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Metabolism pathways of arachidonic acids:mechanisms and potential therapeutic targets

Signal Transduction and Targeted Therapy 2021年第3期6卷 821-850页

作者： Bei Wang Lujin Wu Jing chen Lingli Dong chen chen zheng wen Jiong Hu Ingrid Fleming Dao wen Wang Division of Cardiology Department of Internal Medicine and Gene Therapy CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Huazhong University of Science and TechnologyHubei ProvinceWuhanChina Department of Rheumatology and Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyHubeiWuhanChina Institute for Vascular Signalling Centre for Molecular MedicineGoethe UniversityFrankfurt am MainGermany

The arachidonic acid(AA)pathway plays a key role in cardiovascular biology,carcinogenesis,and many inflammatory diseases,such as asthma,arthritis,*** AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2),which is in turn further metabolized by cyclooxygenases(COXs)and lipoxygenases(LOXs)and cytochrome P450(CYP)enzymes to a spectrum of bioactive mediators that includes prostanoids,leukotrienes(LTs),epoxyeicosatrienoic acids(EETs),dihydroxyeicosatetraenoic acid(diHETEs),eicosatetraenoic acids(ETEs),and lipoxins(LXs).Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases(CVD),cancers,and inflammatory *** review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and *** will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or ***,we herein present a synopsis of AA metabolism in human health,cardiovascular and cancer biology,and the signaling pathways involved in these *** explore the role of the AA metabolism and potential therapies,we also introduce the current newly clinical studies targeting AA metabolisms in the different disease conditions.

关键词： metabolism therapeutic mechanisms

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Caution in building a Burgers circuit for studying secondary dislocations

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Journal of Materials Science & Technology 2019年第6期35卷 1192-1197页

作者： wen-Sheng Xu wen-zheng Zhang Key Laboratory of Advanced Materials (MOE) School of Materials Science and EngineeringTsinghua University

As the Burgers vector of a secondary dislocation may not conform to the translation vectors in the periodic pattern in a high-resolution transmission electron microscope(HRTEM) image, a Burgers circuit directly constructed according to an HRTEM image may render a wrong Burgers vector. The HRTEM images of the habit plane(HP) of δ precipitate in an Inconel 718 alloy were re-examined by using different Burgers circuits, as an example. Evidence is found for predicted secondary dislocation associated with a down step. The Burgers vector of the dislocation is 1/6[112]/1/3[001]δ, determined with the Burgers circuit built on the reference of the displacement shift completely lattice(DSCL). It is consistent with both the calculated and the measured result of the major defects in the habit plane. Different Burgers vectors due to different Burgers circuits were explained quantitatively. The present study has a general implication for the determination of the Burgers vectors of secondary interfacial dislocations in other systems.

关键词： Dislocation Burgers vector Burgers circuit Coincidence site lattice (CSL) Displacement shift completely lattice (DSCL) Lattice correspondence

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Case Report:Recurrent severe vomiting due to hyperthyroidism

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第3期11卷 218-220页

作者： Li-ying chen Bo ZHOU Zhou-wen chen Li-zheng FANG Department of Family Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Department of Family Medicine Community Health Services Center in Pengbu Town Hangzhou 310017 China

Thyrotoxicosis may present in many ways;severe vomiting as a prominent symptom of thyrotoxicosis is *** this paper,we report a 24-year-old Chinese male with hyperthyroidism who presented with recurrent severe *** patient had had intermittent vomiting for seven years and had lost approximately 15 kg of *** examinations revealed chronic gastritis and one occasion peptic *** was treated with antacid and proton pump inhibitors,but his symptoms had no *** presenting symptoms suggested hyperthyroidism and were confirmed by laboratory *** a month of propylthiouracil therapy,his symptoms were *** should be noted that hyperthyroidism patients can have unexplained vomiting,and that hyperthyroidism may coexist with peptic ulcer in rare *** of such atypical presentations of hyperthyroidism may help to make a correct diagnosis.

关键词： Vomiting Hyperthyroidism Peptic ulcer

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基于指数滤波模型的青藏高原根系层土壤水分估算研究

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高原气象 2025年第1期44卷 134-149页

作者：宋雨曦苏建宾文军郑东海成都信息工程大学大气科学学院高原大气与环境四川省重点实验室四川成都610225 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室国家青藏高原科学数据中心北京100101

高精度、长时序的土壤水分数据对青藏高原陆-气相互作用研究十分重要。然而,当前青藏高原土壤水分研究大多聚焦表层土壤水分的卫星反演,根系层土壤水分的估算研究相对匮乏。基于青藏高原五个土壤水分观测网络(狮泉河、帕里、那曲、黑河... 详细信息

高精度、长时序的土壤水分数据对青藏高原陆-气相互作用研究十分重要。然而,当前青藏高原土壤水分研究大多聚焦表层土壤水分的卫星反演,根系层土壤水分的估算研究相对匮乏。基于青藏高原五个土壤水分观测网络(狮泉河、帕里、那曲、黑河上游、玛曲)数据,本文系统评估了指数滤波模型在青藏高原不同气候与下垫面区域估算根系层(10 cm/20 cm/40 cm)土壤水分的适用性,探讨了不同环境因素(土壤、气候、植被)对模型特征时长参数T值的影响,最后评估了利用三种方法(各观测网络或青藏高原站点最优T值(Topt)中位数、随机森林模型)获取的区域T值估算青藏高原根系层土壤水分的可靠性。研究发现:(1)随着土壤深度的增加,根系层与表层土壤水分的相关性降低,而其空间异质性增大,导致指数滤波模型的应用精度降低,而模型T值及其空间异质性增大;(2)空间上随着降水量和土壤含水量的增加,根系层与表层土壤水分的相关性增大,而其空间异质性降低,使得指数滤波模型的应用精度上升,而其在区域内不同站点应用精度的差异呈现降低趋势;(3)土壤性质尤其是砂土含量是控制青藏高原区域T值空间分布的主要因素;(4)T值的获取对指数滤波模型在青藏高原的应用精度影响较小,当前常用的区域Topt中位数和随机森林模型均能获取相对合理的区域T值和取得一致且相对准确的模拟结果。本研究的发现有望推动利用指数滤波模型基于卫星表层土壤水分资料准确获取青藏高原根系层土壤水分。

关键词：青藏高原指数滤波模型根系层土壤水分不同气候与下垫面区域

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Effect of Water Vapor Absorption on Measurements of Atmospheric Nitrate Radical by LP-DOAS

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Chinese Journal of Chemical Physics 2008年第5期21卷 433-437页

作者： Su-wen Li wen-qing Liu Pin-hua Xie Yi-jun Yang De-bao chen zheng Li Department of Physics Huaibei Coal Industry Teachers College Huaibei 235000 China Key Laboratory of Environmental Optical and Technology Anhui Institute of Optics and Fine Me-chanics Chinese Academy of Sciences Hefei 230031 China

During the measurement of atmospheric nitrate radical by long-path differential optical absorption spectroscopy, water vapor strong absorption could affect the measurement of nitrate radical and detection limits of system. Under the tropospheric condition, the optical density of water vapor absorption is non-linearly dependent on column density. An effective method was developed to eliminate the effect of water vapor absorption. Reference spectra of water vapor based on the daytime atmospheric absorption spectra, when fitted together with change of cross section with water vapor column densities, gave a more accurate fitting of water vapor absorptions, thus its effect on the measurements of nitrate radical could be restricted to a minimum and detection limits of system reached 3.6 ppt. The modified method was applied during an intensive field campaign in the Pearl River Delta, China. The NO3 concentration in polluted air masses varied from 3.6 ppt to 82.5 ppt with an average level of 23.6±1.8 ppt.

关键词： Nitrate radical Water vapor absorption Long-path differential optical absorption spectroscopy Detection limit

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Suppressing the phase transition of ZrP_(2)O_(7), by defect and entropy regulation for high-temperature wave-transparent material application

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Journal of Advanced Ceramics 2024年第8期13卷 1164-1177页

作者： Peng Liu Zhilin Tian Zhilin chen Shuping wen Liya zheng Bin Li School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

ZrP_(2)O_(7) is a promising wave-transparent material due to its low dielectric constant and low dielectric loss,but its inherent phase transition characteristic at approximately 300℃ limits its high-temperature ***,suppressing the phase transition is necessary for ZrP_(2)O_(7),to serve in extremely harsh *** this work,introducing Ti and Hf into ZrP_(2)O_(7) causes significant lattice distortion and an increase in entropy,both of which synergistically limit the crystal structure *** addition,enhanced phonon scattering by mismatch of atomic mass and local distortion leads to a reduction in the thermal *** distortions also cause changes in both bond length and tilting angle,so that(Ti_(1/3)Zr_(1/3)Hf_(1/3))P_(2)O_(7) does not undergo sudden expansion as does ZrP_(2)O_(7).(Ti_(1/3)Zr_(1/3)Hf_(1/3))ZrP_(2)O_(7) maintains excellent dielectric properties,which highlights it as a promising high-temperature wave-transparent material.

关键词： wave-transparent material medium-entropy ceramics phase transition dielectric constant thermal expansion thermal conductivity

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中国主要克拉通盆地深层白云岩优质储层发育主控因素及分布

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天然气地球科学 2017年第8期28卷 1165-1175页

作者：张建勇倪新峰吴兴宁李文正郝毅陈娅娜吕学菊谷明峰田瀚朱茂中国石油杭州地质研究院浙江杭州310023 中国石油天然气集团公司碳酸盐岩储层重点实验室浙江杭州310023

克拉通盆地深层白云岩是中国陆上未来天然气勘探的重要领域。通过统计分析四川、塔里木、鄂尔多斯等中国主要克拉通盆地,明确深层白云岩主要类型为颗粒白云岩、微生物白云岩及结晶白云岩,孔隙类型以裂缝—孔洞型和裂缝—孔隙型为主。指... 详细信息

克拉通盆地深层白云岩是中国陆上未来天然气勘探的重要领域。通过统计分析四川、塔里木、鄂尔多斯等中国主要克拉通盆地,明确深层白云岩主要类型为颗粒白云岩、微生物白云岩及结晶白云岩,孔隙类型以裂缝—孔洞型和裂缝—孔隙型为主。指出有利沉积微相是孔隙形成的物质基础,早期溶蚀作用是孔隙形成的必要条件,准同生—浅埋藏期等早期白云石化作用有利于准同生期形成的孔隙保存,表生岩溶及构造破裂作用起到改善储层物性的作用。明确了深层优质白云岩储层仍具有相控性,深层白云岩储层继承性大于改造性,其纵向分布不是受深度控制而是受早期沉积旋回控制,横向分布不是受岩溶作用控制而是受高能沉积相带控制。认为未来深层优质白云岩储层的勘探主要为"台内裂陷两侧"及碳酸盐岩缓坡之内缓坡—中缓坡。

关键词：克拉通盆地深层白云岩储层四川盆地塔里木盆地鄂尔多斯盆地

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Oscillation properties of matter–wave bright solitons in harmonic potentials

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Chinese Physics B 2022年第8期31卷 317-324页

作者： Shu-wen Guan Ling-zheng Meng Li-chen Zhao School of Physics Northwest UniversityXi’an 710127China NSFC–SPTP Peng Huanwu Center for Fundamental Theory Xi’an 710127China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi’an 710127China

We investigate the oscillation periods of bright soliton pair or vector bright soliton pair in harmonic potentials. We demonstrate that periods of low-speed solitons are greatly affected by the position shift during their collisions. The modified oscillation periods are described by defining a characterized speed, with the aid of asymptotic analysis on related exact analytic soliton solutions in integrable cases. The oscillation period can be used to distinguish the inter-and intra-species interactions between solitons. However, a bright soliton cannot oscillate in a harmonic trap, when it is coupled with a dark soliton(without any trapping potentials). Interestingly, it can oscillate in an anti-harmonic potential, and the oscillation behavior is explained by a quasi-particle theory. The modified period of two dark-bright solitons can be also described well by the characterized speed. These results address well the effects of position shift during soliton collision, which provides an important supplement for previous studies without considering phase shift effects.

关键词： matter–wave bright soliton harmonic potential oscillation period

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Minimization of Classification Samples for Supercritical and Subcritical Patterns of Supersonic Inlet

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Journal of Thermal Science 2014年第4期23卷 375-380页

作者： CHANG Juntao zheng Risheng YU Daren BAO wen chen Fu JIANG Weiyu ZHU Shoumei zheng Riheng Harbin Institute of Technology No.92.Xidazhi Street Science and Technology on Scramjet Laboratory

In order to investigate sample minimization for classification of supercritical and subcritical patterns in supersonic inlet, three optimization methods, namely, opposite one towards nearest method, closest one towards the byper-plane method and random selection method, are proposed for investigation on minimization of classification samples for supercritical and subcritical patterns of supersonic inlet. The study has been carried out to analyze wind tunnel test data and to compare the classification accuracy based on those three methods with or without priori knowledge. Those three methods are different from each other by different selecting methods for samples. The results show that one of the optimization methods needs the minimization samples to get the highest classification accuracy without priori knowledge. Meanwhile, the number of minimization samples needed to get highest classification accuracy can be further reduced by introducing priori knowledge. Furthermore, it demonstrates that the best optimization method has been found by comparing all cases studied with or without introducing priori knowledge. This method can be applied to reduce the number of wind tunnel tests to obtain the inlet performance and to identify the supercritical/subcritical modes for supersonic inlet.

关键词： Supersonic inlet Inlet supercritical/subcritical Sample minimization

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Dynamic lithium-compensation mechanism for densification of garnet-type Li_(7)La_(3)Zr_(2)O_(12)electrolyte by Li_(2)O atmosphere buffer pair

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Nano Research 2024年第7期17卷 6184-6191页

作者： Chujun zheng Ya chen Haoxin Dong Yan Lu Jun Jin Zhaoyin wen CAS Key Laboratory of Materials for Energy Conversion Shanghai Institute of CeramicsChinese Academy of ScienceShanghai 200050China State Key Lab High Performance Ceram and Superfine Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Solid-state lithium metal batteries are one of the most promising options for next-generation batteries pursuing high-energy density and ***,the inevitable volatilization of lithium compounds during sintering leads to low relative density and low ionic conductivity of solid-state ***,the dynamic lithium-compensation mechanism is proposed to facilitate the densification of Ta-substituted garnet-type electrolyte(Li_(6.5)La_(3)Zr_(1.5)Ta_(0.5)O_(12)(LLZT))through the reversible manipulating of Li_(2)O ***_(2)ZrO_(3)is used as mother powder additive,which reacts with Li_(2)O in sintering atmosphere and forms Li_(6)Zr_(2)O_(7).Li_(2)ZrO_(3)/Li_(6)Zr_(2)O_(7)buffer pair manipulates the sintering Li_(2)O atmosphere,which is vital for LLZT,within the Li_(2)O partial pressure range corresponding to Li_(2)ZrO_(3)and Li_(6)Zr_(2)O_(7).Furthermore,the reversibility mechanism of buffer pair for Li_(2)O absorption and release is *** obtained LLZT exhibits a relative density of over 96%and an ionic conductivity exceeding 7×10^(−4)S·cm^(−1)with no abnormal grain *** symmetric cell demonstrates an excellent lithium dendrite suppressing ability(stable cycling at a current density of 0.3 mA·cm^(−2)for over 1000 h).Such dynamic lithium-compensation strategy has been successfully applied in atmosphere manipulation of LLZT sintering process,which reduces the dependence of LLZT on the Li_(2)O atmosphere,making it conducive to large-scale preparation of electrolyte ceramics.

关键词： solid-state batteries garnet-type electrolyte high-density electrolyte dynamic lithium-compensation buffer pair

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