检索结果-南通市图书馆

Pancreatic primitive neuroectodermal tumors:Clinical features,treatment,and influencing factors

World Journal of Gastrointestinal Oncology 2025年第2期17卷 230-245页

作者： Yan-fei He Huan-Zhi Wang Xiao-Dong Hu Jun-Qiang liu Hu-Ming Li Jie Wang Shuang-Feng Lu Health Management Center The Sixth Medical CenterChinese PLA General HospitalBeijing 100048China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Endocrinology The Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Thoracic Surgery The Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Respiratory Medicine The Sixth Medical CenterChinese PLA General HospitalBeijing 100048China

BACKGROUND Data on clinical characteristics,treatment outcomes,and prognosis of pancreatic primitive neuroectodermal tumors(PNETs)are *** To analyze the clinical data of 30 patients with pancreatic PNETs to identify their clinical characteristics and factors associated with *** We used the keywords"primary neuroectodermal tumor,""digestive tract,""pancreas,""pancreatic,"and"gastrointestinal,"individually or in combination,to collect data from a global database for all patients with pancreatic PNET to *** and Cox regression analyses were performed to identify prognostic factors for patient *** A total of 30 cases of pancreatic PNET were included in this study:15 males and 15 females with a mean age of 24 *** main symptom was abdominal pain(73.3%),and the median tumor size was 7.85 ***-four patients(80.0%)underwent surgery and nineteen patients received adjuvant *** metastasis was observed in 13 patients(43.3%),lymph node metastasis in 10 patients(33.3%),and distant metastasis in 6 patients(20.0%).Local recurrence was observed in 13 patients(43.3%).The median survival time of all patients was 29.4 months,and the overall estimated 1-year and 3-year survival rates were approximately 66.0%and 36.4%,*** analysis showed that chemotherapy(P=0.036),local metastasis(P=0.041),lymph node metastasis(P=0.003),distant metastasis(P=0.049),and surgical margins(P=0.048)were the prognostic factors affecting *** analysis revealed only lymph node metastasis(P=0.012)as a prognostic *** Pancreatic PNET is extremely rare,occurs in young adults,has no apparent sex predisposition,has a high rate of metastasis and early recurrence,and has a very poor *** diagnosis of pancreatic PNET requires a combination of clinical symptoms,pathologic features,immunohistochemistry,and cytogenetic *** analysis suggested that chemotherapy,metastasis,and surgical ma

关键词： Primitive neuroectodermal tumor Pancreas Sarcoma Diagnosis Prognosis Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

引用

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Colony-stimulating factor 3 and its receptor promote leukocyte immunoglobulin-like receptor B2 expression and ligands in gastric

引用

World Journal of Gastrointestinal Oncology 2025年第2期17卷 198-210页

作者： Long Wang Qi Wu Zong-wen Zhang Hui Zhang Hui Jin Xin-Liang Zhou Jia-Yin liu Dan Li Yan liu Zhi-Song Fan Department of Oncology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Colony-stimulating factor 3(CSF3)and its receptor(CSF3R)are known to promote gastric cancer(GC)growth and ***,their effects on the immune microenvironment remain *** analysis indicated a potential link between CSF3R expression and the immunosuppressive receptor leukocyte immunoglobulin-like receptor B2(LILRB2)in *** hypothesized that CSF3/CSF3R may regulate LILRB2 and its ligands,angiopoietin-like protein 2(ANGPTL2)and human leukocyte antigen-G(HLA-G),contributing to *** To investigate the relationship between CSF3/CSF3R and LILRB2,as well as its ligands ANGPTL2 and HLA-G,in *** Transcriptome sequencing data from The Cancer Genome Atlas were analyzed,stratifying patients by CSF3R *** expressed genes and immune checkpoints were ***(IHC)was performed on GC *** analyses of CSF3R,LILRB2,ANGPTL2,and HLA-G were conducted using The Cancer Genome Atlas data and IHC *** cells were treated with CSF3,and expression levels of LILRB2,ANGPTL2,and HLA-G were measured by quantitative reverse transcriptase-polymerase chain reaction and western *** Among 122 upregulated genes in high CSF3R expression groups,LILRB2 showed the most significant *** results indicated high expression of LILRB2(63.0%),ANGPTL2(56.5%),and HLA-G(73.9%)in GC *** positive correlations existed between CSF3R and LILRB2,ANGPTL2,and HLA-G mRNA levels(P0.05).CSF3 increased LILRB2,ANGPTL2,and HLA-G expression in GC *** nuclear ribonucleoprotein H1 modulation significantly altered their expression,impacting CSF3’s regulatory *** The CSF3/CSF3R pathway may contribute to immunosuppression in GC by upregulating LILRB2 and its ligands,with heterogeneous nuclear ribonucleoprotein H1 playing a regulatory role.

关键词： Gastric cancer Immunosuppressive receptor Colony-stimulating factor 3 Colony-stimulating factor 3 receptor Leukocyte immunoglobulin-like receptor B2 Angiopoietin-like protein 2 Human leukocyte antigen-G Heterogeneous nuclear ribonucleoprotein H1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

引用

Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-Xia Xu Jian-Dang liu Bang-Jiao Ye Zi-wen Pan Jun Lin Jin-Liang Song Jian-Qing Cao Chao Yan Ying-Ping Hao Jin-Xing Cheng Qing-Bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The upper tropospheric-lower stratospheric ozone drives summer precipitation and wildfire changes in West Siberia

引用

Science Bulletin 2025年第2期70卷 255-262页

作者： fei Xie Yan Xia wenshou Tian Martyn P.Chipperfield Wuhu Feng Ke Gui Yingli Niu Na liu Yuanyuan Han School of Systems Science Beijing Normal UniversityBeijing 100875China Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China School of Earth and Environment University of LeedsLeedsLS29JTUK National Centre for Earth Observation University of LeedsLeedsLS29JTUK National Centre for Atmospheric Science University of LeedsLeedsLS29PHUK State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesBeijing 100081China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Key Laboratory of Textile Chemical Engineering Auxiliaries School of Environmental and Chemical EngineeringXi’an Polytechnic UniversityXi’an 710048China

Siberian wildfires are pivotal in determining the carbon cycle and climate dynamics,exerting a profound impact on the ecosystems of the entire Arctic *** the past few decades,variations in summer precipitation in West Siberia have significantly influenced wildfire *** study analyzed precipitation trends in West Siberia from 1982 to 2021 using observations and transient simulations,uncovering a strong correlation between precipitation variability and ozone concentrations in the upper troposphere-lower stratosphere(UTLS).Heightened UTLS ozone levels warm the upper atmosphere over West Siberia during *** warming modifies the regional polar jet stream,intensifying its southern branch and weakening the northern one,leading to a southward shift in the jet ***,cyclonic circulation anomalies emerge in the upper troposphere,characterized by a barotropic structure with unusual upward movements around 60°*** upward motion triggers corresponding anomalies in zonal winds in the lower troposphere,fostering a low-pressure system at the *** atmospheric shift results in an influx of warm,moist air from the south and cold,dry air from the north into Siberia,enhancing cloud formation and ***,our analysis suggests that the rise in summer precipitation in West Siberia between 1993 and 2010 is linked to increased UTLS ozone concentrations during this ***,the decline in UTLS ozone since 2010 may increase the risk of wildfires by suppressing *** findings underscore the pivotal role of stratospheric chemistry in shaping the regional climate and wildfire behavior.?2024 Science China *** by Elsevier *** Science China *** rights are reserved,including those for text and data mining,AI training,and similar technologies.

关键词： Upper troposphere-lower stratosphere Ozone Radiative effect Precipitation Siberia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mixture of Bacillus Amyloliquefaciens and Bacillus Pumilus Modulates Community Structures of Rice Rhizosphere Soil to Suppress Rice Seedling Blight

引用

Rice science 2025年第1期32卷 118-130,I0067-I0070页

作者： JIANG Nan QIU Jiehua TIAN Dagang SHI Huanbin liu Zhiquan wen Hui XIE Shuwei CHEN Huizhe WU Meng KOU Yanjun State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Biotechnology Research Institute Fujian Academy of Agricultural SciencesFuzhou 350003China State Key Laboratory of Soil and Sustainable Agriculture the Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China

Rice seedling blight,caused by various fungi,including Fusarium oxysporum,poses a severe threat to rice *** awareness grows regarding the environmental and safety hazards associated with the application of fungicides for managing rice seedling blight,there has been a shift in focus towards biological control *** this study,we isolated biocontrol bacteria from paddy fields that significantly inhibited the growth of *** in vitro and identified the strains as Bacillus amyloliquefaciens T40 and Bacillus pumilus ***,our findings indicated that the combined application of these Bacillus strains in soil was more effective in reducing the incidence of rice seedling blight than their individual *** of 16S and internal transcribed spacer rRNA gene sequencing data revealed that the mixture of the T40 and T208 strains exhibited the lowest average clustering coefficients,which were negatively correlated with the biomass of ***-inoculated rice ***,this mixture led to higher stochastic assembly(average|βNTI|<2)and reduced selection pressures on rice rhizosphere bacteria compared with individual strain *** mixture of the T40 and T208 strains also significantly increased the expression of defense-related *** conclusion,the mixture of the T40 and T208 strains effectively modulates microbial community structures,enhances microbial network stability,and boosts the resistance against rice seedling *** study supports the development and utilization of biological resources for crop protection.

关键词： application strategy disease control disease resistance microbial community structure microbial community assembly process Oryza sativa

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corrosion resistance and antibacterial properties of Ti−3Cu alloy prepared by selective laser melting

引用

Transactions of Nonferrous Metals Society of China 2025年第1期35卷 143-156页

作者： Meng-zhen ZHU Jing-lei MIAO Xiong-wen ZHOU Er-lin ZHANG Zhi-lin liu Hai-lin YANG State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China The Third Xiangya Hospital Central South UniversityChangsha 410013China Department of Prosthodontics Centre of StomatologyXiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Light Alloy Research Institute College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China

The corrosion resistance and antibacterial properties of Ti−3Cu alloy prepared by selective laser melting were evaluated using electrochemical experiments and a variety of antibacterial *** is found that the charge transfer resistance of Ti−3Cu alloy was 4.89×10^(5)Ω∙cm^(2),which was doubled the data obtained by CP-Ti *** antibacterial rates of Ti−3Cu alloy against *** and *** were 45.0%and 54.5%.And the antibacterial rates increased with the prolongation of cultivation time,reaching up to 62.8%and 68.6%,*** in-situ nano Ti_(2)Cu precipitates were homogeneously distributed in the matrix of the Ti−3Cu alloy,which was the key reason of increasing the corrosion ***,the microscale electric fields between theα-Ti matrix and the Ti_(2)Cu was responsible for the enhancement of the antibacterial properties.

关键词： selective laser melting Ti−3Cu alloy microstructure corrosion resistance antibacterial properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Diffusion Model for Traffic Data Imputation

引用

IEEE/CAA Journal of Automatica Sinica 2025年第3期12卷 606-617页

作者： Bo Lu Qinghai Miao Yahui liu Tariku Sinshaw Tamir Hongxia Zhao Xiqiao Zhang Yisheng Lv fei-Yue Wang the School of Artificial Intelligence University of Chinese Academy of Sciences Baidu Inc. IEEE the State Key Laboratory for Multimodal Artificial Intelligence Systems Institute of Automation Chinese Academy of Sciences Meituan Guangdong University of Technology the Department of Transportation Engineering School of Transportation Science and Technology Harbin Institute of Technology

Imputation of missing data has long been an important topic and an essential application for intelligent transportation systems(ITS) in the real world. As a state-of-the-art generative model, the diffusion model has proven highly successful in image generation, speech generation, time series modelling *** now opens a new avenue for traffic data imputation. In this paper, we propose a conditional diffusion model, called the implicit-explicit diffusion model, for traffic data imputation. This model exploits both the implicit and explicit feature of the data simultaneously. More specifically, we design two types of feature extraction modules, one to capture the implicit dependencies hidden in the raw data at multiple time scales and the other to obtain the long-term temporal dependencies of the time series. This approach not only inherits the advantages of the diffusion model for estimating missing data, but also takes into account the multiscale correlation inherent in traffic data. To illustrate the performance of the model, extensive experiments are conducted on three real-world time series datasets using different missing *** experimental results demonstrate that the model improves imputation accuracy and generalization capability.

关键词： Data imputation diffusion model implicit feature time series traffic data

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Numerical prediction of oceanic mesoscale circulation and satellite altimetry data assimilation in the Western Pacific

引用

Science China Earth Sciences 2025年第3期68卷 909-927页

作者： Zhijin LI Jianfang fei Renhe ZHANG Xingliang JIANG wenlong MA Xiaoping CHENG Lei liu Guihua WANG Changlin CHEN Department of Atmospheric and Oceanic Sciences Institute of Atmospheric Sciences Fudan University Shanghai Key Laboratory of Ocean-land-atmosphere Boundary Dynamics and Climate Change College of Meteorology and Oceanology National University of Defense Technology

Oceanic mesoscale circulations, primarily manifesting as eddies, typically span around 100 km horizontally and persist for about a month. These circulations represent the main component of oceanic kinetic energy and are referred to as the“weather” of the ocean. Forecasting efforts, focused on periods from a day to a month, target these mesoscale *** in eddy-resolving models, observing systems such as Argo floats and satellite altimeters, and data assimilation techniques have enabled systems like HYCOM in the United States and Mercator-Ocean in Europe to predict these features effectively. To further enhance mesoscale forecasting, the Pacific Regional Ocean Forecast System(RPOFS) was developed for the pan-western Pacific(100°E–178°E, 20°S–50°N). Covering the dynamic Kuroshio and Kuroshio Extension regions, RPOFS features a 3 km horizontal grid and 67 vertical levels, with a multi-scale three-dimensional variational data assimilation(MS-3DVAR) scheme implemented. This system assimilates data from various sources, including satellite sea surface height and temperature, as well as subsurface profiles. In particular, an enhanced altimeter data assimilation methodology allows explicitly constraining both barotropic and baroclinic components of sea surface height. RPOFS demonstrates reliable forecasting of mesoscale circulations, with five-day forecasts accurately predicting eddies larger than 150 km and capturing features of the Kuroshio large meander. Forecasting errors are comparable to or smaller than those of HYCOM and Mercator-Ocean systems.

关键词： Western Pacific Ocean Ocean model Mesoscale eddy Numerical prediction Multiscale data assimilation Satellite altimetry

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Design and characterization study of dual D-shaped no-core fiber based SPR sensor for refractive index and temperature measurement

引用

Optoelectronics Letters 2025年

作者： liu Yinggang Li Rui Li fei Xu Xinyi Zhou Rui Shaanxi Engineering Research Center of Oil and Gas Resource Optical Fiber Detection & Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas wells， Xi'an Shiyou University

To address the issue of temperature cross-sensitivity in refractive index （RI） measurement， a fiber-optic Surface Plasmon Resonance （SPR） sensor based on dual D-shaped no-core fiber （NCF） is proposed and designed. The sensor mainly consists of D-shaped NCF， Ag/Fe2O3composite film， and polydimethylsiloxane （PDMS）， where the silver and Fe2O3are successively coated on both D-shaped surfaces of NCF to generate SPR and enhance the oxidation resistance. The layer of PDMS coated on one D-shaped surface acts as a tunable ambient medium sensing the temperature variation and affecting the transmission spectrum of the sensor. Since the surface plasmon waves are excited in the two D-shaped surfaces with different films， the two RI and temperature-dependent spectral resonance peaks with different wavelengths will be produced. Research results demonstrate that the two peaks’ wavelengths have different responses to the variations of ambient RI and temperature. In the refractive index range of 1.36-1.376 and temperature range of 10-100 °C， the RI and temperature sensitivities reach to 5000 nm/RIU and -0.546 nm/°C， respectively. With the sensitivity coefficient matrix， simultaneous measurement of refractive index and temperature can be realized， and the corresponding accuracy is superior to 0.4×10-5RIU and 0.037°C.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：