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Personalized treatment based on mini patient-derived xenografts and WES/RNA sequencing in a patient with metastatic duodenal adenocarcinoma

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Cancer Communications 2018年第1期38卷 586-592页

作者： Peng Zhao Hui chen Danyi wen Shuo Mou Feifei Zhang Shusen zheng Cancer Biotherapy Center The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003P.R.China Department of General Surgery Zhejiang HospitalHangzhou 310013P.R.China LIDE Biotech Co. LtdShanghaiP.R.China OrigiMed Co. LtdShanghaiP.R.China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003P.R.China Key Lab of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhouChina

Background:Treatment guidelines for a variety of cancers have been increasingly used in clinical practice,and have resulted in major improvement in patient ***,recommended regimens(even first-line treat-ments)are clearly not ideal for every *** the present study,we used mini patient-derived xenograft(mini-PDX)and next-generation sequencing to develop personalized treatment in a patient with metastatic duodenal ***:Resected metachronous metastatic tumor tissues were implanted into SCID mice to determine the sensitivity to a variety of drug *** profiles were assessed using both DNA whole-exome sequencing(DNA-WES)and RNA *** results of the analyses were used to select optimal treatment for the patient with metastatic duodenal ***:Assessment with mini-PDX models took only 7 *** results showed high sensitivity to S-1 plus cis-platin,gemcitabine plus cisplatin and everolimus *** patient received gemcitabine plus cisplatin initially,but the treatment was terminated due to *** patient was then switched to treatment with S-1 *** overall disease-free survival was 34 ***-WES and RNA sequencing identified KRAS mutation(A146T),TP53(C229Yfs*10)and RICTOR amplification in the metastatic duodenal *** findings provided further support to the results of the mini-PDX,and suggest mTOR inhibitors should be used if and when relapse eventually occurs in this ***:Mini-PDX model combined with WES/RNA sequencing can rapidly assess drug sensitivity in cancer patients and reveal key genetic *** research on this technology for personalized therapy in patients with refractory malignant tumors is warranted.

关键词： Duodenal adenocarcinoma Mini patient-derived xenograft Whole-exome sequencing RNA sequencing Somatic mutation Personalized therapy

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Reynolds-Averaged Navier-Stokes Equations Describing Turbulent Flow and Heat Transfer Behavior for Supercritical Fluid

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Journal of Thermal Science 2021年第1期30卷 191-200页

作者： YANG zheng chenG Xu zheng Xinghua chen Haisheng Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023China Institute for Applied Thermofluidics Karlsruhe Institute of TechnologyKarlsruhe 76131Germany

Supercritical fluid has been widely applied in many industrial *** traditional Reynolds-averaged Navier-Stokes(RANS)equations are directly applied for turbulent flow and heat transfer of the supercritical fluid,ignoring turbulent effect of the thermal physical properties due to the intense *** paper deduces a set of Reynolds-averaged Navier-Stokes equations for supercritical fluid(SCF-RANS equations)to depict turbulent flow and heat transfer of the supercritical fluid taking all the physical parameters as *** SCF-RANS equations include many new correlation terms due to fluctuation of the thermal physical *** methods for the new correlation term have been discussed for closing the SCF-RANS *** of them have relatively mature models,while others are completely new and need profound physical theoretical analysis for proposing reasonable *** paper provides referable information for these new correlations as far as authors *** SCF-RANS equations not only provide the formulation special for flow and heat transfer of the supercritical fluid,but also represent the most sophisticate form of the RANS equations,for every involved physical property has been considered as variable without any simplification.

关键词： SCF-RANS equations supercritical fluid turbulence Reynolds-averaged Navier-Stokes equations

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Progress on statistical models of evaluating inclusions in clean steels

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Journal of Iron and Steel Research International 2022年第8期29卷 1153-1163页

作者： zheng Wang Yue-hui Guan Hai-wen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Jiang Yin Xing cheng Alloy Material Co. Ltd.Jiangyin 214432JiangsuChina

Non-metallic inclusions are critical for the fatigue failure of clean steels in service;especially,the large and hard inclusions are *** it is not possible to measure all the inclusions in the large-volume clean steels,statistical models have been developed to evaluate inclusions,aiming at predicting the maximum inclusion size in the large volume from the data of inclusions,which are derived from the limited observations on small-volume *** statistical models were reviewed together with their supporting *** particular,the block maxima and the threshold types of models were discussed through a thorough comparison as they are both widely used and based on the extreme value *** predicted results not only are used to distinguish the different cleanliness levels of steels,but also help to estimate fatigue ***,future research is proposed to focus on tackling the present difficulties encountered by statistical models,including the sufficient credibility of obtained results and the robustness of models for applications.

关键词： Clean steel Maximum inclusion prediction Statistical model Extreme value theory Fatigue failure

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Experiments and calculations of wave breaking and evolution of wave groups with high steepness

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Journal of Hydrodynamics 2022年第5期34卷 975-980页

作者： wen-yang Duan Kun zheng Bin-bin Zhao College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China

The evolution of the nonlinear wave groups in deep water is investigated through laboratory measurements and numerical *** experiments are conducted in deep-water wave tank,focusing on the characteristics of breaking waves arising from the evolved wave *** quantitative results are obtained for the significant breaking wave train,including the surface elevation time series,the local geometry,and the energy dissipation.A nonlinear model for the evolution of the wave groups in deep water is developed by adding eddy viscosity dissipation terms in the High Level Irrotational Green-Naghdi(HLIGN)*** results of the simulation are compared with the laboratory measurements,and good agreement is observed for the evolved wave train.

关键词： Wave group evolution wave breaking High-Level Irrotational Green-Naghdi(HLIGN)equations laboratory experiments

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Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein

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World Journal of Gastrointestinal Oncology 2017年第4期9卷 153-159页

作者： zheng-Yun Liang Xing Kang Hong chen Meng Wang wen-Xian Guan Department of General Surgery Qianxinan People’s Hospital Department of General Surgery Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical School

AIM To investigate the effects of Clostridium perfringens enterotoxin(CPE) on gastric cancer cells which highly expressed claudin-4(CL4) *** In this study, we detected expression of CL4 protein in different gastric cancer cell lines. Then, we investigated the effects of CPE on SGC7901 cells which highly expressed CL4 protein and the effects of CPE on sub-cutaneous tumor in nude mice *** CL4 are highly expressed in SGC7901 cells. CPE expressedsignificant cytotoxicity in SGC7901 cells. Suppression of CL4 expression significantly decreased CPE-mediated cytotoxicity. CPE also inhibited tumor growth in subcutaneous tumor xenograft *** CPE showed CL4 mediated cytotoxicity on gastric cancer cells SGC7901 and inhib-ited tumor growth in nude mice models.

关键词： Gastric cancer Clostridium perfringens enterotoxin Claudin-4 protein Cytotoxicity Tight junction

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Directly Knitted Ruthenium Pincer Complexes with Enhanced Activity as Recyclable Single-Site Catalysts for Hydrogenation of CO_(2)to Methanol

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CCS Chemistry 2023年第7期5卷 1602-1611页

作者： Daheng wen Jiangbo chen Qingshu zheng Siqi Yang Tao Tu Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of ChemistryFudan UniversityShanghai 200438 State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Considering the importance of the valorization of CO_(2),a number of phosphine-containing ruthenium pincer complexes have been successfully heterogenized using a“direct knitting”strategy without any *** resulting porous organometallic polymers(POMPs)with high specific-surface areas,hierarchical pores,and uniformly dispersed Ru single-sites exhibited outstanding catalytic activity toward the N-formylation of diverse amines with CO_(2).Besides excellent turnover number(TON,5×10^(5))and turnover frequency(TOF,5592 h-1),the obtained formamides were readily hydrogenated to methanol with the same ***,an amine-assisted direct hydrogenation system of CO_(2)to methanol was established by POMPs with higher activity and TON(1.46×10^(4))than their molecular precursors,shedding light on the direct valorization of CO_(2)and carbon neutral recycling.

关键词： direct knitting hydrogenation of CO_(2) porous organometallic polymers ruthenium pincer complexes single-site catalyst

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Time-optimal guidance for intercepting moving targets with impact-angle constraints

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Chinese Journal of Aeronautics 2022年第7期35卷 157-167页

作者： Yuan zheng zheng chen Xueming SHAO wenjie ZHAO School of Aeronautics and Astronautics Zhejiang UniversityHangzhou 310027China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China

The minimum-time path for intercepting a moving target with a prescribed impact angle is studied in the *** candidate paths from Pontryagin’s maximum principle are synthesized,so that each candidate is related to a zero of a real-valued *** is found that the real-valued functions or their first-order derivatives can be converted to polynomials of at most fourth *** a result,each candidate path can be computed within a constant time by embedding a standard polynomial solver into the typical bisection *** control strategy along the shortest candidate eventually gives rise to the time-optimal guidance ***,the developments of the paper are illustrated and verified by three numerical examples.

关键词： Dubins vehicle Guidance law Minimum-time path Optimal guidance Path planning

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中草药防治犊牛腹泻的研究现状

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动物医学进展 2025年第1期46卷 113-117页

作者：王德志文鹏杨海峰刘永军尹文吴晨晨宁夏博瑞科技有限公司宁夏银川750011 宁夏农垦乳业股份有限公司宁夏银川750004 西北农林科技大学动物医学院陕西杨凌712100

犊牛腹泻作为新生犊牛常见病,也是导致犊牛死亡的主要病因,严重危害牛养殖业的发展。因此,降低腹泻发病率对牛群健康和牧场收益具有重要意义。当前主要以抗菌药物来治疗犊牛腹泻,但大量使用抗菌药物加重了细菌耐药性和抗菌药物残留,危... 详细信息

犊牛腹泻作为新生犊牛常见病,也是导致犊牛死亡的主要病因,严重危害牛养殖业的发展。因此,降低腹泻发病率对牛群健康和牧场收益具有重要意义。当前主要以抗菌药物来治疗犊牛腹泻,但大量使用抗菌药物加重了细菌耐药性和抗菌药物残留,危害公共卫生及食品安全。中草药具有抗菌消炎、提高机体免疫力,逐渐成为治疗疾病的热点,并取得了良好的治疗效果,相比于抗菌药物等西药,毒性低、成本低、对环境造成的危害较小。论文主要综述了犊牛腹泻病原流行情况、中草药在抗菌、抗病毒、抗寄生虫方面的研究及中草药对犊牛腹泻的预防和防治作用,为中草药在犊牛腹泻的应用中提供进一步参考价值。

关键词：中草药犊牛犊牛腹泻

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Analysis of the stress wave and rarefaction wave produced by hypervelocity impact of sphere onto thin plate

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Defence Technology（防务技术） 2020年第5期16卷 969-979页

作者： Ken wen Xiao-wei chen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Institute of Systems Engineering China Academy of Engineering PhysicsMianyangSichuan621999China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China

Shock wave is emitted into the plate and sphere when a sphere hypervelocity impacts onto a thin *** fragmentation and phase change of the material caused by the propagation and unloading of shock wave could result in the formation of debris cloud *** models are deduced based on one-dimensional shock wave theory and the geometry of sphere,which uses elliptic equations(corresponding to ellipsoid equations in physical space)to describe the propagation of shock wave and the rarefaction ***“Effective thickness”is defined as the critical plate thickness that ensures the rarefaction wave overtake the shock wave at the back of the ***“Effective thickness”is directly related to the form of the debris *** relation of the“Effective thickness”and the“Optimum thickness”is also *** impacts of Al spheres onto Al plates are simulated within SPH to verify the propagation models and associated *** results show that the wave fronts predicted by the propagation models are closer to the simulation result at higher impact *** curvatures of the wave fronts decrease with the increase of impact *** predicted“Effective thickness”is consistent with the simulation *** analysis about the shock wave propagation and unloading in this paper can provide a new sight and inspiration for the quantitative study of hypervelocity impact and space debris protection.

关键词： Hypervelocity impact Debris cloud Shock wave Rarefaction wave Effective thickness of plate

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Interaction of Mixed Porphyrin-polypyridyl Ru(II) Complex with Bovine Serum Albumin

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Chemical Research in Chinese Universities 2010年第5期26卷 693-698页

作者： XU Lei LIU Ya-nan MEI wen-jie HUANG Xiao-mei chen Tian-feng LIU Jie zheng wen-jie Department of Chemistry Jinan University Guangzhou 510632 P. R. China School of Pharmacy Guangdong Pharmaceutical University Guangzhou 510006 P. R. China

The interactions of mixed porphyrin-polypyridyl Ru（Ⅱ） complexes [m（Py-3＇）TPP-Ru（phen）2Cl]^＋（1） and its derivatives [Nim（Py-3＇）TPP-Ru（phen）2Cl]＋（2） and [Cum（Py-3＇）TPP-Ru（phen）2Cl]^＋（3）（phen=1,10-phenanthroline; m（Py-3＇）TPP=5-（3＇-pyridyl）-10,15,20-triphenylporphyrin） with bovine serum albumin（BSA） were investigated by fluorescence, UV-Vis and circular dichroism（CD） spectroscopies. The UV-Vis and CD spectral experiments indicated that the secondary structures of the protein were perturbed in the presence of the porphyrin Ru（Ⅱ） complex and the perturbation was enhanced under the irradiation with ultra-violet light. The fluorescence quenching mechanism of BSA by the three complexes was determined to be a static process, and the apparent binding constant K values for complexes 1, 2 and 3 measured by fluorescence quenching method were （3.86±0.03）×10^3 L/mol（n=0.94±0.04）, （5.69±0.04）× 103 L/mol（n=1.03±0.06）, and （6.54±0.02）× 10^3 L/mol（n=1.03±0.05）, respectively.

关键词： Porphyrin Bovine serum albumin(BSA) Ru(Ⅱ) complex Binding

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