou 730070 China

A novel kinetic method for determination of trace amounts of cobalt ion was proposed and validated. The method is based on adding malic acid into classical Belousov-Zhabotinskii （B-Z） oscillating chemical system to form a double substrate one. The results showed that when the concentration of cobalt ion was in the range of 5.27× 10^-8 to 5.37 × 10^-12 mol L^-1, the change of the oscillating period was directly proportional to the negative logarithm of cobalt ion concentration. The sensitivity and precision of the developed method were quite satisfactory. The limit of detection was down to 5.20 × 10^-13 mol L^-1 which was a highest sensitivity found for determination of metal ions using oscillating chemical reaction so far. Some factors influencing the determination were also examined. The method has been successfully used to determine cobalt ion in vitamin B12 injection.

关键词： Two substrate oscillating chemical system Malic acid Cobalt Determination

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Embedded Majorana islands

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 154-164页

作者： jin-Xing Hou Alex Weststrom Rui wang wen-Li Yang Jian Li Institute of Modern Physics Northwest UniversityXi’an 710127China Department of Physics School of ScienceWestlake UniversityHangzhou 310030China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi’an 710127China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center for Advanced Microstructures Nanjing 210093China Peng Huanwu Center for Fundamental Theory Xi’an 710127China

Mesoscopic superconducting islands hosting Majorana zero modes(MZMs),or Majorana islands in short,offer a prototype of topological *** this work we investigate theoretically the model of a generic Majorana island tunneling-coupled to a singlepiece metallic substrate,hence an embedded Majorana *** show the crucial consequences of an interplay between the topological ground states nonlocally addressed by the MZMs and the metallic bath with coherent electron propagation:on the one hand,the topological degeneracy on the Majorana island can be preserved,by virtue of the particle-hole symmetry,despite the apparent bath-induced coupling between MZMs;on the other hand,the electronic interference in the metallic bath may lead to profound alterations to the renormalization group behavior of the hybrid system towards low energy/temperature compared with conventional Kondo *** work serves to establish the model of embedded Majorana islands as an experimentally relevant and theoretically intriguing problem particularly in the direction of topological quantum computation.

关键词： topological quantum computation Majorana zero modes topological qubit mesoscopic superconductor topological Kondo effect

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Testing the first law of black hole mechanics with gravitational waves

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 76-82页

作者： Chao-Wan-Zhen wang jin-Bao Zhu Guo-Qing Huang Fu-wen Shu Department of Physics Nanchang UniversityNanchang 330031China Center for Relativistic Astrophysics and High Energy Physics Nanchang UniversityNanchang 330031China GCAP-CASPER Physics DepartmentBaylor UniversityWaco 76798-7316USA

The successful observation of gravitational waves has provided humanity with an additional method to explore the universe,particularly black *** this study,we utilize data from LIGO and Virgo gravitational wave observations to test the first law of black hole mechanics,employing two different *** consider the secondary compact object as a perturbation to the primary black hole before the merger,and the remnant black hole as a stationary black hole after the *** the pre-merger and post-merger analysis,our results demonstrate consistency with the first law,with an error level of approximate 25%at a68%credibility level for *** the full inspiral-merger-ringdown analysis,our results show consistency with the first law of black hole mechanics,with an error level of about 6%at a 68%credibility level and 10%at a 95%credibility level for ***,we observe that the higher the mass ratio of the gravitational wave source,the more consistent our results are with the first law of black hole ***,our study sheds light on the nature of compact binary coalescence and their implications for black hole mechanics.

关键词： gravitational waves black hole mechanics data analysis ringdown

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