检索结果-南通市图书馆

Evaluation of a risk factor scoring model in screening for undiagnosed diabetes in China population

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 846-852页

作者： Jian-jun DONG Neng-jun LOU Jia-jun ZHAO zhong-wen zhang Division of Endocrinology Department of Medicine Qilu Hospital of Shandong University Jinan 250012 China Division of Endocrinology Department of Medicine the Second Hospital of Shandong University Jinan 250033 China Division of Endocrinology Department of Medicine Shandong Provincial Qianfoshan Hospital Jinan 250014 China Division of Endocrinology Department of Medicine Provincial Hospital Affiliated to Shandong University Jinan 250021 China

Objective:To develop a risk scoring model for screening for undiagnosed type 2 diabetes in Chinese ***:A total of 5348 subjects from two districts of Jinan City,Shandong Province,China were *** A (2985) included individuals from east of the city and Group B (2363) from west of the *** questionnaires and a standard oral glucose tolerance test (OGTT) were completed by all *** on the stepwise logistic regression analysis of Group A,variables were selected to establish the risk scoring *** validity and effectiveness of this model were evaluated in Group ***:Based on stepwise logistic regression analysis performed with data of Group A,variables including age,body mass index (BMI),waist-to-hip ratio (WHR),systolic pressure,diastolic pressure,heart rate,family history of diabetes,and history of high glucose were accepted into the risk scoring *** risk for having diabetes increased along with aggregate *** Youden index was closest to 1,the optimal cutoff value was set up at *** this point,the diabetes risk scoring model could identify diabetes patients with a sensitivity of 83.3% and a specificity of 66.5%,making the positive predictive value 12.83% and negative predictive value 98.53%.We compared our model with the Finnish and Danish model and concluded that our model has superior validity in Chinese ***:Our diabetes risk scoring model has satisfactory sensitivity and specificity for identifying undiagnosed diabetes in our population,which might be a simple and practical tool suitable for massive diabetes screening.

关键词： Diabetes mellitus Screening Questionnaire Risk factor score

Subchronic Toxicity Study on Soy Isoflavones in Rats

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2009年第3期22卷 259-264页

作者： wen-zhong zhang wen-MING CUI XIN zhang WEI WANG XU-DONG JIA XIAO-PENG zhang NING LI Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100021 China

Objective To investigate the subchronic toxicity of soy isoflavones （SIF） in male rats. Method Fifty Sprague-Dawley rats were randomly divided into 5 groups, 10 rats per group. SIF were given to rats in different groups by gavage at dose of 0, 0.2, 0.5, 1.5, and 4.5 g/kg bw, respectively for 13 weeks. Clinical manifestations, body weight, and food consumption were observed weekly. At the end of the study, urinalysis, hematology, clinical chemistry, total testosterone, and follicle-stimulating hormone were tested, and histopathological examinations were performed. Results No mortality, ophthalmic abnormalities or treatment-related clinical signs were identified during the study. As compared with the control group, significantly lower body weights and food consumption were observed in 1.5 and 4.5 g/kg bw groups. In clinical chemistry tests, triglyceride was significantly decreased and high-density lipoprotein cholesterol was significantly increased in all SIF-treated groups. Total testosterone levels were significantly lower in 0.50, 1.50, and 4.5 g/kg bw dose groups than in the control group. Microscopic examination showed that the mammary glands exhibited hyperplasia and excreted latex in rats of the 4.5 g/kg bw group. No changes attributable to treatment of SIF in other parameters were found. Conclusion SIF at high dosages caused significant endocrine disruption in male rats. The no observed adverse effect level （NOAEL） of SIF to male rats in this study is considered to be 0.20 g/kg bw.

关键词： Soy isoflavone Rat Subchronic toxicity

Estrogen Receptor α and β Expressions in Hypothalamus-pituitary-ovary Axis in Rats Exposed Lactationally to Soy Isoflavones and Bisphenol A

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2010年第5期23卷 357-362页

作者： BO YU QING-FENG CHEN ZHAO-PING LIU HE-FEI XU XIAO-PENG zhang QAIN XIANG wen-zhong zhang wen-MING CUI XIN zhang NING LI National Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention7 Panjiayuan NanliBeijing 100021China The Affiliated Hospital of Medical College Qingdao UniversityQingdao 266003ShandongChina Shandong Entry-Exit Inspection and Quarantine Bureau China

Objectives This paper aims to investigate the uterotrophic activities of lactational exposure to combination of soy isoflavones （SIF） and bisphenol A （BPA） and to examine estrogen receptor α （ERα） and estrogen receptor β （ERβ） expressions in hypothalamus-pituitary-ovary axis and *** Maternal rats that were breeding about 8 litters were randomly divided into four groups with seven dams in each *** in different treatment groups received corn oil （control）,150 mg/kg BW of SIF,150 mg/kg BW of BPA or combination of 150 mg/kg BW of SIF and 150 mg/kg BW of BPA,respectively,from postnatal day 5 to 11 （PND5-11） by *** PND12 and PND70,10 female litters were killed and hypothalamus,pituitary,ovary and uterus were ***α and ERβ expressions in these organs were detected with Western blotting *** vaginal opening time and estrus cycle were examined in animals fed for *** On PND12,the relative uterine weight of rats treated with ISF or BPA or their combination was significantly higher than that of untreated rats （P〈0.05）.But the relative uterine weight of rats in the co-exposure group was slightly lower than that in the group only exposed to SIF or *** PND 70,however,the relative uterine weight in each treatment group was not statistically different from that in the control group （P〈0.05）.Vaginal opening time and estrus cycle in groups treated with SIF or BPA or their combination were similar to those in the control group （P〈0.05）.Exposure to SIF or BPA or their combination could up-regulate or down-regulate ERα and ERβ expressions in hypothalamus,pituitary,ovary and uterus on PND12 and *** regulation patterns for ERα and ERβ were different in different organs at different time *** Lactational exposure to ISF or BPA or their combination could induce uterotrophic responses in neonate rats,which disappeared in later *** these data fail to suggest a possibility for synergic actions between SIF and *** was

关键词： Soy isoflavones Bisphenol A Combinatory actions Estrogen receptors

EFFECT OF OPERATING CONDITIONS ON THE SELECTIVITY TO α-OLEFIN IN FISCHER-TROPSCH SYNTHESIS

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 1995年第1期 59-65页

作者： LIU zhong-wen zhang Zhi-Xin ZHOU Jing-LaiInstitute of Cual Chermistry, Academa Sinica Taiyuan, Shanxi 030001 To whom correspondence should be addressed.

The effect of operating conditions on the O/P ratios of hydrocarbons produced from FTS over Fe/Cu/K catalyst was studied in a continuously stirring tank reactor (CSTR, Autoclave Engineers) under conditions of T= 515 -542 K, GHSV = 576-906 h-1 and H2/CO ratio= 1. 12 to 3.97. The O/P ratios of hydrocarbons with different carbon numbers may increase, decrease or keep constant with the increase of reaction temperature, GHSV and H2/CO ratio in reactor, respectively. The O/P ratios decrease with the increase of carbon numbers of hydrocarbons and the effect of operating conditions on the O/P ratios trends to decrease with the increase of carbon numbers from three to fifteen. The ratio of ethylene to ethane is always very low and almost independent of the change of operating conditions which indicates that the ethylene may participate in the process of chain growth.

关键词： Fischer-Tropsch synthesis selectivity α-olefin to n-paraffin ratio

THE　STUDY　OF　POISONING　EFFECT　OF　SULPHUR　COMPOUNDS　ON　ACTIVITY　OF　IRON　CARBONYL　CLUSTERS　FOR　WATER　GAS　SHIET　REACTION

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1994年第5期5卷 427-430页

作者： wen zhong zhang Run Xiong GAO Gui Qin SU Ji Chun XU Yuan Qi YIN (Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences,Lanzhou 730000)

The activities of Fe3(CO)(12), Fe2S2(CO)9, Fe2S2(CO)6 for water gas shift reaction, and the effects of Na2S, K2S, FeS, NH4CNS and thiophene on activity of Fe3(CO)(12) have been studied.

关键词： GAS SHIET WATER REACTION ACTIVITY CARBONYL

C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu zhong-Shang Dai Guo-zhong Gong Min zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(P<0.01).Notably,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

Diffuse systemic scleroderma associated with chronic sun-exposed area and excellent response to treatment: A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diffuse systemic scleroderma associated with chronic sun-exp...

中华医学会第14次全国皮肤性病学术年会

作者： Pei-wen Sun Jin zhong zhang Department of Dermatology, Peking University People’s Hospital (北京100044)

We report a 74-year-old man with diffuse *** skin lesions were well-demarcated in chronic sun-exposed *** was engaged in farming work with the habit of working bare-skinned of the upper body during summer *** examinations revealed sclerotic skin changes on his face,forearms, hands,fingers and *** Raynaud’s phenomenon was *** examination revealed positive anti-nuclear antibody and elevated *** was treated with prednisone and cyclophosphamide which made quite a successful outcome.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

苦荞麦曲奇饼干的研制

食品科技 2003年第12期28卷 31-32页

作者：肖诗明吴中文张忠南京财经大学南京210003 西昌学院食品科学系西昌615013

用正交试验探讨苦荞麦曲奇饼干生产中苦荞粉用量、低筋面粉用量、糖浆水用量和奶油用量4因素对饼干比容及饼干品质的影响,从而确立了苦荞麦曲奇饼干生产的最佳工艺条件。

关键词：苦荞麦饼干正交试验

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li Hui Ye Xue-Zhi zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly