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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia wenting Ye Yan Sun Jing Cai Fubing Yu Haiping wen Xiuwei Yi Taikang Li Mingwei chen Jiayun chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao Xu Ming-Hui chen Peng Zhao wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Ru原子高Rydberg态研究

物理学报 1989年第10期38卷 1665-1672页

作者：许祥源唐建志李良权黄雯张连芳文克玲尚仁成赵文正陈瓞延清华大学现代应用物理系

本文描述用激光共振激发-场电离实验方法测定Ru原子的4d^7(~4F)ns(n=28—45)和4d^7(~4F)nd(n=26—48)系列Rydberg能级,并应用非线性拟合得到了Ru原子的第一电离阈值。采用相对论性自洽场方法对所得能级以及相应的量子亏损作了计算,理论... 详细信息

本文描述用激光共振激发-场电离实验方法测定Ru原子的4d^7(~4F)ns(n=28—45)和4d^7(~4F)nd(n=26—48)系列Rydberg能级,并应用非线性拟合得到了Ru原子的第一电离阈值。采用相对论性自洽场方法对所得能级以及相应的量子亏损作了计算,理论与实验结果符合得很好。此外还将本文所得的第一电离阈值与已有数据作了比较。

关键词： Ru 原子 Rydberg态

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C1q、C1r和C1s的快速分离

上海免疫学杂志 2002年第5期22卷 337-339,349页

作者：李文君陈政良张丽芸第一军医大学免疫学教研室广州510515

建立了一种同时快速分离纯化C1q及酶原形式C1r和C1s的方法。用IgG Sepharose 4B亲和层析将C1q与C1r2 s2 分离 ,接着用DEAE Sephacel离子交换层析将C1r和C1s分离 ,用C1qMcAb Sepharose 4B亲和层析将C1q进一步纯化。在分离Clr和C1s的整个... 详细信息

建立了一种同时快速分离纯化C1q及酶原形式C1r和C1s的方法。用IgG Sepharose 4B亲和层析将C1q与C1r2 s2 分离 ,接着用DEAE Sephacel离子交换层析将C1r和C1s分离 ,用C1qMcAb Sepharose 4B亲和层析将C1q进一步纯化。在分离Clr和C1s的整个过程中加入蛋白水解抑制剂PMSF和NPGB ,并控制温度在 4℃、pH 6 1、无二价阳离子的条件下 ,得到高度纯化的C1q、C1r和C1s。

关键词： C1q C1r C1s 亲和层析离子交换层析补体

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui zheng Bo Shao Chao-Min Xu Ke Wang Jia-Zhu wen Li-Kang Luo Jia-cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Evolution of microstructure and texture of cold-drawn polycrystalline Ag with low stacking fault energy

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Science China(Technological Sciences) 2015年第7期58卷 1146-1153页

作者： MA XiaoGuang chen Jian chen zheng YAN wen State Key Laboratory of Solidification Processing School of Materials Science and Engineering Northwestern Polytechnical University School of Materials Science and Chemical Engineering Xi'an Technological University

The evolution of microstructure and texture for drawn polycrystalline Ag was investigated by transmission electron microscopy and electron backscattering *** results show that there are deformation twins and some un-tangled discrete dislocations at low *** the strain is increased to 0.58,a lot of high density dislocation walls and microbands come into *** the same time,some twins lose the twinning relationship of 60°.At a strain of 0.94,both dislocation boundaries and twin boundaries will rotate to the axis direction of wires and the shear bands start to *** the strain is higher than 1.96,most of the boundaries are parallel to the drawn *** analysis indicates that with the strain increasing,the volume fraction of complex texture component decreases,butandtexture components ***,the variation in the volume fraction of each texture component as strains is not evident when the strains are higher than *** polycrystalline Ag with low stacking fault energy,complex texture components are easily formed.

关键词： polycrystalline Ag cold-drawn deformation microstructure deformation twinning stacking fault energy

ZnO晶体中Mn^(2+)与Fe^(3+)杂质中心的缺陷结构研究

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物理学报 2002年第3期51卷 616-619页

作者：董会宁吴晓轩邬劭轶郑文琛四川大学材料科学系四川师范大学固体物理研究所成都610066 中国民用航空飞行学院计算机与信息科学系中国科学院国际材料物理中心沈阳110016

用建立在强场图像和自旋轨道耦合机理的高阶微扰公式研究了ZnO晶体中Mn2 +和Fe3 +杂质中心的零场分裂 .研究发现 :Mn2 +和Fe3 +离子不能占据准确的Zn2 +位置 ,而是沿c3 轴方向各自位移一段距离ΔR .这些位移及与此相关的缺陷结构也为Ne... 详细信息

用建立在强场图像和自旋轨道耦合机理的高阶微扰公式研究了ZnO晶体中Mn2 +和Fe3 +杂质中心的零场分裂 .研究发现 :Mn2 +和Fe3 +离子不能占据准确的Zn2 +位置 ,而是沿c3 轴方向各自位移一段距离ΔR .这些位移及与此相关的缺陷结构也为Newman叠加模型所证实 .

关键词：零场分型 ZnO晶体 Mn^2+ Fe^3+ 晶格畸变叠加模型氧化锌晶体缺陷结构锰(Ⅱ)掺杂铁(Ⅲ)掺杂

Applying blockchain-based method to smart contract classification for CPS applications

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Digital Communications and Networks 2022年第6期8卷 964-975页

作者： Zigui Jiang Kai chen Hailin wen Zibin zheng School of Software Engineering Sun Yat-Sen UniversityChina School of Mathematics Sun Yat-Sen UniversityChina School of Computer Science and Engineering Sun Yat-Sen UniversityChina

Smart contract has been the core of blockchain systems and other blockchain-based systems since Blockchain *** operations on blockchain are performed through the invocation and execution of smart *** leads to extensive combinations between blockchain,smart contract,Internet of Things(IoT)and Cyber-Physical System(CPS)applications,and then many blockchain-based IoT or CPS applications emerge to provide multiple benefits to the economy and *** this case,obtaining a better understanding of smart contracts will contribute to the easier operation,higher efficiency and stronger security of those blockchain-based systems and *** existing studies on smart contract analysis are based on similarity calculation and smart contract ***,smart contract is a piece of code with special characteristics and most of smart contracts are stored without any category labels,which leads to difficulties of smart contract *** the back end of a blockchain-based Decentralized Application(DApp)is one or several smart contracts,DApps with labeled categories and open source codes are applied to achieve a supervised smart contract classification.A three-phase approach is proposed to categorize DApps based on various data *** this approach,5,659 DApps with smart contract source codes and pre-tagged categories are first obtained based on massive collected DApps and smart contracts from Ethereum,State of the DApps and *** feature extraction and construction methods are designed to form multi-feature vectors that could present the major characteristics of ***,a fused classification model consisting of KNN,XGBoost and random forests is applied to the multi-feature vectors of all DApps for performing DApp *** experimental results show that the method is *** addition,some positive correlations between feature variables and categories,as well as several user behavior patterns of DAp

关键词： Blockchain Blockchain-based application Smart contract DApP classification Solidity

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竞争环境下资金约束企业的召回风险管理策略

管理工程学报 2025年第2期39卷 262-281页

作者：陈静杨艺郑朝南邓开洋东南大学经济管理学院上海财经大学商学院香港中文大学社会科学学院

基于绩效进行采购订单分配是引入供应商竞争、提升零部件质量的一种常见手段。然而资金约束供应商为了避免后期财务困境的发生,很可能在初期削弱其质量投资以增加流动资金的持有量。由资金约束引发的质量竞争失效问题可能在制造商基于... 详细信息

基于绩效进行采购订单分配是引入供应商竞争、提升零部件质量的一种常见手段。然而资金约束供应商为了避免后期财务困境的发生,很可能在初期削弱其质量投资以增加流动资金的持有量。由资金约束引发的质量竞争失效问题可能在制造商基于保障零部件质量而实施的惩罚机制下更为严重。为此,越来越多的制造商采用保险机制提升供应商的财务能力。本文考虑召回成本随机分布,通过构建供应商的质量竞争模型,研究惩罚机制与保险机制对供应商质量竞争行为的影响。研究发现,相较于惩罚机制,保险机制使资金约束供应商更容易在低采购价格下进入市场并参与竞争。此外,惩罚机制或具有较高赔付限额的保险机制会产生“价格黑洞”。当采购价格位于“价格黑洞”中时,提高采购价格反而会带来更低的零部件质量。当保险赔付限额较低时,保险机制可形成非对称均衡,此时仅一家供应商能够进入市场。

关键词：资金约束质量竞争召回风险惩罚与保险

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