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Management and outcomes of surgical patients with intestinal Behçet’s disease and Crohn’s disease in southwest China

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World Journal of Clinical Cases 2021年第16期9卷 3858-3868页

作者： Li Zeng wen-jian meng Zhong-Hui wen Yi-Long Chen Yu-Fang Wang Cheng-Wei Tang Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Biomedical Big Data Center West China Hospital/West China School of MedicineSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Gastrointestinal involvement in Behçet's disease(GIBD)and Crohn’s disease(CD)are inflammatory diseases sharing a considerable number of ***,different from CD,the operative and postoperative management of GIBD remains largely empirical because of the lack of comprehensive treatment *** To compare surgical patients with GIBD and those with CD in a medical center and identify notable clinical features and effective postoperative treatment for surgical patients with *** We searched patients diagnosed with CD and GIBD who underwent operations for gastrointestinal complications from 2009 to 2015 at West China Hospital of Sichuan University.A total of 10 surgical patients with GIBD and 106 surgical patients with CD were *** including demographic data,medication,and operative and postoperative parameters were collected and *** the incidence of surgical GIBD is low,their detailed medical records were reviewed and compared to previous ***,the prognoses of CD and GIBD were evaluated respectively between groups treated with biological and non-biological *** Indication for first surgery was often acute intestinal perforation for GIBDpatients (7/10 vs 0/106, P went reoperations. Theaverage period of postoperative recurrence was 7.87 mo in patients with Behçet'sdisease (BD) and 10.43 mo in patients with CD, whereas the mean duration fromfirst surgery to reoperation was 5.75 mo in BD patients and 18.04 mo in CDpatients. Surgical patients with GIBD more often used cortic

关键词： Gastrointestinal involvement in Behçet's disease Crohn’s disease Surgery Postoperative treatment Biological agents Real-world study

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Study on the mechanism of near-field underwater explosion on supported thin plates with prefabricated holes

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Acta Mechanica Sinica 2024年第8期40卷 32-44页

作者： Si Chen jian Qin Xiangyao meng Zhichao Lai Yanbo wen Ruiyuan Huang School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Naval Academy Beijing100161China College of Civil Engineering Fuzhou UniversityFuzhou350116China

In this study,underwater explosion tests with 2.5 g trinitrotoluene explosive under different fixed plates with prefabricated holes were *** experimental results showed that the air inflow from the prefabricated hole caused the bubble to collapse earlier with an increase in the hole *** addition,the deformation mode of the thin plate transitioned from“convex”to“concave”(up to down).Next,the coupled Eulerian-Lagrangian method was used to perform the corresponding numerical *** accuracy of the numerical simulation method was verified through a comparison with the experimental *** addition,a series of numerical simulations were conducted with different prefabricated-hole diameters,blast distances,and prefabricated-hole *** results showed that the bubble-pulsating water jet substantially influenced the deformation of the thin plate when the diameter of the prefabricated hole was within the theoretical maximum bubble *** the blast distance was within the theoretical maximum bubble radius,the thin plate was subjected to only a single bubble pulsation owing to the air inflow from the prefabricated hole.

关键词： Underwater explosion Hole High-speed camera Bubble pulsation Fixed plate

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Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients

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World Journal of Gastroenterology 2007年第28期13卷 3878-3882页

作者： Chao Tian Zong-Guang Zhou wen-jian meng Xiao-Feng Sun Yong-Yang Yu Li Li Hong-Zhi Luo, Lie Yang Bin Zhou Jun Gu Department of Gastrointestinal Surgery and Division of Digestive Surgery and Organ-Microcirculation West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Oncology Institute of Biomedicine and Surgery University of Linkoping Linkoping Sweden Department of Gastrointestinal Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM： To clarify the expression change of Wnt-induced secreted protein-1 （WISP-l） in human rectal cancer and to determine whether it is correlated with invasion and metastasis of human rectal cancer.METHODS： Eighty-six paired samples of rectal cancer and surgically resected distant normal rectal tissue were collected and allocated into cancer group and control group respectively. WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining.RESULTS： WISP-1 gene overexpression was found in 65% （56/86） primary rectal cancers, 2-30 times that of the level in normal matched rectal tissues （P = 0.001）. The mRNA expression level was correlated with Duke＇s staging, histological differentiation grade and lymph node status. The WISP-1 protein expression was in accordance with mRNA expression level. The positive degree of immunohistochemical staining in the cancer group （1.40±0.35） was different from that in control group （1.04± 0.08, P 〈 0.001）. Moreover, in cancer group the positive staining degree in high-level mRNA cancers （1.46 ±0.37, n = 56） was higher than that in low-level mRNA （1.28 ± 0.28, n = 30, P = 0.018）.CONCLUSION： Aberrant levels of WISP-1 expression may play a role in rectal tumorigenesis. WISP-1 may be used as a specific clinical diagnosis and prognosis marker in rectal cancer.

关键词： Wnt-induced secreted protein-1 Rectal cancer Real time RT-PCR Immunohistochemicy

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Anatomy of the lateral ligaments of the rectum: A controversial point of view

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World Journal of Gastroenterology 2010年第43期16卷 5411-5415页

作者： Guo-Jun Wang, Chun-Fang Gao, Dong Wei, Cun Wang, wen-jian meng, Institute of Digestive Surgery and Department of General Surgery, 150 Hospital of PLA, Gaoxin District, Luoyang 471031, Henan Province, China Institute of Digestive Surgery and Department of General Surgery 150 Hospital of PLA Gaoxin District Luoyang 471031 Henan Province China.

The existence and composition of the lateral ligaments of the rectum (LLR) are still the subjects of anatomical confusion and surgical misconception up to now. Since Miles proposed abdominoperineal excision as radical surgery for rectal cancer, the identification by "hooking them on the finger" has been accepted by many surgeons with no doubt; clamping, dividing and ligating are considered to be essential procedures in mobilization of the rectum in many surgical textbooks. But in cadaveric studies, many anatomists could not find LLR described by the textbooks, and more and more surgeons also failed to find LLR during the proctectomy according to the principle of total mesorectal excision. The anatomy of LLR has diverse descriptions in literatures. According to our clinical observations, the traditional anatomical structures of LLR do exist; LLR are constant dense connective bundles which are located in either lateral side of the lower part of the rectum, run between rectal visceral fascia and pelvic parietal fascia above the levator ani, and covered by superior fascia of pelvic diaphragm. They are pathways of blood vessels and nerve fibers toward the rectum and lymphatic vessels from the lower rectum toward the iliac lymph nodes.

关键词： The lateral ligaments of the rectum Anatomy Total mesorectal excision Abdominoperineal excision Fascia

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In situ embedded bismuth nanoparticles among highly porous carbon fibers for efficient carbon dioxide reduction

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Rare Metals 2024年第9期43卷 4312-4320页

作者： Wei-jian Guo Ao Zhou wen-wen Cai Jin-Tao Zhang Key Laboratory for Colloid and Interface Chemistry (Ministry of Education) School of Chemistry and Chemical EngineeringShandong University

Electrocatalysis provides an optimal approach for the conversion of carbon dioxide(CO2) into high-value chemicals, thereby presenting a promising avenue toward achieve carbon neutrality. However, addressing the selectivity and stability challenges of metal catalysts in electrolytic reduction remains a daunting task. In this study, the electrospinning method is employed to fabricate porous carbon nanofibers loaded with bismuth nanoparticles with the help of in situ pyrolysis. The porous carbon nanofibers as conductive support would facilitate the dispersion of bismuth active sites while inhibiting their aggregation and promoting the mass transfer, thus enhancing their electrocatalytic activity and stability. Additionally, nitrogen doping induces electron delocalization in bismuth atoms through metal-support interactions, thus enabling efficient adsorption of intermediates for improving selectivity based on the theoretical calculation. Consequently, Bi@PCNF-500 exhibits the exceptional selectivity and stability across a wide range of potential windows. Notably, its faradaic efficiency(FE) of formate reaches 92.7% in H-cell and94.9% in flow cell, respectively, with good electrocatalytic stability. The in situ characterization and theoretical calculations elucidate the plausible reaction mechanism to obtain basic rules for designing efficient electrocatalyst.

关键词： Carbon dioxide reduction Electron delocalization N-doping Porous carbon nanofiber

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Observation of gapless corner modes of photonic crystal slabs in synthetic translation dimensions

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Photonics Research 2024年第3期12卷 444-455页

作者： wen-JIN ZHANG HAO-CHANG MO wen-JIE CHEN XIAO-DONG CHEN jian-wen DONG School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Second-order topological photonic crystals support localized corner modes that deviate from the conventional bulk-edge ***,the frequency shift of corner modes spanning the photonic band gap has not been experimentally ***,we observe the gapless corner modes of photonic crystal slabs within a parameter space by considering translation as an additional synthetic *** corner modes,protected by topological pumping in synthetic translation dimensions,are found to exist independently of the specific corner *** gapless corner modes are experimentally imaged via the near-field scanning measurement and validated numerically by full-wave *** propose a topological rainbow with gradient translation,demonstrating the ability to extract and separate specific frequency components of light into different spatial *** work contributes to the advancement of topological photonics and provides valuable insights into the exploration of gapless corner modes in synthetic dimensions.

关键词： translation dimensions corner

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Novel mutations and sequence variants in exons 3-9 of human T Cell Factor-4 gene in sporadic rectal cancer patients stratified by microsatellite instability

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World Journal of Gastroenterology 2007年第27期13卷 3747-3751页

作者： wen-jian meng Ling Wang Chao Tian Yong-Yang Yu Bing Zhou Jun Gu Qing-Jie Xia Xiao-Feng Sun Yuan Li Rong Wang Xue-Lian Zheng Zong-Guang Zhou Department of Gastrointestinal Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Division of Digestive Surgery and Organ-Microcirculation West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Ophthalmologic Surgery Laboratory West China Hospital Sichuan University Chengdu 610041 Sichuan Province China National Key Laboratory of Biotherapy of West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Oncology Linkoping University Linkoping Sweden

AIM： To establish the role of human T Cell Factor-4 （hTCF-4） gene exons 3-9 mutation status in association with sporadic rectal cancer with microsatellite instability （MSI）. METHODS： Microsatellite markers were genotyped in 93 sporadic rectal cancer patients. Eleven cases were found to be high-frequency MSI （MSI-H）. Sequence analysis of the coding region of the exons 3-9 of hTCF-4 gene was carried out for the 11 MSI-H cases and 10 controls （5 microsatellite stability （MSS） cases and 5 cases with normal mucosa）. The sequencing and MSI identification were used. RESULTS： Several novel mutations and variants were revealed. In exon 4, one is a 4-position continuous alteration which caused amino acid change from Q131T and S132I （391insA, 392 G 〉 A, 393 A 〉 G and 395delC） and another nucleotide deletion （395delC） is present in MSI-H cases （5/10 and 4/10, respectively） but completely absent in the controls.CONCLUSION： Novel mutations in exon 4 of hTCF-4 gene were revealed in this study, which might be of importance in the pathogenesis of sporadic rectal cancer patients with MSI-H.

关键词： hTCF-4 Sporadic rectal cancer Microsatellite instability Mutation analysis

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Where is the optimal plane to mobilize the anterior rectal wall in female patients undergoing total mesorectal excision?

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World Journal of Gastroenterology 2023年第19期29卷 2992-3002页

作者： Wei Jin Jun Yang Xin-Yu Li Wei-Cheng Wang wen-jian meng You Li Yi-Chao Liang Yi-Ming Zhou Xin-Dong Yang Yang-Yang Li Shao-Tang Li Department of Colorectal and Anal Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Gastrointestinal Surgery The First Hospital of Quanzhou Affiliated to Fujian Medical UniversityQuanzhou 362002Fujian ProvinceChina Department of Gastrointestinal Surgery West China Hospital.Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of General Surgery Shanghai Jiao Tong University Medical School Affiliated RuijinShanghai 201800China Department of General Surgery Shengjing Hospital of China Medical UniversityShenyang 111300Liaoning ProvinceChina Department of General Surgery Huashan Hospital Fudan UniversityShanghai 201800China School of Basic Medicine Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Pathology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina National Key Clinical Specialty(General Surgery) The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Since Heald proposed the total mesorectal excision(TME)procedure,the prognosis of patients with rectal cancer has been significantly *** Heald did not specifically describe the anterior surgical plane in female *** the surgical plane for mobilizing the anterior rectal wall during TME surgery in female patients remains *** To investigate the anatomy of the female pelvis and identify the optimal plane for mobilizing the anterior rectal *** We retrospectively collected surgical procedure videos and clinical data of female patients diagnosed with middle or low rectal cancer who underwent the TME procedure between January 2020 and October 2022 across six *** patients were divided into two groups based on the surgical approach used to mobilize the anterior rectal wall:The experimental group was to open the peritoneum at the lowest point of the peritonea reflection and enter the plane for mobilizing,while the control group was cut at 0.5-1 cm above the peritoneal reflection and enter another ***,we compared the preoperative and postoperative information between the two *** also dissected and observed ten adult female pelvises to analyze the anatomic structure and compare the entry plane between the two ***,we researched the pathological structure between the rectum and the *** Finally,77 cases that met the criteria were included in our *** observations revealed that the experimental group underwent a smooth procedure,entering the plane amidst the mesorectal fascia and adventitia of the vagina,whereas the control group entered the plane between the vaginal adventitia and muscle *** to the control group,the experimental group showed a significant decrease in intraoperative bleeding[22.5(19.5-50)mL vs 17(5-20)mL,P=0.01],as well as a shorter duration of hospitalization[9(7-11.25)d vs 7(6-10)d,P=0.03].Through the examination of surgical videos and cadaveric stud

关键词： Rectal cancer Procedure Female Rectal surgery specialty Fascia Laparoscopic

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Learning-based counterfactual explanations for recommendation

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Science China(Information Sciences) 2024年第8期67卷 115-129页

作者： Jingxuan wen Huafeng LIU Liping JING jian YU School of Computer and Information Technology Beijing Jiaotong University Beijing Key Lab of Traffic Data Analysis and Mining Beijing Jiaotong University

Counterfactual explanations provide explanations by exploring the changes in effect caused by changes in cause. They have attracted significant attention in recommender system research to explore the impact of changes in certain properties on the recommendation mechanism. Among several counterfactual recommendation methods, item-based counterfactual explanation methods have attracted considerable attention because of their flexibility. The core idea of item-based counterfactual explanation methods is to find a minimal subset of interacted items(i.e., short length) such that the recommended item would topple out of the top-K recommendation list once these items have been removed from user interactions(i.e., good quality). Usually, explanations are generated by ranking the precomputed importance of items, which fails to characterize the true importance of interacted items due to separation from the explanation generation. Additionally, the final explanations are generated according to a certain search strategy given the precomputed importance. This indicates that the quality and length of counterfactual explanations are deterministic;therefore, they cannot be balanced once the search strategy is fixed. To overcome these obstacles, this study proposes learning-based counterfactual explanations for recommendation(LCER) to provide counterfactual explanations based on personalized recommendations by jointly modeling the factual and counterfactual preference. To achieve consistency between the computation of importance and generation of counterfactual explanations, the proposed LCER endows an optimizable importance for each interacted item, which is supervised by the goal of counterfactual explanations to guarantee its credibility. Because of the model's flexibility, the trade-off between quality and length can be customized by setting different proportions. The experimental results on four real-world datasets demonstrate the effectiveness of the proposed LCER over several

关键词： counterfactual explanation counterfactual inference explainable recommendation item-based explanation recommender system

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Mucosa color and size may indicate malignant transformation of chicken skin mucosa-positive colorectal neoplastic polyps

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 750-760页

作者： Ying-Jie Zhang meng-Xia Yuan Wu wen Fan Li Yi jian Chuan-Ming Zhang Ye Yang Feng-Lin Chen Department of Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND Lipid metabolism reprogramming is suspected to exist in pre-cancerous lesions,including colorectal *** colonoscopy frequently reveals chicken skin mucosa(CSM;white or yellow-white speckled mucosa)surrounding colo-rectal polyps,caused by macrophages engulfing and accumulating the lipids decomposed by colon cells or adjacent ***-positive colorectal polyps are associated with various diseases;however,their prognosis varies *** snare polypectomy is commonly used to resect lesions up to 10 to 15 mm in diameter without signs of submucosal invasion but is controversial for CSM-positive colorectal *** imaging is required to diagnose and treat CSM-positive colorectal *** This retrospective cohort study included 177 patients with CSM-positive colorectal polyps diagnosed using *** patient-related information was extracted from the Goldisc soft-clinic DICOM system or electronic medical record *** on the pathological results,patients were classified as non-neoplastic polyps(five juvenile polyps),neoplastic polyps,non-invasive high-grade neoplasia(NHGN),or submucosal invasive carcinoma(SM stage cancer).We analyzed and compared the clinical features,suspected risk factors for malignant transformation of neoplastic polyps,and early infiltration of sub-mucosal *** The diameters of NHGN and SM polyps were much smaller than those of neoplastic *** NHGN polyps had a deeper red mucosal *** logistic regression analyses,diameter and deeper red mucosal color were independent risk factors for malignant transformation of neoplastic *** 1 CSM was more common in high-grade intraepithelial neoplasia and SM;type 2 CSM was more common in neoplastic *** regression analyses revealed no significant differences in the malignant transformation of neoplastic polyps or early submucosal invasion of CSM-positive colorectal *** in the CSM mucosa surrounding neoplastic

关键词： Chicken skin mucosa Colorectal cancer Colorectal polyps Endoscopic resection Malignant transformation White light endoscopy

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