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Association between the cumulative triglyceride-glucose index and the recurrence of atrial fibrillation after radiofrequency catheter ablation

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Journal of Geriatric Cardiology 2024年第2期21卷 200-210页

作者： Qing YAN Jia-Qi LIANG Yi-De YUAN Yuan LI Jia-Li FAN wen-huan wu Pan XU Jia-Hong XUE Department of Cardiovascular Medicine the Second Affiliated Hospital of Xi’an Jiaotong UniversityShaanxiChina Department of Cardiovascular Medicine Zichang People’s HospitalShaanxiChina Department of Ultrasound Xijing HospitalAir Force Military Medical UniversityShaanxiChina

BACKGROUND Triglyceride-glucose(TyG)index values are a new surrogate marker for insulin *** study aimed to explore the relationship between cumulative TyG index values and atrial fibrillation(AF)recurrence after radiofrequency catheter ablation(RFCA).METHODS A total of 576 patients with AF who underwent RFCA at the Second Affiliated Hospital of Xi'an Jiaotong University were included in this *** participants were grouped based on cumulative TyG index values tertiles within 3 months after *** regression and restricted cubic spline analyses were used to determine the relationship between cumulative TyG index values and AF *** predictive value of all risk factors was assessed by receiver operating curve *** There were 375 patients completed the study(age:63.23±10.73 years,64.27%male).The risk of AF recurrence increased with increasing cumulative TyG index values *** adjusting for potential confounders,patients in the medium cumulative TyG index group[hazard ratio(HR)=4.949,95%CI:1.778–13.778,P=0.002]and the high cumulative TyG index group(HR=8.716,95%CI:3.371–22.536,P<0.001)had a higher risk of AF recurrence than those in the low cumulative TyG index *** restricted cubic spline regression model also showed an increased risk of AF recurrence with increasing cumulative TyG index *** considering cumulative TyG index values,left atrial diameter,and lactate dehydrogenase levels as a comprehensive factor,the model could effectively predict AF recurrence after RFCA[area under the curve(AUC)=0.847,95%CI:0.797–0.897,P<0.001].CONCLUSIONS Cumulative TyG index values were a risk factor for AF recurrence after *** longitudinal TyG index values may assist with optimized for risk stratification and outcome prediction for AF recurrence.

关键词： atrial fibrillation index

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Pancreatic cancer with ovarian metastases: A case report and review of the literature

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World Journal of Clinical Cases 2020年第21期8卷 5380-5388页

作者： Shun-Da Wang Liang Zhu huan-wen wu Meng-Hua Dai Yu-Pei Zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND Pancreatic cancer with ovarian metastases is rare and easily *** patients are first diagnosed with ovarian *** report a rare case of ovarian metastases secondary to pancreatic *** also review the literature to analyze the clinical characteristics of,diagnostic methods for,and perioperative management strategies for this rare *** SUMMARY A 48-year-old woman with an abdominal mass presented to our *** tomography revealed lesions in the pancreas and lower *** examination and histological investigation of biopsy specimens revealed either an ovarian metastasis from a pancreatic neoplasm or two primary tumors,with metastasis strongly *** patient simultaneously underwent distal pancreatectomy plus splenectomy by a general surgeon and salpingo-oophorectomy with hysterectomy by a *** examination of the surgical specimen revealed a pancreatic adenocarcinoma(intermediate differentiation,mucinous)and a metastatic mucinous adenocarcinoma in the *** For this rare tumor,surgical resection is the most effective treatment,and the final diagnosis depends on tumor pathology.

关键词： Pancreas Ovary Pancreatic cancer Ovarian cancer Metastasis Case report

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A regression approach for seismic first-break picking

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Petroleum Science 2024年第3期21卷 1584-1596页

作者： huan Yuan San-Yi Yuan Jie wu wen-Jing Sang Yu-He Zhao CNPC Key Laboratory of Geophysical Exploration China University of Petroleum(Beijing)Beijing 102249China Research Institute of Petroleum Exploration&Development—Northwest(NWGI) Key Laboratory of reservoir characterization of CNPCPetroChinaLanzhou 730020GansuChina

The picking efficiency of seismic first breaks(FBs)has been greatly accelerated by deep learning(DL)***,the picking accuracy and efficiency of DL methods still face huge challenges in low signal-to-noise ratio(SNR)*** address this issue,we propose a regression approach to pick FBs based on bidirectional long short-term memory(Bi LSTM)neural network by learning the implicit Eikonal equation of 3D inhomogeneous media with rugged topography in the target *** employ a regressive model that represents the relationships among the elevation of shots,offset and the elevation of receivers with their seismic traveltime to predict the unknown FBs,from common-shot gathers with sparsely distributed *** from image segmentation methods which automatically extract image features and classify FBs from seismic data,the proposed method can learn the inner relationship between field geometry and *** addition,the predicted results by the regressive model are continuous values of FBs rather than the discrete ones of the binary *** picking results of synthetic data shows that the proposed method has low dependence on label data,and can obtain reliable and similar predicted results using two types of label data with large *** picking results of9380 shots for 3D seismic data generated by vibroseis indicate that the proposed method can still accurately predict FBs in low SNR *** subsequent stacked profiles further illustrate the reliability and effectiveness of the proposed *** results of model data and field seismic data demonstrate that the proposed regression method is a robust first-break picker with high potential for field application.

关键词： First-break picking Low signal-to-noiseratio Regression BiLSTM Traveltime Geometry Noisy seismic data

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Study on low noise cryogenic charge readout electronics for liquid xenon time projection chamber

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Radiation Detection Technology and Methods 2021年第1期5卷 71-77页

作者： Xing-cheng Tian Xiao-shan Jiang wen-huan wu Huai-shen Li Wei Wei Jun Hu State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences(UCAS) Beijing 100049China China Spallation Neutron Source Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Dongguan 523803China

Background Liquid xenon time projection chamber(LXe TPC)is widely used in high-energy physics experiments such as particle detection and neutrino(or neutrinoless)double beta *** charge readout accuracy of the LXeTPCdirectly affects the measurement results and success of the *** liquid xenon needs to maintain a cryogenic temperature between 162 and 165 K at atmospheric pressure,the charge generated in the LXe TPC always needs to be read out in the cryogenic environment for minimizing the input capacitance,which has effect in determining the output noise of the charge *** Design a charge readout electronics system applicable to LXe TPC and research a data analysis method to get the exact amount of charge by analyzing the waveform at that output of the designed electronics *** Design a multi-channel charge-reading application specific integrated circuit(ASIC)that can operate in the cryogenic *** signals and power supply of the ASIC are connected to an electronics system at room temperature through micro-coaxial *** electronics at room temperature complete the sampling of the ASIC output.A data acquisition device receives the sampled waveform data and calculates the charge measurement resolution by Gaussian *** The designed ASIC and selected micro-coaxial cable can work in stable condition under the cryogenic environment of 165 *** analyzed integral nonlinearity of the charge measurement of the chip is 0.83%in the range from 1 to 50 fC,and the charge measurement resolution of the chip is lower than 900 e−*** In this paper,a preliminary study of the charge readout method based on the system structure of self-developed ASIC,micro-coaxial cable,and data readout electronics is completed for LXe *** system test results indicate that the designed ASIC can work normally in the cryogenic temperature of 165 K with a high dynamic range and good linearity of the charge ***

关键词： nEXO Cryogenic ASIC Micro-coaxial cable Gaussian fitting

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Low profile cavity-embedded ultra-wideband UHF array antenna with end-fire beams

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Journal of Electronic Science and Technology 2024年第2期22卷 24-35页

作者： huan He wen-Song Wang Southwest China Institute of Electronic Technology Chengdu610036China School of Electrical and Electronic Engineering Department Nanyang Technological UniversitySingapore639798Singapore

A low-profile,vertically polarized,ultra-wideband array antenna with end-fire beams operating in an ultra-high frequency(UHF)band is developed in this *** array antenna consists of 1×16 log-periodic top-hat loaded monopole antenna arrays and is feasible to embed into a shallow cavity to further reduce the array *** is introduced in the proposed antenna element to reduce profile height and the rectangular top hats are carefully designed to minimize the transverse *** results show that when the antenna array operates in a frequency range of 300 MHz-900 MHz,the end-fire radiation pattern achieves±45°scanning range in the horizontal *** prototypes of the proposed end-fire antenna element and a uniformly spaced linear array(1×2)are fabricated and *** end-fire antenna array should be suitable for airborne applications where low-profile and conformal scanning phased antenna arrays with end-fire radiations are *** design is attractive for airborne platform applications that are used to search,discover,identify,and scout the aerial target with vertically polarized beams.

关键词： End-fire radiation Low-profile Vertical polarization Log-periodic array

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Linear Viscoelasticity of ABA-type Vitrimer Based on Dioxaborolane Metathesis

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Chinese Journal of Polymer Science 2024年第10期42卷 1495-1504,I0010页

作者： Shi-Long wu huan-huan Yang Quan Chen State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of ScienceChangchun130022China University of Science and Technology of China Hefei230026China

In this study,we synthesized a series of ABA-type vitrimers by crosslinking the short A moieties of precursors with a bifunctional crosslinker and evaporating the small molecular *** vitrimer samples thus prepared exhibit linear viscoelasticity dependent on the length of A moiety as well as the content of the *** the average number of A monomers per end moiety m=1.1,the crosslinker can only extend the chain but not crosslink the *** m becomes 2.8 or higher,introducing a crosslinker first leads to the gelation,whereas excess in crosslinker molecules leads opening of the crosslinking sites and accordingly reentry into the sol ***,a further increase in the length of the A moieties increases the relaxation time much weaker than the exponential increase seen for the physically crosslinked ABAtype *** attribute this difference to the distinct relaxation mechanisms:the relaxation of the vitrimer samples is based on relatively independent exchange reactions,which contrasts with the ABA-type ionomers that relax through the collective hopping of connected ionic groups from one ion aggregate to another.

关键词： Polymer rheology Linear viscoelasticity ABA-type vitrimer Relaxation mechanism Kinetics and thermodynamics

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Comparison of Measurements for Enhanced Diffusion Problem in Chemical Reaction Systems

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Chinese Journal of Chemistry 2024年第14期42卷 1659-1664页

作者： Ah-Young Jee Ziyang wen huan Wang Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringBeijing Key Laboratory of Polymer Chemistry&Physics of Ministry of EducationPeking UniversityBeijing100871 China

The problem of molecular diffusion in the soup of chemical reactions attracts mounting interest across fields ranging from chemistry to biophysics to material *** reactions involve bond breakup and formation,whose time scale is typically on the orders of fs to ps,while molecular diffusion occurs at time scales ofμs to *** two processes are often considered orthogonal,given the vastly different *** serial results show that the enzyme's diffusion is enhanced in a substrate-dependent manner,which was further extended to small molecule reaction systems,challenging this classical ***,the results from different groups using different techniques do not quantitatively agree,and a general mechanism is yet to be *** summarize experimental studies on diffusion problems and seek to reconcile the interpretation with understanding the limits of measurement tools and the chemical nature of reaction *** molecular diffusion in chemical reactions will provide fresh thoughts in designing chemical systems such as molecular machines that harvest work at the nanoscale in a controllable manner.

关键词： Molecular diffusion Chemical reactions Enzyme reactions Active matter Diffusion measurements Single-molecule studies Fluorescence Time-resolved spectroscopy

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Analysis of metabolic characteristics of metabolic syndrome in elderly patients with gastric cancer by non-targeted metabolomics

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2419-2428页

作者： huan Zhang wen-Bing Shen Lin Chen Medical School of Chinese PLA Chinese PLA General HospitalBeijing 100853China Department of Gastrointestinal Surgery Shanghai Sixth People’s HospitalShanghai 250063China Department of General Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND The relationship between metabolic syndrome(MetS)and gastric cancer(GC),which is a common metabolic disease,has attracted much ***,the specific metabolic characteristics of MetS in elderly patients with GC remain *** To investigate the differentially abundant metabolites and metabolic pathways between preoperative frailty and MetS in elderly patients with GC based on nontargeted metabolomics *** In this study,125 patients with nonfrail nonmeal GC were selected as the control group,and 50 patients with GC in the frail group were selected as the frail ***-five patients with GC combined with MetS alone were included in the MetS group,and 50 patients with GC combined with MetS were included in the MetS *** metabolomics techniques were used to measure plasma metabolite levels by ultrahigh-performance liquid chromatography-mass *** statistical analysis was performed by principal component analysis,orthogonal partial least squares,pattern recognition analysis,cluster analysis,and metabolic pathway *** A total of 125 different metabolites,including amino acids,glycerophospholipids,sphingolipids,fatty acids,sugars,nucleosides and nucleotides,and acidic compounds,were identified via nontargeted metabolomics *** with those in the control group,there were 41,32,and 52 different metabolites in the MetS group,the debilitated group,and the combined group,*** metabolites were significantly increased in the MetS *** the weak group,amino acids and most glycerol phospholipid metabolites decreased significantly,and fatty acids and sphingosine increased *** combined group was characterized by significantly increased levels of nucleotide metabolites and acidic *** alanine,aspartic acid,and glutamate metabolic pathways were obviously enriched in the asthenic group,and the glycerol and phospholipid metabolic pathways were obv

关键词： Nervous breakdown Metabolic syndrome Elderly individuals Gastric cancer Nontargeted metabolomics

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Jiangsen Mao:a pioneer in Chinese hepatitis A vaccine and interferon research,a virologist at the forefront of times

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Protein & Cell 2024年第1期15卷 1-5页

作者： huan Liu Kunlan Zuo Zongzhen wu Hao Cheng University of Science and Technology of China Hefei 230026China State Key Laboratory of Virology Wuhan 430072China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China

There is a renowned virologist who dedicated his life to virology and medicine *** has made important contributions to the study of Chinese polio and hepatitis A vaccines,interferons,and the theory of viral reverse *** invented a live attenuated vaccine for hepatitis A(H2 strain)in the late 1970s,which contributed to the prevention of hepatitis A epidemics in China and earned him the title"Hepatitis A Eradicator"He said.

关键词： prevention hepatitis vaccine

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Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 64-79页

作者： Shuang-Ling wu Xiaoyi Zhang Mengqi Chang Changcai huang Jun Qian Qing Li Fang Yuan Lihong Sun Xinmiao Yu Xinmiao Cui Jiayi Jiang Mengyao Cui Ye Liu huan-wen wu Zhi-Yong Liang Xiaoyue Wang Yamei Niu Wei-Min Tong Feng Jin Department of Surgical Oncology and Breast Surgery the First Affiliated Hospital of China Medical UniversityShenyang 110000China Department of Pathology Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeMolecular Pathology Research CenterChinese Academy of Medical SciencesBeijing 100005China State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Center for BioinformaticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Beijing National Laboratory for Molecular Sciences(BNLMS) MOE Key Laboratory of Bioorganic Chemistry and Molecular EngineeringCollege of ChemistryPeking UniversityBeijing 100871China Center for Experimental Animal Research Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeMolecular Pathology Research CenterChinese Academy of Medical SciencesBeijing 100005China

Although DNA 5-hydroxymethylcytosine(5 hmC)is recognized as an important epigenetic mark in cancer,its precise role in lymph node metastasis remains *** this study,we investigated how 5 hmC associates with lymph node metastasis in breast *** with high expression of TET1 and TET2 proteins,large numbers of genes in the metastasis-positive primary tumors exhibit higher 5 hmC levels than those in the metastasis-negative primary *** contrast,the TET protein expression and DNA 5 hmC decrease significantly within the metastatic lesions in the lymph nodes compared to those in their matched primary *** genomewide analysis of 8 sets of primary tumors,we identified 100 high-confidence metastasis-associated5 hmC signatures,and it is found that increased levels of DNA 5 hmC and gene expression of MAP7 D1 associate with high risk of lymph node ***,we demonstrate that MAP7 D1,regulated by TET1,promotes tumor growth and *** conclusion,the dynamic5 hmC profiles during lymph node metastasis suggest a link between DNA 5 hmC and lymph node ***,the role of MAP7 D1 in breast cancer progression suggests that the metastasis-associated 5 hmC signatures are potential biomarkers to predict the risk for lymph node metastasis,which may serve as diagnostic and therapeutic targets for metastatic breast cancer.

关键词： 5-Hydroxymethylcytosine Breast cancer Lymph node metastasis MAP7D1 Biomarker

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