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Prognostic Factors for Survival of Stage IB Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai, China

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Chinese Journal of Cancer Research 2011年第4期23卷 265-270页

作者： wen-li Wang Yang shen-tu1 zhi-qiang Wang Shanghai Lung Cancer Center Shanghai Chest Hospital School of Medicine Shanghai Jioo Tong University Shanghai 200030 China Center for Chronic Disease School of Medicine University of Queensland Health Sciences Building Royal Brisbane & Women's HospitalHerston QLD 4029 Australia

Objective: To identify clinical and pathologic factors that were associated with the survival of stage IB upper lobe non-small cell lung cancer (NSCLC) patients. Methods: A retrospective study of 147 subjects who had undergone curative resection for stage IB upper lobe NSCLC was performed. Patients who had received any adjuvant or neo-adjuvant chemotherapy were excluded. Survival function curves were estimated using the Kaplan-Meier procedure. Crude and adjusted hazard ratios (HRs) of potential prognostic factors were estimated using Cox proportional hazards models. Results: Five factors, including age, tumor size, histologic grade of differentiation, number of removed superior mediastinal lymph node stations and presence of visceral pleura invasion, were significantly and independently associated with mortality risk. Adjusted HRs were 2.6 [95% confidence interval (95% CI): 1.1?6.5] and 4.6 (95% CI: 1.9?11) for those aged 58?68 years and those >68 years, respectively, relative to those aged 5 cm (vs ?3.0 cm) were 2.3 (95% CI: 1.1?4.9) and 4.3 (95% CI: 1.9?10), respectively. The presence of visceral pleura invasion also increased the risk of mortality (HR=4.0, 95% CI: 1.3?12). Conclusion: Advanced age, larger tumor size, poorly differentiated histology, smaller number of removed superior mediastinal lymph node stations, and presence of visceral pleura invasion were associated with poor survival of surgically treated stage IB upper lobe NSCLC patients.

关键词： Non-small cell lung cancer Stage IB Prognosis Lymphadenectomy

Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor

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World Journal of Gastroenterology 2010年第37期16卷 4716-4724页

作者： Yun Zhang Hui Cao Ming Wang wen-Yi Zhao zhi-Yong shen Dan-Ping shen Xing-zhi Ni zhi-Yong Wu Yan-Ying shen Yan-Yan Song Department of General Surgery Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Pathology China Section of Statistics Teaching and Research Shanghai Jiao Tong University School of MedicineShanghai 200025China

AIM: To investigate loss of heterozygosity (LOH) of chromosome 9p21 and the prognostic relevance of p16 expression in gastrointestinal stromal tumor (GIST). METHODS: Fifty-one GIST patients (30 men and 21 women; median age 59 years; range 29-80 years) treated surgically within a 10-year period were grouped by aggressive behavior risk (17 with very low and low, 14 intermediate, and 20 high risk). GISTs were characterized immunohistochemically and evaluated for LOH of 9p21 by microsatellite analysis at D9S1751, D9S1846, D9S942, and D9S1748. LOH of 9p21 and immunohistochemicalexpression of p16 protein encoded at 9p21 were correlated with clinicopathological parameters, and the prognostic significance of p16 alterations was evaluated. RESULTS: Thirty-one (63.3%) cases showed LOH with at least one microsatellite marker. LOH frequency was 37.0% at D9S1751, 37.5% at D9S1846, 42.1% at D9S942, and 24.2% at D9S1748. There was a higher LOH frequency of D9S942 in high-risk than in non-highrisk tumors (P < 0.05, χ 2 = 4.47). Gender, age, tumor size and site were not correlated with allelic loss. Ninety percent (18/20) of the GIST patients in the high risk group showed LOH with at least one of the 9p21 markers, while 57.1% (8/14) in the intermediate risk group and 33.3% (5/15) in the very low and low risk groups, respectively (P < 0.05, χ 2 = 12.16). Eight (28.5%) of 31 patients with LOH and 1 (5.6%) of 18 patients without LOH died of the disease during the follow-up period. Loss of p16 protein expression occurred in 41.2%, but in 60% of the high risk group and 23.5% of the very low and low risk groups (P < 0.05, χ 2 = 4.98). p16 loss was associated with poor prognosis (P < 0.05, χ 2 = 4.18): the 3and 5-year overall survival rates were 84.8% and 70.8% for p16-negative and 100% and 92.0% for p16-positive patients, respectively. CONCLUSION: LOH at 9p21 appears to play an important role in GIST progression; decreased p16 expression in GIST is highly predictive of poor outcome.

关键词： Gastrointestinal stromal tumor Loss of heterozygosity p16 Prognosis Tumor suppressor gene

The level and influencing factors of quality of life in patients with brachial plexus injury

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International Journal of Nursing Sciences 2014年第2期1卷 171-175页

作者： Jie shen zhi-wen Wang Department of Hand Surgery Beijing Jishuitan HospitalBeijingChina School of Nursing Peking UniversityBeijingChina

Purpose:To investigate the overall quality of life level and identify influencing factors in patients with traumatic brachial plexus ***:One hundred three patients with brachial plexus injury were assessed using the World Health Organization Quality of Life-BREF(WHOQOL-BREF)and Family Adaptability and Cohesion Evaluation Scale(FACESII-CV)***:The overall quality of life score from patients with brachial plexus injury was 65.78*** scores for the physical,psychological and environmental factors were significantly lower than the norm(Ps<0.05).Regression analysis showed that age,injury located ipsilateral to the dominant hand,upper limb function score,score of family intimacy and family income were all factors influencing the of quality of ***:A brachial plexus injury significantly compromises an individual’s quality of *** factors influence this quality,which should be targeted to augment the physical and psychological care provided.

关键词： Brachial plexus injury Family intimacy Influencing factors Quality of life

First-Principles Electronic Structure of Cu^(+) Luminescence Centers in Cu-Doped ZnS

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Chinese Physics Letters 1998年第8期15卷 591-593页

作者： ZHANG zhi-peng shen Yao-wen HUANG Mei-chun Department of Physics Xiamen UniversityXiamen 361005

The electronic structures of various Cu^(+) luminescence centers in wurtzite ZnS are studied by using first-principles linear muffin-tin-orbital method combining atomic sphere *** results for ZnS:Cu:Cl and ZnS:Cu:Al show that Cu acceptor states are anomalously deep(beyond 2.7eV above the top of valence band)and located near the bottom of conduction band in these two *** the other hand,the results for ZnS:Cu with sulfur vacancies manifest that the Cu+center is an associated center,whose Cu d-like states are situated above the top of valence band.

关键词： band. ZnS:Cu conduction

Seven-frequency VLBI Observations of the GHz-Peaked-Spectrum Source OQ 208

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Chinese Journal of Astronomy and Astrophysics 2007年第5期7卷 611-619页

作者： wen-Feng Luo Jun Yang Lang Cui Xiang Liu zhi-Qiang shen National Astronomical Observatories / Urumqi Observatory Chinese Academy of Sciences Urumqi 830011 Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 Graduate School of Chinese Academy of Sciences Beijing 100049 Joint Institute for Galaxy and Cosmology SHAO and USTC

We present quasi-simultaneous VLBI images of the GHz-Peaked-Spectrum radio source OQ 208 obtained with the Very Long Baseline Array at 1.4, 1.7, 2.3, 5.0, 8.4, 15.4 GHz and the European VLBI Network at 6.7 GHz. The low frequency （1.4, 1.7 and 2.3 GHz） observations reveal a weak and extended steep-spectrum component at about 30 mas away at position angle - 110°, which may be a remnant emission. The radio structure of OQ 208 consists of two mini-lobes at 5.0, 6.7, 8.4 and 15.4 GHz. Our spectral analysis further confirms that the southwest lobe undergoes free-free absorption and finds that the free-free absorption is stronger in the inner region. By fitting the 8.4 GHz images from 1994 to 2005, we obtain a separation speed of 0.0314-0.006 mas yr^-1 between the two mini-lobes. This indicates a jet proper motion of 0.1054-0.020 c and a kinematic age of 219±42 yr for the radio source.

关键词： galaxies individual (OQ 208) -- radio continuum galaxies

Ultrasound enhancement of the reduction of the Basic Green dye in wastewater by cast iron

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Journal of Environmental Sciences 2006年第1期18卷 1-3页

作者： shen Zhuang-zhi shen Jian-zhong Institute of Acoustics Chinese Academy of Sciences Beijing 100080 China

Dyes in wastewater are of particular environmental concern since they give an undesirable color to the waters, dye and their derivatives are harmful to human health and the environment （ Annadurai et al., 2002）. Due to their biological persistency, conventional biological treat-ment processes such as activated sludge process are ineffective for their removal（Shaul et al., 1991）. There is a need to develop effective methods for the degradation of such persistent organic pollutants, either to less harmful compounds or, more desirable, to their complete mineralization.

关键词： cast iron ultrasound Basic Green combined effect

Theoretical estimation of sonochemical yield in bubble cluster in acoustic field

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Chinese Physics B 2020年第1期29卷 357-365页

作者： Zhuang-zhi shen School of Physics&Information Technology Shaanxi Normal UniversityShaanxi Key Laboratory of UltrasonicsXi'an 710119China

In order to learn more about the physical phenomena occurring in cloud cavitation,the nonlinear dynamics of a spherical cluster of cavitation bubbles and cavitation bubbles in cluster in an acoustic field excited by a square pressure wave are numerically investigated by considering viscosity,surface tension,and the weak compressibility of the *** theoretical prediction of the yield of oxidants produced inside bubbles during the strong collapse stage of cavitation bubbles is also *** effects of acoustic frequency,acoustic pressure amplitude,and the number of bubbles in cluster on bubble temperature and the quantity of oxidants produced inside bubbles are *** results show that the change of acoustic frequency,acoustic pressure amplitude,and the number of bubbles in cluster have an effect not only on temperature and the quantity of oxidants inside the bubble,but also on the degradation types of pollutants,which provides a guidance in improving the sonochemical degradation of organic pollutants.

关键词： bubble cluster models bubble cluster dynamics chemical kinetics bubble temperature strong oxidants acoustic cavitation

Biomimetic Cilia Based on MEMS Technology

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Journal of Bionic Engineering 2008年第4期5卷 358-365页

作者： zhi-guo Zhou zhi-wen Liu Department of Electronic Engineering Beijing Institute of Technology Beijing 100081 P. R. China

A review on the research of Micro Electromechanical Systems （MEMS） technology based biomimetic cilia is presented. Biomimetic cilia, enabled by the advancement of MEMS technology, have been under dynamic development for the past decade. After a brief description of the background of cilia and MEMS technology, different biomimetic cilia applications are reviewed. Biomimetic cilia micro-actuators, including micromachined polyimide bimorph biomimetic cilia micro-actuator, electro-statically actuated polymer biomimetic cilia micro-actuator, and magnetically actuated nanorod array biomimetic cilia micro-actuator, are presented. Subsequently micromachined underwater flow biomimetic cilia micro-sensor is studied, followed by acoustic flow micro-sensor. The fabrication of these MEMS-based biomimetic cilia devices, characterization of their physical properties, and the results of their application experiments are discussed.

关键词： biomimetic cilia MEMS micro-actuator micro-sensor

Unilateral global interval bifurcation for problem with mean curvature operator in Minkowski space and its applications

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Applied Mathematics(A Journal of Chinese Universities) 2022年第2期37卷 159-176页

作者： shen wen-guo Department of Basic Courses Lanzhou Institute of TechnologyLanzhou 730050China

In this paper,we establish a unilateral global bifurcation result from interval for a class problem with mean curvature operator in Minkowski space with non-differentiable *** applications of the above result,we shall prove the existence of one-sign solutions to the following problem{−div(√∇v 1−|∇v|^(2))=α(x)v^(+)+β(x)v^(−)+λa(x)f(v),in B_(R)(0),v(x)=0,on∂B_(R)(0),whereλ≠=0 is a parameter,R is a positive constant and BR(0)={x∈RN:|x|0 for s≠=0,and f_(0)∈[0,∞],where f0=lim_(|s|)→0 f(s)/*** use unilateral global bifurcation techniques and the approximation of connected components to prove our main *** also study the asymptotic behaviors of positive radial solutions asλ→+∞.

关键词： interval bifurcation unilateral global bifurcation one-sign solutions mean curvature operator