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Evaluating the role of large language models in inflammatory bowel disease patient information

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World Journal of Gastroenterology 2024年第29期30卷 3538-3540页

作者： Eun Jeong gong Chang Seok bang Department of Internal Medicine Hallym University College of MedicineChuncheon 24253Gangwon-doSouth Korea

This letter evaluates the article by Gravina et al on ChatGPT’s potential in providing medical information for inflammatory bowel disease *** promising,it highlights the need for advanced techniques like reasoning+action and retrieval-augmented generation to improve accuracy and *** that simple question and answer testing is insufficient,it calls for more nuanced evaluation methods to truly gauge large language models’capabilities in clinical applications.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Chat generative pre-trained transformer Large language model Artificial intelligence

On the improved dynamics approach in loop quantum black holes

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Communications in Theoretical Physics 2024年第3期76卷 138-143页

作者： Hongchao Zhang wen-Cong Gan Yungui gong Anzhong Wang Institute for Theoretical Physics&Cosmology Zhejiang University of TechnologyHangzhou310023China United Center for Gravitational Wave Physics(UCGWP) Zhejiang University of TechnologyHangzhou310023China College of Physics and Communication Electronics Jiangxi Normal UniversityNanchang 330022China GCAP-CASPER Physics DepartmentBaylor UniversityWacoTX 76798-7316United States of America School of Physics Huazhong University of Science and TechnologyWuhanHubei 430074China Department of Physics School of Physical Science and TechnologyNingbo UniversityNingboZhejiang 315211China

In this paper,we consider the B?hmer–Vandersloot(BV)model of loop quantum black holes obtained from the improved dynamics *** adopt the Saini–Singh gauge,in which it was found analytically that the BV spacetime is geodesically *** show that black/white hole horizons do not exist in this geodesically complete ***,there exists only an infinite number of transition surfaces,which always separate trapped regions from anti-trapped *** on the improved dynamics approach adopted in other models of loop quantum black holes are also given.

关键词： loop quantum gravity black hole dynamics approach

Study of the blocking mechanism in gravel packing based on CFD-DEM

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Particuology 2024年第7期90卷 164-178页

作者： Fucheng Deng Lei wen Gang Li Baitao Fan Ning gong Shenghong Chen Yangtze University Jingzhou434023China Guangzhou Institute of Energy Conversion Chinese Academy of Sciences510640China CNOOC Research Institute Ltd Beijing100028China Tianjin Branch of CNOOC Ltd Tianjin300459China CNOOC Ener Tech-Drilling&Production Co Tianjin300457China

Gravel packing sand control(GPSC),as the optimization of mechanical sand control technology,is widely used in the deep water completion and sand control of loose sandstone heavy oil reservoirs and highly *** explore the blocking mechanism of GPSC,the influence of its structural parameters on the blocking of GPSC is *** paper establishes a particle element model based on computational fluid dynamics-discrete element method coupling using the discrete element method and establishes a fluid flow model combined with computational fluid dynamics to realize their full coupling *** sand control experiments were carried out using a micro visual sand control simulation device to verify the blocking *** blocking mechanism is analyzed from the microscopic point of view,and then,the influence of sand control structure parameters on the blocking in GPSC design is *** results show the following:(1)the blocking process of GPSC can be divided into three stages:an initial stage,sand accumulation stage,and equilibrium stage.(2)There are two main types of gravel packing *** first type of blocking is blocking on the surface of the gravel *** particles on the surface of gravel layer mainly exist in the form of large particle size blocking gravel pores and sand particles bridging each *** second type of blockage is the blockage inside the gravel *** particles mainly exist in the form of internal mud cakes and adsorption on gravels inside the gravel layer.(3)To ensure the sand control performance of the gravel layer,the gravel layer thickness is designed between 23 and 28 *** displacement or pressure of the on-site packing pump should be increased to ensure that the gravel layer packing solidity ranges between 59%and 62%.In the design of GPSC,it should be ensured that the median particle size of gravel is 5–6 times the median particle size of *** study provides an effective technical reference for the

关键词： CFD-DEM Blocking the process Blocking mechanism Structural parameter

Emergent symmetry in quantum phase transition:From deconfined quantum critical point to gapless quantum spin liquid

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Science Bulletin 2024年第2期69卷 190-196页

作者： wen-Yuan Liu Shou-Shu gong Wei-Qiang Chen Zheng-Cheng Gu Department of Physics The Chinese University of Hong KongHong KongChina Division of Chemistry and Chemical Engineering California Institute of TechnologyPasadena CA 91125USA School of Physical Sciences Great Bay UniversityDongguan 523000China Great Bay Institute for Advanced Study Dongguan 523000China Department of Physics and Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The emergence of exotic quantum phenomena in frustrated magnets is rapidly driving the development of quantum many-body physics,raising fundamental questions on the nature of quantum phase *** we unveil the behaviour of emergent symmetry involving two extraordinarily representative phenomena,i.e.,the deconfined quantum critical point(DQCP)and the quantum spin liquid(QSL)*** large-scale tensor network simulations,we study a spatially anisotropic spin-1/2 square-lattice frustrated antiferromagnetic(AFM)model,namely the J1x-J1y-J2 model,which contains anisotropic nearestneighbor couplings J1x,J1y and the next nearest neighbor coupling *** small J1y/J1x,by tuning J2,a direct continuous transition between the AFM and valence bond solid phase is *** growing J1y/J1x,a gapless QSL phase gradually emerges between the AFM and VBS *** observe an emergent O(4)symmetry along the AFM–VBS transition line,which is consistent with the prediction of DQCP *** surprisingly,we find that such an emergent O(4)symmetry holds for the whole QSL–VBS transition line as *** findings reveal the intrinsic relationship between the QSL and DQCP from categorical symmetry point of view,and strongly constrain the quantum field theory description of the QSL *** phase diagram and critical exponents presented in this paper are of direct relevance to future experiments on frustrated magnets and cold atom systems.

关键词： Tensor network Quantum phase transition Emergent symmetry Quantum spin liquid Deconfined quantum critical point Anisotropic

The combined detection of carcinoembryonic antigen,carcinogenic antigen 125,and carcinogenic antigen 19-9 in colorectal cancer patients

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2073-2079页

作者： Ling-Zhen gong Qian-wen Wang Jie-wen Zhu Department of Clinical Laboratory Huangshi Central Hospital(Affiliated Hospital of Hubei Polytechnic University)Hubei Key Laboratory of Kidney Disease Pathogenesis and InterventionHuangshi Tumor Molecular Diagnosis and Treatment Key LaboratoryHuangshi 435000Hubei ProvinceChina

BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)*** predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metastasis is *** To evaluate predictive value of combined tests for CEA,CA125,and CA19-9 levels in patients with liver metastases of *** The retrospective study included patients with CRC alone(50 cases)and patients with CRC combined with liver metastases(50 cases)who were hospitalized between January 2021 and January *** CEA,CA125 and CA19-9 levels were compared between the two groups,and binary logistic regression was used to analyze the predictive value of the combination of these tumor markers in liver *** addition,we performed receiver operating characteristic(ROC)curve analysis to assess its diagnostic *** The results showed that the serum CEA,CA125 and CA19-9 levels in the CRC with liver metastasis group were significantly higher than those in the CRC alone ***,the average serum CEA level in the CRC with liver metastasis group was 162.03±810.01 ng/mL,while that in the CRC alone group was 5.71±9.76 ng/mL;the average serum CA125 levels were 43.47±83.52 U/mL *** 13.5±19.68 U/mL;the average serum CA19-9 levels were 184.46±473.13 U/mL and 26.55±43.96 U/mL *** addition,binary logistic regression analysis showed that CA125 was significant in predicting CRC liver metastasis(P<0.05).ROC curve analysis results showed that the areas under the ROC curves of CEA,CA125 and CA19-9 were 0.607,0.692 and *** These results suggest that combined detection of these tumor markers may help early detection and intervention of CRC liver metastasis,thereby improving patient prognosis.

关键词： Colorectal cancer Liver metastasis Serum markers Carcinoembryonic antigen Cancer antigen 125 Cancer antigen 19-9 Receiver operating characteristic analysis

Clinical significance of peripheral blood immune cells in patients with gastric cancer after surgery

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2521-2527页

作者： Qian-wen Wang Jie-wen Zhu Ling-Zhen gong Department of Clinical Laboratory Huangshi Central Hospital(Affiliated Hospital of Hubei Polytechnic University)Huangshi 435000Hubei ProvinceChina Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention Huangshi 435000Hubei ProvinceChina Huangshi Tumor Molecular Diagnosis and Treatment Key Laboratory Huangshi 435000Hubei ProvinceChina

BACKGROUND Gastric cancer is one of the most common malignant tumors worldwide,and surgical resection is one of the main ways to treat gastric ***,the immune status of postoperative patients is crucial for prognosis and survival,and immune cells play an important role in this ***,it is helpful to understand the immune status of postoperative patients by evaluating the levels of peripheral blood immune cells,especially total T cells(CD3+),helper T cells(CD3+CD4+),and suppressor T cells(CD3+CD8+),and its relationship to *** To analyzed the immune cells in peripheral blood of patients with gastric cancer after surgery,detect the levels of total T cells,helper T cells and suppressor T *** A total of 58 patients with gastric cancer who received surgical treatment were included in the retrospective *** cytometry was used to detect the level of peripheral blood immune cells and analyze the correlation between total T cells,helper T cells and inhibitory T *** explore the relationship between these immune markers and patient *** The results showed that the levels of total T cells,helper T cells,and suppressor T cells changed in patients after gastric cancer *** was a significant positive correlation between total T cells,helper T cells and suppressor T cells(r=0.35,P<0.01;r=0.56,P<0.01).However,there was a negative correlation between helper T cells and suppressor T cells(r=-0.63,P<0.01).Follow-up showed that the survival rate of patients in the high-level total T cell group was significantly higher than that in the low-level group(28.87±24.98 months vs 18.42±16.21 months).The survival curve shows that the curve of patients in the high-level group is shifted to the upper right,and that of the low-level group is shifted *** was no significant difference between the levels of helper T cells and suppressor T cells and patient survival *** By detecting peripheral blood immune c

关键词： Gastric cancer surgery Peripheral blood immune cells Flow cytometry Survival analysis Immune monitoring

Programming molecular switches in water and ethanol via thermo-sensitive polymers for phase control in energetic crystals

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Defence Technology（防务技术） 2024年第8期38卷 75-88页

作者： Xinru Yang Yushi wen Congmei Lin Feiyan gong Zhijian Yang Fude Nie Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China

The practical application of energetic materials, particularly 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20), is frequently impeded by phase transition challenges. In this study, we propose a novel strategy to enhance the stability of CL-20 by employing a thermo-sensitive polymer,poly(N-isopropylacrylamide)(PNIPAM), to modulate its phase transitions. Our approach involves the use of an in-situ polymerized polydopamine(PDA) shell as a platform for surface grafting through atom transfer radical polymerization, yielding a core-shell structured CL-20@PDA-PNIPAM. Through comprehensive characterization, the successful grafting of PNIPAM is confirmed, significantly enhanced the phase stability of CL-20. Notably, our core-shell structure exhibits a 13℃ increase in phase transition temperature compared to raw CL-20, thereby delaying the ε→a phase transition by over 80 min under combined thermal and solvent conditions. The enhanced stability is attributed to the hydrophobic nature of PNIPAM above its low critical solution temperature in water, which effectively shields the CL-20 crystal. These findings provide new insights into enhancing the stability and safety of energetic materials in complex environments, highlighting the potential of our molecular switch mechanism.

关键词： 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane(CL-20) Phase stability Polydopamine(PDA) Poly-N-Isopropylacrylamide(PNIPAM) Thermal and solvent effects

The role of the auxin-response genes MdGH3.1 and MdSAUR36 in bitter pit formation in apple

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Horticultural Plant Journal 2024年第5期10卷 1085-1098页

作者： Daqing Huang wen Peng Na gong Lina Qiu Yongzhang Wang Haiyong Qu College of Horticulture Qingdao Agricultural UniversityQingdaoShandong 266109China

Apples often exhibit bitter pits in response to metabolic disorders during ripening and storage;however,the mechanisms underlying the bitter pit(BP)development remain ***,metabolome and transcriptome analyses were performed to investigate BP pulp of‘Fuji’.Two auxin-response genes,MdGH3.1 and MdSAUR36,were *** expression as well as the auxin content in BP pulp were found to be higher than those in healthy pulp(P<0.01).In the field,excess CO(NH2)2 increased the incidence of ***,the auxin content and MdGH3.1 expression increased in apples after nitrogen *** Day 30 before harvest,the two genes were transiently transferred to the fruit,and 20.69%and 23.21%of BP fruits were *** 10 mmol$L1 auxin was infiltrated at low pressure into postharvest fruit,the increase in MdGH3.1 expression occurred earlier than that in ***3.1 increased the expression of MdSAUR36,but MdSAUR36 did not increase expression of ***,we suggest that MdGH3.1 acts upstream of MdSAUR36 during BP formation and that these genes induce BP formation by regulating auxin and phenylpropanoid biosynthesis.

关键词： Apple Malusdomestica Auxin Bitter pit Flavonoids Nitrogen fertilizer Widely targeted metabolomics

Nonexistence of quantum black and white hole horizons in an improved dynamic approach

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 56-73页

作者： wen-Cong Gan Xiao-Mei Kuang Zhen-Hao Yang Yungui gong Anzhong Wang Bin Wang College of Physics and Communication Electronics Jiangxi Normal UniversityNanchang 330022China GCAP-CASPER Physics DepartmentBaylor UniversityWaco 76798-7316USA Institute for Theoretical Physics&Cosmology Zhejiang University of TechnologyHangzhou 310023China United Center for Gravitational Wave Physics(UCGWP) Zhejiang University of TechnologyHangzhou 310023China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Department of Physics School of Physical Science and TechnologyNingbo UniversityNingbo 315211China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

In this paper,we study the quantum geometric effects near the locations where classical black hole horizons used to appear in Einstein's classical theory,within the framework of an improved dynamic approach,in which the internal region of a black hole is modeled by the Kantowski-Sachs(KS)spacetime and the two polymerization parameters are functions of the phase space *** detailed analysis shows that the effects are so strong that black and white hole horizons of the effective quantum theory do not exist at all and instead are replaced by transition surfaces,across which the metric coefficients and their inverses are smooth and remain finite,as are the corresponding curvatures,including the Kretschmann *** surfaces always separate trapped regions from anti-trapped *** number of such surfaces is infinite,so the corresponding KS spacetimes become geodesically complete,and no black and white hole-like structures exist in this scheme.

关键词： canonical quantization loop quantum gravity quantum aspects of black holes

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