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Tunable Phase Structure of Side-chain Liquid Crystalline Polymers Enabled by Molecular Engineering of Dual Mesogenic Cores

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Chinese Journal of Polymer Science 2024年第10期42卷 1459-1469,I0009页

作者： wen-huan yao Lan-Sheng Liu Jie Zhao Yan-Xia Wang An-Zhi Ma Zheng-Rui Ma Lan-Ying Zhang Ruo-Chen Lan College of Chemistry and Chemical Engineering Hunan UniversityChangsha410082China Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-Environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China Institute of Advanced Materials&Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China

A series of novel side-chain liquid crystalline(SCLC)copolymers were synthesized by attaching two distinct mesogenic units,namely a chiral cholesteryl-based monomer(M1)and an achiral biphenyl-based monomer(M2),to a poly(3-mercaptopropylmethylsiloxane)(PMMS)backbone via thiol-ene click *** influence of side chain composition on the self-assembly behavior and phase structures of these SCLC copolymers was systematically investigated using different *** indicate that three distinct liquid crystalline phases and four unique molecular configurations were identified within the polymer series,with the emergence of the liquid crystalline phase being a synergistic outcome of the two distinct side *** study underscores the critical influence of side chain dimensions,rigidity,and spatial volume on the self-assembly structures and phase characteristics of liquid crystalline polymers,providing valuable insights for the rational design and development of advanced functional materials with tailored properties.

关键词： Liquid crystalline copolymers Self-assembly Phase structure Chiral molar ratio

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： yao Yuan Lingqi Yu Xudong Zhuang Dongjing wen Jin He Jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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以职业生涯规划为载体的外语专业大学生理想信念教育研究

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四川文理学院学报 2017年第3期27卷 140-143页

作者：杨俊付文奂婷婷鲜耀四川师范大学外国语学院四川成都610101

外语专业大学生作为我国高校大学生中的庞大群体,深受西方多元文化思潮影响,在面临严峻就业压力的同时,也应不断增强理想信念教育,从而形成正确的世界观、人生观、价值观。通过开展问卷调查,分析大学生职业生涯规划与理想信念教育的整... 详细信息

外语专业大学生作为我国高校大学生中的庞大群体,深受西方多元文化思潮影响,在面临严峻就业压力的同时,也应不断增强理想信念教育,从而形成正确的世界观、人生观、价值观。通过开展问卷调查,分析大学生职业生涯规划与理想信念教育的整合现状,并提出了有关路径的探讨。

关键词：理想信念教育外语专业大学生职业生涯规划载体

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中国鹦鹉分布的变迁

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兰州大学学报 1981年第1期 130-141页

作者：何业恒文焕然谭耀匡湖南师院中科院地理所中科院动物所

中国鹦鹉见于文献的记载很早,历史时期它的分布有很大的变化。在清道光以前,黄土高原西部兰州、六盘山、陇山一带的鹦鹉久已灭绝:长江流域从滇东北、黔西北、成都附近到安徽南部、浙江东部鹦鹉在清中叶以后,也已绝迹;就是华南、滇南的鹦... 详细信息

中国鹦鹉见于文献的记载很早,历史时期它的分布有很大的变化。在清道光以前,黄土高原西部兰州、六盘山、陇山一带的鹦鹉久已灭绝:长江流域从滇东北、黔西北、成都附近到安徽南部、浙江东部鹦鹉在清中叶以后,也已绝迹;就是华南、滇南的鹦鹉,在分布范围和数量上也有很大的缩小和减少。中国鹦鹉分布的变迁,在一定程度上反映着我国森林的变迁。

关键词：鹦鹉兰州森林云南省甘肃陇山物产中华人民共和国

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本质与价值:数字时代广告本体的再认识

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武汉大学学报（哲学社会科学版） 2025年第1期78卷 125-132页

作者：姚曦任文姣武汉大学新闻与传播学院湖北武汉430072 武汉大学媒体发展研究中心

用传播的方式促进从生产到消费转换的行为皆为存在意义上的广告,广告的本体是本质与价值的统一。本体的坚守要建立开放的认识观,在不变的广告本质中解释变化着的广告形态,而非用未触及本体的不确定认识窄化新的广告事实。彰显广告价值... 详细信息

用传播的方式促进从生产到消费转换的行为皆为存在意义上的广告,广告的本体是本质与价值的统一。本体的坚守要建立开放的认识观,在不变的广告本质中解释变化着的广告形态,而非用未触及本体的不确定认识窄化新的广告事实。彰显广告价值需深耕数字广告实践,用创意提升广告的社会吸引力,建构多主体参与的沟通网络。彰显广告价值还需要在理论层面,以本体观为支点,立足于本土广告实践,重新组织数字广告研究范畴,使用大数据技术与混合研究法探究新问题,为广告学知识体系的建构提供框架与方向。

关键词：广告广告本质广告价值广告本体

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo wen Jing Miao huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Metal-organic framework[NH_(2)-MIL-53(Al)]functionalized TiO_(2)nanotube photoanodes for highly stable and efficient photoelectrochemical cathodic protection of nickel-coated Mg alloy

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Journal of Materials Science & Technology 2024年第15期182卷 67-78页

作者： huan yao Ruifeng Zhang Yu wen Yue Liu Gang Yu Zhi-Hui Xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China School of Materials Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Metal-organic framework[MOF,i.e.,NH_(2)-MIL-53(Al)]modified TiO_(2)(NMT)composite photoanodes were successfully prepared by hydrothermal synthesis and were used for the photoelectrochemical cathodic protection(PECCP)of nickel-plated magnesium alloy(Mg/Ni).Results showed that the synthesis tem-perature significantly impacted the morphology and PECCP performance of the NMT *** NMT@150 photoanode prepared at a reaction temperature of 150℃exhibited the best PECCP perfor-mance and produced a current density of 1980μA cm^(-2)under visible light irradiation,which was 19.8 times higher than that of a single TiO_(2)*** composite photoanode could polarize the open circuit potential of the coupled Mg/Ni electrode to-876 mV and remain relatively stable within 35 *** and EPR tests showed that a Z-scheme heterojunction was formed between the NH_(2)-MIL-53(Al)and TiO_(2)nanotubes,allowing the photogenerated electrons to accumulate mainly on the conduction band of NH_(2)-MIL-53(Al).The heterojunction greatly promoted the separation and transfer of photogenerated electron-hole in the NMT composite photoanode,significantly enhancing the PECCP performance for Mg/Ni.

关键词： Magnesium alloy Corrosion Nickel coating Electroless Photoelectrochemical cathodic protection

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Dynamic Movement Primitives Based Robot Skills Learning

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Machine Intelligence Research 2023年第3期20卷 396-407页

作者： Ling-huan Kong Wei He wen-Shi Chen Hui Zhang yao-Nan Wang School of Intelligence Science and Technology University of Science and Technology BeijingBeijing 100083China Institute of Artificial Intelligence University of Science and Technology BeijingBeijing 100083China School of Robotics and the National Engineering Laboratory of Robot Visual Perception and Control Technology Hunan UniversityChangsha 410082China

In this article,a robot skills learning framework is developed,which considers both motion modeling and *** order to enable the robot to learn skills from demonstrations,a learning method called dynamic movement primitives(DMPs)is introduced to model motion.A staged teaching strategy is integrated into DMPs frameworks to enhance the generality such that the complicated tasks can be also performed for multi-joint *** DMP connection method is used to make an accurate and smooth transition in position and velocity space to connect complex motion *** addition,motions are categorized into different goals and *** is worth mentioning that an adaptive neural networks(NNs)control method is proposed to achieve highly accurate trajectory tracking and to ensure the performance of action execution,which is beneficial to the improvement of reliability of the skills learning *** experiment test on the Baxter robot verifies the effectiveness of the proposed method.

关键词： Dynamic movement primitives(DMPs) trajectory tracking control robot learning from demonstrations neural networks(NNs) adaptive control

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Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang wentao Jiang Xue-wen Zhang Hao-Long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei He Long Chen Qiang Chen He-Qi Zheng Yuanjing Cui wen-Jie Shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli Zhong Yong Cui Shuao Wang Jian-Rong Li Guodong Qian Tong-Bu Lu huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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