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Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1αPathway

Current Medical Science 2022年第4期42卷 733-741页

作者： wen-bo long Xia PU Yi TANG Ming LI Yun LIU Qin SHE Ya-lan WANG Qin-xi GUO Department of Pathology Affiliated Hospital of Southwest Medical UniversityLuzhou 646099China Clinical Skills Center of Affiliated Hospital of Southwest Medical University Luzhou 646099China Department of Pathology School of Basic MedicineChongqing Medical UniversityChongqing 400016China

Objective:Arginine ADP-ribosyltransferase 1(ART1)is involved in the regulation of a diverse array of pathophysiological processes,including proliferation,invasion,apoptosis,autophagy and angiogenesis of colorectal cancer(CRC)***,how ART1 regulates glycolysis in CRC remains ***:To elucidate the role of ART1 in glycolysis in CRC,we assessed the protein level of ART1,hypoxia-inducible factor 1α(HIF1α),and glucose transporter type 1(GLUT1)in 61 CRC tumor tissue specimens obtained from patients with different 2-[^(18)F]fluoro-2-deoxy-D-glucose(^(18)F-FDG)uptake as analyzed by PET/CT before *** adenocarcinoma CT26 cells with ART1 knockdown and overexpression were established,respectively,and the molecular mechanism underlying the effect of ART1 on glycolysis in CRC was determined both in vivo and in ***:The expression of ART1 and GLUT1 was significantly associated with FDG uptake(P=0.037 and P=0.022,respectively)in CRC ***,the expression of hexokinase 2(HK2)and lactate dehydrogenase(LDH)was upregulated in ART1-overexpressed CT26 cells,but was downregulated in ART1-knockdown CT26 *** volume and weight of subcutaneously transplanted tumors were markedly increased in the ART1-overexpressed BALB/c mice group and decreased in the ART1-knockdown *** CT26 cells,the overexpression of ART1 promoted the expression levels of HK2 and LDH,and knockdown of ART1 suppressed them in the CT26 *** both normal and hypoxic conditions,ART1 expression was associated with the protein level of phospho-serine/threonine kinase(p-AKT),HIF1α,and GLUT1 but not with that of AKT in CT26 cells and subcutaneous transplanted ***:ART1 plays a crucial role in the elevation of glucose consumption in CT26 cells and may regulate GLUT1-dependent glycolysis in CRC via the PI3K/AKT/HIF1αpathway.

关键词： arginine ADP-ribosyltransferases 1 colorectal cancer Warburg effect hypoxiainducible factor glucose transporter type 1

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Time-resolved laser-induced breakdown spectroscopy of aluminum

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Optoelectronics Letters 2008年第5期4卷 369-370页

作者： LIU Xian-yun ZHANG Wei-jun WANG Zhen-ya HAO Li-qing HUANG Ming-qiang ZHAO wen-wu long bo Zhao Wei Laboratory of Environment Spectroscopy Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

We develop a system to measure the elemental composition of unprepared samples using laser-induced breakdown spec-troscopy (LIBS) in our laboratory,which can be used for the determination of elements in solids,liquids and aerosols. A description of the instrumentation,including laser,sample chamber and detection,is followed by a brief discussion. The time-resolved LIBS of aluminum at atmospheric pressure is presented. At the end,the possibilities and later uses of this technique are briefly discussed.

关键词：铝光谱学 LIBS 烟雾剂测试技术

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Research on the balance optimization algorithm of image recognition accuracy and speed based on autocollimator measurement

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Optoelectronics Letters 2025年第2期21卷 121-128页

作者： LI Renpu MA long CUI Jiwen GUO Junqi Andrei KULIKOV wen Dandan Chongqing Engineering Research Center of Intelligent Sensing Technology and Microsystem Chongqing University of Post and Telecommunications School of Instrumentation Science and Engineering Harbin Institute of Technology Higher School of Engineering and Technology ITMO University

The autocollimator is an important device for achieving precise,small-angle,non-contact *** primarily obtains angular parameters of a plane target mirror indirectly by detecting the position of the imaging *** is limited report on the core algorithmic techniques in current commercial products and recent scientific *** paper addresses the performance requirements of coordinate reading accuracy and operational speed in autocollimator image *** proposes a cross-image center recognition scheme based on the Hough transform and another based on Zernike moments and the least squares *** experimental evaluation of the accuracy and speed of both schemes,the optimal image recognition scheme balancing measurement accuracy and speed for the autocollimator is *** these,the center recognition method based on Zernike moments and the least squares method offers higher measurement accuracy and stability,while the Hough transform-based method provides faster measurement speed.

关键词： Least squares approximations

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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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个人碳交易对消费者电动汽车选择行为的影响研究

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软科学 2017年第7期31卷 112-115页

作者：李文博龙如银杨彤中国矿业大学管理学院江苏徐州221116

应用选择实验法并结合随机参数Logit模型,分析了个人碳交易对消费者电动汽车选择行为的影响。结果表明:个人碳交易会对消费者电动汽车选择行为产生显著的正向影响,其对消费者的影响高于免购置税、免停车费、免车船税、免过路费这4类政策... 详细信息

应用选择实验法并结合随机参数Logit模型,分析了个人碳交易对消费者电动汽车选择行为的影响。结果表明:个人碳交易会对消费者电动汽车选择行为产生显著的正向影响,其对消费者的影响高于免购置税、免停车费、免车船税、免过路费这4类政策,但低于政府补贴政策。此外,个人碳交易对消费者的影响还低于电动汽车性能属性改善所带来的影响。最后,有针对地提出了一些政策建议。

关键词：个人碳交易电动汽车选择实验随机参数Logit模型

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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设施土壤重金属污染物累积的影响因素分析

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土壤 2008年第3期40卷 469-473页

作者：段永蕙史静张乃明文波龙山西财经大学环境经济系太原030006 云南农业大学资源与环境学院昆明650201

通过实地调查、采样分析,研究了云南主要设施栽培区土壤重金属污染的累积状况及其影响因素。结果表明,云南省设施土壤重金属综合污染指数均>1.00,设施土壤已经开始受到污染,并且随着栽培年限的延长有累积程度加重的趋势,其中以Cd的污染... 详细信息

通过实地调查、采样分析,研究了云南主要设施栽培区土壤重金属污染的累积状况及其影响因素。结果表明,云南省设施土壤重金属综合污染指数均>1.00,设施土壤已经开始受到污染,并且随着栽培年限的延长有累积程度加重的趋势,其中以Cd的污染程度较严重:重金属Pb、Cu、zn、Ni、As均在花-菜轮作方式下累积量最大,而Cd在花-花轮作方式下累积量最大;不同棚型对重金属元素含量没有显著影响;多元线性回归分析表明,土壤理化性状对重金属元素的综合影响大小顺序为:Hg>Cr>Zn>Ni>As>Cu>Cd>Pb,且从不同的影响因素来看,有机质、pH和速效P的影响较大。

关键词：设施土壤重金属累积影响因素

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云南元阳哈尼梯田土壤养分垂直变异特征研究

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云南农业大学学报（自然科学版） 2009年第1期24卷 78-81,93页

作者：文波龙任国张乃明云南农业大学资源与环境学院云南昆明650201

元阳梯田的垂直变化特性是它主要的特征,为促进元阳梯田的持续利用,对元阳梯田不同海拔、不同土层土壤进行实地采样调查,并分析测定了有机质和碱解氮,结果表明:(1)元阳梯田表层土壤有机质含量总体达到二级水平,含量比同区域平坝区的水... 详细信息

元阳梯田的垂直变化特性是它主要的特征,为促进元阳梯田的持续利用,对元阳梯田不同海拔、不同土层土壤进行实地采样调查,并分析测定了有机质和碱解氮,结果表明:(1)元阳梯田表层土壤有机质含量总体达到二级水平,含量比同区域平坝区的水稻土还高;而梯田土壤中的碱解氮含量较低,含量低于同区域平坝区的水稻土;(2)元阳梯田相同土层中有机质含量随着海拔的降低而减少,但在谷底低海拔区含量突增;同一海拔段土壤有机质随着土层深度增加而呈下降趋势,但谷底低海拔区上层土壤中有机质含量相对均匀;(3)元阳梯田同一土壤层中碱解氮含量随着海拔的降低而增加,但在谷底呈现出突减;同一海拔段土壤碱解氮含量随着土层深度增加而增加,但在离村庄最近的中高海拔位置却随深度增加先减后增。云阳梯田土壤养分垂直变异特征明显。

关键词：元阳梯田土壤养分海拔土层

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大庆市油田开发区湿地水环境质量现状与污染防治对策

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湿地科学 2010年第4期8卷 312-319页

作者：文波龙刘兴土王继富中国科学院湿地生态与环境重点实验室中国科学院东北地理与农业生态研究所吉林长春130012 中国科学院研究生院北京100049 哈尔滨师范大学生命与环境科学学院黑龙江哈尔滨150025

大庆市资源开发与湿地生态环境保护矛盾日益突出,通过对典型泡沼和排干水体采样监测,采用单因子指数法和综合污染指数法对大庆市油田开发区湿地水环境质量现状进行评价和污染特征分析。研究结果表明,按照水环境功能标准,在研究区,除了... 详细信息

大庆市资源开发与湿地生态环境保护矛盾日益突出,通过对典型泡沼和排干水体采样监测,采用单因子指数法和综合污染指数法对大庆市油田开发区湿地水环境质量现状进行评价和污染特征分析。研究结果表明,按照水环境功能标准,在研究区,除了库里泡和排水干渠水质的综合评价污染强度为轻度、中度污染外,其余泡沼的水质均为重度或严重污染;但在单因素污染评价中,所有水体水质都为劣Ⅴ类。其中,各个泡沼水体都是化学需氧量、总磷和挥发酚3项指标超标,龙凤湿地的氮污染也比较严重,三永泡和中内泡水体石油污染物超标;而各个排干水体主要受氮和磷的污染。同时基于评价结果分析,提出了大庆市湿地生态系统污染综合防治对策。

关键词：大庆市油田开发区湿地水环境污染防治

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支气管哮喘患儿CHI3L1基因多态性与糖皮质激素疗效的关系研究

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中国现代医学杂志 2021年第3期31卷 24-30页

作者：彭昊龙博文钟炜李德优萍乡市妇幼保健院儿科江西萍乡337000 萍乡市妇幼保健院PICU 江西萍乡337000 萍乡市妇幼保健院小儿呼吸内科江西萍乡337000

目的探讨CHI3L1基因rs10399805、rs4950928、rs883125位点单核苷酸多态性与支气管哮喘患儿糖皮质激素治疗疗效的关系。方法选取2018年1月—2018年12月在萍乡市妇幼保健院儿科就诊的慢性中度持续期支气管哮喘患儿130例,均接受布地奈德吸... 详细信息

目的探讨CHI3L1基因rs10399805、rs4950928、rs883125位点单核苷酸多态性与支气管哮喘患儿糖皮质激素治疗疗效的关系。方法选取2018年1月—2018年12月在萍乡市妇幼保健院儿科就诊的慢性中度持续期支气管哮喘患儿130例,均接受布地奈德吸入治疗,连续12周。另取同期在该院儿保科体检的健康儿童50例作为对照组。采用TaqMan-PCR反应检测CHI3L1基因rs10399805、rs4950928、rs883125位点单核苷酸多态性,以及肺功能。结果对照组与哮喘组CHI3L1基因rs10399805位点基因型分布频率比较,差异无统计学意义(P>0.05)。对照组rs4950928位点CC基因型分布频率高于哮喘组(P0.05)。疗效良好组rs4950928位点CC基因型分布频率高于疗效不良组(P0.05)。rs4950928位点CC型、CG型和GG型患儿治疗前后FEV1、FVC、FEV1/FVC的差值比较,经方差分析,差异有统计学意义(P<0.05);CG型和GG型低于CC型(P<0.05),CG型低于GG型(P<0.05)。rs883125位点CC型、CG型和GG型患儿治疗前后FEV1、FVC、FEV1/FVC的差值比较,经方差分析,差异有统计学意义(P<0.05);CC型和CG型高于GG型(P<0.05)。结论在萍乡地区儿童中,CHI3L1基因rs4950928和rs883125位点基因多态性可能与哮喘易感性和糖皮质激素治疗效果有关。

关键词：支气管哮喘/哮喘 CHI3L1基因/基因多态性单核苷酸糖皮质激素儿童

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