检索结果-南通市图书馆

World Journal of Hepatology 2024年第4期16卷 537-549页

作者： Jing-Jing Li Jia-Xi Mao Han-Xiang Zhong yuan-Yu Zhao Fei Teng Xin-Yi Lu Li-Ye Zhu Yang Gao Hong Fu wen-yuan guo Department of Liver Surgery and Organ Transplantation Shanghai Changzheng HospitalNaval Medical UniversityShanghai 200003China

The tumor microenvironment is a complex network of cells,extracellular matrix,and signaling molecules that plays a critical role in tumor progression and *** and blood vessels are major routes for solid tumor metastasis and essential parts of tumor drainage ***,recent studies have shown that lymphatic endothelial cells(LECs)and blood endothelial cells(BECs)also play multifaceted roles in the tumor microenvironment beyond their structural functions,particularly in hepatocellular carcinoma(HCC).This comprehensive review summarizes the diverse roles played by LECs and BECs in HCC,including their involvement in angiogenesis,immune modulation,lymphangiogenesis,and *** providing a detailed account of the complex interplay between LECs,BECs,and tumor cells,this review aims to shed light on future research directions regarding the immune regulatory function of LECs and potential therapeutic targets for HCC.

关键词： Lymphatic endothelial cells Blood endothelial cells Hepatocellular carcinoma Tumor microenvironment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

茶黄素体外抑菌作用研究

动物医学进展 2024年第8期45卷 135-139页

作者：卢琴郭云清张腾飞张蓉蓉胡巧张文婷温国元罗青平湖北省农业科学院畜牧兽医研究所农业部畜禽细菌病防治制剂创制重点实验室湖北洪山实验室湖北武汉430070

通过体外试验研究茶黄素对大肠埃希氏菌、金黄色葡萄球菌、枯草芽孢杆菌、肠球菌、禽肺炎克雷伯、鸭源鸡杆菌、禽肠炎沙门氏菌、野鸟黏质沙雷氏菌、禽巴氏杆菌的抑菌作用。采用最低抑菌浓度(MIC)和最小杀菌浓度(MBC)测定法研究茶黄素的... 详细信息

通过体外试验研究茶黄素对大肠埃希氏菌、金黄色葡萄球菌、枯草芽孢杆菌、肠球菌、禽肺炎克雷伯、鸭源鸡杆菌、禽肠炎沙门氏菌、野鸟黏质沙雷氏菌、禽巴氏杆菌的抑菌作用。采用最低抑菌浓度(MIC)和最小杀菌浓度(MBC)测定法研究茶黄素的抑菌作用及杀菌作用。结果显示,茶黄素对禽巴氏杆菌、鸭源鸡杆菌等具有抑菌作用,并与其浓度呈正相关,而对大肠埃希氏菌、禽肠炎沙门氏菌、黏质沙雷氏菌等无作用;茶黄素浓度为128μg/mL时,其对鸭源鸡杆菌生长具有抑制作用,当茶黄素浓度为512μg/mL时,其对禽巴氏杆菌C48-1生长具有抑制作用;当茶黄素浓度为512μg/mL时,其对禽巴氏杆菌和鸭源鸡杆菌具有杀菌作用。茶黄素在MBC浓度时能抑制生物被膜的形成能力。结果表明,茶黄素是一种天然抗菌剂,具有优良的替抗前景,促进绿色健康养殖。

关键词：茶黄素禽致病菌抑菌作用

Molecular recognition of cyclophanes in water

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 32-44页

作者： Fang-yuan Chen wen-Chao Geng Kang Cai Dong-Sheng guo College of Chemistry State Key Laboratory of Elemento-Organic ChemistryKey Laboratory of Functional Polymer Materials(Ministry of Education)Frontiers Science Center for New Organic MatterCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China College of Chemistry Nankai UniversityTianjin 300071China

Molecular recognition in water,the biological solvent,always receives significant research focus in supramolecular *** mechanisms of molecular recognition in water is key to comprehending biological processes at the molecular *** the past five decades,supramolecular chemists have developed a vast array of synthetic receptors with highly diverse structures and recognition *** them,cyclophanes represent an important family of macrocyclic receptors that have been extensively *** aromatic moieties in cyclophanes not only facilitate chemical modifications to impart water solubility but also enable forming hydrophobic cavities for guest inclusion in aqueous *** by Koga et al.,who reported the first inclusion complex of cyclophanes in water and solid state,numerous water-soluble cyclophanes,including derivatives of blue box,calixarenes,resorcinarenes,pillararenes,octopusarenes,biphenarenes,coronarenes,and naphthotubes,etc.,have been synthesized and subjected to investigation of the recognition capabilities in aqueous *** review provides an overview of cyclophane receptors designed to bind organic guests in *** categorize them into two classes based on the modifications made to their hydrophobic cavities:those with“exo-functionalized hydrophobic cavities”and those with“endo-functionalized hydrophobic cavities”.We introduce their distinctive features and discuss strategies to enhance recognition affinity and *** review aims to inspire the development of novel synthetic receptors with intriguing properties and foster practical applications of cyclophanes.

关键词： Biomimetic receptor Cyclophane Molecular recognition Hydrophobic effect High-affinity Macrocycles

维普期刊数据库

Multi-Time-Scale Variational Mode Decomposition-Based Robust Fault Diagnosis of Railway Point Machines Under Multiple Noises

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第3期33卷 814-822页

作者： Junqi LIU Tao wen guo XIE yuan CAO Clive Roberts Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi'an University of Technology The School of Electronic and Information Engineering Beijing Jiaotong University Birmingham Centre for Railway Research and Education University of Birmingham

The fault diagnosis of railway point machines(RPMs) has attracted the attention of engineers and *** have studies considered diverse noises along the *** fulfill this aspect,a multi-time-scale variational mode decomposition(MTSVMD) is proposed in this paper to realize the accurate and robust fault diagnosis of RPMs under multiple *** decomposes condition monitoring signals after coarse-grained processing in varying *** this manner,the information contained in the signal components at multiple time scales can construct a more abundant feature space than at a single *** the experimental validation,a random position,random type,random number,and random length(4R) noise-adding algorithm helps to verify the robustness of the *** adequate experimental results demoristrate the superiority of the proposed MTSVMD-based fault diagnosis.

关键词： Fault diagnosis Condition monitoring Noise Signal processing algorithms Aerospace electronics Rail transportation Robustness

P-and SV-wave dispersion and attenuation in saturated microcracked porous rock with aligned penny-shaped fractures

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第1期21卷 143-161页

作者： Sheng-Qing Li wen-Hao Wang yuan-Da Su Jun-Xin guo Xiao-Ming Tang School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Laoshan National Laboratory Qingdao 266071ShangdongChina Guangdong Provincial Key Laboratory of Geophysical High-resolution Imaging Technology Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen 518055GuangdongChina

P-and SV-wave dispersion and attenuation have been extensively investigated in saturated poroelastic media with aligned ***,there are few existing models that incorporate the multiple wave attenuation mechanisms from the microscopic scale to the macroscopic ***,in this work,we developed a unified model to incorporate the wave attenuation mechanisms at different scales,which includes the microscopic squirt flow between the microcracks and pores,the mesoscopic wave-induced fluid flow between fractures and background(FB-WIFF),and the macroscopic Biot's global flow and elastic scattering(ES)from the *** Tang's modified Biot's theory and the mixed-boundary conditions,we derived the exact frequency-dependent solutions of the scattering problem for a single penny-shaped fracture with oblique incident P-and *** then developed theoretical models for a set of aligned fractures and randomly oriented fractures using the Foldy *** results indicated that microcrack squirt flow considerably influences the dispersion and attenuation of P-and SV-wave *** coupling effects of microcrack squirt flow with the FB-WIFF and ES of fractures cause much higher velocity dispersion and attenuation for P waves than for SV *** oriented fractures substantially reduce the attenuation caused by the FB-WIFF and ES,particularly for the ES attenuation of SV *** a comparison with existing models in the limiting cases and previous experimental measurements,we validated our model.

关键词： Aligned fractures P-and SV-wave Dispersion and attenuation Microcracked porous background FB-WIFF Elastic scattering Squirt flow

维普期刊数据库

Vibration-Based Fault Diagnosis for Railway Point Machines Using VMD and Multiscale Fluctuation-Based Dispersion Entropy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第3期33卷 803-813页

作者： Yongkui SUN yuan CAO Peng LI guo XIE Tao wen Shuai SU National Engineering Research Center of Rail Transportation Operation and Control System Beijing Jiaotong University School of Electronic and Information Engineering Beijing Jiaotong University Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi'an University of Technology Frontiers Science Center for Smart High-speed Railway System Beijing Jiaotong University

As one of the most important railway signaling equipment,railway point machines undertake the major task of ensuring train operation *** fault diagnosis for railway point machines becomes a hot *** the advantage of the anti-interference characteristics of vibration signals,this paper proposes an novel intelligent fault diagnosis method for railway point machines based on vibration signals.A feature extraction method combining variational mode decomposition(VMD) and multiscale fluctuation-based dispersion entropy is developed,which is verified a more effective tool for feature ***,a two-stage feature selection method based on Fisher discrimination and ReliefF is proposed,which is validated more powerful than single feature selection ***,support vector machine is utilized for fault *** comparisons show that the proposed method performs *** diagnosis accuracies of normal-reverse and reverse-normal switching processes reach 100% and 96.57% ***,it is a try to use new means for fault diagnosis on railway point machines,which can also provide references for similar fields.

关键词： Fault diagnosis Vibrations Support vector machines Diversity reception Switches Feature extraction Rail transportation

同方期刊数据库

Middle Devonian ostracods from Jiwozhai patch reef(Dushan, Guizhou Province, South China):Biostratigraphic and palaeoecological implication

在线全文

学校读者我要写书评

暂无评论

Journal of Palaeogeography 2024年第3期13卷 581-593页

作者： Jun-Jun Song Jia-yuan Huang wen guo Kun Liang Yu-Cong Sun Zhi-Hong Wang wen-Kun Qie State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences Hubei Key Laboratory of Paleontology and Geological Environment Evolution Wuhan Center of China Geological Survey University of Chinese Academy of Sciences

The Middle Devonian ostracods from the Jiwozhai patch reef in Dushan, Guizhou Province, South China were described for the first time in this study. Twenty-nine species belonging to 20 genera were identified and figured, including a new species named Wangshangkia jiwozhaiensis sp. nov. The ostracod fauna in the Jiwozhai patch reef represents a Givetian age. The ostracod assemblage belongs to the smooth-podocopid association, which is also ecologically equivalent to the Eifelian Mega-Assemblage Ⅲ. This association is indicative of shallow open-marine environments. The Jiwozhai patch reef fauna is primarily comprised of suspension feeders, including filter-feeding ostracods, corals, brachiopods and bryozoans. Ostracods from the Jiwozhai patch reef were compared to the ostracod faunas from Laurentia-Baltica at generic level, which reveals limited faunal exchanges between South China and Laurentia-Baltica during the Middle Devonian.

关键词： Ostracods Givetian Jiwozhai patch reef Dushan Palaeoecology

Reliability-based life-cycle cost seismic design optimization of coastal bridge piers with nonuniform corrosion using different materials

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2024年第1期23卷 209-225页

作者： Wu Xiangtong yuan wenting guo Anxin Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin 150090China Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Harbin Institute of TechnologyHarbin 150090China Institute of Transportation Inner Mongolia UniversityHohhot 010070China

Reinforcement corrosion is the main cause of performance deterioration of reinforced concrete(RC)*** research has been performed to investigate the life-cycle cost(LCC)of coastal bridge piers with nonuniform corrosion using different *** this study,a reliability-based design optimization(RBDO)procedure is improved for the design of coastal bridge piers using six groups of commonly used materials,i.e.,normal performance concrete(NPC)with black steel(BS)rebar,high strength steel(HSS)rebar,epoxy coated(EC)rebar,and stainless steel(SS)rebar(named NPC-BS,NPC-HSS,NPC-EC,and NPC-SS,respectively),NPC with BS with silane soakage on the pier surface(named NPC-Silane),and high-performance concrete(HPC)with BS rebar(named HPC-BS).First,the RBDO procedure is improved for the design optimization of coastal bridge piers,and a bridge is selected to illustrate the ***,reliability analysis of the pier designed with each group of materials is carried out to obtain the time-dependent reliability in terms of the ultimate and serviceability ***,the repair time of the pier is predicted based on the time-dependent reliability ***,the time-dependent LCCs for the pier are obtained for the selection of the optimal design.

关键词： reliability-based design optimization(RBDO) life-cycle cost(LCC) nonuniform corrosion coastal bridge pier repair

维普期刊数据库

Discovery potential of the Glashow resonance in an air shower neutrino telescope

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第8期48卷 266-275页

作者： guo-yuan Huang School of Mathematics and Physics China University of GeosciencesWuhan 430074China Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany

The in-ice or in-water Cherenkov neutrino telescope,such as IceCube,has already proved its power in measuring the Glashow resonance by searching for the bump around E_(ν)=6.3PeV arising from the W-boson *** are many proposals for the next few decades for observations of cosmic tau neutrinos with extensive air showers,also known as tau neutrino *** air shower telescope is,in principle,sensitive to the Glashow resonance via the channel W→τν_(τ)followed by the tau decay in the air(e.g.,TAMBO,which has a geometric area of approximately 500km^(2)).Using a thorough numerical analysis,we find that the discovery significance can be up to 90%with a TAMBO-like setup if PeV neutrinos primarily originate from neutron decays,considering the flux parameters measured by IceCube as the *** presence of new physics affecting the neutrino flavor composition can also increase the ***,if ultrahigh-energy neutrinos are dominantly produced from meson decays,it will be statistically difficult for an advanced proposal such as TAMBO to discriminate the Glashow resonance induced byν¯e from the intrinsicντ/ν¯_(τ)*** have identified several limitations for such advanced telescopes,in comparison with the in-ice or in-water telescope,when measuring resonances:(i)a suppressed branching ratio of 11%for the decay W→τν_(τ);(ii)the smearing effect and reduced acceptance because the daughter neutrino takes away(y)∼75%of the energy from the W decay;and(iii)a large attenuation effect for Earth-skimming neutrinos with the resonance.

关键词： Ultrahigh-energy neutrinos Neutrino telescopes Glashow resonance

Effect of post rolling stress on phase transformation behavior of microalloyed dual phase steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research(International) 2024年第3期31卷 688-699页

作者： wen-quan Sun Sheng-yi Yong Tie-heng yuan Ting-song Yang An-rui He Chao Liu Rui-chun guo National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing 100083China

The slow phase transformation of microalloyed dual phase steel makes the nonuniform stress and temperature fields during the post rolling cooling process have a significant impact on the phase transformation *** the relatively slow phase transformation of DP780 steel within the microalloyed dual phase steel series,the influence of stress on the phase transformation behavior of DP780 steel was *** quantify the nonuniform thermal and stress conditions in the steel coil,a thermo-mechanical coupled finite element model of the hot-rolled strip cooling process was *** on the simulation data,DP780 steel was chosen as the research material,and Gleeble 3500 thermal simulation equipment was used for experimental *** thermal expansion curves were analyzed through regression to establish the dynamic model of DP780 steel phase transformation under ***,metallographic analysis was conducted to determine phase transformation type and grain size of DP780 *** results confirmed that the stress promotes the occurrence of semi-diffusion-type bainite ***,an appropriate level of stress facilitates the growth of bainitic grains,while the increased stress inhibits the growth of ferritic grains.

关键词： Microalloyed dual phase steel Stress Bainitic transformation Grain Finite element method