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Testosterone is negatively associated with the severity of coronary atherosclerosis in men

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Asian Journal of Andrology 2012年第6期14卷 875-878页

作者： Li Li Chang-Yan Guo En-Zhi Jia Tie-Bing zhu Lian-Sheng Wang Ke-Jiang Cao wen-zhu ma Zhi-Jian Yang Department of Cardiovascular Medicine First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

This study aimed to determine whether plasma testosterone is associated with the severity of coronary atherosclerosis in a group of 803 men who underwent elective coronary angiography. Testosterone levels were measured in 803 male patients who were categorized into three groups according to testosterone level tertiles. All patients underwent elective coronary angiography, and the severity of coronary artery disease （CAD） was determined by the Gensini score. Moreover, patients were classified into two groups according to Gensini scores （score ≤ 26 and score 〉26） using the median values as cutoff points. The plasma testosterone levels were measured by an ELISA kit. The level of testosterone was negatively associated with the Gensini score （r=-0. 188; P=0.000）. A multiple linear regression analysis revealed that testosterone was an independent risk factor for the Gensini score （β=-0,110; P=0.002） after adjusting for confounding covariates. In a multivariate logistic regression model, the severity of CAD was shown to be significantly lower in the third tertile （highest） of testosterone compared to the first tertile （lowest） of testosterone （odds ratio （0R）=0.465; 95% confidence interval （C1）. 0.327-0.662; P=0.000）. In this study, patients with lower testosterone levels had higher Gensini scores in a group of 803 men who underwent elective coronary angiography. Additional studies are needed to clarify the direction of causality and possible underlying mechanisms.

关键词： coronary artery disease (CAD) Gensini score testosterone

A review of recent advances in the effects of surface and interface properties on marine propellers

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Friction 2024年第2期12卷 185-214页

作者： manfu zhu Liran ma State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

marine propellers are important propulsion devices for both surface ships and underwater *** severe environmental problems have required further performance enhancement for ***,traditional methods to improve propeller performances through geometrical and structural optimizations have been extensively investigated,while the underlying mechanisms of the effects of surface and interface properties on marine propellers are still far from being fully *** paper presented a comprehensive review of recent advances in the effects of surface and interface properties,such as surface roughness and surface wettability,on marine propellers with an emphasis on the significant improvements in both hydrodynamic and cavitation performances,hoping to arouse more in-depth investigations in the field of surface/interface science and technologies on marine propellers,and also promote the state-of-the-art technologies,such as superlubricity technology,into practical applications.

关键词： marine propellers hydrodynamics cavitation surface roughness surface wettability

A combined Liouville integrable hierarchy associated with a fourth-order matrix spectral problem

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Communications in Theoretical Physics 2024年第7期76卷 1-8页

作者： wen-Xiu ma Department of mathematics Zhejiang Normal UniversityJinhua 321004China Department of mathematics King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of mathematics and Statistics University of South Florida TampaFL 33620-5700United States of America material Science Innovation and Modelling Department of Mathematical SciencesNorth-West UniversityMafikeng CampusMmabatho 2735South Africa

This paper aims to propose a fourth-order matrix spectral problem involving four potentials and generate an associated Liouville integrable hierarchy via the zero curvature formulation.A bi-Hamiltonian formulation is furnished by applying the trace identity and a recursion operator is explicitly worked out,which exhibits the Liouville integrability of each model in the resulting *** specific examples,consisting of novel generalized combined nonlinear Schrodinger equations and modified Korteweg-de Vries equations,are given.

关键词： integrable hierarchy Hamiltonian structure zero curvature equation Lax pair matrix spectral problem

Gradient sparsification for efficient wireless federated learning with differential privacy

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Science China(Information Sciences) 2024年第4期67卷 272-288页

作者： Kang WEI Jun LI Chuan ma Ming DING Feng SHU Haitao ZHAO wen CHEN Hongbo zhu School of Electronic and Optical Engineering Nanjing University of Science and Technology Zhejiang Lab Key Laboratory of Computer Network and Information Integration(Southeast University) Ministry of Education Data61 Commonwealth Scientific and Industrial Research Organisation School of Information and Communication Engineering Hainan University School of Communications and Information Engineering Nanjing University of Posts and Telecommunications School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University

Federated learning(FL) enables distributed clients to collaboratively train a machine learning model without sharing raw data with each other. However, it suffers from the leakage of private information from uploading models. In addition, as the model size grows, the training latency increases due to the limited transmission bandwidth and model performance degradation while using differential privacy(DP)protection. In this paper, we propose a gradient sparsification empowered FL framework with DP over wireless channels, to improve training efficiency without sacrificing convergence performance. Specifically, we first design a random sparsification algorithm to retain a fraction of the gradient elements in each client’s local model, thereby mitigating the performance degradation induced by DP and reducing the number of transmission parameters over wireless channels. Then, we analyze the convergence bound of the proposed algorithm, by modeling a non-convex FL problem. Next, we formulate a time-sequential stochastic optimization problem for minimizing the developed convergence bound, under the constraints of transmit power, the average transmitting delay, as well as the client’s DP requirement. Utilizing the Lyapunov drift-plus-penalty framework, we develop an analytical solution to the optimization problem. Extensive experiments have been implemented on three real-life datasets to demonstrate the effectiveness of our proposed algorithm. We show that our proposed algorithms can fully exploit the interworking between communication and computation to outperform the baselines, i.e., random scheduling, round robin, and delay-minimization algorithms.

关键词： federated learning differential privacy gradient sparsification Lyapunov drift convergence analysis

Measuring Financial Systemic Risk:Net Liability Clearing Mechanism and Contagion Effect

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Journal of Systems Science & Complexity 2024年第3期37卷 1114-1146页

作者： ma Jiali zhu Shushang LI Duan College of Big Data Statistics Guizhou University of Finance and EconomicsGuiyang 550025China School of Business Sun Yat-Sen UniversityGuangzhou 510275China School of Data Science City University of Hong KongHong Kong 999077China

Following the framework of E-N model(Eisenberg and Noe,2001),the authors consider a new clearing mechanism based on net liabilities among financial institutions since the liabilities between the counterparties should be deducted accordingly when clearing in *** the basis for systemic risk measurement,similar to the original E-N model,the authors first establish some good properties for the clearing payment vector according to a more general ***,the authors investigate how risk spreads among institutions through the liability network forming the risk contagion ***,the authors illustrate with a specific example that the original E-N clearing mechanism may misidentify the systemic important institutions,and theoretically show that it may also overestimate the risk compared with the netting clearing mechanism.

关键词： Clearing mechanism contagion net liability network systemic risk

Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： ZHONG Yi LI Xin-yue LIANG Tian-jun DING Bao-zhu ma Ke-xin REN wen-xuan LIANG wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and *** RNAs(nc RNAs)are important regulatory *** Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting *** mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator *** NLRP3 protein is an important regulatory target for CVD prevention and treatment with *** the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms

CdS/LaFeO_(3) heterojunctions with improved optical properties for visible-light catalytic applications

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Journal of Rare Earths 2024年第5期42卷 879-888,I0003页

作者： Jiaqi Wei wen zhu Xuelian Xu Xiao Xu Junjiang zhu Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile University ChemistryWuhan430200China

Construction of heterojunctions is a normal and effective strategy to improve the photocatalytic performances of semiconductors,through which both the lifetime and the redox ability of electrons/holes can be improved,as co mpared to the respective *** this basis,we constructed Z-scheme CdS/LaFeO_(3) heterojunctions(CdS/LFO),by in-situ growing different amounts of CdS on the surface of LaFeO_(3),for photocatalytic degradation of tetracycline hydrochloride(TC)in aqueous solution at room *** crystal structure,surface morphology and optoelectronic properties of the COS/LFO heterojunctions were systemically characterized to correlate the reaction *** tests indicate that the CdS/LFO heterojunctions exhibit promising activity for TC degradation under visible light irradiation(λ≥420 nm),with 85%TC conversion obtained at reaction time of 45 min,which is 3.4 and 1.9 times higher than that of CdS and LaFeO_(3).The CdS/LFO heterojunctions are also stable in the reaction and can be reused for four cycles with no appreciable activity *** applicability of CdS/LFO to photocatalytic degradation of organic dyes,as well as the reaction mechanism,was also explored.

关键词： LaFeO_(3) CdS Photocatalytic degradation Tetracycline hydrochloride Reaction mechanism Rare earths

Level of proinsulin in association with cardiovascular risk factors and sleep snoring

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World Journal of Gastroenterology 2005年第32期11卷 5047-5052页

作者： En-Zhi Jia Zhi-Jian Yang Shi-Wei Chen Guang-Yao Qi Chun-Fa You Jian-Feng ma Jing-Xin Zhang Zhen-Zhen Wang Wei-Chong Qian Hai-Yan Wang wen-zhu ma Department of Cardiovascular Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China The Disease Control Center of Pizhou City Pizhou 221300 Jiangsu Province China Department of Central Clinical Laboratory The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Nuclear Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM: To explore the relationship between the level of proinsulin with cardiovascular risk factors and sleep ***: Based on the random stratified sampling principle, 1 193 Chinese residents in Pizhou City, Jiangsu Province (530 males and 663 females, aged 35-59 years with an average age of 46.69 years) were recruited. Their sleep snoring habits were investigated. Biotin-avidin based double mabs ELISA was used to detect specific insulin and proinsulin, and a risk factor score was established to evaluate the individuals according to the number of their risk ***: The results of Spearman correlation analysis and covariate ANOVA analysis after age and sex were controlled, indicated that not only the level of proinsulin (r = 0.156, P = 0.000, F= 5.980 P = 0.000), but also cardiovascular risk factors score (r = 0.194, P = 0.000,F= 11.135, P = 0.000) significantly associated with the frequency of sleep snoring, and the significant relationship between true insulin and frequency of sleep snoring was only shown in the covariate ANOVA analysis (F = 2.868,P = 0.022). The result of multivariate stepwise logistic regression after age, sex, body mass index, waist circumference and true insulin were controlled showed that proinsulin (division by interval of quartile) was an independent risk factor for sleep snoring (OR = 1.220,95%CI: 1.085-1.373, P = 0.001).CONCLUSION: The interaction of cardiovascular risk factors clustering, high proinsulin level and sleep breathing disorder may be a syndrome, which has not been recognized in human beings so far.

关键词： True insulin Proinsulin Snoring Epidemiology

L^(*)—An index for evaluating long range performance of autonomous underwater vehicles(AUVs)

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Friction 2024年第10期12卷 2205-2221页

作者： manfu zhu Liran ma Jianbin LUO State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

Autonomous underwater vehicles(AUVs)have various applications in both military and civilian fields.A wider operation area and more complex tasks require better overall range performance of ***,until recently,there have been few unified criteria for evaluating the range performance of *** the present work,a unified range index,i.e.,L^(*),considering the cruising speed,the sailing distance,and the volume of an AUV,is proposed for the first time,which can overcome the shortcomings of previous criteria using merely one single parameter,and provide a uniform criterion for the overall range performance of various *** constructing the expression of the L^(*)index,the relevant data of 49 AUVs from 12 countries worldwide have been collected,and the characteristics of the L^(*)range index in different countries and different categories were compared and ***,by analyzing the complex factors affecting the range index,methods to enhance the L^(*)range index value,such as efficiency enhancement and drag reduction,have been introduced and *** this condition,the work proposes a unified and scientific criterion for evaluating the range performance of AUVs for the first time,provides valuable theoretical insight for the development of AUVs with higher performance,and then arouses more attention to the application of the cutting-edge superlubricity technology to the field of underwater vehicles,which might greatly help to accelerate the coming of the era of the superlubricitive engineering.

关键词： autonomous underwater vehicles(AUVs) range performance range index superlubricity drag reduction