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(-)-Epigallocatechin-3-gallate enhances poly I:C-induced interferon-λ1 production and inhibits hepatitis C virus replication in hepatocytes

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World Journal of Gastroenterology 2017年第32期23卷 5895-5903页

作者： Yi-Zhong Wang Jie-Liang Li Xu Wang Ting Zhang wen-zhe ho Department of Infectious Diseases Shanghai Children’s Hospital Shanghai Jiao Tong University Department of Pathology and Laboratory Medicine Temple University Lewis Katz School of Medicine

AIM To investigate the effect of(-)-epigallocatechin-3-gallate(EGCG) on polyinosinic-polycytidylic acid(poly I:C)-triggered intracellular innate immunity against hepatitis C virus(HCV) in hepatocytes. METhoDS A cell culture model of HCV infection was generated by infecting a hepatoma cell line, Huh7, with HCV JFH-1 strain(JFH-1-Huh7). Poly I:C with a high molecular weight and EGCG were used to stimulate the JFH-1-Huh7 cells. Real-time reverse transcription-polymerase chain reaction was used to detect the expression levels of intracellular m RNAs and of intracellular and extracellular HCV RNA. Enzyme-linked immunosorbent assay was used to evaluate the interferon(IFN)-λ1 protein level in the cell culture supernatant. Immunostaining was used to examine HCV core protein expression in Huh7 *** Our recent study showed that HCV replication could impair poly I:C-triggered intracellular innate immune responses in hepatocytes. In the current study, we showed that EGCG treatment significantly increased the poly I:C-induced expression of Toll-like receptor 3(TLR3), retinoic acid-inducible gene I, and IFN-λ1 in JFH-1-Huh7 cells. In addition, supplementation with EGCG increased the poly I:C-mediated antiviral activity in JFH-1-Huh7 cells at the intracellular and extracellular HCV RNA and protein levels. Further investigation of the mechanisms showed that EGCG treatment significantly enhanced the poly I:C-induced expression of IFN-regulatory factor 9 and several antiviral IFNstimulated genes, including ISG15, ISG56, myxovirus resistance A, and 2'-5'-oligoadenylate synthetase 1, which encode the key antiviral elements in the IFN signaling pathway. CONCLUSION Our observations provide experimental evidence that EGCG has the ability to enhance poly I:C-induced intracellular antiviral innate immunity against HCV replication in hepatocytes.

关键词： (-)-Epigallocatechin-3-gallate Toll-like receptor 3 Retinoic acid-inducible gene I IFN-λ1 Hepatitis C virus IFN-stimulated genes

Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou zhe-Yi Han Jun Xiao Jian-Feng Ma wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Ultrafast magnetization enhancement and spin current injection in magnetic multilayers by exciting the nonmagnetic metal

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Science China(Physics,Mechanics & Astronomy) 2023年第12期66卷 158-168页

作者： wen-Tian Lu zhe Yuan Xiaohong Xu Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China

A systematic investigation of spin injection behavior in Au/FM(FM=Fe and Ni)multilayers is performed using the superdiffusive spin transport *** exciting the nonmagnetic layer,the laser-induced hot electrons may transfer spin angular momentum into the adjacent ferromagnetic(FM)metals resulting in ultrafast demagnetization or *** find that these experimental phenomena sensitively depend on the particular interface reflectivity of hot electrons and may reconcile the different observations in the *** by the ultrafast spin currents carried by the hot electrons,we propose the multilayer structures to generate highly spin-polarized currents for the development of future ultrafast spintronics *** spin polarization of the electric currents carried by the hot electrons can be significantly enhanced by the joint effects of bulk and interfacial spin ***,the intensity of the generated spin current can be optimized by varying the number of repeated stacking units and the thickness of each metallic layer.

关键词： spintronics ultrafast magnetodynamics spin polarization transport magnetic multilayer

Efficient Video Transmission in D2D Assisted Mobile Cloud Networks

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China Communications 2016年第8期13卷 74-83页

作者： Cheng Zhan zhe wen School of Computer and Information Science Southwest University

The increasing popularity of smart mobile devices and the rise of online services has increased the requirements for efficient dissemination of social video contents. In this paper,we study the problem of distributing video from cloud server to users in partially connected cooperative D2 D network using network coding. In such a scenario, the transmission conflicts occur from simultaneous transmissions of multiple devices, and the scheduling decision should be made not only on the encoded packets but also on the set of transmitting devices. We analyze the lower bound and give an integer linear formulation of the joint optimization problem over the set of transmitting devices and the packet *** also propose a heuristic solution for this setup using a conflict graph and local graph at every device. Simulation results show that our coding scheme significantly reduces the number of transmission slots, which will increase the efficiency of video delivery.

关键词： network coding video delivery device-to-device mobile cloud networks

Application of Short Sequential Extraction Procedure(SSEP) for the Determination of Zn, Cu, and Cd Contents in Riverbed Sludge in Hejiagou, Harbin, China

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Chemical Research in Chinese Universities 2006年第6期22卷 696-702页

作者： LI Yu WANG zhe ZHAO wen-Jin Energy and Environment Research Center North China Electric Power University Beijing 102206 P. R. China College of Enviromnent and Resources Jilin University Changchun 130012 P. R. China Department of Internal Medicine of Digestion China -Japan Union Hospital Jilin University Changchun 130033 P. R. China

A short sequential extraction procedure（SSEP） was applied to the determination of more readily available metal fractions of Zn, Cu, and Cd in the riverbed sludge in Hejiagou, Harbin, China. From the results, a potential order of metal availability in seven sludge samples was proposed： Cd 〈 Cu 〈 Zn, and samples S1 , S2, and S4 were used for the determination of total Zn content, and sample S3 used for the determination of total Cu content in the mobile and the mobilizable fractions showed the highest pollution risk. The results with regard to metal mobility in sludge samples were confirmed by the individual and global contamination factors that were calculated from the nonresidual and residual metal contents. The results obtained from metal-release experiments after exposure of sludge to environmental conditions agreed well with those obtained from both SSEP and the individual and global contamination factors, indicating that the maximum metal release could be an additional factor to evaluate the heavy metal availability in contaminated sludge. A substantial time saving was achieved by using the metal-release method in the present study.

关键词： Riverbed sludge Zn, Cu, and Cd Metal bioavailability Retention Release Sequential extraction procedure

Comparative study on flow and heat transfer characteristics of sinusoidal and zigzag channel printed circuit heat exchangers

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Science China(Technological Sciences) 2020年第4期63卷 655-667页

作者： wen zhe-Xi LV Yi-Gao LI Qing School of Energy Science and EngineeringCentral South UniversityChangsha 410083China

Printed circuit heat exchangers(PCHEs)are promising candidates for recuperators in supercritical CO2 Brayton cycles.A comparative study is given in this paper on the flow and heat transfer characteristics of PCHEs with sinusoidal and zigzag *** mass flow rates of 0.6–1.8 kg/h and the bend angles of 15°–30°,the thermal-hydraulic performance of the PCHEs is *** show that the sinusoidal channel is superior to the zigzag channel in its comprehensive *** bend angles result in greater reductions in pressure drop if sinusoidal channels are used instead of zigzag channels and a maximum of 48.4%reduction can be obtained in the considered working ***,the inlet sections should be carefully optimized since these sections account for up to 31%and 17%of the total pressure drop in the sinusoidal and zigzag channels,*** corner shape of the zigzag channel can be specially designed to further reduce the pressure *** nonuniform density and heat flux distributions in both channels are found to be related to the periodic changes of flow directions and the centrifugal forces should not be ignored when optimizing the sinusoidal and zigzag channels.

关键词： printed circuit heat exchanger supercritical CO2 thermal-hydraulic performance sinusoidal channel numerical simulation

Distributed dynamic task allocation for unmanned aerial vehicle swarm systems:A networked evolutionary game-theoretic approach

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Chinese Journal of Aeronautics 2024年第6期37卷 182-204页

作者： zhe ZHANG Ju JIANG Haiyan XU wen-An ZHANG College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China

Task allocation is a key aspect of Unmanned Aerial Vehicle(UAV)swarm collaborative *** an continuous increase of UAVs’scale and the complexity and uncertainty of tasks,existing methods have poor performance in computing efficiency,robustness,and realtime allocation,and there is a lack of theoretical analysis on the convergence and optimality of the *** paper presents a novel intelligent framework for distributed decision-making based on the evolutionary game theory to address task allocation for a UAV swarm system in uncertain scenarios.A task allocation model is designed with the local utility of an individual and the global utility of the ***,the paper analytically derives a potential function in the networked evolutionary potential game and proves that the optimal solution of the task allocation problem is a pure strategy Nash equilibrium of a finite strategy ***,a PayOff-based Time-Variant Log-linear Learning Algorithm(POTVLLA)is proposed,which includes a novel learning strategy based on payoffs for an individual and a time-dependent Boltzmann *** former aims to reduce the system’s computational burden and enhance the individual’s effectiveness,while the latter can ensure that the POTVLLA converges to the optimal Nash equilibrium with a probability of *** simulation results show that the approach is optimal,robust,scalable,and fast adaptable to environmental changes,even in some realistic situations where some UAVs or tasks are likely to be lost and increased,further validating the effectiveness and superiority of the proposed framework and algorithm.

关键词： Task allocation Unmanned Aerial Vehicles(UAV) Game theory Log-linear learning Distributed optimization algorithm

Effect of nano-carbon black content on wetting phenomenon of molten steel and alumina-carbon ceramic filter substrates

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Journal of Iron and Steel Research International 2024年第8期31卷 1900-1913页

作者： Jin-wen Song wen Yan zhe Chen Ying Liu Shao-song hong The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina National-provincial Joint Engineering Research Center of High Temperature Materials and Lining Technology Wuhan University of Science and TechnologyWuhan 430081HubeiChina Jiangsu Sheng Nai New Materials Co. Ltd.Taizhou 225503JiangsuChina

The effect of nano-carbon black content(O,8 and 12 wt.%)on the wettability of molten steel on Al_(2)O_(3)-C substrates was investigated by the sessile drop wetting method at 1500℃ under argon *** the beginning of the wetting experiment,the contact angle decreased with the increase in nano-carbon black *** the wetting experiment progressed,FeAl_(2)0_(4) layer and sheet Al_(2)O_(3) layer were found at the interface between the molten steel and the Al_(2)O_(3)-C substrates with O and 8 wt.% nano-carbon black content,and the contact angle deceased with *** the content of nano-carbon black was 12 wt.%,a large number of nano-Al_(2)O_(3) whiskers were observed,which made the contact angle between the molten steel and Al_(2)O_(3)-C substrate become *** on the scanning electron microscope and energy dispersive spectrometry results,the formation mechanism of FeAl2O4 layer and Al_(2)O_(3) layer and the interfacial reaction mechanism were proposed.

关键词： Contact angle Nano-carbon black Al_(2)O_(3)-C substrate Molten steel Interfacial reaction

Index-free triangle-based graph local clustering

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Frontiers of Computer Science 2024年第3期18卷 143-153页

作者： zhe YUAN zhewei WEI Fangrui LV Ji-Rong wen The Country and Area Studies Academy Beijing Foreign Studies UniversityBeijing 100089China Gaoling School of Artificial Intelligence Renmin University of ChinaBeijing 100872China

Motif-based graph local clustering(MGLC)is a popular method for graph mining tasks due to its various ***,the traditional two-phase approach of precomputing motif weights before performing local clustering loses locality and is impractical for large *** some attempts have been made to address the efficiency bottleneck,there is still no applicable algorithm for large scale graphs with billions of *** this paper,we propose a purely local and index-free method called Index-free Triangle-based Graph Local Clustering(TGLC^(*))to solve the MGLC problem w.r.t.a ***^(*)directly estimates the Personalized PageRank(PPR)vector using random walks with the desired triangleweighted distribution and proposes the clustering result using a standard sweep *** demonstrate TGLC^(*)’s scalability through theoretical analysis and its practical benefits through a novel visualization ***^(*)is the first algorithm to solve the MGLC problem without precomputing the motif *** experiments on seven real-world large-scale datasets show that TGLC^(*)is applicable and scalable for large graphs.

关键词： graph local clustering triangle motif index-free sampling method visualization