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Nonexistence of quantum black and white hole horizons in an improved dynamic approach

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 56-73页

作者： wen-cong gan Xiao-Mei Kuang Zhen-Hao Yang Yungui Gong Anzhong Wang Bin Wang College of Physics and Communication Electronics Jiangxi Normal UniversityNanchang 330022China GCAP-CASPER Physics DepartmentBaylor UniversityWaco 76798-7316USA Institute for Theoretical Physics&Cosmology Zhejiang University of TechnologyHangzhou 310023China United Center for Gravitational Wave Physics(UCGWP) Zhejiang University of TechnologyHangzhou 310023China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Department of Physics School of Physical Science and TechnologyNingbo UniversityNingbo 315211China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

In this paper,we study the quantum geometric effects near the locations where classical black hole horizons used to appear in Einstein's classical theory,within the framework of an improved dynamic approach,in which the internal region of a black hole is modeled by the Kantowski-Sachs(KS)spacetime and the two polymerization parameters are functions of the phase space *** detailed analysis shows that the effects are so strong that black and white hole horizons of the effective quantum theory do not exist at all and instead are replaced by transition surfaces,across which the metric coefficients and their inverses are smooth and remain finite,as are the corresponding curvatures,including the Kretschmann *** surfaces always separate trapped regions from anti-trapped *** number of such surfaces is infinite,so the corresponding KS spacetimes become geodesically complete,and no black and white hole-like structures exist in this scheme.

关键词： canonical quantization loop quantum gravity quantum aspects of black holes

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Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2006-2025页

作者： Bingwen Ding Zhu Zhu cong Guo Jiaxin Li Yong gan Miaorong Yu State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Pharmacy Henan UniversityKaifeng 475004China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China

Diabetes,characterized by hyperglycemia,is a major cause of death and disability ***,such as insulin and glucagon-like peptide-1(GLP-1)analogs,have shown promise as treatments for diabetes due to their ability to mimic or enhance insulin's actions in the *** to subcutaneous injection,oral administration of anti-diabetic peptides is a preferred ***,biological barriers significantly reduce the efficacy of oral peptide *** advancements in drug delivery systems and formulation techniques have greatly improved the oral delivery of peptide therapeutics and their efficacy in treating *** review will highlight(1)the benefits of oral anti-diabetic peptide therapeutics;(2)the biological barriers for oral peptide delivery,including pH and enzyme degradation,intestinal mucosa barrier,and biodistribution barrier;(3)the delivery platforms to overcome these biological ***,the review will discuss the prospects in this *** information provided in this review will serve as a valuable guide for future developments in oral anti-diabetic peptide therapeutics.

关键词： Oral peptides Diabetes Delivery platforms Insulin Glucagon-like peptide-1 Biodistribution Biological barriers Targeted delivery

Synthesis and characterization of iron clusters with an icosahedral [Fe@Fe12]16+ Core

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National Science Review 2024年第4期11卷 123-129页

作者： gan Xu Yun-Shu Cui Xue-Lian Jiang cong-Qiao Xu Jun Li Xu-Dong Chen Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials Science Nanjing Normal University Department of Chemistry and Guangdong Provincial Key Laboratory of Catalytic Chemistry Southern University of Science and Technology Department of Chemistry and Engineering Research Center of Advanced Rare-Earth Materials of Ministry of Education Tsinghua University State Key Laboratory of Coordination Chemistry Nanjing University

Iron-metal clusters are crucial in a variety of critical biological and material systems,including metalloenzymes,catalysts,and magnetic storage ***,a synthetic high-nuclear iron cluster has been absent due to the extreme difficulty in stabilizing species with direct iron-iron *** this work,we have synthesized,crystallized,and characterized a（Tp*）4W4S12(Fe@Fe12) cluster(Tp*=tris（3,5-dimethyl-1-pyrazolyl）borate（1-）),which features a rare trideca-nuclear,icosahedral[Fe@Fe12] cluster core with direct multicenter iron-iron bonding between the interstitial iron（Fei） and peripheral irons（Fep）,as well as Fep…Fepferromagnetic *** chemistry studies reveal that the stability of the cluster arises from the 18-electron shell-closing of the [Fe@Fe12]16+core,assisted by its bonding interactions with the peripheral tridentate [（Tp*）WS3]4-ligands which possess both S→Fe donation and spin-polarized Fe-Wσ *** ground-state electron spin is theoretically predicted to be S=32/2 for the *** existence of low oxidation-state（OS～+1.23） iron in this compound may find interesting applications in magnetic storage,spintronics,redox chemistry,and cluster catalysis.

关键词： Fe13 cluster iron-sulfur cluster low-valence iron iron−iron bond high spin complex

Numerical Simulation of the Mass Movement Process of the 2018 Sedongpu Glacial Debris Flow by Using the Fluid-Solid Coupling Method

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Journal of Earth Science 2024年第2期35卷 583-596页

作者： Xing-Yu Long Yu-Xiang Hu Bin-Rui gan Jia-wen Zhou State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu610065China College of Water Resource and Hydropower Sichuan UniversityChengdu610065China

In the context of global warming and intensified human activities,glacier instability in plateau regions has increased,and glacier debris flows have become active,which poses a significant threat to the lives and property of people and socioeconomic *** mass movement process of glacier debris flows is extremely complex,so this paper uses the 2018 Sedongpu glacier debris flow event on the Qinghai-Tibet Plateau as an example and applies a numerical simulation method to invert the whole process of mass *** view of the interaction between phases in the process of motion,we use the fluid-solid coupling method to describe the mass *** granular-flow model and drift-flux model are employed in FLOW3D software to study the mass movement process of glacier debris flows and explore their dynamic *** results indicate that the glacier debris flow lasted for 700 s,and the movement process was roughly divided into four stages,including initiation,scraping,surging and deposition;the depositional characteristics calculated by the fluid-solid coupling model are consistent with the actual survey results and have good reliability;strong erosion occurs during the mass movement,the clear volume amplification effect,and the first wave climbs 17.8 m across the *** fluid-solid coupling method can better simulate glacier debris flows in plateau regions,which is helpful for the study of the mechanism and dynamic characteristics of such disasters.

关键词： glacial debris flow Qinghai-Tibet Plateau fluid-solid coupling FLOW3D mass movement depositional characteristics disasters engineering geology

Review of gan-Based Research on Chinese Character Font Generation

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Chinese Journal of Electronics 2024年第3期33卷 584-600页

作者： Xuanhong WANG cong LI Zengguo SUN Luying HUI Xi'an University of Posts and Telecommunications School of Computer Science Shaanxi Normal University Key Laboratory of Intelligent Computing and Service Technology for Folk Song Ministry of Culture and Tourism

With the rapid development of deep learning,generative adversarial network(gan) has become a research hotspot in the field of computer *** has a wide range of applications in image *** by gan,a series of models of Chinese character font generation have been proposed in recent *** this paper,the latest research progress of Chinese character font generation is analyzed and *** and its development history are ***-based methods for Chinese character font generation are clarified as well as their improvements,based on whether the specific elements of Chinese characters are *** public datasets used for font generation are summarized in detail,and various application scenarios of font generation are *** evaluation metrics of font generation are systematically summarized from both qualitative and quantitative *** paper contributes to the in-depth research on Chinese character font generation and has a positive effect on the inheritance and development of Chinese culture with Chinese characters as its carrier.

关键词： Generative adversarial network Font generation Image-to-image translation Deep learning

Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2

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Science China(Life Sciences) 2024年第6期67卷 1305-1307页

作者： Songlin gan wen-Si Yang Liting Wei Zhiguo Zhang Rui-Ming Xu Key Laboratory of Epigenetic Regulation and Intervention Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Institute for Cancer Genetics Department of Pediatrics and Department of Genetics and DevelopmentColumbia University Irving Medical CenterNew York 10032USA School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Dear Editor,The passage of DNA replication forks during eukaryotic cell division disrupts the nucleosomes they encounter,and de novo assembly of nucleosomes onto replicated DNA must take place to restore chromatin ***... 详细信息

关键词： structure nucleosome passage

Effect of Oxygen-Rich Combustion on Flame Propagation of Syngas in a Half-Open Pipe at Elevated Temperatures

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Journal of Thermal Science 2024年第5期33卷 1920-1934页

作者： LI Ningning DENG Haoxin XU Zhuangzhuang YAN Mengmeng WEI Shengnan SUN Guangzhen wen Xiaoping gan Haowen WANG Fahui School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo 454003China

The investigation of syngas flame propagation has great benefits for the effective use of gas *** essay sets out to study the flame propagation of premixed oxygen-rich combustion(oxygen enrichment coefficient in volumeΩ:0.21,0.27,0.32,0.37)of syngas(H_(2):CO=2:8)in half-closed rectangular ducts at elevated temperatures(T:300 K,400 K,500 K)and evaluate the effects of initial temperature and oxygen enrichment coefficient on the LBV from sensitivity analysis and kinetic *** paper presents the effect of the expansion effect on laminar burning velocity for the first time,and separates the effect of the expansion effect on laminar burning velocity by a new *** shows that as the initial temperature goes up,the faster the exponential growth phase of the flame front velocity,the slower the slow growth *** smaller and earlier the maximum flame front velocity arrives,the slower the average flame speed *** the oxygen enrichment coefficient goes up,the peak value of the flame front velocity gradually ***-rich combustion and increasing initial temperature inhibit flame propagation in a half-open tube,but promote laminar burning velocity,which increases the key chemical bond and adiabatic flame *** net reaction rate shows that oxygen-rich combustion mainly promotes the combustion reaction of H_(2)(R2).However,increasing the initial temperature mainly promoted the oxidation of CO(R29).Analysis of the reaction path showed that oxygen-rich combustion and increased initial temperature promoted the reaction of H_(2)and CO with key chemical bonds,increased OH concentration,and inhibited OH cracking reaction.

关键词： gas turbines oxyfuel combustion numerical simulation combustion kinetics fire and flame

A note on the entanglement entropy of primary fermion fields in JT gravity

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中国物理C:英文版 2023年第8期47卷 173-183页

作者：郭长仲甘文聪舒富文 Department of Physics Nanchang UniversityNanchang 330031China GCAP-CASPER Physics DepartmentBaylor UniversityWacoTexas 76798-7316USA Center for Relativistic Astrophysics and High Energy Physics Nanchang UniversityNanchang 330031China Center for Gravitation and Cosmology Yangzhou UniversityYangzhou 225009China

In this paper we analyze and discuss 2D Jackiw-Teitelboim(JT)gravity coupled to primary fermion fields in asymptotically anti-de Sitter(AdS)*** obtain a particular solution of the massless Dirac field outside the extremal black hole horizon and find the solution for the dilaton in JT *** two dimensional JT gravity spacetime is conformally flat,we calculate the two point correlators of primary fermion fields under the Weyl *** primary goal of this work is to present a standard technique,called resolvent,rather than using CFT *** redefine the fields in terms of the conformal factor as fermion fields and use the resolvent technique to derive the renormalized entanglement entropy for massless Dirac fields in JT gravity.

关键词： Jackiw-Teitelboim gravity black hole information loss hogographic entanglement entropy

New recessive compound heterozygous variants of RP1L1 in RP1L1 maculopathy

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 107-112页

作者： wen-Chao Cao Qing-Shan Chen Run gan Tao Huang Xiao-He Yan The Second Clinical Medical College Jinan UniversityShenzhen 518040Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChin

AIM:To identify a maculopathy patient caused by new recessive compound heterozygous variants in ***:Comprehensive retinal morphological and functional examinations were evaluated for the patient with RP1L1 *** sequence capture array technique was used to screen potential pathologic *** chain reaction and Sanger sequencing were used to confirm the screening ***:Fundus examination showed round macular lesions appeared in both *** coherence tomography showed that the inner segment/outer segment continuity was disorganized and disruptive in the left eye,but it was uneven and slightly elevated in the right *** autofluorescence showed patchy hyper-autofluorescence in the *** field examination indicates central defects in both ***(ERG)and multifocal ERG showed no obvious *** fluorescein angiography in the macula showed obviously irregular hyper-fluorescence in the right eye and slightly hyper-fluorescence in the left *** found that the proband carried a missense variant(c.1972C>T)and a deletion variant(c.4717_4718del)of RP1L1,which were originated from the parents and formed compound heterozygous *** variants are likely pathogenic according to the ACMG *** imaging,ERG and detailed medical history are important diagnostic tools for differentiating between acquired and inherited retinal ***:A maculopathy case with detailed retinal phenotype and new recessive compound heterozygous variants of RP1L1 is identified in a Chinese family,which expands the understanding of phenotype and genotype in RP1L1 maculopathy.

关键词： maculopathy recessive compound heterozygous variants RP1L1