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Neoadjuvant chemotherapy for patients with resectable colorectal cancer liver metastases: A systematic review and meta-analysis

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World Journal of Clinical Cases 2021年第22期9卷 6357-6379页

作者： yue Zhang Long Ge Jun weng wen-yu tuo Bin Liu Shi-Xun Ma Ke-Hu Yang Hui Cai General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Evidence Based Social Science Research Center School of Public HealthLanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND In recent years,neoadjuvant chemotherapy(NAC)has been increasingly used in patients with resectable colorectal liver ***,the efficacy and safety of NAC in the treatment of resectable colorectal liver metastases(CRLM)are still *** To assess the efficacy and application value of NAC in patients with resectable *** We searched PubMed,Embase,Web of Science,and the Cochrane Library from inception to December 2020 to collect clinical studies comparing NAC with *** processing and statistical analyses were performed using Stata V.15.0 and Review Manager 5.0 *** In total,32 studies involving 11236 patients were included in this *** divided the patients into two groups,the NAC group(that received neoadjuvant chemotherapy)and the non-NAC group(that received no neoadjuvant chemotherapy).The meta-analysis outcome showed a statistically significant difference in the 5-year overall survival and 5-year disease-free survival between the two *** hazard ratio(HR)and 95%confidence interval(CI)were HR=0.49,95%CI:0.39-0.61,P=0.000 and HR=0.4895%CI:0.36-0.63,P=*** duration of surgery in the NAC group was longer than that of the non-NAC group[standardized mean difference(SMD)=0.41,95%CI:0.01-0.82,P=0.044)].The meta-analysis showed that the number of liver metastases in the NAC group was significantly higher than that in the non-NAC group(SMD=0.73,95%CI:0.02-1.43,P=0.043).The lymph node metastasis in the NAC group was significantly higher than that in the non-NAC group(SMD=1.24,95%CI:1.07-1.43,P=0.004).CONCLUSION We found that NAC could improve the long-term prognosis of patients with resectable *** the same time,the NAC group did not increase the risk of any adverse event compared to the non-NAC group.

关键词： Colorectal neoplasm Neoadjuvant chemotherapy Systematic review Randomized controlled trials Meta-analysis Colorectal liver metastases

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Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da Wan Shuwei Tang Shulin Bai Xiaodong Li Peng Ai Wanrong Guo tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： yunhan Yang Han Jia tuo Liu yuzhen Yang Jun Yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

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Formation of Vacancy-Type Dislocation Loops in Hydrogen-Ion-Implanted Fe–Cr Alloy

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Acta Metallurgica Sinica(English Letters) 2019年第5期32卷 566-572页

作者： yu-Feng Du Li-Juan Cui wen-tuo Han Fa-Rong Wan Department of Materials Physics and Chemistry School of Materials Science and Engineering University of Science and Technology

Fe-10 at.%Cr alloy was implanted with hydrogen ions at room temperature, followed by annealing at high *** annealing process made the defects develop into large dislocation loops. The nature of the dislocation loops formed after annealing was studied by the evolution of loops under in situ electron irradiation in high-voltage electron *** indicated that only interstitial-type loops were observed when annealed at 550 °C and below, but vacancy-type loops started to form at the temperature higher than 600 °C. According to the previous study of our group, the presence of chromium element made the formation temperature of vacancy-type loops higher than that in pure iron. The effect of alloying elements on the formation temperature of the vacancy-type loops was discussed.

关键词： Hydrogen implantation Interstitial-type loops Vacancy-type loops Fe–Cr alloy High-voltage electron microscope

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Numerical simulation of radiated noise during combustion of energetic materials in a closed bomb

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Defence Technology（防务技术） 2022年第7期18卷 1167-1178页

作者： Shi-hui Xiong tuo Yang yu-jun Wu Jing-cheng Wang yuan Li yu-quan wen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Xi'an Qinghua Cooperation North Special Energy Group Co.Ltd.Xi'an710025China Institute of Extreme Mechanics and School of Aeronautics Northwestern Polytechnical UniversityXi'an710072China

In this study,based on a closed bomb test combined with computational fluid dynamics,a structural finite element method,and an acoustic boundary element method,a fluid-solid acoustic one-way coupling calculation model is established for the combustion process of energetic materials in a closed bomb,and the effectiveness of the model is verified by *** is found that the maximum peak sound pressure increases exponentially with an increase in loading doses or gas ***,a change in the combustion coefficient of the energetic materials has little effect on the noise generated during the combustion process in the closed *** the combustion coefficient is reduced by a multiple of 16,the maximum transient sound pressure is reduced by 1.79 dB,and the sound pressure level in the frequency band is reduced by 1.75 *** an increase in shell thickness,the combustion noise of the energetic materials in the closed bomb decreases,and the reduction range of the combustion noise increases with the increase in shell thickness.

关键词： Pyrotechnics Noise Energetic materials Fluid-structure interaction Acoustic boundary element

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Solidification segregation behavior of Nb-containing 310S steel

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Journal of Iron and Steel Research International 2023年第1期30卷 82-87页

作者： yu-tuo Zhang Hao Zou School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159LiaoningChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina

The solidification characteristics and segregation behavior of solute elements Nb,Ni,Mn,Si,Cr and C in 0.3 wt.%Nb-310S steel were investigated using the isothermal solidification quenching experiment and Thermo-Calc *** phase transformation for 0.3%Nb-310S steel under equilibrium condition can be summarized as follows:liquid(L)→L+γ(1406℃)→γ(1334℃)→γ+NbC(1322℃)→γ+NbC+M_(23)C_(6)(1006℃)→γ+NbC+M_(23)C_(6)→σ(755℃).The results showed that the solidification began with the formation of primary austenite *** volume fraction of the liquid phase decreased rapidly as the temperature decreased in the initial solidification stage,and then,the liquid phase fraction decreased *** austenite formed,Mn and Ni were enriched in the solid phase,while Nb and C were rejected into the *** was present the highest segregation coefficient in 0.3%Nb-310S austenitic stainless *** segregation of Nb was the most serious,followed by Mn,Ni and *** and Si exhibited slight segregation during the *** solidification was terminated by the formation of NbC phase.

关键词： 310S steel Nb Solidification Segregation Thermo-Calc calculation

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Road model prediction based unstructured road detection

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第11期14卷 822-834页

作者： wen-hui ZUO tuo-zhong YAO Department of Information Science and Electronic Engineering Zhejiang University Ningbo Institute of Materials Technology&Engineering Chinese Academy of Sciences

Vision-based road detection is an important research topic in different areas of computer vision such as the autonomous navigation of mobile *** outdoor unstructured environments such as villages and deserts,the roads are usually not well-paved and have variant colors or texture *** region- or edge-based approaches,however,are effective only in specific environments,and most of them have weak adaptability to varying road types and *** this paper we describe a novel top-down based hybrid algorithm which properly combines both region and edge cues from the *** main difference between our proposed algorithm and previous ones is that,before road detection,an off-line scene classifier is efficiently learned by both low- and high-level image cues to predict the unstructured road *** scene classification can be considered a decision process which guides the selection of the optimal solution from region- or edge-based approaches to detect the ***,a temporal smoothing mechanism is incorporated,which further makes both model prediction and region classification more *** results demonstrate that compared with traditional region- and edge-based algorithms,our algorithm is more robust in detecting the road areas with diverse road types and varying appearances in unstructured conditions.

关键词： Road detection Surface layout Road model prediction Temporal smoothing

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A novel polymer gel with high-temperature and high-salinity resistance for conformance control in carbonate reservoirs

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Petroleum Science 2022年第6期19卷 3159-3170页

作者： Wei-Peng Wu Ji-Rui Hou Ming Qu yu-Long Yang Wei Zhang wen-Ming Wu yu-Chen wen tuo Liang Li-Xiao Xiao Unconventional Petroleum Research Institute China University of PetroleumBeijing102249China Sinopec Northwest Oilfield Company UrumqiXinjiang830000China

Plugging agents have been widely used to enhance oil recovery in fractured-vuggy carbonate ***,the harsh conditions of fractured-vuggy carbonate reservoirs yield a significant challenge in maintaining a long-term stabilization of plugging *** this work,we developed an anti-hightemperature and high-salinity polymer gel(APG)with excellent resistance to high temperature(140℃)and ultra-high salinity(240000 mg/L).The rheology and microstructure of APG were characterized before and after *** plugging tests on fractured cubic cores were conducted to quantify the plugging performance of the gel *** results showed that the Sclerglucan and Cobalt(Ⅱ)Chloride Hexahydrate filled the three-dimensional(3-D)network with various morphologies,providing extra protection to the cross-linking points of the 3D network structure of APG and thus,leading to a prolongation of the dehydration *** dehydration rate of APG was only 5%within 30days,and the strength of APG could be maintained at a rigid or near-rigid level over 150 ***,APG exhibited satisfactory shear and scour *** plugging tests showed that APG could achieve a plugging rate of 90%and demonstrate ignorable minor damage to the *** results indicate that APG can serve as a great candidate in channel plugging in fractured-vuggy carbonate reservoirs where fractures are fully developed.

关键词： Conformance control Fractured-vuggy reservoir High temperature High salinity Thermal stability

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Extrusion process of 304L H-shaped stainless steel used in passive residual heat removal heat exchanger

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Nuclear Science and Techniques 2019年第4期30卷 70-79页

作者： Lei-Feng tuo Gen-Shu Zhou Zhi-Qiang yu Xi-Tang Kang Bo-wen Wang State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Stainless Steel Tube Branch Company Taiyuan Iron & Steel Group CO.LTD Stainless Steel Tube Branch Company Taiyuan Iron & Steel (Group) CO.LTD

304L H-shaped stainless steel is used as the support frame of the passive residual heat removal heat exchanger(PRHR HX) in a nuclear fission reactor. The extrusion process is adopted to manufacture the 304L H-shaped stainless steel. Finite element method simulation is herein used to analyze metal flow characteristics, optimize the extrusion die, and predict the extrusion force at different temperatures and speeds. A Φ400-mm container and Φ388-mm forging billet are selected, and the 304L H-shaped stainless steel is successfully manufactured using a Germany SMS 60 MN horizontal extruder. The mechanical properties and microstructure of the manufactured 304L H-shaped stainless steel meet the requirements of the PRHR HX, and the surfaces of the product pass the dye penetration test. The H-shaped stainless steels are used in Haiyang nuclear power plant in Shandong Province.

关键词： PRHR HX Support frame Extrusion process 304L H-shaped stainless steel

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Robust water hazard detection for autonomous off-road navigation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 786-793页

作者： tuo-zhong YAO Zhi-yu XIANG Ji-lin LIU Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China

Existing water hazard detection methods usually fail when the features of water surfaces are greatly changed by the surroundings, e.g., by a change in illumination. This paper proposes a novel algorithm to robustly detect different kinds of water hazards for autonomous navigation. Our algorithm combines traditional machine learning and image segmentation and uses only digital cameras, which are usually affordable, as the visual sensors. Active learning is used for automatically dealing with problems caused by the selection, labeling and classification of large numbers of training sets. Mean-shift based image segmentation is used to refine the final classification. Our experimental results show that our new algorithm can accurately detect not only ‘common’ water hazards, which usually have the features of both high brightness and low texture, but also ‘special’ water hazards that may have lots of ripples or low brightness.

关键词： Water hazard detection Active leaming Adaboost Mean-shift

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