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Effects of atorvastatin on progression of diabetic nephropathy and local RAGE and soluble RAGE expressions in rats

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第8期12卷 652-659页

作者： Lin LU wen-hui peng Wei WANG Ling-jie WANG Qiu-jing CHEN Wei-feng SHEN Department of Cardiology Ruoin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Institute of Cardiovascular Diseases School of Medicine Shanghai Jiao Tong University Shanghai 200025 China

Objective:Advanced glycation end-products (AGEs) exert inflammatory and oxidative stress insults to produce diabetic nephropathy mainly through the receptor for AGEs (RAGE).This study aimed to assess the effect of atorvastatin on diabetic nephropathy via soluble RAGE (sRAGE) and RAGE expressions in the rat ***:Thirty-two male Sprague-Dawley rats were divided into four groups based on the presence or absence of streptozotocin-induced diabetes with or without atorvastatin treatment (10 mg/kg for 24 weeks).Serum sRAGE and glycated albumin (GA) levels were measured with enzyme-linked immunosorbent assay (ELISA) and improved bromocresol purple *** AGEs,RAGE,endogenous secretory RAGE (esRAGE),and sRAGE were determined with reverse transcription-polymerase chain reaction (RT-PCR) and Western ***:Mesangial expansion and microalbuminuria were aggravated in diabetic rats,and improved with atorvastatin *** sRAGE levels were lower in diabetic than in normal *** atorvastatin treatment,serum and renal sRAGE levels were up-regulated,while renal RAGE expression was decreased in diabetic rats,associated with a reduction in accumulation of AGEs,though renal esRAGE mRNA expression was not significantly ***:Atorvastatin exerted a beneficial effect on diabetic nephropathy with reduced AGE accumulation,down-regulating RAGE expression and up-regulating sRAGE in the kidney.

关键词： Receptor for advanced glycation end-product (RAGE) Endogenous secretory RAGE (esRAGE) Soluble RAGE (sRAGE) Diabetic nephropathy Atorvastatin

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Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model

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Chinese Medical Journal 2008年第21期121卷 2167-2171页

作者： WANG Liang CAI Shi-rong ZHANG Chang-hua HE Yu-long ZHAN wen-hua WU hui peng Jian-jun Department of Gastroenteropancreatic Surgery First Affiliated Hospital Center of Gastric Cancer Sun Yat-sen University Guangzhou Guangdong 510080 China

Background Angiotensin-converting enzyme inhibitors （ACEI） and angiotensin II type 1 receptor blockers （ARB） can inhibit tumor growth by inhibition of angiogenesis. This study was designed to study the anticancer effects of ACEI and ARB on tumor growth and lymphangiogenesis in an implanted gastric cancer mouse model. Methods A model of gastric cancer was established by subcutaneously inoculating human gastric cancer cell line SGC-7901 into 60 nude mice. One week later, all mice were randomly divided into 5 groups. A control group received physiologic saline once daily for 21 days. Mice in the 4 treatment groups received one of the following agents by gavage once daily for 21 days： perindopril, 2 mg/kg; captopril, 5 mg/kg; Iosartan, 50 mg/kg; or valsartan, 40 mg/kg. Twenty-one days after treatment, all the mice were sacrificed and the tumors were removed. Tumor sections were processed, and immunohistochemical methods were used to observe the expressions of vascular endothelial growth factor C （VEGF-C）, matrix metalloproteinase 7 （MMP-7）, and lymphatic microvessel density （LMVD）. Results Tumor volume was significantly inhibited in all ACEI and ARB groups, compared with the control group （all P 〈0,01）. LMVD in the ACEI and ARB groups was also significantly lower than that of the control group （all P 〈0.01）. In the ACEI groups, the expressions of VEGF-C and MMP-7 were both significantly decreased, compared with the control group （all P 〈0.05）. In the ARB groups, expression of VEGF-C was significantly decreased compared with the control group （all P 〈0.05）. However, no significant difference was found in the expression of MMP-7 between ARB groups and the control group. Conclusion In a mouse model, ACEI and ARB might inhibit gastric cancer tumor growth by suppressing lymphangiogenesis.

关键词： stomach neoplasms angiotensin-converting enzyme inhibitor angiotensin Ⅱ type Ⅰ receptor blocker lymphangiogenesis

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基于颗粒破碎特性的盐岩集料基层级配组成设计研究

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岩土力学 2024年第2期45卷 340-352页

作者：王朝辉问鹏辉宋亮牛亮亮奚鹤长安大学特殊地区公路工程教育部重点实验室陕西西安710064 新疆交通规划勘察设计研究院有限公司新疆乌鲁木齐830006 新疆交投建设管理有限责任公司新疆乌鲁木齐830049

为实现内陆干盐湖区盐岩集料基层级配组成的科学设计,以罗布泊盐岩为研究对象,分析了不同粒径及含卤水率条件下单粒组盐岩集料颗粒破碎演化特征,构建了复杂粒组下盐岩集料级配转移模型,提出了盐岩集料基层级配组成设计方法,验证了盐岩... 详细信息

为实现内陆干盐湖区盐岩集料基层级配组成的科学设计,以罗布泊盐岩为研究对象,分析了不同粒径及含卤水率条件下单粒组盐岩集料颗粒破碎演化特征,构建了复杂粒组下盐岩集料级配转移模型,提出了盐岩集料基层级配组成设计方法,验证了盐岩集料基层级配组成设计方法的合理性,并对比了不同级配组成及失水率下盐岩集料的工程性质。结果表明:击实作用下各粒组盐岩集料均发生颗粒破碎,随着击实能量增加,盐岩集料级配趋于稳定,卤水的赋存会降低单粒组盐岩颗粒破碎率。Weibull分布可有效表征盐岩集料破碎颗粒级配分布特征。推荐的盐岩集料基层级配组成设计方法可有效推演盐岩集料基层的级配演化特征并实现考虑卤水影响的级配修正。盐岩集料颗粒间卤水盐分结晶有利于盐岩集料基层强度形成,失水率为75%的盐岩集料无侧限抗压强度可达到4.1 MPa,盐岩集料可用于干盐湖区公路基层填筑工程。

关键词：道路工程盐岩集料级配组成设计基层颗粒破碎罗布泊

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li hui Ye Xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-peng Wang Guo-Cui Mao hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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基于注浆模拟的道路基层碱激发材料加固效果研究

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硅酸盐通报 2019年第1期38卷 276-282页

作者：问鹏辉王朝辉张磊长安大学公路学院西安710064

为更好地将碱激发材料应用于道路基层注浆加固工程中,开发了室内注浆模拟小型足尺试验装置,测试评价了不同级配水稳碎石基层及不同脱空工况下的碱激发材料注浆加固效果,预测了碱激发注浆材料及其注浆后形成结石体的7 d抗压强度相关关系... 详细信息

为更好地将碱激发材料应用于道路基层注浆加固工程中,开发了室内注浆模拟小型足尺试验装置,测试评价了不同级配水稳碎石基层及不同脱空工况下的碱激发材料注浆加固效果,预测了碱激发注浆材料及其注浆后形成结石体的7 d抗压强度相关关系。结果表明:碱激发注浆材料对于处治水稳碎石基层脱空病害具有良好的适应性,对于间断级配型基层的处治效果更优,其处治后结石体7 d抗压强度可达10. 91～12. 54 MPa,满足重载交通下水稳碎石基层的强度要求;在处治不同脱空程度的基层病害时,整体芯样的抗压强度随着注浆高度的增加而增大,碱激发注浆材料形成结石体早期强度形成速度较快,有利于快速开放交通;注浆后的混合料结石体与注浆材料的7 d抗压强度呈现出较强的相关性。

关键词：道路工程注浆模拟碱激发材料加固

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The Direction of Marketing in E-commerce

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厦门大学学报（自然科学版） 2002年第S1期41卷 263-264页

作者： ZHANG Wu-yi 1, wen Shu-hui 2, peng Lan-ping 3 (1. School of Management, Huazhong University of Science and Technology, Wuhan 430074, China 2. Department of Management, Kunming University of Science and Technology, Kun ming 650093, China 3. Human Resource Bureau of Yunnan Province)

E-commerce is the execution of business transactio ns over the Internet. Companies conducting e-commerce can perform most of the tra nsactions which they are doing now. Most of the marketing method should coincide nt with the changes in e-commerce world. Brand ability will be depressed, but corporate identity and brand identity will be upgraded. So the enterprise should lower the cost of distribution, manufactur ing, and supplying. We can also upgrade the product value which consumer con ceded. Logistic will be core ability. The 3pl and 4pl will be used more and more often. The importance of transportation has grown with the increasing globalization as well as the growth in e-commerce. Firms should identify various transportation network design options and their relative strengths and weaknesses. They should also use methodologies for routing and scheduling deliveries in transportation network. The savings matrix and the generalized assignment methodology can be us ed to minimize the transportation cost while meeting delivery commitments to cus tomers. Information is essential to making good decisions. Information technology provid es the tools to gather information and analyze it in order to make the best deci sions. Information plays a key in every company. Information technology will be used broadly. It is a factual component on which decisions about each of the transportation, facilities, and inventory. In essence, information is the glue that holds the company to other firms, and allows it to function, making informa tion the most important firms drivers. Custom relation management, data based marketing, one to one marketing, electron ic odder system, electronic data exchange, will be used frequent. These new mark eting method is using information technology all. IT investment in program will greatly increase. The consumer can find and compare the price in every character easily on Interne t. Cost becomes the most important factor in product selecting. So the e

关键词： marketing e-commerce direction

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新疆杏果实发育过程中香气物质的变化及其特征成分的确定

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园艺学报 2016年第10期43卷 1878-1890页

作者：卢娟芳郑惠文郑巧张秋云李文慧席万鹏西南大学园艺园林学院重庆400716 新疆农科院轮台国家果树资源圃新疆轮台841600 南方山地园艺学教育部重点实验室重庆400715

以5个新疆主栽杏品种不同发育阶段的果皮和果肉为试验材料,使用GC–MS法检测分析其香气物质,共检测到154种香气物质,其中58种含量较为丰富。成熟期对果实香气物质的组成与含量有显著影响。随果实发育,芳樟醇、α–萜品醇、香叶醇、β–... 详细信息

以5个新疆主栽杏品种不同发育阶段的果皮和果肉为试验材料,使用GC–MS法检测分析其香气物质,共检测到154种香气物质,其中58种含量较为丰富。成熟期对果实香气物质的组成与含量有显著影响。随果实发育,芳樟醇、α–萜品醇、香叶醇、β–月桂烯、罗勒烯、2–己烯醇、苯乙醛和己醛的含量均迅速下降,而β–紫罗兰酮、香叶基丙酮、γ–癸内酯、δ–癸内酯和γ–十二内酯的含量迅速增加。果实发育前期以积累醇类、醛类、萜类和萜烯类为主,果实成熟过程中以积累酮类和内酯为主。果皮中萜类、萜烯类、醇、醛和内酯的含量均显著高于果肉中,而酮类物质的含量却显著低于果肉中。基于风味阈值法,共鉴别出新疆杏果实特征香气成分22种,其中芳樟醇、γ–癸内酯、δ–十二内酯、β–大马酮、顺,反–2,6–壬烯醛、苯乙醛、己醛、α–萜品醇、乙酸己酯、香叶醇和β–月桂烯等的贡献最大。

关键词：杏果实发育成熟香气物质风味

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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基于Newmark-β法的地震作用下顺层岩质边坡可靠度时程分析方法

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中国公路学报 2017年第7期30卷 33-40页

作者：陈训龙高荣雄龚文惠李逸彭永浩华中科技大学岩土与地下工程研究所湖北武汉430074

为了提高传统顺层岩质边坡地震响应的时程分析方法的计算效率,以及在地震作用下边坡动力可靠度评价指标的选取方法中考虑地震随机性的特征,运用Newmark-β法和MATLAB/Simulink工具建立了顺层岩质边坡地震响应的简化计算方法,基于Monte C... 详细信息

为了提高传统顺层岩质边坡地震响应的时程分析方法的计算效率,以及在地震作用下边坡动力可靠度评价指标的选取方法中考虑地震随机性的特征,运用Newmark-β法和MATLAB/Simulink工具建立了顺层岩质边坡地震响应的简化计算方法,基于Monte Carlo法进一步给出了安全系数与可靠度时程的计算方法。根据边坡工程技术规范中规定的边坡稳定安全系数最低要求值和实际工程中可接受的边坡最大允许破坏概率,提出了最低安全要求可靠度和最大允许失效可靠度2个新的评价指标,并给出了相应的计算方法。最后,采用2个新的评价指标对地震作用下边坡动力可靠性进行综合评判。结果表明:提出的顺层岩质边坡地震响应简化计算方法合理可行,且具有较高的计算效率和精度;与其他的边坡地震可靠度评价方法相比,该方法采用2个新的评价指标评价地震作用下边坡动力可靠性的方法可靠,其考虑了边坡地震可靠度随机性的特征,且与边坡工程技术规范和实际工程风险相结合,计算结果能更真实地反映地震作用下边坡的安全状况,更具合理性和工程适用性。

关键词：道路工程顺层岩质边坡 Newmark-β法动力可靠度地震响应评价指标

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