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Neoadjuvant immunotherapy for non-small cell lung cancer:State of the art

Cancer Communications 2021年第4期41卷 287-302页

作者： Jin Kang Chao Zhang wen-zhao zhong Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSchool of MedicineGuangzhouGuangdong 510080P.R.China Southern Medical University GuangzhouGuangdong 510515P.R.China

Lung cancer mortality has decreased over the past decade and can be partly attributed to advances in targeted therapy and *** checkpoint inhibitors(ICIs)have rapidly evolved from investigational drugs to standard of care for the treatment ofmetastatic non-small cell lung cancer(NSCLC).In particular,antibodies that block inhibitory immune checkpoints,such as programmed cell death protein 1(PD-1)and programmed cell death 1 ligand 1(PD-L1),have revolutionized the treatment of advanced NSCLC,when administered alone or in combination with *** is associated with higher response rates,improved overall survival(OS),and increased tolerability compared with conventional cytotoxic *** benefits may increase the utility of immunotherapy and its combinational use with chemotherapy in the neoadjuvant treatment of patients with *** findings from various ongoing clinical trials suggest that neoadjuvant ICIs alone or combined with chemotherapy may significantly reduce systemic recurrence and improve long-term OS or cure rates in resectable *** we further summarize the safety and efficacy of various neoadjuvant treatment regimens including immunotherapy from ongoing clinical trials and elaborate the role of neoadjuvant immunotherapy in patients with resectable *** addition,we discuss several unresolved challenges,including the evaluations to assess neoadjuvant immunotherapy response,the role of adjuvant treatment after neoadjuvant immunotherapy,the efficacy of treatment for oncogenic-addicted tumors,and predictive *** also provide our perspective on ways to overcome current obstacles and establish neoadjuvant immunotherapy as a standard of care.

关键词： chemoimmunotherapy clinical trials imaging immunotherapy neoadjuvant non-small cell lung cancer perioperative radiotherapy surgery

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A lobe-specific lymphadenectomy protocol for solitary pulmonary nodules in non-small cell lung cancer

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Chinese Journal of Cancer Research 2015年第6期27卷 538-544页

作者： Xue-Ning Yang Ze-Rui zhao wen-zhao zhong Qiang Nie Ri-Qiang Liao Song Dong Division of Surgery Department of Pulmonary Oncology Guangdong Lung Cancer Institute Guangdong General Hospital and Guangdong Academy of Medical Sciences

Background： We want to establish a lobe-specific mediastinal lymphadenectomy protocol for solitary pulmonary nodules （SPNs） in non-small cell lung cancer （NSCLC）. Methods： We retrospectively analyzed 401 patients with pathological diagnoses of NSCLC who underwent lobectomy, bilobectomy, or pneumonectomy with systematic lymphadenectomy from March 2004 to June 2011 in our hospital. All of the patients enrolled had a SPN preoperatively. Information about the primary tumor location, lymph node metastasis, and other baseline data were collected. Stepwise logistic regression was used to identify the key factors indicating non-regional mediastinal lymph node metastases （NRM）. Results： Of the primary tumors, 117, 39, 74, 104, and 67 were in the right upper lung （RUL）, right middle lung （RML）, right lower lung （RLL）, left upper lung （LUL）, and left lower lung （LLL）, respectively. Stepwise regression showed that #2,4, #10,11, and #10,11 as well as #7 was the key lymph node station for RUL, LUL, and lower lobes： #2,4 [odds ratio （OR）=28.000, 95% confidence interval （CI）： 2.917-268.790, P=0.004] for RUL, #10,11 （OR=31.667, 95% CI： 2.502-400.833, P=0.008） for LUL, #10,11 （OR=19.540, 95% CI： 4.217-90.541, P〈0.001） and #7 （OR=7.395, 95% CI： 1.586-34.484, P=0.011） for lower lobes, respectively. Patients with tumors 〉2 cm rarely had NRM without primary regional mediastinal involvement. Conclusions： With rigid consideration, a lobe-specific lymphadenectomy is feasible in practice. This protocol can be used when the lobe-specific key nodes are negative in intraoperative frozen sections, especially for NSCLC diagnosed as SPN 〈2 cm preoperatively.

关键词： Lung cancer surgery lymph nodes selective dissection lobe-specific

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First Fatal Infection and Phylodynamic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Jilin Province,Northeastern China

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Virologica Sinica 2021年第2期36卷 329-332页

作者： Xu Zhang Nina Wang Zedong Wang Lihe Che Chen Chen wen-zhong zhao Quan Liu School of Life Sciences and Engineering Foshan UniversityFoshan 528225China The First Hospital of Jilin University Changchun 130021China Key Laboratory of National Health and Family Planning Commission of China for Male Reproduction and Genetics Family Planning Research Institute of Guangdong ProvinceGuangzhou 510600China

Dear Editor,Severe fever with thrombocytopenia syndrome(SFTS),caused by SFTS virus(SFTSV)in the genus Banyangvirus of the family Phenuiviridae,is an emerging tick-borne viral zoonosis(Liu et al.2014).Typical clinical symptoms of SFTS include fever,headache,thrombocytopenia,and leukocytopenia(Yu et al.2011).Since SFTSV was identified in 2009,it has been found in more than 20 provinces in China and is closely related to strains from Japan and South Korea(Kim et al.2013;Takahashi et al.2014).

关键词： eastern dynamic Jilin

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Genomic Evolution of Lung Cancer Metastasis:Current Status and Perspectives

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Cancer Communications 2021年第12期41卷 1252-1256页

作者： wen-Fang Tang Rui Fu Yi Liang Jie-Shan Lin Zhen-Bin Qiu Yi-Long Wu wen-zhao zhong Department of Cardiothoracic Surgery Zhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital&Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080P.R.China Department of Nephrology Blood Purification CenterZhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Southern Medical University GuangzhouGuangdong 510515P.R.China

INTRODUCTION Lung cancer is one of the cancers with the highest morbidity and mortality *** the two past decades,although the treatment of non-small cell lung cancer(NSCLC)has been revolutionized by the use of tyrosine kinase inhibitor(TKI)and immune treatments,metastatic disease remains largely incurable and presents a 5-year survival rate of approximately 10%[1].

关键词： Lung mortality lung

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Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay

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Chinese Journal of Cancer 2014年第7期33卷 346-350页

作者： Jian Su Xu-Chao Zhang She-Juan An wen-zhao zhong Ying Huang Shi-Liang Chen Hong-Hong Yan Zhi-Hong Chen Wei-Bang Guo Xiao-Sui Huang Yi-Long Wu Medical Research Center of Guangdong General Hospital Guangdong Lung Cancer Institute Guangdong Academy of Medical Sciences

As molecular targets continue to be identified and more targeted inhibitors are developed for personalized treatment of non-small cell lung cancer(NSCLC), multigene mutation determination will be needed for routine oncology practice and for clinical trials. In this study, we evaluated the sensitivity and specificity of multigene mutation testing by using the Snapshot assay in NSCLC. We retrospectively reviewed a cohort of 110 consecutive NSCLC specimens for which epidermal growth factor receptor(EGFR) mutation testing was performed between November 2011 and December 2011 using Sanger sequencing. Using the Snapshot assay, mutation statuses were detected for EGFR, Kirsten rate sarcoma viral oncogene homolog(KRAS), phosphoinositide-3-kinase catalytic alpha polypeptide(PIK3CA), v-Raf murine sarcoma viral oncogene homolog B1(BRAF), v-ras neuroblastoma viral oncogene homolog(NRAS), dual specificity mitogen activated protein kinase kinase 1(MEK1), phosphatase and tensin homolog(PTEN), and human epidermal growth factor receptor 2(HER2) in patient specimens and cell line DNA. Snapshot data were compared to Sanger sequencing data. Of the 110 samples, 51(46.4%) harbored at least one mutation. The mutation frequency in adenocarcinoma specimens was 55.6%, and the frequencies of EGFR, KRAS, PIK3 CA, PTEN, and MEK1 mutations were 35.5%, 9.1%, 3.6%, 0.9%, and 0.9%, respectively. No mutation was found in the HER2, NRAS, or BRAF genes. Three of the 51 mutant samples harbored double mutations: two PIK3 CA mutations coexisted with KRAS or EGFR mutations, and another KRAS mutation coexisted with a PTEN mutation. Among the 110 samples, 47 were surgical specimens, 60 were biopsy specimens, and 3 were cytological specimens; the corresponding mutation frequencies were 51.1%, 41.7%, and 66.7%, respectively(P = 0.532). Compared to Sanger sequencing, Snapshot specificity was 98.4% and sensitivity was 100%(positive predictive value, 97.9%; negative predictive value, 100%). The Snapshot assay is

关键词：基因突变检测非小细胞肺癌有丝分裂原活化蛋白激酶快照表皮生长因子受体 EGFR 频谱同源基因

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Clinical outcomes of serolimus-eluting stents versus bare metal stents in ST-segment elevation myocardial infarction patients： a meta-analysis

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Chinese Medical Journal 2009年第1期122卷 88-92页

作者： PAN Xiao-hong zhong wen-zhao XIANG Mei-xiang XU Geng SHAN Jiang WANG Jian-an Department of Cardiology 2nd Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Lung Cancer Research Institute & Cancer Center Guangdong Provincial People's Hospital Guangzhou Guangdong 510080 China

Background The benefits and safety of sirolimus-eluting stent （SES） have not been systematically quantified in different trials in ST-segment elevation myocardial infarction （STEMI） patients with primary or rescue percutaneous coronary intervention （PCI）. A meta-analysis of randomised trials comparing SES and bare-metal stent （BMS） was performed. Methods A systematic literature search was conducted to identify all randomized clinical trials. The primary outcome was the rate of major adverse cardiac events （MACEs）. The secondary outcomes included death, recurrent myocardial infarction, recurrent revascularization, and stent thrombosis.Results Totally, 1973 STEMI patients were enrolled in seven eligible randomized trials comparing SES with BMS. The pooled rate of major adverse cardiac events was significantly lower in the SES group than in the BMS group （9.7% vs 20.3%, OR 2.45, 95% Cl 1.88-3.19, P 〈 0.00001）. No significant difference in all causes of death was found between the SES and BMS groups, as well as in the pooled recurrent myocardial infarction rates. The pooled recurrent revascularization rate was significantly lower in the SES group than in the BMS group （5.1% vs 14.8%, OR 3.30, 95%CI 2.37-4.60, P 〈 0.00001）. No significant difference was found between the pooled rates of stent thrombosis （1.2% in the SES group and 2.0% in the BMS group, OR 1.61, 95%CI 0.79-3.26, P = 0.19）.Conclusions SES is associated with a decreased risk of major adverse cardiac events compared with BMS by the greater reduction in repeat revascularization in STEMI patients. Larger trials with longer follow up are warranted to better define the role of SES in STEMI.

关键词： myocardial infarction sirolimus-eluting stents bare-metal stents

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Neoadjuvant immune checkpoint inhibitor plus chemotherapy in rare tracheal tumors

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Cancer Communications 2021年第11期41卷 1243-1245页

作者： Ben-Yuan Jiang Jia-Tao Zhang Li-Xu Yan Xiang-Peng Chu Qiang Nie Jian-Xiu Cui Xue-Ning Yang wen-zhao zhong Yi-Long Wu Guangdong Provincial People’s Hospital Guangdong Key Laboratory of Lung Cancer Translational MedicineGuangdong Lung Cancer InstituteSouth China University of Technology&Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080P.R.China Department of Pathology Guangdong Provincial People’s HospitalGuangzhouGuangdong 510080P.R.China Department of Anaesthesiology Guangdong Provincial People’s HospitalGuangzhouGuangdong 510080P.R.China

Dear Editor,Primary malignant tumors of the trachea account for 0.01%-0.4%of all cancer cases[1].Due to their locally aggressive growth,surgical resection including carinal resection and airway reconstruction was most frequently applied for these diseases[2].However,tracheal surgery is technically challenging and is associated with high rates of operative morbidity and *** neoadjuvant treatment is expected to reduce the tumor load and lessen the extent of resecting primary tracheal ***,evidence regarding neoadjuvant treatment for tracheal tumors remains relatively scarce and platinumbased doublet chemotherapy remains the standard in this *** checkpoint inhibitors are a promising approach to neoadjuvant treatment.

关键词： chemotherapy operative treatment

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Different dissecting orders of the pulmonary bronchus and vessels during right upper lobectomy are associated with surgical feasibility and postoperative recovery for lung cancer patients

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Chinese Journal of Cancer 2017年第10期36卷 468-477页

作者： Hao-Ran Zhai Xue-Ning Yang Qiang Nie Ri-Qiang Liao Song Dong Wei Li Ben-Yuan Jiang Jin-Ji Yang Qing Zhou Hai-Yan Tu Xu-Chao Zhang Yi-Long Wu wen-zhao zhong Graduate School Southern Medical University Guangdong Lung Cancer Institute Guangdong General Hospital&Guangdong Academy of Medical Sciences

Background: Right upper lobectomy(RUL) for lung cancer with di erent dissecting orders involves the most vari?able anatomical structures, but no studies have analyzed its e ects on postoperative recovery. This study compared the conventional surgical approach, VAB(dissecting pulmonary vessels first, followed by the bronchus), and the alter?native surgical approach, a BVA(dissecting the posterior ascending arterial branch first, followed by the bronchus and vessels) on improving surgical feasibility and postoperative recovery for lung cancer ***: According to the surgical approach, consecutive lung cancer patients undergoing RUL were grouped into a BVA and VAB cohorts. Their clinical, pathologic, and perioperative characteristics were collected to compare periop?erative ***: Three hundred one patients were selected(109 in the a BVA cohort and 192 in the VAB cohort). The mean operation time was shorter in the a BVA cohort than in the VAB cohort(164 vs. 221 min, P 0.05). The median disease?free survival was comparable for all patients in the two cohorts(not arrived vs. 41.97 months) and for patients with disease recurrences(13.25 vs. 9.44 months)(both P > 0.05). The recurrence models in two cohorts were also comparable for patients with local recurrences(6.4% vs. 7.8%), distant metastases(10.1% vs. 8.3%), and both(1.8% vs. 1.6%)(all P > 0.05).Conclusions: Dissecting the right upper bronchus before turning over the lobe repeatedly and dissecting veins via the a BVA approach during

关键词： Lung cancer Dissecting order Video-assisted thoracic surgery Pulmonary veins Bronchus

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Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen wen zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai zhong Lirou Su Mingkun Xu Desmond Loke Bin Yu Yishu Zhang Rong zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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