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Acta Metallurgica Sinica(English Letters) 2018年第8期31卷 807-814页

作者： Lin-Zhi Wang wen-hou wei Chongqing Key Laboratory of Additive Manufacturing Technology and Systems Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences

Three-dimensional parts of the 30 CrMnSiA steel were successfully fabricated using selective laser melting（SLM）. The microstructures and mechanical properties of the SLM-processed 30 CrMnSiA samples were investigated by scanning electron microscope and transmission electron microscopy. The results indicate that the microstructures of the 30 CrMnSiA samples consist mainly of lath martensite and acicular martensite. The value of the surface roughness decreases with increasing laser energy density（LED） before it reaches a minimum and then increases with further increasing LED. The relative density, microhardness and ultimate tensile strength of the SLM-processed samples initially increase and then decrease with increasing LED. By taking the relative density, surface roughness, microhardness and ultimate tensile strength into account, the optimized LED should be in the range of 46.15–51.28 J mm^（-3） for the SLM-processed30 CrMnSiA alloys. In addition, the differences in the microstructures and mechanical properties between the conventionally wrought 30 CrMnSiA sample and SLM-processed 30 CrMnSiA samples were also studied.

关键词： 30CrMnSiA Selective laser melting Laser energy density Microstructure Mechanical properties

Preparation of CNT/AlS i10Mg composite powders by high-energy ball milling and their physical properties

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International Journal of Minerals,Metallurgy and Materials 2016年第3期23卷 330-338页

作者： Lin-zhi Wang Ying Liu wen-hou wei Xu-guang An Tao Zhang Ya-yun Pu College of Materials Science and Engineering Sichuan University Chongqing Key Laboratory of Multi-scale Manufacturing Technology Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences College of Materials Science and Engineering Chongqing University

This study investigated the effects of carbon nanotube （CNT） concentration on the micro-morphologies and laser absorption proper- ties of CNT/AlSi10Mg composite powders produced by high-energy ball milling. A scanning electron microscope, X-ray diffractometer, laser particle size analyzer, high-temperature synchronous thermal analyzer, and UV/VIS/NIR spectrophotometer were used for the analysis of micro- graphs, phases, granulometric parameters, thermal properties, and laser absorption properties of the composite powders, respectively. The results showed that the powders gradually changed from flake- to granule-like morphology and the average particle size sharply decreased with in- creases in milling rotational speed and milling time. Moreover, a uniform dispersion of CNTs in AlSi10Mg powders was achieved only for a CNT content of 1.5wt%. Laser absorption values of the composite powders were also observed to gradually increase with the increase of CNT concentration, and different spectra displayed characteristic absorption peaks at a wavelength of approximately 826 nm.

关键词： metal matrix composites aluminum alloys carbon nanotubes powder metallurgy particle size distribution ball milling physi-cal properties

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-wen Pan Jun-Qing Qi Qiang Zhou wei-Feng Tang Guo-wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue wei wen-Bo Cao Sai-Jun Mo Zhi-Yan Sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou wei Chen Aidong wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

微藻DHA的营养保健功能及在食品工业中的应用

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食品科学 2010年第21期31卷 446-450页

作者：温雪馨李建平侯文伟彭晓芳马金余广东润科生物工程有限公司广东广州510613 润科生物工程(福建)有限公司福建漳州363500 香港大学生物科学学院

DHA是婴幼儿的成长因子,也是成年人不可缺少的保健元素。由于人体不能自身合成DHA,且在日常膳食中摄入量不足,因此需要额外服用DHA补充产品。本文在综合中国人饮食习惯和国际权威机构DHA相关推荐摄入量的基础上,得出我国不同人群的DHA... 详细信息

DHA是婴幼儿的成长因子,也是成年人不可缺少的保健元素。由于人体不能自身合成DHA,且在日常膳食中摄入量不足,因此需要额外服用DHA补充产品。本文在综合中国人饮食习惯和国际权威机构DHA相关推荐摄入量的基础上,得出我国不同人群的DHA推荐摄入量标准。与鱼油DHA相比,微藻DHA不含鱼腥味、DHA与EPA含量配比适当、不存在海洋污染和破坏生态平衡的问题,是一种天然、安全、环保的功能性食品添加剂。微藻DHA在国外已有广泛的认知及应用,在国内的保健品行业和食品行业中的食用油、液态奶领域日益受到业内人士的关注,其在应用过程中的技术问题也具有积极的研究意义。微藻DHA作为一种新型的功能性食品添加剂,将成为保健品和食品行业产品未来发展的趋势。

关键词：微藻DHA DHA来源推荐摄入量食品添加剂

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某步枪“冷热偏”分析与研究

火力与指挥控制 2019年第7期44卷 57-62页

作者：蔡翘楚杨臻侯文伟蓝维彬龙建华中北大学机电工程学院太原030051 重庆建设工业(集团)有限责任公司重庆400054

针对某小口径步枪因枪管过热而导致射击准确度降低的问题,利用ABAQUS软件平台建立某步枪\弹相互作用的仿真模型。基于非线性热力学理论,在射击过程中,对身管内外壁的对流传热和内部的热传递过程进行了仿真分析,得出击发热冲击下身管温... 详细信息

针对某小口径步枪因枪管过热而导致射击准确度降低的问题,利用ABAQUS软件平台建立某步枪\弹相互作用的仿真模型。基于非线性热力学理论,在射击过程中,对身管内外壁的对流传热和内部的热传递过程进行了仿真分析,得出击发热冲击下身管温度场的分布规律,通过对弹丸挤进阻力、身管弯曲量和弹丸姿态仿真计算,来验证温度对射击准确度的影响。通过从实验测量、仿真、理论进行枪械不同温下度射击状态的分析与研究,可为提出步枪冷热偏抑制措施提供依据,对提高武器射击准确度具有重要的现实意义。

关键词：身管温度挤进弯曲弹丸姿态准确度

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一种卫星对接装置空间凸轮机构传动分析验证

火力与指挥控制 2019年第4期44卷 74-77,81页

作者：侯文伟杨臻高碧祥黄剑斌中北大学机电工程学院太原030051 中国空间技术研究院北京100094

针对某新型GEO卫星与其他航天器的对接过程,设计了一种卫星对接装置。该对接装置主要采用空间凸轮机构,首先对其进行详细结构设计,并建立空间凸轮曲线的数学模型,通过理论计算分析空间凸轮机构传动特性。制造样机进行试验验证,通过高速... 详细信息

针对某新型GEO卫星与其他航天器的对接过程,设计了一种卫星对接装置。该对接装置主要采用空间凸轮机构,首先对其进行详细结构设计,并建立空间凸轮曲线的数学模型,通过理论计算分析空间凸轮机构传动特性。制造样机进行试验验证,通过高速摄影对凸轮机构传动特性进行记录。通过对比表明,试验结果与理论结果高度吻合,验证了空间凸轮曲线数学模型的合理性以及对接装置的可行性。对接装置具有碰撞接触力小、锁紧力大、运动平稳可靠等优点,能够有效地满足GEO卫星对接任务的要求。

关键词：卫星对接空间凸轮传动特性高速摄影分析验证

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu wei Wu Zhi-Han Yao Chun-wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding Yuan-Yuan Fang wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing Hu wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics