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Biological correlates of psychological states among young children:a cross-sectional examination of roles of aspartate transaminase/alanine aminotransferase,insulin,and cytokines

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Chinese Science Bulletin 2014年第35期59卷 5102-5112页

作者： Kuo-Hsuan Chung Chien-Ming Hu Ying-Ru Chen Hung-Yi chiou Yi-Hua Chen Department of Psychiatry and Psychiatric Research Center Taipei Medical University Hospital Department of Psychiatry College of MedicineTaipei Medical University Emergency Department Taipei Medical University Hospital Department of General Medicine School of MedicineCollege of MedicineTaipei Medical University Department of Psychiatry Shuang Ho HospitalTaipei Medical University School of Public Health College of Public Health and NutritionTaipei Medical University

Compared to data on adolescents and adults,limited research has been conducted on biological correlates among young children with possible psychological difficulties,especially in Asian *** focusing on various peripheral biochemical indicators,we investigated potential biological correlates of psychological states in a community sample of Taiwan Residents school children aged6–10 *** total,307 students(159 obese children and148 normal-weight children) were selected from first- and fourth-grade school children in eight elementary schools in the Taipei metropolitan area in *** children underwent a comprehensive health examination,including a physical examination,blood sample analysis,andquestionnaire administration in a *** in anthropometric and serum biochemical readings were compared between children with average and worse levels on each of the five psychological *** found that interleukin(IL)-1β [b = 1.29,95 % confidence interval(CI) 0.50–2.09],IL-10(b = 1.61,95 % CI \0.01–3.24),fasting blood glucose(b = 0.08,95 % CI 0.01–0.15),homocysteine(b = 0.63,95 % CI 0.09–1.18),and aspartate transaminase(AST)(b = 0.15,95 % CI \0.01–0.31)were significantly positively associated with *** addition,IL-1β,insulin,AST,and alanine aminotransaminase(ALT) were significantly positively associated with *** and disruptive behaviors were also related to specific biological *** biological correlates,including AST/ALT,cardiovascular diseaserelated variables,and specific cytokines,were linked to particular psychological states among young children in this Asian *** might provide a route for better understanding the biological aspects of children's mental health and might contribute to research on diagnostic or predictive biomarkers for psychiatric diseases in young children.

关键词：心理状态谷丙转氨酶细胞因子健康检查天冬氨酸转氨酶生物相胰岛素幼儿

Synthesis and Characterization of Novel Hybrid Poly(methyl methacrylate)/Iron Nanowires for Potential Hyperthemia Therapy

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Journal of Biomaterials and Nanobiotechnology 2010年第1期1卷 50-60页

作者： Huey-wen Liou Hong-Ming Lin Yeu-Kuang Hwu wen-Chang Chen Wei-Jen Liou Li-Chung Lai Wei-Syuan Lin wen-An chiou Department of Chemical and Materials Engineering National Yunlin University of Science and Technology University Road Section Douliou Yunlin Taiwan Department of Materials Engineering Tatung University DeHui St. Taipei Taiwan Institute of Physics Academia Sinica Academia Rd. Nankang Taipei Taiwan NISP Lab Jeong H. Kim Engineering Building NanoCenter University of Maryland College Park U.S.A.

Externally applied magnetic fields have been used in this study to fabricate bamboo-like iron nanowires with or without a layer of Poly(methyl methacrylate) (PMMA). The hybrid PMMA/Fe nanowires were synthesized via hard X-ray synchrotron radiation polymerization with various treatment parameters. The results of XRD show that an oxide layer formed on the surface of the iron nanowires. The Fe2O3 and Fe3O4 phases coexist in the iron nanowires without X-ray irradiation. After X-ray irradiation, the Fe2O3 phase transformed into Fe3O4, which stabilized the iron nanowires. The results of XAS proved this phase transformation. TGA analysis confirmed the thermal properties and solid contents in these specimens. Their ferromagnetic behaviors were examined by magnetic hysteresis measurement, which indicated that the magnetic and structural properties of the nanowires can be manipulated by irradiation treatment. This may lead to a novel synthesis for iron nanowires that can be used in high thermal efficiency hyperthermia therapy.

关键词： Iron Nanowires Poly(methyl methacrylate) Hybrid X-Ray Irradiation XAS Magnetic Materials

Conjugated hyperbilirubinemia presenting in first fourteen days in term neonates

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World Journal of Hepatology 2017年第26期9卷 1108-1114页

作者： Fang Kuan chiou Christina Ong Kong Boo Phua Fares Chedid Ajmal Kader Gastro-enterology Service Paediatric Medicine KK Women’s and Children’s Hospital Neonatal Medicine Al Jalila Children’s Specialty Hospital Pediatric Gastroenterology Dubai Hospital

AIM To describe the etiology and characteristics of earlyonset conjugated hyperbilirubinemia(ECHB) presenting within 14 d of life in term *** Retrospective review was performed of term infants up to 28-d-old who presented with conjugated hyperbilirubinemia(CHB) at a tertiary center over a 5-year period from January 2010 to December 2014. CHB is defined as conjugated bilirubin(CB) fraction greater than 15% of total bilirubin and CB greater or equal to 25 μmol/L. ECHB is defined as CHB detected within 14 d of life. "Late-onset" CHB(LCHB) is detected at 15-28 d of life and served as the comparison *** Total of 117 patients were recruited: 65 had ECHB, 52had LCHB. Neonates with ECHB were more likely to be clinically unwell(80.0% vs 42.3%, P < 0.001) and associated with non-hepatic causes(73.8% vs 44.2%, P = 0.001) compared to LCHB. Multifactorial liver injury(75.0%) and sepsis(17.3%) were the most common causes of ECHB in clinically unwell infants, majority(87.5%) had resolution of CHB with no progression to chronic liver disease. Inborn errors of metabolism were rare(5.8%) but associated with high mortality(100%) in our series. In the subgroup of clinically well infants(n = 13) with ECHB, biliary atresia(BA) was the most common diagnosis(61.5%), all presented initially with normal stools and decline in total bilirubin but with persistent CHB. CONCLUSION Secondary hepatic injury is the most common reason for ECHB. BA presents with ECHB in well infants without classical symptoms of pale stools and deep jaundice.

关键词： Conjugated hyperbilirubinemia Biliary atresia Cholestasis Direct hyperbilirubinemia Neonatal jaundice

Iron phthalocyanine-catalyzed radical phosphinoylazidation of alkenes:A facile synthesis of β-azido-phosphine oxide with a fast azido transfer step

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Chinese Journal of Catalysis 2021年第10期42卷 1634-1640页

作者： Xiaoxu Ma Mong-Feng chiou Liang Ge Xiaoyan Li Yajun Li Li Wu Hongli Bao Key Laboratory of Coal to Ethylene Glycol and Its Related Technology State Key Laboratory of Structural ChemistryCenter for Excellence in Molecular SynthesisFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430205HubeiChina University of Chinese Academy of Sciences Beijing 100049China

Phosphinoylazidation of alkenes is a direct method to build nitrogen-and phosphorus-containing compounds from feed-stock *** the advances in other phosphinyl radical related difunctionalization of alkenes,catalytic phosphinoylazidation of alkenes has not yet been ***,we describe the first iron-catalyzed intermolecular phosphinoylazidation of styrenes and unactivated *** method is practically useful and requires a relatively low loading of *** studies confirmed the radical nature of the reaction and disclosed the unusually low activation energy 4.8 kcal/mol of radical azido group transfer from the azidyl iron(III)phthalocyanine species(PcFeulN3)to a benzylic *** work may help to clarify the mechanism of iron-catalyzed azidation,inspire other mechanism studies and spur further synthetic applications.

关键词： Iron phthalocyanine Phosphinoylazidation Difunctionalization Radical group transfer Density functional theory calculation

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纵向数据的中介效应分析

心理科学 2021年第4期44卷 989-996页

作者：方杰温忠麟邱皓政广东财经大学应用心理学系广州510320 华南师范大学心理学院/心理应用研究中心广州510631 台湾师范大学管理学院中国台湾台北

目前中介效应检验主要是基于截面数据,但许多时候截面数据的中介分析不适合进行因果推断,因而需要收集历时性的纵向数据,进行纵向数据的中介分析。评介了基于交叉滞后面板模型、多水平模型和潜变量增长模型的纵向数据的中介分析方法及... 详细信息

目前中介效应检验主要是基于截面数据,但许多时候截面数据的中介分析不适合进行因果推断,因而需要收集历时性的纵向数据,进行纵向数据的中介分析。评介了基于交叉滞后面板模型、多水平模型和潜变量增长模型的纵向数据的中介分析方法及其四个发展。第一,中介效应随时间变化,如连续时间模型、多层时变系数模型。第二,中介效应随个体变化,如随机效应的交叉滞后面板模型和多层自回归中介模型。第三,中介模型的整合,如交叉滞后面板模型与多水平模型整合为多层自回归中介模型。第四,中介检验方法的发展,建议使用Bootstrap和贝叶斯法进行纵向数据的中介分析。总结出一个纵向数据的中介分析流程并给出相应的Mplus程序。随后展望了纵向数据的中介分析的拓展方向。

关键词：纵向数据中介效应交叉滞后面板模型多水平模型潜变量增长模型

Cauda equina syndrome caused by the application of DuraSeal^(TM) in a microlaminectomy surgery:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11178-11184页

作者： Kuei-Lin Yeh Szu-Hsien Wu chiou-Shann Fuh Yi-Hung Huang Chu-Song Chen Shing-Sheng Wu Department of Orthopaedics Ditmanson Medical Foundation Chia-Yi Christian HospitalChia-Yi City 600Taiwan Department of Computer Science and Information Engineering National Taiwan UniversityTaipei 10617Taiwan Department of Long-Term Care and Management WuFeng UniversityChiayi County 621303Taiwan Department of Physical Medicine and Rehabilitation Taipei Veterans General HospitalTaipei 11217Taiwan Department of Orthopaedics Shin Kong Wu-Ho Su Memorial HospitalTaiepi 111Taiwan

BACKGROUND The management of dural tears is *** a massive dura can be repaired with absorbable suture lines,cerebrospinal fluid leakage can be attenuated by dural sealant when an unintended tiny durotomy occurs *** is often used because it can expand to seal *** case emphasizes the need for caution when DuraSeal is used as high expansion can cause complications following *** SUMMARY A 77-year-old woman presented with L2/3 and L3/4 lateral recess *** underwent microlaminectomy,foraminal decompression,and disk height restoration using an IntraSPINE~? device.A tiny incident durotomy occurred intraoperatively and was sealed using DuraSeal ^(TM).However,decreased muscle power,urinary incontinence,and absence of anal reflexes were observed *** magnetic resonance imaging revealed fluid collection causing thecal sac indentation and central canal *** exploration revealed that the gel-like DuraSeal had entrapped the hematoma and,consequently,compressed the thecal sac and nerve *** we removed all DuraSeal ^(TM) and exposed the nerve root,the patient’s neurological function did not recover *** DuraSeal expansion must not be *** in neurological status require investigation for cauda equina syndrome due to expansion.

关键词： Cauda equina syndrome DuraSeal Microlaminectomy Spinal stenosis Case report

(R,R)-XY-10和(S,S)-XY-10诱导的视网膜色素上皮细胞增生作用及其作用机制(英文)

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国际眼科杂志 2009年第9期9卷 1641-1645页

作者： Yu-wen Cheng 王玉良张奕华彭司勋 George C Y chiou 美国德州大学城德州农工大学医学院眼科药理学研究所中国药科大学新药研究中心中国江苏省南京市210009

目的:观察(R, R)-XY-10和(S, S)-XY-10对视网膜色素上皮细胞的增生作用,并且进一步的研究其作用机制。但(R, R)-XY-10和(S, S)-XY-10对人脐静脉内皮细胞并无增生的作用。方法:通过人视网膜色素上皮细胞(ARPE-19)和人脐静脉内皮细胞(HUVE... 详细信息

目的:观察(R, R)-XY-10和(S, S)-XY-10对视网膜色素上皮细胞的增生作用,并且进一步的研究其作用机制。但(R, R)-XY-10和(S, S)-XY-10对人脐静脉内皮细胞并无增生的作用。方法:通过人视网膜色素上皮细胞(ARPE-19)和人脐静脉内皮细胞(HUVECs)研究(R, R)-XY-10和(S, S)-XY-10对视网膜色素上皮细胞的增生作用,并且采用ERK、KT、PI3K、蛋白激酶C(PKC)和一氧化氮合酶(NOS)抑制剂来研究其作用机制。结果:(R, R)-XY-10和(S, S)-XY-10促进了ARPE-19细胞的增生,并具有剂量依赖性,但是对HUVECs细胞没有影响。如果同时加入增生抑制剂H7 (5μmol/L)、金丝桃素(20μmol/L)、PD98059(2μmol/L)、LY294002(50μmol/L)、SH-5(10μmol/L)和L-NAME (100μmol/L),则给予H7、金丝桃素、PD98059和LY294002各组的增生作用受到了抑制,而给予SH-5和L-NAME两组的增生作用没有影响。结论:(R, R)-XY-10和(S, S)-XY-10能够诱导ARPE-19细胞增生,其作用可能是通过MAPK和PI3K的途径来发挥该作用。因此,(R, R)-XY-10和(S, S)-XY-10能通过修复损伤的RPE细胞来治疗老年性黄斑变性。

关键词：年龄相关性黄斑变性 (R R)-XY-10 (S S)-XY-10 ARPE-19 cells 人脐静脉血管内皮细胞增生

Application of artificial intelligence-driven endoscopic screening and diagnosis of gastric cancer

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World Journal of Gastroenterology 2021年第22期27卷 2979-2993页

作者： Yu-Jer Hsiao Yuan-Chih wen Wei-Yi Lai Yi-Ying Lin Yi-Ping Yang Yueh Chien Aliaksandr A Yarmishyn De-Kuang Hwang Tai-Chi Lin Yun-Chia Chang Ting-Yi Lin Kao-Jung Chang Shih-Hwa chiou Ying-Chun Jheng Department of Medical Research Taipei Veterans General HospitalTaipei 112201Taiwan School of Medicine National Yang-Ming Chiao Tung UniversityTaipei 112304Taiwan Department of Medical Education Taipei Veterans General HospitalTaipei 112201Taiwan Institute of Pharmacology National Yang-Ming Chiao Tung UniversityTaipei 112304Taiwan Department of Internal Medicine Taipei Veterans General HospitalTaipei 112201Taiwan Critical Center Taipei Veterans General HospitalTaipei 112201Taiwan Department of Ophthalmology Taipei Veterans General HospitalTaipei 112201Taiwan Institute of Clinical Medicine National Yang-Ming Chiao Tung UniversityTaipei 112201Taiwan Department of Medicine Kaohsiung Medical UniversityKaohsiung 80708Taiwan Institute of Clinical Medicine National Yang-Ming Chiao Tung UniversityTaipei 112304Taiwan Big Data Center Taipei Veterans General HospitalTaipei 112201Taiwan

The landscape of gastrointestinal endoscopy continues to evolve as new technologies and techniques become *** advent of image-enhanced and magnifying endoscopies has highlighted the step toward perfecting endoscopic screening and diagnosis of gastric ***,with the development of convolutional neural network,artificial intelligence(AI)has made unprecedented breakthroughs in medical imaging,including the ongoing trials of computer-aided detection of colorectal polyps and gastrointestinal *** the past demi-decade,applications of AI systems in gastric cancer have also *** AI’s efficient computational power and learning capacities,endoscopists can improve their diagnostic accuracies and avoid the missing or mischaracterization of gastric neoplastic *** far,several AI systems that incorporated both traditional and novel endoscopy technologies have been developed for various purposes,with most systems achieving an accuracy of more than 80%.However,their feasibility,effectiveness,and safety in clinical practice remain to be seen as there have been no clinical trials ***,AI-assisted endoscopies shed light on more accurate and sensitive ways for early detection,treatment guidance and prognosis prediction of gastric *** review summarizes the current status of various AI applications in gastric cancer and pinpoints directions for future research and clinical practice implementation from a clinical perspective.

关键词： Artificial intelligence Diagnostic Therapeutic Endoscopy Gastric cancer Gastritis

Unusual gastric tumors and tumor-like lesions: Radiological with pathological correlation and literature review

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World Journal of Gastroenterology 2017年第14期23卷 2493-2504页

作者： Yuan-Mao Lin Nai-Chi Chiu Anna Fen-Yao Li Chien-An Liu Yi-Hong Chou Yi-You chiou Division of Gastrointestinal Radiology Department of RadiologyTaipei Veterans General Hospital Faculty of Medicine School of MedicineNational Yang-Ming University Department of Pathology and Laboratory Medicine Taipei Veterans General Hospital

Although gastric tumors have overlapping radiologic appearances, some unusual tumors may present specific imaging features. Using multidetector computed tomography(MDCT), with water as a negative oral contrast agent and intravenous contrast medium, can provide critical information for the diagnosis of gastric diseases. In addition, MDCT can evaluate the involvement of the gastric wall and extragastric extent of the disease, as compared with gastroenteroscopy and double-contrast upper gastrointestinal study. Regarding lesion location and size, enhancing and growth patterns, presence of calcification or fat, and involvement of the gastric wall and adjacent structures, CT may provide useful information. In this review article, we review the relevant literature and discuss the CT features and the histopathologic findings of different types of gastric lesions. The lesions are divided into benign(glomus tumors, schwannomas, leiomyomas, and lipomas), malignant(gastrointestinal stromal tumors, mucinous carcinomas, lymphomas, and carcinoid tumors), and tumor-like lesions(ectopic pancreas and bezoar). Familiarity with imaging appearances and pathologic findings can help physicians make an accurate diagnosis.

关键词： Multidetector computed tomography stomach neoplasm adenocarcinoma carcinoid lymphoma lipoma glomus tumor heterotopic pancreas schwannoma gastrointestinal submucosal tumor leiomyoma bezoar