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Heterogeneity of mature oligodendrocytes in the central nervous system

Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao weng Adam M.R.Groh Moein Yaqubi Qiao-Ling cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo wen Jing Miao Huan-Tian cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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丁苯酞治疗阿尔茨海默病MoCA评分和ADAS-Cog评分改变及其相关性分析的临床研究

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湖南师范大学学报（医学版） 2019年第1期16卷 22-24页

作者：陈庆华张凤强李立新凌丽薛文翠河北省秦皇岛军工医院老年病科秦皇岛066000

目的 :评价丁苯酞对阿尔茨海默病的治疗作用以及MoCA评分和ADAS-Cog评分的相关性。方法 :采用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)和阿尔茨海默病评估量表认知部分(Alzheimer's disease Assessment Scale Cogniti... 详细信息

目的 :评价丁苯酞对阿尔茨海默病的治疗作用以及MoCA评分和ADAS-Cog评分的相关性。方法 :采用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)和阿尔茨海默病评估量表认知部分(Alzheimer's disease Assessment Scale Cognitive part,ADAS-Cog),对34例病人丁苯酞软胶囊口服治疗前及治疗后18天、36天、72天MoCA评分和ADAS-Cog评分数据采用单因素方差分析和Pearson相关系数分析。结果 :治疗后72天MoCA评分和ADAS-Cog评分与治疗前、治疗后18天、36天比较差异有统计学意义,MoCA评分和ADAS-Cog评分经过Pearson相关系数分析显示具有显著负相关。结论 :丁苯酞对阿尔茨海默病人的认知功能有显著改善作用,MoCA评分和ADAS-Cog评分具有显著负相关性。

关键词：丁苯酞阿尔茨海默病 MoCA ADAS-Cog

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In situ growth of NiSe@Co_(0.85)Se heterointerface structure with electronic modulation on nickel foam for overall water splitting

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Rare Metals 2021年第6期40卷 1373-1382页

作者： wen-Long Ding Yan-Hui Cao Hui Liu Ao-Xuan Wang cui-Juan Zhang xue-Rong Zheng Key Laboratory for Green Chemical Technology of Ministry of Education State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA Tianjin Kaben New Materials Technology Co. Ltd.Tianjin 300350China

Constructing heterointerface engineering has becoming an effective and general strategy for developing highly efficient and durable nonnoble electrocatalysts for catalyzing both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).In this work,we synthesized a self-supporting heterogeneous NiSe@Co_(0.85)Se/NF electrocatalyst using a facile in situ selenization of transition metal precursors that coated on the nickel foam(NF)in polyol *** NF was used as both conductive substrate and nickel source,ensuring superior electronic conductivity for *** NiSe@-Co_(0.85)Se/NF exhibited remarkable bifunctional electrocatalytic activities with HER overpotential of 168 mV and OER overpotential of 258 mV to achieve 10 mA·*** water splitting system using NiSe@Co_(0.85)Se/NF as both anode and cathode electrodes achieved a current density of 10 mA·cm^(-2) at 1.61 V with nearly 100% faradaic efficiency and impressively long-term *** efficient bifunctional catalytic performance of NiSe@-Co_(0.85)Se/NF should be attributed to the electronic modulation and synergistic effect between NiSe and Co_(0.85)Se,the intrinsic metallic conductivity and the enlarged active sites *** work provides a facile method for developing heterogeneous bifunctional catalysts for advanced electrochemical energy conversion technologies.

关键词： NiSe@Co_(0.85)Se/NF Heterointerface structure Electronic modulation Bifunctional electrocatalyst Overall water splitting

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Perovskite LiBaH3 for photo-assisted dinitrogen fixation

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Science China Chemistry 2025年

作者： Kaixun cui Yeqin Guan Yongli Cai Runze Wang Qianru Wang wenbo Gao Jianping Guo Ping Chen Department of Chemical Physics University of Science and Technology of China Dalian Institute of Chemical Physics Chinese Academy of Sciences Center of Materials and Optoelectronics Engineering University of Chinese Academy of Sciences

Establishing supply chains for future ammonia energy systems requires the development of efficient materials and processes for ammonia production under mild conditions. Recent researches disclose unique functionalities of binary alkali and alkaline earth metal hydrides in mediating ammonia synthesis. Thanks to the rich compositional and structural properties of the metalhydrogen system, we herein report that LiBaH3, as a narrow band gap perovskite hydride, exhibits a strong response to visible light illumination. Specifically, hydridic hydrogen undergoes reductive elimination of producing H2and creates an electron-rich surface. Such an environment favors dinitrogen fixation to form N–H bonds. Based on this chemical property, a chemical looping ammonia synthesis process mediated by LiBaH3and driven by both photo and thermal energies was proposed and *** work demonstrates that hydride perovskites are promising candidates for mediating photo-assisted nitrogen fixation reactions.

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Enhancing output performance of triboelectric nanogenerator by increasing charge storage capacity of electrodes

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Nano Research 2025年第1期18卷 395-403页

作者： Congcong Hao Zekun Wang Mingzhe Cai Shuaining Cheng Zhongxin Wang Cong Zhai Juan cui Yongqiu Zheng Chenyang xue Key Laboratory of Instrumentation Science and Dynamic Measurement Ministry of Education North University of ChinaTaiyuan 030051China

ABSTRACT:The practical application of rotating triboelectric nanogenerators is often limited by the wear of high-friction surface materials and low surface charge *** addition to the charge pump replenishment strategy,suppressing charge decay is also crucial for increasing surface charge ***,we present a high performance rotary triboelectric nanogenerator(HPR-TENG)based on a coplanar charge pumping strategy and polyvinyl chloride(PVC)*** has been demonstrated that applying PVC film to the surface of the storage electrode of the main TENG(M-TENG)significantly enhances the M-TENG’s output ***,the HPR-TENG with three layers of PVC film pasted achieved the best output performance,with a peak-topeak output voltage of 2828 V,a peak-to-peak output current of 327μA and a charge transfer of 0.81μC at 500 *** addition,the output improvement effects of different materials are *** TENG with 3 layers of PVC film pasted on it has a maximum output power of 748 mW at a load resistance of 4×10^(6)Ω.HPR-TENG’s output performance remains consistent after 100,000 cycles,which shows excellent *** excellent electrical performance of the HPR-TENG can be used as the energy supply for the tip high-voltage breakdown sensor system,which can achieve 14 breakdowns in 10 *** to its extraordinary electrical performance,HPRTENG can not only serve as an energy supply for cutting-edge high-voltage breakdown sensor systems,but also has the potential to serve as an energy supply for high-pressure sterilization,high-pressure vacuum and water electrolysis.

关键词： triboelectric nanogenerator coplanar charge pump enhancing charge density suppressing charge decay polyvinyl chloride(PVC)film

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An ECR-PCR rule for fusion of evidences defined on a non-exclusive framework of discernment

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Chinese Journal of Aeronautics 2022年第8期35卷 179-192页

作者： Xinyang DENG Yebi cui wen JIANG School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China

In the research of uncertain information processing,Dempster-Shafer Theory(DST)provides a framework for dealing with uncertain information,where evidence is defined on a Frame of Discernment(FOD)consisting of mutually exclusive ***,the requirement of exclusiveness on FOD sometimes is not satisfied,as shown in Dezert-Smarandache Theory(DSm T),a derivative of *** DSm T,the non-exclusiveness is expressed by propositions’intersection and the fusion of evidence is realized through a Proportional Conflict Redistribution(PCR)*** order to handle non-exclusive FODs,a new framework called D Number Theory(DNT)has been proposed recently,which quantifies the non-exclusive degree between propositions different from DSm *** previous studies,an Exclusive Conflict Redistribution(ECR)rule has been designed in DNT to implement the fusion of evidence defined on a non-exclusive FOD,but there are some deficiencies in the ECR *** this paper,a new rule called ECR-PCR rule is proposed by combining the ECR and PCR rules to better implement the fusion of evidence defined on a nonexclusive *** the proposed rule,the definition of conflict utilizes the idea of ECR’s exclusive conflict,and the disposal of conflict is following the idea of PCR’s proportional *** of the ECR-PCR rule are *** effectiveness of the proposed new rule is verified through numerical examples and applications,in comparison with other fusion methods.

关键词： D number theory Dempster-Shafer theory Evidence combination Non-exclusiveness Proportional Conflict Redistribution rule Information fusion

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Weighting Function Modification Used for Phase Transform-Based Time Delay Estimation

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China Communications 2022年第11期19卷 241-256页

作者： xue Yang Changchun Bao Zihao cui Speech and Audio Signal Processing Laboratory Faculty of Information TechnologyBeijing University of TechnologyBeijing 100124China

Generalized cross-correlation is considered as the most straightforward time delay estimation *** on various weighting function,different methods were derived and a straightforward method,named phase transform(PHAT)has been widely *** is well-known for its robustness to reverberation and its sensitivity to noise,which is partly due to the fact that PHAT distributes same weights to the frequencies dominated by signal or *** alleviate this problem,two weighting functions are proposed in this *** taking a posteriori signal-to-noise ratio(SNR)into account to classify reliable and unreliable frequencies,different weights could be *** first proposed weighting function borrows the idea of binary mask and distributes same weights to frequencies in same set,whereas,the second one assigns weights based on coherence *** showed the robustness of proposed methods to reverberation and noise for improving the performance of time delay estimation through various criteria.

关键词： time delay estimation generalized crosscorrelation PHAT a posteriori SNR coherence function

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Understanding the thermal stability of human serum proteins with the related near-infrared spectral variables selected by Monte Carlo-uninformative variable elimination

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Chinese Chemical Letters 2017年第7期28卷 1447-1452页

作者： Xiu-Wei Liu Xiao-Yu cui Xiao-Ming Yu wen-Sheng Cai xue-Guang Shao Research Center for Analytical Sciences College of ChemistryNankai UniversityTianjin 300071Chino Laboratory of Clinic People's Hospital of Gaorni CityShandong 261000China Tianjin Key Laboratory of Biosensing and Molecular Recognition Tianjin 300071China State Key Laboratory of Medicinal Chemical Biology Tianjin 300071China Collaborative Innovation Center of Chernical Science and Engineering Tianjin 300071China

Understanding the thermal stability of the proteins in human serum is essential since human serum is the important source of pharmaceutical proteins. Near-infrared（NIR） spectroscopy was applied to the investigation of thermal changes in secondary structure and hydration of human serum ***, as a multicomponent system, the overlap of the broad NIR bands makes the structural analysis very difficult directly using the spectra of serum samples. Therefore, continuous wavelet transform（CWT） was used to improve the resolution of NIR spectra, and Monte Carlo-uninformative variable elimination（MC-UVE） method was applied to the selection of the variables associated with the proteins for the structural analysis. The variables（5956, 5867, 5815, 5747, 4525, 4401, 4359 and 4328 cm^-1） related to protein secondary structures and those（7074, 6951, 6827 and 6700 cm 1） connected with water species were selected. Then, the thermal stability was analyzed through the intensity variations of the selected variables with temperature from 30℃ to 80 ℃. It was found that the variation of the spectral variables related to both a-helix and b-sheet changes apparently around 60 ℃, indicating the beginning of the thermal denaturation and the transition from a-helix to b-sheet. Moreover, an obvious change was found around 60℃for the content of the water specie S3, i.e., the water cluster containing three hydrogen bonds. The result demonstrates that MC-UVE can identify the protein-related NIR spectral variables, and the water species may be a marker for investigation of the structural change of proteins in biochemical systems.

关键词： Near-infrared spectroscopy Temperature dependent spectroscopy Monte Carlo-uninformative variable elimination Protein Human serum

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单晶NCM811正极材料的制备以及电化学性能的研究

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现代化工 2025年第1期45卷 149-155页

作者：吴允龙江晓雪郭旗李翠芹贵州大学化学与化工学院贵州贵阳550025 贵州省磷氟资源高效利用协同创新中心贵州贵阳550025

富镍层状正极材料(LiNi0.8Co0.1Mn0.1O2,NCM811)因具有极高的充放电比容量被广泛关注,但是其在循环过程中面临着严重的结构退化以及界面不稳定的问题。采用多步煅烧法协同球磨法成功制备了单晶NCM811正极材料(SC-NCM),并对其电化学性能... 详细信息

富镍层状正极材料(LiNi0.8Co0.1Mn0.1O2,NCM811)因具有极高的充放电比容量被广泛关注,但是其在循环过程中面临着严重的结构退化以及界面不稳定的问题。采用多步煅烧法协同球磨法成功制备了单晶NCM811正极材料(SC-NCM),并对其电化学性能进行了测试。结果表明,以SC-NCM为正极、锂片为负极组装的半电池首圈库伦效率为85.4%,在1 C循环200次后拥有86.2%的容量保持率;以石墨为负极、SC-NCM为正极组装的全电池在相同的测试条件下达到了94.1%的容量保持率。通过对比传统NCM811(PC-NCM)与SC-NCM在循环期间的差异,分析得出对高镍三元正极材料长循环稳定性最大的影响因素;同时提出了多步煅烧法协同球磨法合成SC-NCM正极材料的新策略,以加速NCM811商业化。

关键词：单晶NCM811 循环稳定性 SC-NCM||石墨全电池多步煅烧法

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