检索结果-南通市图书馆

Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages:an autopsy-based study

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2023年第4期8卷 267-275,I0002-I0009页

作者： Yuan Cao Mei-ying Huang Chen-Hui Mao Xue Wang Yuan-Yuan Xu Xiao-Jing Qian Chao Ma wen-ying qiu Yi-Cheng Zhu Department of Neurology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Human Anatomy Histology and EmbryologyInstitute of Basic Medical SciencesNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijingChina

Background and purpose Cerebrovascular parenchymal damage is prevalent in ageing brains;however,its vascular aetiology has not been fully *** addition to the underlying role of sclerotic arterioles,the correlation between collagenised venules has not been ***,we aimed to investigate the associations between microvascular injuries,including arteriolosclerosis and venular collagenosis,and related parenchymal damages in ageing brains,to investigate the underlying *** We evaluated arteriolosclerosis and venular collagenosis in 7 regions from 27 autopsy cases with no history of stroke or brain *** correlations between the ratio of arteriolosclerosis,venular collagenosis and the severity of cerebrovascular parenchymal damage,including lacunes,microinfarcts,myelin loss,and parenchymal and perivascular haemosiderin deposits,were *** Arteriolosclerosis and venular collagenosis became more evident with *** was associated with lacunes(p=0.004)and brain parenchymal haemosiderin deposits in the superior frontal cortex(p=0.024)but not with leukoaraiosis *** collagenosis was not associated with the number of lacunes or haemosiderin,while white matter generally became paler with severe venular collagenosis in the periventricular(β=−0.430,p=0.028)and deep white matter(β=−0.437,p=0.025).Conclusion Our findings imply an important role for venular lesions in relation to microvessel-related parenchymal damage which is different from that for *** underlying mechanisms of both cerebral arterioles and venules require further investigation.

关键词： sclerosis damage injuries

Development of general practice education and training in China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第17期127卷 3181-3184页

作者： Ren wen Liu ying qiu Yan Ren Jingjing Department of General Practice First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

General practice as a discipline has largely evolved over the past 30 years in the field of primary health care. It originated in the 18th century m Europe. It was established in the United States in the 1960s and introduced to China in the late 1980s. In earlier times, medicine was not specialized, and general physicians dominated the medical field. At the end of the 19th century, with the development of basic medical disciplines, such as biology and anatomy, the development of more specialized medical practices began.

关键词： general medicine general practice training mode education

The joint Laplace transforms for killed diffusion occupation times

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 398-415页

作者： LI ying-qiu CHEN Ye School of Mathematics and Statistics Changsha University of Science and TechnologyChangsha 410114China College of Mathematics and Computational Science Hunan University of Arts and ScienceChangde 415000China

The approach of Li and Zhou(2014)is adopted to find the Laplace transform of occupation time over interval(0,a)and joint occupation times over semi-infinite intervals(-∞,a)and(b,∞)for a time-homogeneous diffusion pr... 详细信息

关键词： time-homogeneous diffusion process occupation time joint occupation time Laplace transform Brownian motion with drift

Interface engineering enabled sintering-resistant metal nanocatalysts via reverse Ostwald ripening

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第9期67卷 2789-2791页

作者： ying Sun wenhui Fang Jieshan qiu Institute of Clean Energy Chemistry Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials of Liaoning ProvinceCollege of ChemistryLiaoning UniversityShenyang 110036China State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China

The design and fabrication of advanced nanocatalysts with the high activity,selectivity,and superior durability remains a big challenge in industrial catalysis[1,2].The sintering of nanocatalysts under the thermally and/or chemically triggered conditions is a bottle-neck issue,which seriously decreases the amount of the exposed active sites and changes the original electronic structure of catalysts,resulting in the irreversible catalyst deactivation and high capital and time cost in industrial operation[3].

关键词： durability irreversible catalysis

Application of artificial synapse based on all-inorganic perovskite memristor in neuromorphic computing

在线全文

学校读者我要写书评

暂无评论

Nano Materials Science 2024年第1期6卷 68-76页

作者： Fang Luo wen-Min Zhong Xin-Gui Tang Jia-ying Chen Yan-Ping Jiang qiu-Xiang Liu School of Physics&Optoelectric Engineering Guangdong University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou510006China

Artificial synapse inspired by the biological brain has great potential in the field of neuromorphic computing and artificial *** memristor is an ideal artificial synaptic device with fast operation and good ***,we have prepared a memristor device with Au/CsPbBr_(3)/ITO *** memristor device exhibits resistance switching behavior,the high and low resistance states no obvious decline after 400 switching *** memristor device is stimulated by voltage pulses to simulate biological synaptic plasticity,such as long-term potentiation,long-term depression,pair-pulse facilitation,short-term depression,and short-term *** transformation from short-term memory to long-term memory is achieved by changing the stimulation *** addition,a convolutional neural network was constructed to train/recognize MNIST handwritten data sets;a distinguished recognition accuracy of~96.7%on the digital image was obtained in 100 epochs,which is more accurate than other memristor-based neural *** results show that the memristor device based on CsPbBr3 has immense potential in the neuromorphic computing system.

关键词： Memristor CsPbBr_(3) Resistive switching Artificial synapse Neuromorphic computing

Synthesis of granulated Li_(1.33)Mn_(1.67)O_(4) via two antisolvent methods for lithium adsorption from gas-produced water

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第5期69卷 34-46页

作者： Jun qiu Lu-Ri Bao Wei Guo ying Yang Shu-ying Sun National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China

Gas-produced water is an accompanying wastewater in the natural gas extraction process,and it is a potential liquid lithium resource that contains a considerable amount of *** study investigated the feasibility of using manganese-based ion sieves to adsorb and extract lithium from gas-produced *** we focused on the applicability of two different granulation methods,extrusion and droplet,in gas-produced water *** types of H_(1.33)Mn_(1.67)O_(4) particles were prepared by the extrusion method(EHMO)and the droplet method(DHMO).The porosity of DHMO was much higher than that of EHMO,and the adsorption performance of DHMO increased with the decrease of binder *** prepared with a binder concentration of 0.14 g·ml^(-1)exhibited the best adsorption performance in gas-produced water,and the Li^(+)adsorption capacity could reach 25.14 mg·g^(-1).In gas-produced water,the adsorption equilibrium of DHMO only took 9 h,and the adsorption process conformed to the Langmuir model and pseudo-second-order kinetic *** pore diffusion model(PDM)could well describe its adsorption ***,DHMO showed a great selectivity to Li^(+),and the selectivity order of DHMO in gas-produced water was Li^(+)>Ba^(2+)>>Mg^(2+),Ca^(2+),Sr^(2+)>>Na^(+)>>K^(+).After 20 cycles,the Li^(+)adsorption capacity was still higher than 17.30 mg·g^(-1),and the rate of manganese dissolution was less than 1%.

关键词： Gas-produced water Granulation Li_(1.33)Mn_(1.67)O_(4)

Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1395-1406页

作者： qiu-Xiao Yu Ping-ying Fu Chi Zhang Li Li wen-Ting Huang Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related mortality ***-epithelial transition factor(MET)gene participates in multiple tumor biology and shows clinical potential for pharmacological manipulation in tumor *** amplification has been reported in CRC,but data are very *** pathological values of MET in CRC may provide new therapeutic and genetic screening options in future clinical *** To determine the pathological significance of MET amplification in CRC and to propose a feasible screening *** A number of 205 newly diagnosed CRC patients undergoing surgical resection without any preoperative therapy at Shenzhen Cancer Hospital of Chinese Academy of Medical Sciences were *** patients were without RAS/RAF mutation or microsatellite *** amplification and c-MET protein expression were analyzed using fluorescence in situ hybridization(FISH)and immunohistochemistry(IHC),*** between MET aberration and pathological features were detected using the chi-squared *** free survival(PFS)during the two-year follow-up was detected using the Kaplan-Meier method and log rank *** results of MET FISH and IHC were com pared using one-way *** Polysomy-induced MET amplification was observed in 14.4%of cases,and focal MET amplification was not ***-induced MET amplification was associated with a higher frequency of lymph node metastasis(LNM)(P<0.001)and higher tumor budding grade(P=0.02).In the survival analysis,significant difference was detected between patients with amplified-and non-amplified MET in a two-year follow-up after the first diagnosis(P=0.001).C-MET scores of 0,1+,2+,and 3+were observed in 1.4%,24.9%,54.7%,and 19.0%of tumors,respectively.C-MET overexpression correlated with higher frequency of LNM(P=0.002),but no significant difference of PFS was dete

关键词： Colorectal cancer MET Amplification Pathological features Prognosis Fluorescence in situ hybridization

One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM) in Water

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第1期42卷 1-6,I0004页

作者： Zi-Shan Li Jing Lyu Bei qiu ying-Hao Li Ruth Foley Ri-Jian Song Melissa Johnson Qiang Geng wen-Xin Wang Institute of Precision Medicine(AUST-IPM) Anhui University of Science and TechnologyHuainan 232001China Charles Institute of Dermatology School of MedicineUniversity College DublinDublin D04 V1W8Ireland

Copper(0)-mediated reversible-deactivation radical polymerization(Cu(0)-mediated RDRP) of the water-soluble monomer Nisopropylacrylamide(NIPAM) has been challenging with the problems of high dispersity, poor control over the molecular weights(MWs) or complex or multi reaction steps, etc. In this work, we report the well-controlled polymerization of NIPAM in water via a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu~I at the very beginning, and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM, which has a high propagation rate constant, the deactivation control can be effectively enhanced by extra adding deactivator(i.e., Cu~II) to the system. Moreover, a low reaction temperature(4 ℃) is necessary in the controlled synthesis of higher MW poly(Nisopropylacrylamide)(PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature(LCST). Through this new kinetically controlled strategy, PNIPAMs with well-defined structure, narrow molecular weight distributions(MWDs) and varied MWs were successfully achieved.

关键词： Cu(0)-mediated RDRP N-isopropylacrylamide Propagation Deactivation Reaction parameters

Spatial structural characteristics of the Deda ancient landslide in the eastern Tibetan Plateau:Insights from Audio-frequency Magnetotellurics and the Microtremor Survey Method

在线全文

学校读者我要写书评

暂无评论

China Geology 2024年第2期7卷 188-202页

作者： Zhen-dong qiu Chang-bao Guo Yi-ying Zhang Zhi-hua Yang Rui-an Wu Yi-qiu Yan wen-kai Chen Feng Jin Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Faculty of Engineering China University of GeosciencesWuhan 430074China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China Research Center of Neotectonism and Crustal Stability China Geological SurveyBeijing 100081China China Water Resources Beifang Investigation Design and Research Co.Ltd.Tianjin 300222China

It is of crucial importance to investigate the spatial structures of ancient landslides in the eastern Tibetan Plateau’s alpine canyons as they could provide valuable insights into the evolutionary history of the landslides and indicate the potential for future *** study examines the Deda ancient landslide,situated in the Chalong-ranbu fault zone,where creep deformation suggests a complex underground *** integrating remote sensing,field surveys,Audio-frequency Magnetotellurics(AMT),and Microtremor Survey Method(MSM)techniques,along with engineering geological drilling for validation,to uncover the landslide’s spatial feature *** research indicates that a fault is developed in the upper part of the Deda ancient landslide,and the gully divides it into Deda landslide accumulation zoneⅠand Deda landslide accumulation zoneⅡin *** distinctive geological characteristics detectable by MSM in the shallow subsurface and by AMT in deeper *** findings include the identification of two sliding zones in the Deda I landslide,the shallow sliding zone(DD-I-S1)depth is approximately 20 m,and the deep sliding zone(DD-I-S2)depth is 36.2-49.9 *** sliding zone(DD-Ⅱ-S1)depth of the DedaⅡlandslide is 37.6-43.1 m.A novel MSM-based method for sliding zone identification is proposed,achieving less than 5%discrepancy in depth determination when compared with drilling *** results provide a valuable reference for the spatial structural analysis of large-deepseated landslides in geologically complex regions like the eastern Tibetan Plateau.

关键词： Ancient landslide Remote sensing Audio-frequency Magnetotellurics(AMT) Microtremor Survey Method(MSM) Geological drilling engineering Spatial structure Tibetan Plateau Geological hazard survey engineering