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A novel method to detect bacterial resistance to disinfectants

Genes & Diseases 2017年第3期4卷 163-169页

作者： Xiao-Feng He Hui-jie Zhang Jin-Gui Cao Fang Liu Jian-Kang Wang wen-jie ma wen Yin Department of Infection Control Air Force General HospitalBeijing 100142China Department of Pharmacy Air Force General HospitalBeijing 100142China Department of Transfusion Medicine Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Ministry of Education Key Laboratory of Diagnostic Medicine College of Laboratory MedicineChongqing Medical UniversityChongqing 400016China

In clinical practice,the important hygienic prevention of bacterial pathogen spread is disinfection of potentially contaminated area.Benzalkonium bromide and chlorhexidine acetate are commonly used disinfectants with a broad spectrum of antimicrobial effect.It is vital to inhibit the spread of pathogen in hospital.However,a large number of pathogens with the decreased antiseptic susceptibility have been isolated from clinical samples which showed an increased minimal inhibitory concentration(MIC)against those antiseptics.These resistant pathogens are the major causes for nosocomial crossinfections in hospital.The present study demonstrated the utility of Oxford plate assay system in determining the potential disinfectant resistance of bacteria.The microbiological assay is based on the inhibitory effect of tested disinfectants upon the strains of Staphylococcus aureus and Escherichia coli.Statistical analysis of the bioassay results indicated the linear correlation(r=-0.87-0.99,Pmal inhibitory concentration(MIC)(r=-0.574,P<0.001).These results suggest that the Oxford plate is a simple and time-saving method in detecting potential clinical disinfectant resistance and its usefulness for routine surveillance of pathogenic resistance to disinfectants warrants further investigation.

关键词： Clinical technology Disinfectants resistance Inhibitory efficacy Oxford plate method Staphylococcus aureus

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Extended lymphadenectomy in hilar cholangiocarcinoma: What it will bring?

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World Journal of Gastroenterology 2020年第24期26卷 3318-3325页

作者： Jian Li Meng-Hao Zhou wen-jie ma Fu-Yu Li Yi-Lei Deng Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Department of Biliary Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Lymph node dissection is always a hot issue in radical resection of hilar cholangiocarcinoma(HCCA).There are still controversies regarding whether some lymph nodes should be dissected,of which the para-aortic lymph nodes are the most controversial.This review synthesized findings in the literature using the PubMed database of articles in the English language published between 1990 and 2019 on the effectiveness of extended lymphadenectomy including paraaortic lymph nodes dissection in radical resection of HCCA.Hepatobiliary surgeons have basically achieved a consensus that enough lymph nodes should be obtained to accurately stage HCCA.Only a very small number of studies have focused on the effectiveness of extended lymphadenectomy including para-aortic nodes dissection on HCCA.They reported that extended lymphadenectomy can bring some survival benefits for patients with potential para-aortic lymph node metastasis and more lymph nodes can be obtained to make the patient's tumor staging more accurate without increasing the related complications.Extended lymphadenectomy should not be adopted for HCCA patients with intraoperatively confirmed distant lymph node metastases.For these patients,radical resection combined with postoperative adjuvant chemotherapy seems to be a better choice.A prospective,multicenter,randomized,controlled clinical study of regional lymphotomy and extended lymphadenectomy in HCCA should be conducted to guide clinical practice.A standardized extended lymphadenectomy may help to more accurately stage HCCA.Future studies are required to further assess whether extended lymphadenectomy can improve long-term survival in negative celiac,superior mesenteric,and para-aortic lymph node diseases.

关键词： Hilar cholangiocarcinoma Lymphadenectomy Prognosis

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Effects of epidermal growth factor receptor inhibitor on proliferative cholangitis in hepatolithiasis

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 509-515页

作者： Qin Yang Yong Zhou Fu-Yu Li Hui mao Anuj Shrestha wen-jie ma Nan-Sheng Cheng Wei Zhang Department of Hepatobiliary Surgery West China Hospital of Sichuan University Department of Medicine The George Washington University

BACKGROUND： There is currently no effective medication to prevent stone recurrence after choledochoscopic lithotomy or to treat proliferative cholangitis（PC）, which is the pathologic basis of hepatolithiasis. This study aimed to investigate whether gefitinib, an epidermal growth factor receptor（EGFR） inhibitor, inhibited cholangio hyperplasia and lithogenesis in PC.METHODS： After cholangioscopic lithotomy, indwelling catheters were placed in the diseased bile duct lumens in 94 patients with hepatolithiasis. Subsequently, 49 of the 94 patients were treated with 250 mg gefitinib solution via a catheter twice a week, and they were subjected to choledochoscopic biopsy at 6 and 12 weeks. The rest 45 hepatolithiasis patients without gefitinib treatment served as controls.RESULTS： The expressions of EGFR, PCNA and procollagen I were significantly reduced in the patients treated with gefitinib in 12 weeks compared with those in the control group. Patients in the gefitinib group had a much lower degree of hyperplasia of the biliary epithelium, submucosal glands and collagen fibers compared with those in the control group. Gefitinib treatment significantly decreased mucin 3 expression and β-glucuronidase activity.CONCLUSION： Postoperative gefitinib treatment could significantly inhibit PC-mediated hyperplasia and lithogenesis, which might provide a novel strategy for the prevention of biliary restenosis and stone recurrence in patients with hepatolithiasis.

关键词： hepatolithiasis proliferative cholangitis epidermal growth factor receptor blockade recurrence restenosis prevention

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Histological examination of frozen sections for patients with acute cholecystitis during cholecystectomy

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Hepatobiliary & Pancreatic Diseases International 2015年第3期14卷 300-304页

作者： Zhen You wen-jie ma Yi-Lei Deng Xian-Ze Xiong Anuj Shrestha Fu-Yu Li Nan-Sheng Cheng Department of Biliary Surgery West China HospitalSichuan University

BACKGROUND： Unexpected gallbladder cancer may present with acute cholecystitis-like manifestat/ons. Some authors rec- ommended that frozen section analysis should be performed during laparoscopic cholecystectomy for all cases of acute cholecystitis. Others advocate selective use of frozen section analysis based on gross examination of the specimen by the surgeon. The aim of the present study was to evaluate whether surgeons could effectively identify suspected gallbladder with macroscopic examination alone. If not, is routine frozen sec- tion analysis worth advocating？

关键词： unexpected gallbladder cancer acute cholecystitis cholecystectomy frozen section analysis

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Sequential embolization of the branches of the bile duct and portal vein to the targeted hepatic lobe in rats

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 55-59页

作者： Anuj Shrestha Yong Zhou Hui mao Fu-Yu Li wen-jie ma Nan-Sheng Cheng Ri-Hua Xu Yong-Qiong Zhang Ting Jiang Huan Feng wen Li Qiang Han Department of Hepatobiliary Surgery West China Hospital of Sichuan University Department of Medicine West China Hospital of Sichuan University

BACKGROUND: The high recurrence rate of hepatolithiasis and the high operative risk of right posterior, caudate or multiple lobe hepatectomy are the unsettled problems in hepatobiliary surgery. The present study was to investigate the efficacy of chemical hepatectomy performed via applying sequential embolization of the branches of the bile duct and portal vein to the targeted hepatic lobe. METHODS: The bile duct and portal vein branches of the median hepatic lobe of rats were treated with: 1) bile duct embolization followed by portal vein ligation(BDE+PVL) and 2) portal vein ligation followed by bile duct embolization(PVL+BDE). The efficacy of chemical hepatectomy in BDE+PVL and PVL+BDE groups was compared with that of sole BDE by histology and Western blotting analysis of collagen I expression. RESULTS: After six weeks of the chemical hepatectomy, rats in the BDE group showed hepatocyte damages, fibrosis and 'selfcut' only in the periphery of the embolized lobe. In contrast, rats in the PVL+BDE and BDE+PVL groups exhibited complete necrosis of hepatocytes and replacement with proliferative ductules and collagen fibers, leading to complete fibrosis and 'self-cut' phenomenon in the whole targeted lobe. Collagen I expression in the PVL+BDE group was slightly higher than that in the BDE+PVL group; however, no statistically significant difference was noted. CONCLUSION: The sequential embolization of the bile duct and portal vein branches to the targeted hepatic lobe may bea feasible and effective approach to acheive the ideal effect of chemical hepatectomy in a short period of time.

关键词： hepatolithiasis bile duct portal vein sequential embolization chemical hepatectomy

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Effectiveness of additional resection of the invasive cancer-positive proximal bile duct margin in cases of hilar cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 251-269页

作者： wen-jie ma Zhen-Ru Wu Anuj Shrestha Qin Yang Hai-jie Hu Jun-Ke Wang Fei Liu Rong-Xing Zhou Quan-Sheng Li Fu-Yu Li Department of Biliary Surgery West China HospitalSichuan UniversityChengdu 610041China Laboratory of Pathology West China HospitalSichuan UniversityChengdu 610041China Department of General Surgery Andaki Medical CollegePokharaNepal

Background: The survival benefits of additional resection of the positive proximal ductal margin (PM) in hilar cholangiocarcinoma (HCCA) remains controversial. This retrospective study investigated the effectiveness of additional resection of the invasive cancer PM under different levels of preoperative carbohydrate antigen 19-9 (CA19-9). Methods: Patients who underwent hepatectomy for HCCA from 2000 to 2017 were analyzed. Surgical variables, resection margin status, length of the PM (LPM), prognostic factors, and survival were evaluated. Results: A total of 228 patients were enrolled: 175 PM(?) without additional resection patients (group A), 21 PM(?) after additional resection (group B), 16 PM(+) without additional resection (group C), and 16 PM(+) after additional resection (group D). The median survival of group B (20.99 months) was similar to that of group A (23.00 months;P=0.16), and both were significantly better than those of group C (11.60 months) and D (9.50 months), especially when preoperative CA19-9>150 U/mL (P10 mm was significantly better compared with those with an LPM ≤10 mm, especially when preoperative CA19-9 was >150 U/mL (P10 mm group, the survival of group B was comparable with that of group A (P>0.05). Conclusions: HCCA patients could get a survival benefit from a negative PM resulting from additional resection. Survival could be comparable with that of negative PM without additional resection among HCCA patients. An LPM >10 mm is possibly more associated with better survival compared with whether additional resection of the positive PM is performed under different levels of preoperative CA19-9.

关键词： Klatskin tumor margins of excision bile ducts antigens neoplasm carbohydrate antigen 19-9 (CA19-9)

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联合肝外胆管切除应用于进展期胆囊癌是否合理?

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Gastroenterology Report 2019年第6期7卷 426-433,I0002页

作者： Jun-Ke Wang wen-jie ma Zhen-Ru Wu Qin Yang Hai-jie Hu Fei Liu Fu-Yu Li Department of Biliary Surgery West China HospitalSichuan UniversityChengduSichuanP.R.China Laboratory of Pathology West China HospitalSichuan UniversityChengduSichuanP.R.China

背景:胆囊癌手术中,肝外胆管是否应常规切除仍然存在争议。本研究旨在探讨联合肝外胆管应用于进展期胆管癌根治性手术的临床意义。方法:213例行根治性手术的T2-T4期胆囊癌患者纳入研究。比较术中联合与未联合胆外胆管切除患者的临床病... 详细信息

背景:胆囊癌手术中,肝外胆管是否应常规切除仍然存在争议。本研究旨在探讨联合肝外胆管应用于进展期胆管癌根治性手术的临床意义。方法:213例行根治性手术的T2-T4期胆囊癌患者纳入研究。比较术中联合与未联合胆外胆管切除患者的临床病理特征。同时,采用单因素和多因素Cox比例风险回归模型来明确影响总体生存(OS)的危险因素。结果:213例入组患者中,87例(40.8%)行联合肝外胆管切除。与未行肝外胆管切除者相比,联合肝外胆管切除者术后并发症发生率更高(33.3%vs 21.4%,P=0.046)。然而,联合肝外胆管切除者中位OS显著延长(25 vs 11个月,P=0.008)。按T分期和N分期进行的亚组分析显示,在T3、T4或有淋巴结转移病例中,联合肝外胆管切除者中位OS均优于未行肝外胆管切除者(T3:15 vs 7个月,P=0.002;T4:11 vs 6个月,P=0.021;N+:12 vs 7个月,P<0.001);而在T2或无淋巴结转移病例中,联合肝外胆管切除则未显示出生存获益。多因素预后危险因素分析显示,T分期、淋巴结转移、切缘状态、术前CA19-9水平及肝外胆管切除是进展期胆囊癌患者总体生存的独立预后因素(均P<0.05)。结论:联合肝外胆管切除可独立影响进展期胆囊癌患者的总体生存时间。对于T3、T4或有淋巴结转移的胆囊癌,联合肝外胆管切除是合理的,可改善患者总体生存。

关键词：肝外胆管切除 Cox比例风险回归模型进展期胆囊癌根治性手术胆管癌亚组分析无淋巴结转移 T分期

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Prognostic factors and long-term outcomes of hilar cholangiocarcinoma:A single-institution experience in China

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World Journal of Gastroenterology 2016年第8期22卷 2601-2610页

作者： Hai-jie Hu Hui mao Anuj Shrestha Yong-Qiong Tan wen-jie ma Qin Yang Jun-Ke Wang Nan-Sheng Cheng Fu-Yu Li Department of Biliary Surgery West China Hospital of Sichuan University Department of Respiratory Medicine West China Hospital of Sichuan University Department of General Surgery Gandaki Medical College

AIM: To evaluate the prognostic factors of hilar cholangiocarcinoma in a large series of patients in a single institution.METHODS: Eight hundred and fourteen patients with a diagnosis of hilar cholangiocarcinoma that were evaluated and treated between 1990 and 2014, of which 381 patients underwent curative surgery, were included in this study. Potential factors associated with overall survival(OS) and disease-free survival(DFS) were evaluated by univariate and multivariate analyses.RESULTS: Curative surgery provided the best long-term survival with a median OS of 26.3 mo. The median DFS was 18.1 mo. Multivariate analysis showed that patients with tumor size > 3 cm [hazard ratio(HR) = 1.482, 95%CI: 1.127-1.949; P = 0.005], positive nodal disease(HR = 1.701, 95%CI: 1.346-2.149; P margins(HR = 1.798, 95%CI: 1.314-2.461; P margins(HR = 1.835, 95%CI: 1.256-2.679; P margin, and surgical procedures could indirectly affect survival outcome by influencing the tumor resection margin. CONCLUSION: Tumor margin, tumor differentiation, vascular invasion, and lymph node status were independent factors for OS and DFS. Surgical procedures can indirectly affect surv

关键词： Hilar cholangiocarcinoma Prognosis Surgical outcome Survival Tumor-free margin

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Research on denoising of joint detection signal of water quality with multi-parameter based on IEEMD

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Optoelectronics Letters 2024年第2期20卷 107-115页

作者： LI wen LI Dejian ma Yongyue TIAN Wang wen Xin LI jie Institute of Mechanical and Electrical Engineering North China University of TechnologyBeijing 100144China1

An improved ensemble empirical mode decomposition(IEEMD) is suggested to process water quality spectral signals in order to address the issue that noise interference makes it difficult to extract and evaluate water quality spectral signals.This algorithm effectively solves the problems of modal mixing,poor reconstruction accuracy in the empirical mode decomposition(EMD),and a large amount of calculation in the ensemble empirical mode decomposition(EEMD).Based on EEMD,IEEMD firstly preprocesses the original water quality spectral signals,then performs Savitzky-Golay(S-G) smoothing on the decomposed effective intrinsic mode function(IMF) components,and finally reconstructs them to obtain the denoised signals.Water sample data at different concentrations can be accurately analyzed based on the noise-reduced spectral signals.In this paper,three water quality parameters are used as research objects:benzene(C_(6)H_(6)),benzo(b)fluoranthene(C_(20)H_(12)),and chemical oxygen demand(COD).The original water quality multi-parameter(C_(6)H_(6),C_(20)H_(12),COD) spectral signals were subjected to denoising based on the IEEMD and the water quality multi-parameter joint detection technology.The signal-to-noise ratio(SNR) and the correlation coefficient(R^(2)) of the fitted curves obtained from the processing of the IEEMD were compared and analyzed with those obtained from the processing of the EMD and the EEMD.The experimental results show that the SNR of the spectral signals and the R^(2) of the fitting curve in three water quality parameters have been significantly improved.Therefore,the IEEMD effectively improves the phenomenon of modal mixing,reduces the amount of calculation,improves the reconstruction accuracy,and provides an important guarantee for the effective extraction of multi-parameter spectral signals of water quality.

关键词： signal parameter noise

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Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： ZHONG Yi LI Xin-yue LIANG Tian-jun DING Bao-zhu ma Ke-xin REN wen-xuan LIANG wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and hypertension.Noncoding RNAs(nc RNAs)are important regulatory factors.many Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting effects.The mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator 1.The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM.Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms

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