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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-wen Pan Jun-Qing Qi Qiang Zhou Wei-feng Tang Guo-wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Early prediction cardiac arrest in intensive care units:the value of laboratory indicator trends

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World Journal of Emergency Medicine 2025年第1期16卷 67-70页

作者： wentao Sang Jiaxin Ma Xuan Zhang Shuo Wu Chang Pan Jiaqi Zheng wen Zheng Qiuhuan Yuan Jian Zhang Jingjing Ma feng Xu Department of Emergency Medicine Qilu HospitalShandong UniversityJinan 250012China Chest Pain Center Qilu HospitalShandong UniversityJinan 250012China Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical Sciencesthe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalShandong UniversityJinan 250012China

The incidence of in-hospital cardiac arrest (IHCA) has increased over the past decade,with more than half occurring in intensive care units (ICUs).^([1])ICU cardiac arrest (ICU-CA)presents unique challenges,with worse outcomes than those in monitored wards,highlighting the need for early detection and intervention.^([2])Up to 80%of patients exhibit signs of deterioration hours before IHCA.^([3])Although early warning scores based on vital signs are useful,their eff ectiveness in ICUs is limited due to abnormal physiological parameters.^([4])Laboratory markers,such as sodium,potassium,and lactate,are predictive of poor outcomes,^([5])but static measurements may not capture the patient’s *** in laboratory indicators,such as variability and extremes,may offer better predictive value.^([6])This study aimed to evaluate ICU-CA predictive factors,with a focus on vital signs and trends of laboratory indicators.

关键词： prediction signs arrest

基于降雨过程理论的城市内河洪峰流量计算方法及应用

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中国给水排水 2017年第4期33卷 43-47页

作者：夏绍凤高文乔程峻峰王矛矛成国保合肥市市政设计研究总院有限公司安徽合肥230001

当前城市河道洪峰流量可采用水利部门或市政部门暴雨计算公式进行计算,以上两个计算公式受各自成立的前提条件限制,若直接用于城市河道洪峰流量计算,与实际流量存在较大偏差。以市政部门暴雨计算公式的极限强度理论为基础,将一条河道流... 详细信息

当前城市河道洪峰流量可采用水利部门或市政部门暴雨计算公式进行计算,以上两个计算公式受各自成立的前提条件限制,若直接用于城市河道洪峰流量计算,与实际流量存在较大偏差。以市政部门暴雨计算公式的极限强度理论为基础,将一条河道流域划分为若干子汇水分区,分别计算各子汇水分区汇入河道的洪峰流量及时间,从上游至下游依次将各汇水子分区排口洪峰流量与该排口上游河道洪峰流量错峰叠加,计算出每个子汇水分区排口下游两个可能的洪峰流量,将两个计算结果进行比较并取最大值,该最大值即为该处排口下游河道的洪峰流量。

关键词：暴雨强度公式极限强度理论城市内河洪峰流量

Reduced graphene oxide-mediated electron-hole separation using titanium dioxide increases the photocatalytic antibacterial activity of bone scaffolds

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Bio-Design and Manufacturing 2025年第1期8卷 100-115,I0044页

作者： Pei feng Haifeng Tian feng Yang Shuping Peng Hao Pan Cijun Shuai State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Cancer Research InstituteSchool of Basic Medical ScienceCentral South UniversityChangsha 410013China RESEARCH ARTICLE The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education of Xiangya Hospital and School of Basic Medical Science Central South UniversityChangsha 410013China Department of Periodontics&Oral Mucosal Section Xiangya Stomatological Hospital&Xiangya School of StomatologyCentral South UniversityChangsha 410013China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017China

Fast electron-hole recombination issues during titanium dioxide(TiO_(2))photocatalysis limit its application in preventing bacterial infection during bone defect *** this study,TiO_(2)@reduced graphene oxide(rGO)composites were synthesized using a hydrothermal method in which rGO,which possesses very high electrical conductivity,promotes the separation of photoelectron-hole pairs of TiO_(2),thus improving the efficiency of photocatalytic production of reactive oxygen species(ROS).Subsequently,TiO_(2)@rGO composites were introduced into poly-L-lactic acid(PLLA)to prepare bone scaffolds with photocatalytic antibacterial function via selective laser *** results showed that TiO_(2)grew on the surface of rGO and formed a covalent bond connection(Ti-O-C)with rGO.A decreased electrochemical impedance of TiO_(2)@rGO composites was observed,and the transient photocurrent intensity increased from 0.05 to 0.5μA/cm^(2).Analysis of electron spin resonance found that the photocatalytic products of TiO_(2)were·OH and·O^(2-),two kinds of ROS capable of killing bacteria via disrupting the structure of the bacterial membrane in *** experiments showed that the PLLA/TiO_(2)@rGO scaffolds had good antibacterial properties against Escherichia coli and Staphylococcus ***,we report that these scaffolds exhibited both enhanced mechanical properties due to the addition of TiO_(2)@rGO as a reinforcement material and good biocompatibility during cell proliferation.

关键词： Reduced graphene oxide Photocatalysis Reactive oxygen species Antibacterial properties Bone scaffold

Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway

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Chinese Journal of Integrative Medicine 2025年第2期31卷 118-130页

作者： LI Zhu-qing ZHANG feng LI Qi WANG Li SUN Xiao-qiang LI Chao YIN Xue-mei LIU Chun-lei WANG Yan-xin DU Xiao-yu LU cheng-zhi Department of Cardiology Tianjin First Central HospitalTianjin300192China The First Central Clinical School Tianjin Medical UniversityTianjin300070China Department of Cardiology The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People’s HospitalYichangHubei Province443003China School of Medicine Nankai UniversityTianjin300071China

Objective:To evaluate the protective effects of gentiopicroside(GPS)against reactive oxygen species(ROS)-induced NOD-like receptor family,pyrin domain containing 3(NLRP3)inflammasome activation in endothelial cells,aiming to reduce ***:Eight-week-old male ApoE-deficient mice were randomly divided into 2 groups(n=10 per group):the vehicle group and the GPS treatment *** groups were fed a high-fat diet for 16 ***(40 mg/kg per day)was administered by oral gavage to the GPS group,while the vehicle group received an equivalent volume of the vehicle *** the end of the treatment,blood and aortic tissues were collected for assessments of atherosclerosis,lipid profiles,oxidative stress,and molecular expressions related to NLRP3 inflammasome activation,ROS production,and ***,in vitro experiments on human aortic endothelial cells treated with oxidized low-density lipoprotein(ox-LDL)were conducted to evaluate the effects of GPS on NLRP3 inflammasome activation,pyroptosis,apoptosis,and ROS production,specifically examining the role of the sirtuin 1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)***1 and Nrf2 inhibitors were used to confirm the pathway's ***:GPS treatment significantly reduced atherosclerotic lesions in the en face aorta(P<0.01),as well as in the thoracic and abdominal aortic regions,and markedly decreased sinus lesions within the aortic root(P<0.05 or P<0.01).Additionally,GPS reduced oxidative stress markers and proinflammatory cytokines,including interleukin(IL)-1βand IL-18,in lesion areas(P<0.05,P<0.01).In vitro,GPS inhibited ox-LDL-induced NLRP3 activation,as evidenced by reduced NLRP3(P<0.01),apoptosis-associated speck-like protein containing a CARD,cleaved-caspase-1,and cleavedgasdermin D expressions(all P<0.01).GPS also decreased ROS production,apoptosis,and pyroptosis,with the beneficial effects being significantly reversed by SIRT1 or Nrf2 ***:GPS exe

关键词： endothelial dysfunction gentiopicroside NLRP3 inflammasome SIRT1 nuclear factor erythroid 2-related factor 2 Chinese medicine

Group frames via magic states with applications to SIC-POVMs and MUBs

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Communications in Theoretical Physics 2025年第1期77卷 41-53页

作者： Lingxuan feng Shunlong Luo Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

We connect magic(non-stabilizer)states,symmetric informationally complete positive operator valued measures(SIC-POVMs),and mutually unbiased bases(MUBs)in the context of group frames,and study their *** states are quantum resources in the stabilizer formalism of quantum ***-POVMs and MUBs are fundamental structures in quantum information theory with many applications in quantum foundations,quantum state tomography,and quantum cryptography,*** this work,we study group frames constructed from some prominent magic states,and further investigate their *** method exploits the orbit of discrete Heisenberg-Weyl group acting on an initial fiducial *** quantify the distance of the group frames from SIC-POVMs and MUBs,*** a simple corollary,we reproduce a complete family of MUBs of any prime dimensional system by introducing the concept of MUB fiducial states,analogous to the well-known SIC-POVM fiducial *** present an intuitive and direct construction of MUB fiducial states via quantum T-gates,and demonstrate that for the qubit system,there are twelve MUB fiducial states,which coincide with the H-type magic *** compare MUB fiducial states and SIC-POVM fiducial states from the perspective of magic resource for stabilizer quantum *** further pose the challenging issue of identifying all MUB fiducial states in general dimensions.

关键词： Group frames magic states MUBs SIC-POVMs quantum T-gates

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输电线路杆塔突发电流自动监测系统

电测与仪表 2008年第7期45卷 57-60页

作者：程文锋何志伟梁江东华南理工大学广州510640 武汉高压研究院武汉430072

针对目前输电线路在维护、抢修中所带来的麻烦,本文提出并研发了输电线路杆塔突发电流自动监测系统,它能够定点监测、准确定位、实时记录、及时通知输电线路杆塔绝缘子因雷击、雾闪、污闪以及风偏偏移等所造成的杆塔工频接地故障,特别... 详细信息

针对目前输电线路在维护、抢修中所带来的麻烦,本文提出并研发了输电线路杆塔突发电流自动监测系统,它能够定点监测、准确定位、实时记录、及时通知输电线路杆塔绝缘子因雷击、雾闪、污闪以及风偏偏移等所造成的杆塔工频接地故障,特别是当杆塔遭雷击时,监测器能快速测量雷电流值,这样可以很方便地让引导巡线人员准确找出故障点,及时清除故障,是一套功能非常强大的实时监测系统。本文从功能和技术上全面论述了系统各项功能和原理,它除了能及时测量数据外,还能通过监测器互传方式送入到服务器。

关键词：故障突发电流杆塔电流监测

Autocyclic switching processes and architecture of lobes in river-dominated lacustrine deltas

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Journal of Palaeogeography 2025年第1期14卷 126-140页

作者： Zhen-Hua Xu Sheng-He Wu Piret Plink-Bj?rklund Tao Zhang Da-Li Yue Qi-Hao Qian Qing Li wen-Jie feng National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) College of Geosciences China University of Petroleum (Beijing) Department of Geology and Geological Engineering Colorado School of Mines Gas Production Plant 2 PetroChina Changqing Oilfield Company PetroChina Research Institute of Petroleum Exploration and Development College of Geosciences Yangtze University

River-dominated lacustrine deltas typically consist of multiple lobes due to autogenic lobe switching that occurs over short time scales. However, the switching patterns of multiple lobes in these deltas remain poorly understood, and the architectural features attributed to lobe switching are also lacking. By integrating Delft3D simulations, flume experiments, and modern deposit analysis, we proposed that autogenic lobe switching follows a cyclic pattern. Autocyclicity begins with the formation of an offshore lobe and concludes after a series of longshore lobe growth events, marked by longshore avulsions occurring along the sides of offshore distributary *** avulsions follow a sequence that usually occurs earlier distally than proximally and subsequently occurs on one longshore side and then on the other side. Each lobe begins with rapid growth, which gradually slows and then stops once a channel avulsion is influenced by the backwater effect that triggers lobe switching. Three signals indicate lobe switching: a decrease in progradation rate, foreset slope steepening coupled with topset slope gentling, and the deposition of mud-dominated sediments. The number of autocyclic events never exceeds *** first two autocyclicities contribute to more than 55% of delta length and 70% of delta area. The lobes are separated by 1-6 stages of mud-dominated accretion beds that exhibit a downstream-inclined shape and convexup or lateral overlapping pattern. This study conducts a coupled growth-geometric assessment to establish an architectural pattern for river-dominated lacustrine deltas. This architectural pattern offers valuable insights into predicting sandy lobe distribution in river-dominated lacustrine delta reservoirs, and the architecture of muddy accretion beds aids in predicting the rule of oil-water movement and distribution of remaining oil.

关键词： Autocyclic lobe switching River-dominated lacustrine delta Architecture Avulsion sequence Backwater effect

新型避雷器对110 kV线路复合绝缘子电场分布的影响

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长沙理工大学学报（自然科学版） 2017年第4期14卷 69-74页

作者：程文锋瞿杨全文武广东电网电力科学研究院广东广州510600 武汉力中电气科技有限公司湖北武汉430072

为了研究在110 kV架空输电线路中安装新型避雷器对复合绝缘子电场分布的影响,根据110 kV架空输电线路中杆塔、新型避雷器、复合绝缘子、均压环及金具的实际结构,采用时谐电场三维有限元计算方法,建模计算了安装新型避雷器前后复合绝缘... 详细信息

为了研究在110 kV架空输电线路中安装新型避雷器对复合绝缘子电场分布的影响,根据110 kV架空输电线路中杆塔、新型避雷器、复合绝缘子、均压环及金具的实际结构,采用时谐电场三维有限元计算方法,建模计算了安装新型避雷器前后复合绝缘子串的电场强度。通过分析对比安装新型避雷器前后复合绝缘子以及均压环表面的电位和电场分布特性可知,安装新型避雷器增加了复合绝缘子表面电位及电场分布的均匀性,提高了均压效果,影响是良性的。

关键词： 110 kV输电线路新型避雷器复合绝缘子串均压环电场分布电位分布