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I-DCGAN and TOPSIS-IFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images

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China Foundry 2024年第3期21卷 239-247页

作者： Ming-jun Hou Hao Dong Xiao-yuan Ji wen-bing zou Xiang-sheng Xia Meng Li Ya-jun Yin Bao-hui Li Qiang Chen Jian-xin Zhou State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Xinjiang Technology(Jiangsu)Co. Ltd.Nantong 226100JiangsuChina Southwest Technique and Engineering Research Institute Chongqing 400039China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy ***,the efficacy of deep learning models hinges upon a substantial abundance of flaw *** existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality *** this end,a novel approach was put forward,which involves the creation of the Interpolation-Deep Convolutional Generative Adversarial Network(I-DCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSIS-IFP.I-DCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational ***-IFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion *** results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,*** TOPSIS-IFP value reaches 78.7%and 73.8%similarity to the ideal solution,*** to single index evaluation,the TOPSIS-IFP algorithm achieves higher-quality simulated images at the optimal training *** approach successfully mitigates the issue of unreliable quality associated with single index *** image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks.

关键词： light alloy casting flaw detection image generator discriminator comprehensive evaluation index

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Energy-based Directional Pilot Protection for Distribution Networks with IBDGs Considering Unmeasured Load Switching

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 139-150页

作者： Chenghan Zhou Guibin zou Shuo Zhang Xuhui wen Key Laboratory of Power System Intelligent Dispatch and Control of Ministry of Education Shandong UniversityJinan 250061China

Inverter-based distributed generations(IBDGs)are the main approach to utilizing clean energy in distribution networks(DNs).Compared with synchronous source,fault response of IBDG is very *** a result,in DNs with high penetration of IBDGs,legacy protection schemes will no longer be *** this paper,an energy-based directional pilot protection scheme suitabie for DNs with IBDGs is *** scheme considers the large range of phase angle caused by IBDG integration and uses improved energy polarity criterion to determine fault *** addition,magnitude of energy is used to distinguish between faults and load switching to overcome maloperation of directional pilot protection caused by internal unmeasured load *** proposed scheme first uses local measured information to determine fault direction sign and then exchanges the direction sign with the remote *** scheme does not require high-bandwidth communication and strict data synchronization,so it can be implemented at a low ***,simulation studies verify effectiveness of the proposed scheme.

关键词： Distribution network energy polarity inverterbased distributed generation pilot protection unmeasured load

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Advances in functional coatings on biliary stents

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Regenerative Biomaterials 2024年第2期3卷 55-75页

作者： Kaining Yang wenxin Sun Lanyue Cui Yuhong zou Cuie wen Rongchang Zeng Department of Bioengineering College of Chemical and Biological EngineeringShandong University of Science and TechnologyQingdao 266590China Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao 266590China school of Engineering RMIT UniversityMelbourneVIC3001Australia

Biliary stenting is an important interventional method for the prevention and treatment of biliary tract ***,complications,such as postoperative biliary infection and re-stenosis,frequently occur due to the extensive scope of the biliary system and the complex composition of *** com-bination of coating technology and biliary stents is expected to bring new approaches to the solution of these *** cutting-edge advance on functional coatings on biliary stents is reviewed from seven perspectives:anticorrosion,-bacterial,-tumor,stone-dissolving,X-ray visibility,anti-stent migration and functional composite *** de-velopment trend is also *** performance of the numerous functional coatings for various purposes is generally up to expectations,but the balance between the medica tions'effectiveness and their safety needs to be further *** contemporary investigations have advanced to the leve of animal experiments,offering crucial fundamental assurance for broader human *** combination of biliary stent and functional coatings is an innovative idea with great potential for future development.

关键词： biliary stent coating anticorrosion antibacterial antitumor stone-dissolving X-ray visibility antistent migration

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Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2598-2612页

作者： Jinbo Hu wen Liu Yi zou Chenyang Jiao Jiazhen Zhu Qiang Xu Jianjun zou Yang Sun wenjie Guo State Key Laboratory of Pharmaceutical Biotechnology Nanjing Drum Tower HospitalSchool of Life SciencesNanjing UniversityNanjing 210093China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

Src homology 2 domain-containing tyrosine phosphatase 2(SHP2)is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth,differentiation,and *** activation of SHP2 has been shown to have a therapeutic effect in colitis and Parkinson's ***,the identification of SHP2 activators and a complete understanding of their mechanism is *** used a two-step screening assay to determine a novel allosteric activator of SHP2 that stabilizes it in an open *** acid was identified as a suitable *** binding to R362,K364,and K366 in the active center of the PTP domain,oleanolic acid maintained the active open state of SHP2,which facilitated the binding between SHP2 and its *** oleanolic acid-activated SHP2 hindered Th17 differentiation by disturbing the interaction between STAT3 and IL-6Rαand inhibiting the activation of ***,via the activation of SHP2 and subsequent attenuation of the STAT3-Th17 axis,oleanolic acid effectively mitigated colitis in *** protective effect was abrogated by SHP2 knockout or administration of the SHP2 inhibitor *** findings underscore the potential of oleanolic acid as a promising therapeutic agent for treating inflammatory bowel diseases.

关键词： Oleanolic acid SHP2 STAT3 Th17 Colitis Allosteric activator

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Strain-promoted S-arylation and alkenylation of sulfinamides using arynes and cyclic alkynes

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Science China Chemistry 2024年第3期67卷 928-935页

作者： Xi zou Boming Shen Gao-lin Li Qian Liang Yanhua Ouyang binghe Yang Peiyuan Yu bing Gao State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringInstitute of Chemical Biology and NanomedicineHunan UniversityChangsha 410082China Department of Chemistry and Shenzhen Grubbs Institute Guangdong Provincial Key Laboratory of CatalysisSouthern University of Science and TechnologyShenzhen 518055China

The conversion of commercially available chiral sulfinamides into pharmaceutically useful chiral sulfoximines via direct SIVfunctionalization is synthetically attractive but challenging due to the competitive reaction of N-functionalization. Herein, we disclose a novel strain-release strategy to access stereospecific and chemoselective SIV-arylation and alkenylation of sulfinamides using arynes and strained cyclic alkynes. This method tolerates an unprecedented chemical diversity of functional groups attached to the nitrogen center(N-R). The origin of the high SIV-selectivity is elucidated by density functional theory calculations, suggesting a stepwise mechanism for the aryne substrates and a concerted mechanism for the cyclic alkynes.

关键词： arylation alkenylation sulfoximines sulfinamides arynes

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Long noncoding RNAs HAND2-AS1 ultrasound microbubbles suppress hepatocellular carcinoma progression by regulating the miR-873-5p/tissue inhibitor of matrix metalloproteinase-2 axis

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1547-1563页

作者： Qiang zou Hao-wen Wang Xi-Liang Di Yuan Li Hui Gao Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalTianjin 300060China National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China College of Animal Science and Technology Northeast Agricultural UniversityHarbin 150030Heilongjiang ProvinceChina Department of Hematology and Oncology Linyi People’s HospitalLinyi 251500Shandong ProvinceChina Department of Comprehensive Oncology Baotou Cancer HospitalBaotou 014030Inner Mongolia Autonomous RegionChina

BACKGROUND Increasing data indicated that long noncoding RNAs(lncRNAs)were directly or indirectly involved in the occurrence and development of tumors,including hepatocellular carcinoma(HCC).Recent studies had found that the expression of lncRNA HAND2-AS1 was downregulated in HCC tissues,but its role in HCC progression is *** targeted microbubble destruction mediated gene transfection is a new method to overexpress *** To study the role of ultrasound microbubbles(UTMBs)mediated HAND2-AS1 in the progression of HCC,in order to provide a new reference for the treatment of *** In vitro,we transfected HAND2-AS1 siRNA into HepG2 cells by UTMBs,and detected cell proliferation,apoptosis,invasion and epithelial-mesenchymal transition(EMT)by cell counting kit-8 assay,flow cytometry,Transwell invasion assay and Western blotting,*** addition,we transfected miR-837-5p mimic into UTMBs treated cells and observed the changes of cell ***,the UTMBs treated HepG2 cells were transfected together with miR-837-5p mimic and tissue inhibitor of matrix metalloproteinase-2(TIMP2)overexpression vector,and we detected cell proliferation,apoptosis,invasion and *** vivo,we established a mouse model of subcutaneous transplantation of HepG2 cells and observed the effect of HAND2-AS1 silencing on tumor formation *** We found that UTMBs carrying HAND2-AS1 restricted cell proliferation,invasion,and EMT,encouraged apoptosis,and HAND2-AS1 silencing eliminated the effect of ***,miR-873-5p targets the gene HAND2-AS1,which also targets the 3’UTR of *** miR-873-5p mimic counteracted the impact of ***,miR-873-5p mimic solely or in combination with pcDNA-TIMP2 had been transformed into HepG2 cells exposed to *** discovered that TIMP2 reversed the effect of miR-873-5p mimic caused by the blocked signalling cascade for matrix metalloproteinase(MMP)2/*** vivo results showed that HAND2-AS1 silencing sig

关键词： Hepatocellular carcinoma Ultrasound microbubbles Long noncoding RNA HAND2-AS1 miR-873-5p Tissue inhibitor of matrix metalloproteinase-2

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Effect of casting methods on microstructure and mechanical properties of ZM5 space flight magnesium alloy

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China Foundry 2018年第6期15卷 418-421页

作者： Xu-liang Zhang Guo-kang Yu wen-bing zou Yan-shuo Ji Ying-zhuo Liu Jia-lin Cheng Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China School of Materials Engineering Nanjing Institute of TechnologyNanjing 211167China

The counter-gravity casting methods have been developed to remove the casting defects of Mg based alloys. However, the effects of different counter-gravity casting methods on the microstructure and mechanical properties have not been studied in detail. ZM5 alloys were prepared by gravity casting, low-pressure casting and counter-pressure casting, respectively. The mechanical properties, microstructure and fracture morphologies were examined and compared by means of optical microscopy, scanning electron microscopy methods and tensile testing. Results show that casting defects such as gas pore, shrinkage porosity and cavity can be eliminated by counter-pressure casting. The grain size of α-Mg is decreased significantly by counterpressure casting. Moreover, the precipitated particles are more uniform and finer in the counter-pressure casting sample. As a result, the mechanical properties of the alloys are greatly improved. The tensile strength and elongation of the samples by counter-pressure casting are 285 MPa and 13.9%, respectively, which are much higher than those of the low pressure casting and gravity casting.

关键词： counter-pressure casting ZM5 alloy microstructure mechanical properties

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Griseofulvin enantiomers and bromine-containing griseofulvin derivatives with antifungal activity produced by the mangrove endophytic fungus Nigrospora ***1

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Marine Life Science & Technology 2024年第1期6卷 102-114页

作者： Ge zou wencong Yang Tao Chen Zhaoming Liu Yan Chen Taobo Li Gulab Said bing Sun Bo Wang Zhigang She School of Chemistry Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510070China School of Pharmacy Anhui Medical UniversityHefei 230032China Department of Chemistry Women University SwabiSwabi 23430Pakistan

Marine microorganisms have long been recognized as potential sources for drug *** was one of the first antifungal natural products and has been used as an antifungal agent for *** this study,12 new griseofulvin derivatives[(±)-1-2,(+)-3,(±)-4,10-12,and 14-15]and two new griseofulvin natural products(9 and 16)together with six known analogues[(-)-3,5-8,and 13]were isolated from the mangrove-derived fungus Nigrospora ***1 treated with 0.3%NaCl or 2%NaBr in rice solid *** 2D structures and absolute configurations were established by extensive spectroscopic analysis(1D and 2D NMR,HRESIMS),ECD spectra,computational calculation,DP4+analysis,and X-ray single-crystal *** 1-4 represent the first griseofulvin enantiomers with four absolute configurations(2S,6'S;2R,6'R;2S,6'R;2R,6'S),and compounds 9-12 represent the first successful production of brominated griseofulvin derivatives from fungi via the addition of NaBr to the culture *** the antifungal assays,compounds 6 and 9 demonstrated significant inhibitory activities against the fungi Colletotrichum truncatum,Microsporum gypseum,and Trichophyton mentagrophyte with inhibition zones varying between 28 and 41 mm(10μg/disc).The structure-activity relationship(SAR)was analyzed,which showed that substituents at C-6,C-7,C-6'and the positions of the carbonyl and double bond of griseofulvin derivatives significantly affected the antifungal activity.

关键词： Mangrove endophytic fungus Nigrospora sp. Griseofulvin Antifungal activity

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Process-driven susceptibility assessment of glacial lake outburst debris flow in the Himalayas under climate change

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Advances in Climate Change Research 2024年第3期15卷 500-514页

作者： Bin ZHOU Qiang zou Hu JIANG Tao YANG wen-Tao ZHOU Si-Yu CHEN Hong-Kun YAO Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China School of Environment and Resource Southwest University of Science and TechnologyMianyang 621010China

Global warming is causing glaciers to retreat and glacial lakes to expand in the Himalayas,which amplifies the risk of glacial lake outburst debris flows(GLODFs)and poses a significant threat to downstream lives and ***,the complex interplay between GLODF occurrences and associated indicators,coupled with the lack of a comprehensive susceptibility indicator system that considers the entire GLODF process,presents a substantial challenge in assessing GLODF susceptibility in the *** study proposes a process-driven GLODF susceptibility assessment indicator system responding to climate change that considers the complete process of GLODF formation,incorporating relevant parameters about upstream,themselves,and downstream of glacial ***,to mitigate subjective factors associated with traditional evaluation methods,we developed three novel hybrid machine-learning models by integrating classic machine-learning algorithms with the whale optimization algorithm(WOA)to delineate the distribution of GLODF susceptibility in the *** the hybrid models effectively predicted the GLODFs occurrence,with the WOA-SVC model demonstrating the highest prediction *** 34%of the catchments exhibit high and very high susceptibility levels,primarily concentrated along the north and south sides of the Himalayan ridge,particularly in the eastern and central *** capturing the physical formation process of hazards,such as topographic potential(highest relative importance value of 40%),can precisely identify GLODF.A total of 128 catchments pose potential transboundary threats,with 24 classified as having a very high susceptibility level and 25 as having a high susceptibility ***,the border region between China and Nepal is a prominent hotspot for transboundary threats of *** findings can provide valuable clues for disaster prevention,mitigation,and cross-border coordination in the Himalayas.

关键词： Glacial lake outburst debris flow Susceptibility assessment Climate change Himalayas

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Image Fusion Based on Bioinspired Rattlesnake Visual Mechanism Under Lighting Environments of Day and Night Two Levels

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Journal of Bionic Engineering 2024年第3期21卷 1496-1510页

作者： Yong Wang Hongmin zou College of Communication Engineering Jilin UniversityChangchun130012China

This study,grounded in Waxman fusion method,introduces an algorithm for the fusion of visible and infrared images,tailored to a two-level lighting environment,inspired by the mathematical model of the visual receptive field of rattlesnakes and the two-mode cells'*** research presented here is segmented into three *** the first segment,we design a preprocessing module to judge the ambient light intensity and divide the lighting environment into two levels:day and *** second segment proposes two distinct network structures designed specifically for these daytime and nighttime *** the daytime images,where visible light information is predominant,we feed the ON-VIS signal and the IR-enhanced visual signal into the central excitation and surrounding suppression regions of the ON-center receptive field in the B channel,***,for nighttime images where infrared information takes precedence,the ON-IR signal and the Visual-enhanced IR signal are separately input into the central excitation and surrounding suppression regions of the ON-center receptive field in the B *** outcome is a pseudo-color fused *** third segment employs five different no-reference image quality assessment methods to evaluate the quality of thirteen sets of pseudo-color images produced by fusing infrared and visible *** images are then compared with those obtained by six other methods cited in the relevant *** empirical results indicate that this study's outcomes surpass the comparative results in terms of average gradient and spatial *** one or two sets of fused images underperformed in terms of standard deviation and entropy when compared to the control *** sets of fused images did not perform as well as the comparison in the QAB/F *** conclusion,the fused images generated through the proposed method show superior performance in terms of scene detail,visual perception,and image sharpness

关键词： Rattlesnake Visible image Infrared image Daylight Bionic

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