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Current and future research directions in cellular metabolism of colorectal cancer:A bibliometric analysis

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3732-3737页

作者： bo-wen jiang Xiu-Hua Zhang Rui Ma wen-Yu Luan Yan-Dong Miao Department of Emergency Yantai Affiliated Hospital of Binzhou Medical UniversityThe Second Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina Department of Oncology Laiyang Central HospitalYantai 265200Shandong ProvinceChina Department of Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe Second Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

The primary aim of this study was to analyze the evolving trends and key focal points in research on cellular metabolism of colorectal cancer(CRC).Relevant publications on cellular metabolism in CRC were sourced from the Science Citation Index Expanded within the Web of Science Core Collection *** analysis and visualization were conducted using VOSviewer(version 1.6.18)software and CiteSpace 6.1.R6(64-bit)Basic.A comprehensive compilation of 4722 English-language publications,covering the period from January 1,1991 to December 31,2022,was carefully identified and included in the *** the authors,“Ogino,Shuji”contributed the most publications in this field,while“Giovannucci,E”garnered the highest number of *** journal“Cancer Research”ranked first in both publication volume and ***,“Shanghai Jiao Tong University”emerged as the top contributor in terms of published articles,while“Harvard University”led in citation *** country-based analysis,the United States held the top position in both publication output and citations,closely followed by *** increasing recognition of the significance of cellular metabolism in CRC underscores its potential for novel therapeutic approaches aimed at improving CRC management and prognosis.

关键词： Cellular metabolism Colorectal cancer Bibliometric analysis Metabolic reprogramming Cellular metabolism

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Morphologies of Core-Shell-Cylinder-Forming ABC Star Triblock Copolymers in Nanopores

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Chinese Journal of Chemical Physics 2014年第3期27卷 337-342页

作者： wen-bo jiang wen-chang Lang Shi-ben Li Xiang-hong Wang Department of Physics Wenzhou University Wenzhou 325035 China Department of Physics Wenzhou Vocational and Technical College Wenzhou 325035 China

The self-assembly behavior of ABC star triblock copolymers can lead to a large number of nanostructures. Indeed, many new and interesting structures have already been discovered and proven to be hotspot in soft matter physics research. In this work, we introduce different phase diagrams of core-shell-cylinder-forming ABC star triblock copolymers under different conditions, including in-bulk and pore geometries with different sizes. The relation between the pore size geometries and their corresponding structures are also revealed. The different properties of the surface potential field that significantly affect the self-assembly process of ABC star triblock copolymers are investigated as well.

关键词： Nanopore ABC star triblock copolymer Core-shell-cylinder-forming

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Further monopole effects in neutron-rich Sb isotopes

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Chinese Physics C 2024年第1期48卷 138-143页

作者：王韩奎孙雨乐蒋博文曾凡斐柳敏良 Department of Physics Zhejiang SCI-TECH UniversityHangzhou 310018China School of Physics Xi'an Jiaotong UniversityXi'an 710049China Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China

The level spectra of neutron-rich Sb isotopes have been investigated within a shell-model space containing cross-shell excitations and the intruder orbit i_(13/2).High-spin levels(27/2^(-))and(29/2^(-))in 135 Sb are taken over by the monopole effect induced by orbit i_(13/2).The ground state and excited levels in ^(136)Sb are well improved by considering the monopole correction between neutron orbits f_(7/2) and h_(9/2).The energy shrinking of the first excited state 5/2^(+)in ^(135,137)Sb isotopes is explained by theπd_(5/2) shift due to the attractiveπd5/2νf_(7/2) monopole interaction when increasingly more neutrons occupy orbit f_(7/2).The ground state of ^(139)Sb is predicted as 5/2^(+)owing to the shrinking of the 5/2^(+)states in Sb isotopes that causes ground state inversion when N=*** monopole effects extend the applicable range of the present Hamiltonian to nuclei with more neutrons above the N=82 *** Hamiltonian will be public,and researchers are encouraged to contact the authors.

关键词： level spectra neutron rich monopole effects ground state prediction

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Surface-induced Morphologies of ABC Star Triblock Copolymer in Spherical Cavities

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Chinese Journal of Polymer Science 2015年第11期33卷 1503-1515页

作者： wen-bo jiang Yong-yun Ji wen-chang Lang 李士本王向红 Department of Physics Wenzhou University Department of Physics Wenzhou Vocational and Technical College

The morphologies and phase diagrams exhibited by symmetric ABC star triblock copolymer nanoparticles are investigated on the basis of real-space self-consistent field theory. The ABC star triblock copolymers were chosen to be tiling-forming with fixed polymer parameter and the spherical boundaries were modeled using the masking technique. We first study a number of examples where the ABC triblock copolymers confined in spherical cavities with neutral surface. Then, two types of spherical cavity distinct preferential surfaces are considered, including both A-block attractive and repulsive preferential surfaces. We aim at the effects due to various spherical cavity diameters and the degree of interactions between the polymer and the spherical surface. A variety of morphologies, such as ring-like structures, concentric sphere, and irregular cylinder, were identified in phase diagrams. The results show that both the degree of interactions and spherical diameters can influence the formation of morphologies so that ring-like structures and other novel structures could be obtained.

关键词： Morphology Star triblock copolymer Spherical cavity SCFT

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Determinants of saturation magnetic flux density in Fe-based metallic glasses: insights from machine-learning models

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Rare Metals 2024年第10期43卷 5256-5267页

作者： Jie Xiong bo-wen Bai Hao-Ran jiang Angeles Faus-Golfe Materials Genome Institute Shanghai University Institute of Special Environments Physical Sciences Harbin Institute of Technology Laboratoire de Physique des 2 Infinis Irene Joliot-Curie (IJCLab) CNRS-IN2P3Universite′Paris-Saclay

Fe-based metallic glasses have garnered significant attention due to their low coercivity force and core loss. Enhancing the saturation magnetic flux density(Bs) of Fe-based metallic glasses is crucial for their industry applications. This work constructed a dataset comprising330 training data and 157 test data. The support vector regression model surpassed the tree-based ensemble models in the test set and demonstrated comparable accuracy to the tree-based ensemble models in the training set. Additionally, we proposed an indicator for Bsbased on symbolic regression. This newly proposed indicator exhibits a Pearson correlation coefficient exceeding 0.92 with Bs. The present work provides a simple and accurate formula for predicting the Bsof Fe-based amorphous alloys, demonstrating the effectiveness of machine learning approaches in discovering novel soft magnetic materials.

关键词： Fe-based metallic glasses Machine learning Saturation magnetic flux density Symbolic regression

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BR Signal Influences Arabidopsis Ovule and Seed Number through Regulating Related Genes Expression by BZR1

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Molecular Plant 2013年第2期6卷 456-469页

作者： Hui-Ya Huang wen-bo jiang Yu-Wei Hu Ping Wu Jia-Ying Zhu Wan-Qi Liang Zhi-Yong Wang wen-Hui-Lin Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China Shanghai Jiaotong University Shanghai 200240 China Department of Plant Biology Carnegie Institution for Science Stanford CA 94305 USA

Ovule and seed developments are crucial processes during plant growth, which are affected by different signaling pathways. In this paper, we demonstrate that the brassinosteroid （BR） signal is involved in ovule initiation and development. Ovule and seed numbers are significantly different when comparing BR-related mutants to wild-type con-trols. Detailed observation indicates that BR regulates the expression level of genes related to ovule development, includ-ing HLL, ANT, and AP2, either directly by targeting the promoter sequences or indirectly via regulation by BR-induced transcription factor BZR1. Also, Western blot demonstrates that the dephosphorylation level of BZR1 is consistent with ovule and seed number. The intragenic bzrl-lD suppressors bzs247 and bzs248 have much fewer ovules and seeds than bzrl-lD, which are similar to wild-type, suggesting that the phenotype can be rescued. The molecular and genetic experi-ments confirm that BZR1 and AP2 probably affect Arabidopsis ovule number determination antagonistically.

关键词： ovule and seed number BR ovule development-related genes.

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Single‑cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes

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Journal of Animal Science and Biotechnology 2024年第2期15卷 614-631页

作者： Ting Ge Yifan wen bo Li Xiaoyu Huang Shaohua jiang Enping Zhang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China

Background In the modern sheep production systems,the reproductive performance of ewes determines the economic profitability of *** the genetic mechanisms underlying differences in the litter size is important for the selection and breeding of highly prolific *** sheep,a high-quality Chinese sheep breed,is known for its high fecundity and is often used as a model to study prolificacy *** the current study,animals were divided into two groups according to their delivery rates in three consecutive lambing seasons(namely,the high and low reproductive groups with≥3 lambs and one lamb per season,n=3,respectively).The ewes were slaughtered within 12 h of estrus,and unilateral ovarian tissues were collected and analyzed by 10×Genomics single-cell RNA *** A total of 5 types of somatic cells were identified and corresponding expression profiles were mapped in the ovaries of each ***,the differences in the ovary somatic cell expression profiles between the high and low reproductive groups were mainly clustered in the granulosa ***,four granulosa cell subtypes were *** analysis revealed that the abundance of JPH1 expression and the reduction of LOC101112291 expression could lead to different evolutionary directions of the granulosa ***,the expression levels of FTH1 and FTL in mural granulosa cells of the highly reproductive group were significantly *** genes inhibit necroptosis and ferroptosis of mural granulosa cells,which helps prevent follicular *** This study provides insights into the molecular mechanisms underlying the high fecundity of Hu *** differences in gene expression profiles,particularly in the granulosa cells,suggest that these cells play a critical role in female *** findings also highlight the importance of genes such as JPH1,LOC101112291,FTH1,and FTL in regulating granulosa cell function and follicular development.

关键词： Granulosa cells Hu sheep Lambing number Ovarian somatic cells Single-cell RNA sequencing

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Protein-spatiotemporal partition releasing gradient porous scaffolds and anti-inflammatory and antioxidant regulation remodel tissue engineered anisotropic meniscus

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Bioactive Materials 2023年第2期20卷 194-207页

作者： Bingbing Xu Jing Ye Bao-Shi Fan Xinjie Wang Ji-Ying Zhang Shitang Song Yifan Song wen-bo jiang Xing Wang Jia-Kuo Yu Sports Medicine Department Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalNo.49North Garden RoadHaidian DistrictBeijing 100191PR China Peking University Institute of Sports Medicine No.49North Garden RoadHaidian DistrictBeijing 100191PR China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics&ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190PR China University of Chinese Academy of Sciences Beijing100049PR China Clinical Translational R&D Center of 3D Printing Technology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011PR China

Meniscus is a wedge-shaped fibrocartilaginous tissue,playing important roles in maintaining joint stability and *** injuries are difficult to heal and frequently progress into structural breakdown,which then leads to *** of heterogeneous tissue engineering meniscus(TEM)continues to be a scientific and translational *** morphology,tissue architecture,mechanical strength,and functional applications of the cultivated TEMs have not been able to meet clinical needs,which may due to the negligent attention on the importance of microenvironment in vitro and in ***,we combined the 3D(three-dimensional)-printed gradient porous scaffolds,spatiotemporal partition release of growth factors,and anti-inflammatory and anti-oxidant microenvironment regulation of Ac2-26 peptide to prepare a versatile meniscus composite scaffold with heterogeneous bionic structures,excellent biomechanical properties and anti-inflammatory and anti-oxidant *** observing the results of cell activity and differentiation,and biomechanics under anti-inflammatory and anti-oxidant microenvironments in vitro,we explored the effects of anti-inflammatory and anti-oxidant microenvironments on construction of regional and functional heterogeneous TEM via the growth process regulation,with a view to cultivating a high-quality of TEM from bench to bedside.

关键词： Tissue engineering meniscus Gradient porous scaffolds Spatiotemporal partition release Ac2-26 peptide Anti-inflammatory and anti-oxidant regulation

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Black hole evaporation and its remnants with the generalized uncertainty principle including a linear term

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Communications in Theoretical Physics 2024年第2期76卷 125-136页

作者： bo Yu Zheng-wen Long College of Physics Guizhou UniversityGuiyang550025China

In recent years,researchers have investigated the evaporation of Schwarzschild black holes using various forms of the generalized uncertainty principle(GUP),metric quantum correction,and noncommutative geometry,***,there are differences between the GUP correction and the other two methods in terms of describing the later stages of black hole ***,some studies argue that the GUP with a negative parameter cannot effectively correct black hole evaporation,while others contend that the positivity or negativity of the GUP parameters should not affect the correction *** the above into consideration,we reconsider black hole evaporation with the generalized uncertainty principle including a linear term(LGUP),and examine the case of negative *** results indicate that the evaporation behavior of both Schwarzschild black holes and Reissner–Nordstr?m black holes,under LGUP correction,is consistent with the results of metric quantum correction and non-commutative ***,the negative parameter LGUP can also effectively correct for black hole evaporation.

关键词： black hole evaporation generalized uncertainty principle negative parameter

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Mesenteric adipose tissue B lymphocytes promote intestinal injury in severe acute pancreatitis by mediating enteric pyroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 300-309页

作者： Qing Huang Jia-wen Liu Hai-Bin Dong Zheng-Jie Wei Jin-Zhe Liu Yu-Tang Ren Xuan jiang bo jiang Department of Gastroenterology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Background:Visceral adipose tissue(VAT)has been linked to the severe acute pancreatitis(SAP)prognosis,although the underlying mechanism remains *** has been reported that pyroptosis worsens *** present study aimed to verify whether mesenteric adipose tissue(MAT,a component of VAT)can cause secondary intestinal injury through the pyroptotic ***:Thirty-six male Sprague Dawley(SD)rats were divided into six different *** rats were randomly divided into the SAP and control *** monitored the changes of MAT and B lymphocytes infiltration in MAT of SAP *** SAP rats were injected with MAT B lymphocytes or phosphate buffer solution(PBS).The remaining twelve SAP rats were first injected with MAT B lymphocytes,and then with MCC950(NLRP3 inhibitor)or *** collected blood and tissue samples from pancreas,gut and MAT for ***:Compared to the control rats,the SAP group showed inflammation in MAT,including higher expression of tumor necrosis factor(TNF-α)and interleukin-6(IL-6),lower expression of IL-10,and histological *** cytometry analysis revealed B lymphocytes infiltration in MAT but not T lymphocytes and *** SAP rats also exhibited intestinal injury,characterized by lower expression of zonula occludens-1(ZO-1)and occludin,higher levels of lipopolysaccharide and diamine oxidase,and pathological *** expression of NLRP3 and n-GSDMD,which are responsible for pyroptosis,was increased in the intestine of SAP *** injection of MAT B lymphocytes into SAP rats exacerbated the inflammation in *** upregulation of pyroptosis reduced tight junction in the intestine,which contributed to the SAP progression,including higher inflammatory indicators and worse histological *** administration of MCC950 to SAP+MAT B rats downregulated pyroptosis,which subsequently improved the intestinal barrier and ameliorated inflammatory response of ***:In SAP,MAT B lymphocytes aggravated local

关键词： Acute pancreatitis Mesenteric adipose tissue B lymphocyte Intestinal barrier Pyroptosis

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