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Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission

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Neuroscience Bulletin 2021年第4期37卷 478-496页

作者： wen-Juan Han Sui-bin Ma wen-bin wu Fu-Dong Wang Xiu-Li Cao Dong-Hao Wang Hai-Ning wu Rou-Gang Xie Zhen-Zhen Li Fei Wang Sheng-Xi wu Min-Hua Zheng Ceng Luo Hua Han Department of Biochemistry and Molecular Biology School of Basic MedicineFourth Military Medical UniversityXi’an710032China Department of Neurobiology School of Basic MedicineFourth Military Medical UniversityXi’an710032China The Fourth Regiment School of Basic MedicineFourth Military Medical UniversityXi’an710032China Department of Medical Genetics and Developmental Biology Fourth Military Medical UniversityXi’an710032China National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China Key Laboratory of Medicinal Resources and Natural Pharmaceutical ChemistryMinistry of EducationCollege of Life SciencesShaanxi Normal UniversityXi’an710119China

Tweety-homolog 1(Ttyh1)is expressed in neural tissue and has been implicated in the generation of several brain ***,its functional significance in pain processing is not *** disrupting the gene encoding Ttyh1,we found a loss of Ttyh1 in nociceptors and their central terminals in Ttyh1-deficient mice,along with a reduction in nociceptor excitability and synaptic transmission at identified synapses between nociceptors and spinal neurons projecting to the periaqueductal grey(PAG)in the basal *** importantly,the peripheral inflammationevoked nociceptor hyperexcitability and spinal synaptic potentiation recorded in spinal-PAG projection neurons were compromised in Ttyh1-deficient *** of the paired-pulse ratio and miniature excitatory postsynaptic currents indicated a role of presynaptic Ttyh1 from spinal nociceptor terminals in the regulation of neurotransmitter *** with Ttyh1 specifically in nociceptors produces a comparable pain ***,in this study we demonstrated that Ttyh1 is a critical determinant of acute nociception and pain sensitization caused by peripheral inflammation.

关键词： Ttyh1 Inflammatory pain Peripheral sensitization Long-term potentiation

Thermodynamic geometry of the RN-Ad S black hole and non-local observables

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Communications in Theoretical Physics 2024年第2期76卷 137-144页

作者： Chao Wang bin wu Zhen-Ming Xu wen-Li Yang Institute of Physics Shaanxi University of TechnologyHanzhong 723000China School of Physics Northwest UniversityXi'an 710127China Institute of Modern Physics Northwest UniversityXi'an 710127China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi'an 710127China Peng Huanwu Center for Fundamental Theory Xi'an 710127China

This paper studies the thermodynamic geometry of the Reissner–Nordstr?m-anti-de Sitter(RN-AdS)black hole via detection of the non-local observables in the dual field theory,including the entanglement entropy and equal-time two-point correlation *** the dimensional analysis,we construct the principle of corresponding states of black hole *** a result,our findings can be applied to black holes with different Ad S *** this sense,the probe of the thermodynamic geometry of the RN-Ad S black hole though the non-local observables in dual field theory has been confirmed numerically.

关键词： black hole thermodynamic thermodynamic geometry phase transition non-local observables

Lightweight,Strong and High Heat-Resistant Poly(lactide acid)Foams via Microcellular Injection Molding with Self-Assembly Nucleating Agent

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Chinese Journal of Polymer Science 2024年第6期42卷 739-750页

作者： Xiao-Hu bing wen-Yu Ma Ming-Hui wu Peng Gao Xiao Zhou Hai-bin Luo Long Wang wen-Ge Zheng School of materials Science and Engineering Shanghai UniversityShanghai200444China Ningbo Key Lab of Polymer Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(lactide acid)(PLA)foams have shown considerable promise as eco-friendly alternatives to nondegradable plastic foams,such as polystyrene(PS)***,PLA foam typically suffers from low heat-resistance and poor cellular structure stemming from its inherent slow crystallization rate and low melt *** this study,a high-performance PLA foam with well-defined cell morphology,exceptional strength and enhanced heat-resistance was successfully fabricated via a core-back microcellular injection molding(MIM)*** scanning calorimetry(DSC)results revealed that the added hydrazine-based nucleating agent(HNA)significantly increased the crystallization temperature and accelerated the crystallization process of ***,the addition of a 1.5 wt%of HNA led to a significant reduction in PLA’s cell size,from 43.5µm to 2.87µm,and a remarkable increase in cell density,from 1.08×10^(7)cells/cm^(3)to 2.15×10^(10)cells/cm^(3).This enhancement resulted in a final crystallinity of approximately 55.7%for the PLA blend foam,a marked improvement compared to the pure PLA ***,at 1.5 wt%HNA concentration,the tensile strength and tensile toughness of PLA blend foams demonstrated remarkable improvements of 136%and 463%,***,the Vicat softening temperature of PLA blend foam increased significantly to 134.8°C,whereas the pure PLA foam exhibited only about 59.7℃.These findings underscore the potential for the preparation of lightweight injection-molded PLA foam with enhanced toughness and heat-resistance,which offers a viable approach for the production of high-performance PLA foams suitable for large-scale applications.

关键词： Poly(lactide acid) Nucleating agent Microcellular injection molding Heat-resistance Toughness

New apotirucallane-type triterpenoids from Chisocheton paniculatus

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Natural Products and Bioprospecting 2012年第6期2卷 235-239页

作者： Feng ZHANG Xiu-Feng HE wen-bin wu Wan-Sheng CHEN Jian-Min YUE Department of Pharmacy Changzheng HospitalSecond Military Medical University415 Fengyang RoadShanghai 200003China State Key Laboratory of Drug Research Institute of Materia MedicaShanghai Institutes for Biological SciencesChinese Academy of Sciences555 Zuchongzhi RoadZhangjiang Hi-Tech ParkShanghai 201203China

Two new apotirucallane triterpenoids,namely chisiamols G(1)and H(2),featuring a 21,23-lactone,together with five known triterpenoids,were isolated from the twigs of Chisocheton *** structures of the new compounds were... 详细信息

关键词： Chisocheton paniculatus apotirucallane triterpenoids chisiamols G and H

Activation of the TRAAK two-pore domain potassium channels in rd1 mice protects photoreceptor cells from apoptosis

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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1243-1249页

作者： Lei Wang Kang-Pei Shi Han Li Hao Huang wen-bin wu Chu-Sheng Cai Xiao-Tong Zhang Xiao-Bo Zhu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University

AIM: To investigate the expression of TWIK-related arachidonic acid-stimulated K+ channel(TRAAK) in retinal degeneration mice(rd1) and further evaluate how TRAAK affect photoreceptor cell ***: The rd1 mice were distributed into blank(no treatment), control(1.4% DMSO, intraperitoneal injection) and riluzole groups(4 mg/kg·d, intraperitoneal injection) from postnatal 7 d to 10, 14 and 18 d;C57 group(no treatment), as age-matched wild-type control. The thickness of the outer nuclear layer(ONL) of retina was detected by paraffin section hematoxylin and eosin staining. The expression of TRAAK and the apoptosis of the ONL cells were detected by immunostaining, Western blotting, and real-time polymerase chain reaction. RESULTS: The channel agonist riluzole activated TRAAK and delayed the apoptosis of photoreceptor cells in ONL layer of rd1 mice. Both at mRNA and protein levels, after riluzole treatment, TRAAK expression was significantly upregulated, when compared with the control and blank group. Then we detected a series of apoptosis related mRNA and protein. The anti-apoptotic factor Bcl-2 downregulated and the pro-apoptotic factors Bax and cleaved-caspase-3 upregulated significantly. CONCLUSION: Riluzole elevates the expression of TRAAK and inhibits the development of apoptosis. Activation of TRAAK may have some potential effects to put off photoreceptor apoptosis.

关键词： TRAAK riluzole photoreceptor cell apoptosis

A miniaturized 2.45 GHz ECR ion source at Peking University

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Chinese Physics B 2018年第5期27卷 374-377页

作者： Jia-Mei wen Shi-Xiang Peng Hai-Tao Ren Tao Zhang Jing-Feng Zhang wen-bin wu Jiang Sun Zhi-Yu Guo Jia-Er Chen State Key Laboratory of Nuclear Physics and Technology ＆ Institute of Heavy Ion Physics School of Physics Peking University Beijing 100871 China

A miniaturized 2.45 GHz permanent magnet electron cyclotron resonance（PMECR） ion source, which has the ability of producing a tens-m A H＋beam, has been built and tested at Peking University（PKU）. Its plasma chamber dimension is Φ30 mm×40 mm and the whole size of the ion source is Φ180 mm×130 mm. This source has a unique structure with the whole source body embedded into the extraction system. It can be operated in both continuous wave（CW） mode and pulse mode. In the CW mode, more than 20 m A hydrogen ion beam at 40 k V can be obtained with the microwave power of 180 W and about 1 m A hydrogen ion beam is produced with a microwave power of 10 W. In the pulse mode, more than50 m A hydrogen ion beam with a duty factor of 10% can be extracted when the peak microwave power is 1800 W.

关键词： miniaturized ECR ion source hydrogen plasma continuous wave (CW) beam pulse beam

DLP:towards active defense against backdoor attacks with decoupled learning process

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Cybersecurity 2024年第1期7卷 122-134页

作者： Zonghao Ying bin wu State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of SciencesBeijingChina School of Cyber Security University of Chinese Academy of SciencesBeijingChina

Deep learning models are well known to be susceptible to backdoor attack,where the attacker only needs to provide a tampered dataset on which the triggers are *** trained on the dataset will passively implant the backdoor,and triggers on the input can mislead the models during *** study shows that the model shows different learning behaviors in clean and poisoned subsets during *** on this observation,we propose a general training pipeline to defend against backdoor attacks *** models can be trained from the unreli-able dataset by decoupling the learning process into three stages,i.e.,supervised learning,active unlearning,and active semi-supervised *** effectiveness of our approach has been shown in numerous experiments across various backdoor attacks and datasets.

关键词： Deep learning Backdoor attack Active defense

An improved bound on accelerated light dark matter

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 105-118页

作者： Liangliang Su Lei wu bin Zhu Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China School of Physics Yantai UniversityYantai 264005China

Light(sub-GeV)dark matter has gained increasing interest in terms of direct *** dark matter is a promising candidate that can generate detectable nuclear recoil energy within the sub-GeV *** of the large kinetic energy,its interactions with the nucleus are predominantly governed by inelastic scattering,including quasi-elastic and deep inelastic *** this work,we calculated the inelastic effects in dark matter-Earth scattering mediated by a vector *** analysis revealed that the impact of inelastic scattering relies on the mediator mass and the kinetic energy spectrum of dark *** results exhibited considerable disparity:the upper bounds of the exclusion limit for the spin-independent cross-section between accelerated dark matter and nuclei via a heavy mediator differ by several tens of times when inelastic scattering is considered.

关键词： accelerated dark matter inelastic scattering direct detection experiment

Relationship of Retinal Nerve Fiber Layer Thickness and Retinal Vessel Calibers with Cognitive Impairment in the Asymptomatic Polyvascular Abnormalities Population

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Biomedical and Environmental Sciences 2024年第2期37卷 196-203页

作者： WANG Dan Dan WANG An Xin ZHANG Xiao Li WEI wen bin wu Shou Ling ZHAO Xing Quan Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China China National Clinical Research Center for Neurological Diseases Beijing 100070China Beijing Tongren Eye Center Beijing Key Laboratory of Ophthalmology and Visual ScienceBeijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Cardiology Kailuan HospitalTangshan 063001HebeiChina

Objective Cognitive impairment(CI)in older individuals has a high morbidity rate worldwide,with poor diagnostic methods and susceptible population *** study aimed to investigate the relationship between different retinal metrics and CI in a particular population,emphasizing polyvascular *** We collected information from the Asymptomatic Polyvascular Abnormalities Community Study on retinal vessel calibers,retinal nerve fiber layer(RNFL)thickness,and cognitive function of 3,785participants,aged 40 years or *** regression was used to analyze the relationship between retinal metrics and cognitive *** stratified by different vascular statuses were also *** RNFL thickness was significantly thinner in the CI group(odds ratio:0.973,95%confidence interval:0.953–0.994).In the subgroup analysis,the difference still existed in the non-intracranial arterial stenosis,non-extracranial carotid arterial stenosis,and peripheral arterial disease subgroups(P<0.05).Conclusion A thin RNFL is associated with CI,especially in people with non-large vessel *** underlying small vessel change in RNFL and CI should be investigated in the future.

关键词： Retinal nerve fiber layer Cognitive impairment Polyvascular abnormality