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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li Hui Ye Xue-Zhi Zhang Jian-xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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超等长训练方法的应用及其训练启示

体育学研究 2018年第5期1卷 78-88页

作者：刘瑞东徐文祥姜自立李庆清华大学体育部北京100084 杭州电子科技大学体育教学部浙江杭州310018 国家体育总局体育科学研究所北京100061

以生理学适应机制为依托,阐述了超等长训练方法的演变与进展,以及如何更合理地应用该训练方法。重点介绍了在训练实践中较为热门的负重超等长训练,以及在训练中最新兴起的水中和沙上超等长训练。水中和沙上超等长训练更加突出预防损伤... 详细信息

以生理学适应机制为依托,阐述了超等长训练方法的演变与进展,以及如何更合理地应用该训练方法。重点介绍了在训练实践中较为热门的负重超等长训练,以及在训练中最新兴起的水中和沙上超等长训练。水中和沙上超等长训练更加突出预防损伤的重要性,因此,如何更加合理地应用这一新方法,对于提高这一群体的运动成绩和防止运动损伤具有重要意义。研究认为:(1)弹跳高度、负重大小、弹跳速度和频率以及跳跃技巧等是影响超等长训练的关键因素。在进行超等长训练时,要强调"SSC"收缩的连贯性和动作速度;(2)在进行超等长训练时,不能过分追求跳深的高负重,较高的负重会使跳深触地时间和"SSC"收缩耦联时间延长,从而降低练习效果。因此,进行较低负重的跳深练习更利于提高爆发力;(3)沙上或水中超等长训练可作为陆上训练的辅助或交叉方式融入整个训练计划,促进超等长力量和专项成绩的提高,为运动员、特别是处于康复期运动员、青少年或女性运动员提供更多的选择。

关键词：运动训练等长训练超等长训练维尔霍山斯基运动损伤反应力量爆发力跳深

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： xiu-Ying Chen Fa Shen Chang Cheng Yu-Han Wang wen-Chao Cheng De-Zhi Yuan wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-xiu Yuan Jia-Fu Zhu wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

A Note on Exact Solutions to Linear Differential Equations by the Matrix Exponential

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Advances in Applied Mathematics and Mechanics 2009年第4期1卷 573-580页

作者： wen-xiu Ma xiang Gu Liang Gao Department of Mathematics and Statistics University of South FloridaTampaFL 33620-5700USA Department of Physics University of South FloridaTampaFL 33620-5700USA Department of Applied Mathematics Northwestern Polytechnical UniversityXi’anShaanxi 710072P.R.China

It is known that the solution to a Cauchy problem of linear differential equations:x'(t)=A(t)x(t),with x(t0)=x0,can be presented by the matrix exponential as exp(∫_(t0)^(t)A(s)ds)x0,if the commutativity condition for the coefficient matrix A(t)holds:[∫_(t0)^(t)A(s)ds,A(t)]=0.A natural question is whether this is true without the commutativity *** give a definite answer to this question,we present two classes of illustrative examples of coefficient matrices,which satisfy the chain rule d/dt exp(∫_(t0)^(t)A(s)ds)=A(t)exp(∫_(t0)^(t)A(s)ds),but do not possess the commutativity *** presented matrices consist of finite-times continuously differentiable entries or smooth entries.

关键词： Cauchy problem chain rule commutativity condition fundamental matrix solution

Reduced nonlocal integrable mKdV equations of type(-λ, λ) and their exact soliton solutions

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Communications in Theoretical Physics 2022年第6期74卷 15-20页

作者： wen-xiu Ma Department of Mathematics Zhejiang Normal UniversityJinhua 321004China Department of Mathematics King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics and Statistics University of South FloridaTampaFL 33620-5700United States of America

We conduct two group reductions of the Ablowitz-Kaup-Newell-Segur matrix spectral problems to present a class of novel reduced nonlocal reverse-spacetime integrable modified Korteweg-de Vries equations. One reduction is local, replacing the spectral parameter with its negative and the other is nonlocal, replacing the spectral parameter with itself. Then by taking advantage of distribution of eigenvalues, we generate soliton solutions from the reflectionless Riemann-Hilbert problems, where eigenvalues could equal adjoint eigenvalues.

关键词： nonlocal integrable equation soliton solution Riemann-Hilbert problem

Novel combined shield design for eye and face protection from COVID-19

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Advances in Manufacturing 2021年第1期9卷 130-135页

作者： xiu-Ling Huang Jin-Rong Yang Yu-xiang Sun Yi-wen Chen xiu-Mei Wang Shui-Miao Du Zi-Kai Hua School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444People's Republic of China Sino European School of Technology of Shanghai University Shanghai 200444People's Republic of China

The World Health Organization emphasized the importance of goggles and face shields for protection of medical personnel at the outbreak of the COVID-19 ***,almost all countries suffered from a critical supply shortage of goggles and face shields,as well as many other types of personal protective equipment(PPE),for a long period,owing to the lack of key medical material supplies and the inefficiency of existing fabrication methods arising from the need to avoid crowds during the outbreak of *** this paper,we propose a novel combined shield design for eye and face protection that can be rapidly fabricated using three-dimensional printing *** designed prototype eye-face shield is accessible to the general public,offering more possibilities for yield improvement in PPE during emergent infectious disease events such as COVID-19.

关键词： Goggles Face shield Three-dimensional(3D)printing COVID-19

Behavioral responses of potato tuber moth (Phthorimaea operculella) to tobacco plant volatiles

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Journal of Integrative Agriculture 2020年第2期19卷 325-332页

作者： LI xiang ZHANG xiu-ge XIAO Chun GAO Yu-lin DONG wen-xia State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan College of Plant ProtectionYunnan Agricultural UniversityKunming 650201P.R.China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070P.R.China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Potato tuber moth(PTM)Phthorimaea operculella,also known as tobacco splitworm,is an important pest of tobacco *** knowledge on the interaction of tobacco plant volatiles and PTM behavior is *** clarify the effect of tobacco plant volatiles on the orientation and oviposition behaviors of PTM and to identify potential compounds for PTM control,tobacco plant volatiles were collected by headspace collection method,and volatile compounds were identified by gas chromatography-mass *** electrophysiological active compounds were screened by employing coupled gas chromatography-electroantennogram detection and from which nine available compounds were further verified by electroantennogram ***-3-Hexen-1-ol showed significant attractant effect on the orientation behaviors of both male and female *** and decanal could only attract females,while octanal exhibited repellent effect on *** selection experiment indicated that nonanal,decanal,decane and methyl hexadecanoate could stimulate the gravid females to lay more eggs,while octanal and 2,6-bis(1,1-dimethylenthyl)-4-methyl phenol inhibited their *** study added more compounds to the list that could serve as potential PTM deterrents or attractants.

关键词： Phthorimaea operculella tobacco volatiles electrophysiological response orientation oviposition

Linear Integral Analysis of Bar Rough Rolling by Strain Rate Vector

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Journal of Iron and Steel Research International 2010年第3期17卷 28-33页

作者： DENG Wei ZHAO De-wen QIN Xiao-mei GAO xiu-hua DU Lin-xiu LIU xiang-hua State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

A new linear integral method for bar hot rolling on roughing train was obtained. First, for plastic deformation energy rate, equivalent strain rate about Kobayashi＇s three-dimensional velocity field was expressed by two-dimensional strain rate vector; then, the two-dimensional strain rate vector was inverted into inner product and was integrated term by term. During those processes, boundary equation and mean value theorem were introduced; for friction and shear energy dissipation rate, definite integral was applied to the solution process. Sequentially, the total upper bound power was minimized, and the analytical expressions of rolling torque, separating force, and stress state factor were obtained. The calculated results by these expressions were compared with those of experimental values. The results show that the new linear integral method is available for bar rough rolling analysis and the calculated results by this method are a little higher than those of experimental ones. However, the maximum error between them is less than 10%.

关键词： bar rough rolling linear integration strain rate vector roll separating force