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International Journal of Ophthalmology(English edition) 2019年第8期12卷 1351-1355页

作者： Lian-Yong Xie Chao Chen wen-Jun Kong Kui-Fang Du Chun-Gang Guo Hong-wei Dong wen-bin wei Beijing YouAn Hospital Capital Medical UniversityBeijing100069China Beijing Tongren Eye Center Beijing Key Laboratoryof Intraocular Tumor Diagnosis and TreatmentBeijingOphthalmology&Visual Sciences Key LabBeijing Tong RenHospitalCapital Medical UniversityBeijing100730China

The effect of intravitreal ganciclovir injection combined with intravenous infusion on acquired immune deficiency syndrome(AIDS) patients with cytomegalovirus retinitis(CMVR) was investigated. A total of 32 eyes in 23 AIDS patients diagnosed as CMVR from 2017 to 2018 were included in the retrospective study. All patients underwent induction therapy by using intravenous drip of the anticytomegalovirus(CMV) agent ganciclovir(5 mg/kg q12 h) combined with intravitreal ganciclovir injection(3 mg/time, 2 times/wk). The visual acuity, fundus photographs, lesion location, and number of intravitreal injections were observed preoperatively and postoperatively. Totally 14 eyes were cured during induction therapy. The number of injections [4.13(2 to 6)] in CMVR patients with peripherally fundus lesions were significantly lower than those with central lesions (4.89(2 to 6))The individualized therapy of intravitreal ganciclovir injections for AIDS patients with CMVR can effectively reduce the numbers of intravitreal injections.

关键词： cytomegalovirus retinitis acquired immune deficiency syndrome ganciclovir intravitreal injection monotherapy

Acute Pulmonary Embolism Caused by Local Resection of Choroidal Melanoma

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Chinese Medical Journal 2016年第6期129卷 743-745页

作者： Yao Huang wen-bin wei Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Science Key Lab Beijing 100730 China

Uveal melanoma is the most malignancy in adults, with 6-7 cases/million people.^-~j common primary ocular an annual incidence of The choroid is the most common site of involvement occurring in more than 90% *** We conducted a retrospective study for uveal melanoma at Yongren Eye Center from 1997 to 201 I. A total of 682 cases of uveal melanoma were recorded. Among them, 176 （25.8%） cases received local resection surgery. Most of them survived after surgery and had good recovery. However, life-threatening complication of acute pulmonary embolism （APE） occurred in 3 choroidal melanoma patients shortly after surgery. Till now, to the best of our knowledge, there are few reports of severe postsurgical complications of choroidal melanoma.

关键词： Acute Pulmonary Embolism Choroidal Melanoma Controlled Hypotension Local Resection

Adenocarcinoma of the nonpigmented ciliary epithelium manifested as an anterior chamber mass

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 485-487页

作者： Hai-Xia Bai wen-bin wei bin Li Xiao-Lin Xu wen-Li Yang Fei Gao Zhi-Bao Zhang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology & Visual Sciences Key Laboratory Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University

Dear Editor,Adenocarcinoma of the nonpigmented ciliary epithelium（NPCE）is a rare malignant tumor which is not easy to be found in the early stage（[1]）.Herein,we report a case of adenocarcinoma of the NPCE in a Chi... 详细信息

关键词： epithelium chamber adenocarcinoma moderately Figure neoplasm papillary fundus malignancy bilateral

Application of optical coherence tomography angiography in assessment of posterior scleral reinforcement for pathologic myopia

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1761-1765页

作者： Jing Mo An-Li Duan Szy-Yann Chan Xue-Fei Wang wen-bin wei Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing 100730 China Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing 100730 China

AIM： To investigate the effect of posterior scleral reinforcement （PSR） on circulation of pathologic myopia eyes with posterior staphyloma by optical coherence tomography angiography （OCTA）.METHODS： The study included 30 pathologic myopia eyes with posterior staphyloma which underwent PSR （PSR group） for 6 to 18mo ago, and 30 age and myopia matched eyes without PSR surgery as control group. Macular, choriocapillaris and radial peripapillary capillary （RPC） flow density were measured by OCTA, and the measurements were compared between groups. RESULTS： OCTA found no significant differences in macular flow density between PSR and control groups. For the superficial flow, whole enface flow density （WED）, fovea density （FD）, and parafoveal density （PD） were 46.55%±5.19% vs 47.29%±4.12% （P=0.542）, 31.45%±6.35% vs 31.17%±4.48% （P=0.841）, and 48.82%±5.66% vs 49.21%±4.15% （P=0.756） in PSR and control groups, respectively. For the deep flow, WED, FD, and PD were 52.07%±5.78% vs 53.95%±4.62% （P=0.168）, 29.62%±6.55% vs 29.50%±6.38% （P=0.940）, and 56.93%±6.17% vs 58.15%±5.13% （P=0.407） in PSR and control groups, respectively. The choriocapillary flow density was 61.18±3.25% in PSR group vs 60.88%±2.56% in control group （P=0.692）. Also, OCTA found no significant differences in RPCs flow density between PSR and control groups. The optic disc WED, inside disc flow density and peripapillary flow density were 48.47%±4.77% vs 48.11%±4.57% （P=0.813）, 45.47%±11.44% vs 46.68%±9.02% （P=0.709）, 54.32%±5.29% vs 52.47%±6.62% （P=0.349） in PSR and control groups, ***： OCTA provides a non-invasive and quantitative approach for monitoring macular and papillary blood flow in pathologic myopia. PSR can not improve but may maintain the circulation of pathologic myopia eyes with posterior staphyloma.

关键词： optical coherence tomography angiography posterior scleral reinforcement pathologic myopia

Comparative analysis of cytomegalovirus retinitis and microvascular retinopathy in patients with acquired immunodeficiency syndrome

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1396-1401页

作者： Chao Chen Chun-Gang Guo Li Meng Jing Yu Lian-Yong Xie Hong-wei Dong wen-bin wei Beijing You An Hospital Capital Medical UniversityBeijing 100069China Beijing Tongren Eye Center Beijing Key Laboratoryof Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology and Visual Sciences Key LabBeijing TongrenHospitalCapital Medical UniversityBeijing 100730China Xi'an Aier Ancient City Eye Hospital Xi'an 710021Shaanxi ProvinceChina

AIM：To compare the clinical manifestation of cytomegalovirus（CMV）retinitis and microvascular retinopathy（MVR）in patients with acquired immunodeficiency syndrome（AIDS）in ***：A total of 93 consecutive patients with AIDS,including 41 cases of CMV retinitis and 52 cases of MVR were retrospectively *** active antiretroviral therapy（HAART）status was *** and CMV immunoassay were also ***4＋T-lymphocyte count and blood CMV-DNA test were performed in all *** humor CMV-DNA test was completed in *** examinations including best corrected visual acuity（BCVA,by International Standard Vision Chart）,intraocular pressure（IOP）,slit-lamp biomicroscopy,indirect ophthalmoscopy were ***：In MVR group,the anterior segment examination was normal in all patients with a mean BCVA of 0.93±*** CMV-DNA was 0（0,269 000）and 42 patients（80.77%）did not receive *** CMV retinitis group,13 patients（31.71%）had anterior segment *** mean BCVA was 0.64±0.35 and blood CMV-DNA was 3470（0,1 450 000）.Nineteen patients（46.34%）had not received *** group and CMV retinitis group the positive rates of aqueous CMV-DNA were 0 and 50%,*** patients with MVR progressed to CMV retinitis during the follow-up ***：In comparison of CMV,patients with MVR have relatively mild visual function *** ophthalmological examination and close follow-up are mandatory,especially for patients who have systemic complications,positive CMV-DNA test and without received HAART.

关键词： acquired immunodeficiency syndrome cytomegalovirus retinitis microvascular retinopathy CD4+ T-lymphocyte CMV-DNA highly active antiretroviral therapy

Immune oppression array elucidating immune escape and survival mechanisms in uveal melanoma

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1701-1712页

作者： Fang Hou Qi-Ming Huang Dan-Ning Hu Jost B.Jonas wen-bin wei Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science Key Lab Departments of Ophthalmology and Pathology New York Eye and Ear Infirmary of Mount Sinai Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University

AIM： To examine the genetic profile of primary uveal melanoma （UM） as compared to UM in immune ***： Dendritic cells （DC） loaded with lysates of UM cells of high metastatic potential were used to stimulate CTLs（CTLs）. When CTLs co-cultured with the UM cells, most UM cells could be eliminated. Survival UM cells grew slowly and were considered to be survival variants and examined by a microarray analysis. These differential genes were analyzed further with Venn Diagrams and functions related to immune escape. We additionally examined transcriptional changes of manually selected survival variants of UM cells and of clinical UM samples by quantitative real-time polymerase chain reaction （qRT-PCR）, and analyzed the correlation of these expressions and patients’ ***： Gene expression analyses revealed a marked up-regulation of SLAMF7 and CCL22 and a significant down-regulation of KRT10, FXYD3 and ABCC2. The expression of these genes in the relapsed UM was significantly greater than those in primary UM. UM patients with overexpression of these genes had a shorter survival period as compared with those of their ***： Gene expression, in particular of SLAMF7, CCL22, KRT10, FXYD3 and ABCC2, differed between primary UM cells and survival variants of UM cells.

关键词： uveal melanoma dendritic cells immuneescape gene expression profile b"~2

Combined photodynamic therapy and ranibizumab for polypoidal choroidal vasculopathy：a 2-year result and systematic review

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 413-422页

作者： Meng Zhao Hai-Ying Zhou Jun Xu Feng Zhang wen-bin wei Ning-Pu Liu Beijing Tongren Eye Center Beijing Tongren HospitalCapita Medical UniversityBeijing Ophthalmology and Visua Sciences Key Laboratory

AIM：To report a cohort of patients with polypoidal choroidal vasculopathy（PCV）treated with photodynamic therapy（PDT）followed by intravitreal ranibizumab injection 24-48 h later,and to compare the results between eyes with PCV treated by PDT followed by intravitreal anti-vascular endothelial growth factor（VEGF）injection and intravitreal anti-VEGF injection followed by PDT by ***：Retrospective study and systematic literature review. Medical records of patients with PCV who were initially treated using PDT followed by intravitreal ranibizumab injection 24-48 h after PDT and had completed at least 2y follow-up were reviewed and analyzed. Clinical data,including age,sex,best-corrected visual acuity（BCVA）,fundus photograph,fluorescein angiography,indocyanine green angiography and optical coherence tomography were investigated. A systematic literature review was also conducted,and a visual outcome of studies over 1y was compared using Meta-analysis. RESULTS：A total of 52 patients were included in the study. Mean BCVA at baseline and follow-up at 1 or 2y were 0.71± 0.61,0.51±0.36 and 0.68±0.51 log MAR,respectively. The cumulative hazard rate for recurrence at 1 and 2y followup was 15.4% and 30.3% respectively. The percentage of eyes with polyps regression at 3,12 and 24 mo follow-up was 88.5%,84.6% and 67.3% respectively. A Meta-analysis based on 22 independent studies showed the overall vision improvements at 1,2 and 3y follow-up were 0.13±0.04（P〈0.001）,0.12±0.03（P〈0.001）,0.16±0.06（P〈0.001）,respectively. The proportion of polyps regression at 1y follow-up was 64.6%（95%CI：51.5%,77.7%,P〈0.001）in 434 eyes treated by intravitreal anti-VEGF agents beforePDT and 76.0%（95%CI：64.8%,87.3%,P=0.001）in 199 eyes treated by intravitreal anti-VEGF agents after PDT. CONCLUSION：Intravitreal ranibizumab injection 24-48 h following PDT effectively stabilizes visual acuity in the eye with PCV. PDT followed by intravitreal anti-VEGF agents may contribute to a relatively highe

关键词： polypoidal choroidal vasculopathy photodynamic therapy intravitreal ranibizumab injection Metaanalysis

A 10-year fight for vision in a patient with recurrent uveal melanoma:a case report

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International Journal of Ophthalmology(English edition) 2023年第10期16卷 1718-1720页

作者： Heng Wang Jing-Ting Luo Yang-Xu Tao Yang Li wen-bin wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Dear Editor,Uveal melanoma(UM)is the most common primary intraocular malignancy in adults[1].We are writing to present a case of recurrent *** case presents an important clinical challenge:vision preservation in patients with recurrent anterior UM,especially in young *** consent was obtained from the *** case study adhered to the tenets of the Declaration of Helsinki and was approved by the Institutional Review Board of Beijing Tongren Hospital(approval number:TRECKY2018-056).

关键词： melanoma patient clinical

Retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal miners in northern China:a community-based observational study

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 135-140页

作者： Jing-Yan Yang wen-Jia Zhou Qian Wang Yang Li Yan-Ni Yan Ya-Xing Wang Shou-Ling Wu wen-bin wei Beijing Tongren Eye Center Beijing Tongren HospitalBeijing Ophthalmology and Visual Science Key LabBeijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China Cardiology Department Kailuan General HospitalTangshan 063000Hebei ProvinceChina

AIM:To evaluate retinal nerve fiber layer thickness and retinal vascular caliber alterations in coal mine ***:The community-based observational crosssectional study included 4004 participants of a subpopulation of the Kailuan *** the study participants underwent structured interviews with a standardized questionnaire,fundus photography and spectral-domain optical coherence tomography(OCT)examinations performed by trained ***:The retinal nerve fiber layer thickness was significantly higher(P=0.006)and the central macular thickness was lower in coal miners(n=659,51.0±7.8 y)as compared to the control(working above the ground;n=477,51.8±7.5 y;P=0.032).Additionally,the downhole workers showed a significantly thicker retinal artery(P=0.012)and vein diameters(P<0.001).In multivariable regression,a thicker retinal nerve fiber layer was associated with a higher cumulative silica dust exposure(P=0.005)after adjusting for younger age and larger spherical *** a reverse pattern,a higher cumulative silica dust exposure(P=0.004)was significantly associated with a thicker retinal nerve fiber layer after adjusting for age,high-density lipoproteins and uric *** retinal vein diameters were associated with higher cumulative silica dust exposure(P=0.036)after adjusting for younger age and larger spherical ***:The retinal vessels diameters and retinal nerve fiber layer thickness are significantly thicker in long term of coal *** results of our study indicate that underground working environment may lead to retinal vessel dilation and ***,ocular examination might be needed within coal miners in order to monitor the occupational eye health as well as the incidence and progression of eye diseases.

关键词： retinal vessels diameter retinal nerve fiber layer thickness cumulative silica dust exposure

XbaⅠpolymorphisms of apolipoprotein B gene:Another risk factor of gallstone formation after radical gastrectomy

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World Journal of Gastroenterology 2010年第20期16卷 2549-2553页

作者： Feng-Lin Liu,wen-bin Lu,wei-Xin Niu,Department of General Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China Department of General Surgery Zhongshan Hospital Fudan University #180 Fenglin Road Shanghai 200032 China.

AIM:To prospectively investigate the association between the XbaⅠpolymorphisms of apolipoprotein B (APOB)gene and gallstone formation following ***:The study was conducted between January 2005 and December 2006.A total of 186 gastric cancer patients who had undergone radical gastrectomy were grouped according to XbaⅠpolymorphisms of APOB gene(X+X-group,n=24 and X-X-group,n =162)and *** XbaⅠpolymorphisms of APOB gene were detected by polymerase chain reaction-restriction fragment length polymorphism(PCRRFLP).RESULTS:The incidence of gallstone was significantly higher in the X + X-group than in the X-X-group[54.2% vs 9.3%,RR=5.85(2.23-15.32),P<0.001].The serum levels of total cholesterol(TC)and low-density lipoprotein(LDL)were higher in the X + X-than in the X-X-group(4.02±1.12 vs 3.48±0.88,P=0.004 before surgery and 3.88±1.09 vs 3.40±0.86,P=0.008 after surgery).LDL was 2.21±0.96 vs 1.89±0.84(P =0.042)before surgery and 2.09±0.95 vs 1.72±0.85 (P=0.029)after surgery in the two *** relationship was found between XbaⅠpolymorphisms and gallbladder ***:In Chinese patients after radical gastrectomy,X + allele of APOB gene is another risk factor for the development of gallstone besides the gallbladder motility disorder after surgery.

关键词： Gastric cancer Gastrectomy Gallstone Apolipoprotein B gene Polymorphism