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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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RepColor: deep coloring algorithm combining semantic categories

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Optoelectronics Letters 2025年

作者： Lei sun Dongjie Ju School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Complicated Industry Systems， Tianjin University of Technology

Image coloring is an inherently uncertain and multimodal problem. By inputting a grayscale image into a coloring network， visually plausible colored photos can be generated. Conventional methods primarily rely on semantic information for image colorization. Although effective in coloring images with clear semantic information， these methods still suffer from color contamination and semantic confusion. This is largely due to the limited capacity of convolutional neural networks to effectively learn deep semantic information inherent in *** this paper， we propose a network structure that addresses these limitations by leveraging multi-level semantic information classification and fusion. Additionally， we introduce a global semantic fusion network to combat the issues of color contamination. The proposed coloring encoder accurately extracts object-level semantic information from *** further enhance visual plausibility， we employ a self-supervised adversarial training method. We train the network structure on various datasets with varying amounts of data and evaluate its performance using the ImageNet validation set and COCO validation set. Experimental results demonstrate that our proposed RepColor can generate more realistic images compared to previous approaches， showcasing its high generalization ability.

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

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Effect of the Coefficient on the Performance of A Two-Layer Boussinesq- Type Model

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China Ocean Engineering 2021年第1期35卷 36-47页

作者： sun Jia-wen LIU Zhong-bo WANG xing-gang FANG Ke-zhao DU Xin-yuan WANG Ping State Environmental Protection Key Laboratory of Marine Ecosystem Restoration National Marine Environmental Monitoring CenterDalian 116023China Transportation Engineering College Dalian Maritime UniversityDalian 116026China Nanjing Hydraulic Research Institute Nanjing 210029China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Liaoning natural resources Affairs Service Center Shenyang 110032China

The coefficients embodied in a Boussinesq-type model are very important since they are determined to optimize the linear and nonlinear *** most conventional Boussinesq-type models,these coefficients are assigned the specific *** for the multi-layer Boussinesq-type models with the inclusion of the vertical velocity,however,the effect of the different values of these coefficients on linear and nonlinear performances has never been investigated *** present study focuses on a two-layer Boussinesq-type model with the highest spatial derivatives being 2 and theoretically and numerically examines the effect of the coefficient on model *** analysis show that different values for(0.13≤α≤0.25)do not have great effects on the high accuracy of the linear shoaling,linear phase celerity and even third-order nonlinearity for water depth range of 0

关键词： two-layer Boussinesq-type model dispersion nonlinear properties shoaling amplitude

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Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen Shen Xiaoming Xiao Zhichao Li Qi Zhou Wei Yang Bin Jiang Yongli sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： Ultraviolet photoelectron spectroscopy

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Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang wentao Jiang Xue-wen Zhang Hao-Long Zhou Yuxiu sun Wei Gong Bin Wang Fuyin Ma Linwei He Long Chen Qiang Chen He-Qi Zheng Yuanjing Cui wen-Jie Shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli Zhong Yong Cui Shuao Wang Jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo sun Huijun Wang Yi Zheng Siyu Zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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Spatio-temporal reconstruction of air temperature maps and their application to estimate rice growing season heat accumulation using multi-temporal MODIS data

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第2期14卷 144-161页

作者： Li-wen ZHANG Jing-feng HUANG Rui-fang GUO Xin-xing LI wen-bo sun Xiu-zhen WANG Institute of Remote Sensing and Information Application Zhejiang University Key Laboratory of Polluted Environment Remediation and Ecological Health Ministry of EducationCollege of Natural Resources and Environmental ScienceZhejiang University Key Laboratory of Agricultural Remote Sensing and Information System of Zhejiang Province Meteorological Information Technology Support Center of Jilin Province Institute of Remote Sensing and Earth Sciences Hangzhou Normal University

The accumulation of thermal time usually represents the local heat resources to drive crop *** of temperature-based agro-meteorological indices are commonly generated by the spatial interpolation of data collected from meteorological stations with coarse geographic *** solve the critical problems of estimating air temperature(T a) and filling in missing pixels due to cloudy and low-quality images in growing degree days(GDDs) calculation from remotely sensed data,a novel spatio-temporal algorithm for T a estimation from Terra and Aqua moderate resolution imaging spectroradiometer(MODIS) data was *** is a preliminary study to calculate heat accumulation,expressed in accumulative growing degree days(AGDDs) above 10 ℃,from reconstructed T a based on MODIS land surface temperature(LST) *** verification results of maximum T a,minimum T a,GDD,and AGDD from MODIS-derived data to meteorological calculation were all satisfied with high correlations over 0.01 significant ***,MODIS-derived AGDD was slightly underestimated with almost 10% relative ***,the feasibility of employing AGDD anomaly maps to characterize the 2001-2010 spatio-temporal variability of heat accumulation and estimating the 2011 heat accumulation distribution using only MODIS data was finally demonstrated in the current *** study may supply a novel way to calculate AGDD in heat-related study concerning crop growth monitoring,agricultural climatic regionalization,and agro-meteorological disaster detection at the regional scale.

关键词： MODIS land surface temperature Air temperature estimation Reconstruction Heat accumulation Rice growing season Growing degree day (GDD)

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Novel noninvasive quantification of penile corpus caver no sum lesions in hyperlipidemia-induced erectile dysfunction in rabbits by two-dimensional shear-wave elastography

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Asian Journal of Andrology 2019年第2期21卷 143-149页

作者： Jian-Lin Hu Hui-xing Chen Hui-Rong Chen Yu Wu Xiao-wen sun Zheng Li Jin-Fang xing Department of Reproductive Medicine Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 201620China Department of Andrology Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China Department of Urology Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 201620China Department of Medical Ultrasound Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China

Structural alterations in fibroelastic compone nts of the penile corpus caver no usum(CC)may impair its compliance,resulting in venous leakage and erectile dysfunction(ED).Our study evaluated the effectiveness of noninvasive two-dimensional shear-wave elastography(2-D SWE)in quantifying penile CC lesions in rabbits with hyperlipidemia-induced ED.A total of 12 New Zealand white rabbits were randomly divided into two *** were fed a high-cholesterol diet containing 2%cholesterol and 8.5%lard for 10 weeks and the other six were fed normal diet as *** measured the shear-wave elastic quantitative(SWQ)value of penile CC by 2-D *** function was inv estigated by intracavernous injecti on of pa pa ver i ne,and immunohistochemical(IHC)stain inga nd the wester n blot analysis to determine the penile CC *** 10 weeks,the SWQ values obtained from penile CC were remarkably higher in the high-cholesterol-fed compared with the control group,and the AICP(ICP plateau minus ICP baseline)/MAP(ICP:intracavernous pressure,MAP:mean arterial pressure)was markedly *** IHC staining and western blot revealed extracellular matrix(ECM)accumulation in penile cavernous tissues,and the smooth muscle cell(SMC)phenotypic transition was affected,as indicated by reduced alpha-smooth muscle actin and calponinexpression and increased phospho-myosin light chain?。(p-MLC20)/MLC20 and osteopontin *** resulted in ECM accumulation accompanied with SMC phenotypic transition in penile CC and impaired the erectile function *** might,in turn,lead to variations in the SWQ *** suggests that 2-D SWE may be a novel,noninvasive and effective approach that distinguishes penile CC lesions secondary to hyperlipidemia from normal.

关键词： corpus cavernosum erectile dysfunction extracellular matrix accumulation phenotypic transition shear-wave elastography smooth muscle cells

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Spin-orbit coupling and spin current in mesoscopic devices

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Science China(Physics,Mechanics & Astronomy) 2013年第1期56卷 196-206页

作者： xing YanXia sun QingFeng Department of Physics Beijing Institute of Technology International Center for Quantum Materials Peking University Institute of Physics Chinese Academy of Sciences

Recently,the spin-orbit coupling and spin current in nanodevice have been investigated *** this paper,we review the recent progresses in this *** introduce the real space Hamiltonian and the second quantization Hamiltonian of a typical quantum transport mesoscopic device,metal-QD-metal configuration,containing the spin-orbit interaction,e-e interactions,and magnetic *** noteworthy effects(e.g.,the spin-polarized current,spin accumulation,persistent spin current) originated from the spin-orbit interaction are reviewed,and the electric field induced by spin-current is ***,we introduce some unsolved problems and prospects in this field.

关键词： spin-orbital coupling spin polarization spin current mesoscopic device

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