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Characteristics of home oxygen therapy for preterm infants with bronchopulmonary dysplasia in China:results of a multicenter cohort

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World Journal of Pediatrics 2023年第6期19卷 557-567页

作者： wen-xing jiang Yan-Chen Wang Hong-Xia Song Mi Xiao Fan He Si-Yuan jiang Xin-Yue Gu Jian-Hua Sun Yun Cao wen-Hao Zhou Shoo Kim Lee Li-Ping Chen Li-Yuan Hu Division of Neonatology Jiangxi Provincial Children’s Hospital1666 Diezihu AvenueHonggutan New AreaNanchang 330038China NHC Key Laboratory of Neonatal Diseases Fudan UniversityChildren’s Hospital of Fudan UniversityShanghai 201102China Division of Neonatology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Division of Neonatology Children’s Hospital of Fudan University399 Wanyuan RoadMinhang DistrictShanghai 201102China Division of Neonatology Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Maternal-Infants Care Research Centre and Department of Pediatrics Mount Sinai HospitalTorontoON M5G 1X5Canada University of Toronto TorontoON M5T 3M7Canada

Background Home oxygen therapy(HOT)is indicated upon discharge in some preterm infants with severe bronchopulmonary dysplasia(BPD).There is a lack of evidence-based consensus on the indication for HOT among these *** wide variation in the institutional use of HOT exists,little is known about the role of regional social-economic level in the wide variation of *** This was a secondary analysis of Chinese Neonatal Network(CHNN)data from January 1,2019 to December 31,*** at gestational ages<32 weeks,with a birth weight<1500 g,and with moderate or severe BPD who survived to discharge from tertiary hospitals located in 25 provinces were included in this *** with major congenital anomalies and those who were discharged against medical advice were *** Of 1768 preterm infants with BPD,474 infants(26.8%)were discharged to home with *** proportion of HOT use in participating member hospitals varied from 0 to 89%,with five of 52 hospitals’observing proportions of HOT use that were significantly greater than expected,with 14 hospitals with observing proportions significantly less than expected,and with 33 hospitals with appropriate *** noted a negative correlation between different performance groups of HOT and median GDP per capita(P=0.04).Conclusions The use of HOT varied across China and was negatively correlated with the levels of provincial economic levels.A local HOT guideline is needed to address the wide variation in HOT use with respect to different regional economic levels in countries like China.

关键词： Bronchopulmonary dysplasia Chinese Neonatal Network Gross domestic product Home oxygen therapy Preterm infants

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin wenzhen Zhu Tingting Guo Yiran Zhang Tingting xing Peng Yin Shihua Li Xiao-jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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锂电池铬氧化物材料研究进展

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电源技术 2018年第8期42卷 1223-1225页

作者：彭庆文刘兴江中国电子科技集团公司第十八研究所化学与物理电源重点实验室天津300384

过渡金属氧化物由于具有很高的容量可作为锂电池正极或负极材料而引起了众多学者的关注,其中铬氧化物因本身的三电子转移特性和非常高的储锂容量而得到广泛研究。铬氧化物(CrO_3、Cr_3O_8、Cr_2O_5、CrO_2、Cr_2O_3)中,重点介绍了正极材... 详细信息

过渡金属氧化物由于具有很高的容量可作为锂电池正极或负极材料而引起了众多学者的关注,其中铬氧化物因本身的三电子转移特性和非常高的储锂容量而得到广泛研究。铬氧化物(CrO_3、Cr_3O_8、Cr_2O_5、CrO_2、Cr_2O_3)中,重点介绍了正极材料Cr_3O_8和负极材料Cr_2O_3的最新研究成果。

关键词：锂电池铬氧化物正极材料负极材料

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song jiang Congwen Zhu Ning jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

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Efficient large-area flexible organic photovoltaic modules on transparent thin silver electrodes

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Science China Chemistry 2025年

作者： Cong Xie Zedong Xiong Xinlu Liu wen Wang Yang Liu Xueshi jiang Xin Lu Lulu Sun Yinhua Zhou Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Kunming Institute of Physics

Large-area flexible organic photovoltaic（OPV） modules are challenging to achieve high power conversion efficiency（PCE）.Electrical shunts or shortages generally occur in large-area OPV modules due to the ultrathin（100–200 nm） and soft active layers. Improving the surface smoothness of bottom transparent electrode will be able to suppress the shunts and shortages. In this work, we report a method to fabricate smooth and flexible transparent electrodes based on thin silver film, and further to fabricate efficient large-area flexible OPV modules. The fabricated thin silver transparent electrodes simultaneously have high conductivity, high optical transmittance, good mechanical flexibility and low surface roughness. Humidity exposure（h.e.）treatment on MoO3effectively facilitates the continuous growth of the thin transparent silver electrode. 6 nm silver film on MoO3（h.e.） on plastic substrate shows a transmittance up to 89%, a sheet resistance of 15 Ω/sq, and a low surface roughness with a rootmean-square value of 0.276 nm. Furthermore, 52-cm2flexible organic solar modules（15 subcells） showed a certified PCE of12.66%. Furthermore, a 1350 cm2flexible component assembled by 25 pieces of 52–55 cm2modules showed certified PCE of12.10% with an open-circuit voltage of 62.85 V.

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： jiang-Yu Bian Yu-Fang Feng wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

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Optimal Scheduling of an Independent Electro-Hydrogen System with Hybrid Energy Storage Using a Multi-Objective Standardization Fusion Method

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Energy Engineering 2025年第1期122卷 63-84页

作者： SuliangMa ZeqingMeng Mingxuan Chen Yuan jiang School of Electrical and Control Engineering North China University of TechnologyBeijing100144China ChinaThree Gorges Technology Co. Ltd.Beijing100032China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China

In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is ***,it presents a challenge due to the significant deviations in values ofmultiple optimization objective functions caused by their physical *** deviations seriously affect the scheduling process.A novel standardization fusion method has been established to address this issue by analyzing the variation process of each objective function’s *** optimal scheduling results of IEHS with HESS indicate that the economy and overall energy loss can be improved 2–3 times under different optimization *** proposed method better balances all optimization objective functions and reduces the impact of their *** the cost of BESS decreases by approximately 30%,its participation deepens by about 1 ***,if the price of the electrolyzer is less than 15￥/kWh or if the cost of the fuel cell drops below 4￥/kWh,their participation will increase *** study aims to provide a more reasonable approach to solving multi-objective optimization problems.

关键词： Electro-hydrogen system multi-objective optimization standardization method hybrid energy storage system

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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关于构建矿业投资-地学合作-信息整合的国际矿业战略探索

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资源与产业 2016年第4期18卷 1-6页

作者：丁群安王林黄兴文姜雅中国地质图书馆北京100083 中国地质大学继续教育学院北京100083 中海石油研究中心北京100027 国土资源部信息中心北京100812

在全球化的背景下,随着中国经济的崛起和经济增长模式的转变,我国以资源采购和矿业投资为主要手段的资源安全战略表现出对信息、国际合作的支撑需求。目前我国矿产资源需求量大,通过矿业投资优化资源布局的效果有限,分析其原因一方面是... 详细信息

在全球化的背景下,随着中国经济的崛起和经济增长模式的转变,我国以资源采购和矿业投资为主要手段的资源安全战略表现出对信息、国际合作的支撑需求。目前我国矿产资源需求量大,通过矿业投资优化资源布局的效果有限,分析其原因一方面是地质国际合作落后,缺少科技话语权和投资目的国的国际合作布局,这种不足无法满足国家国际矿业战略的科技支撑需求;另一方面是信息不对称,获得相关国家的地质、科技、政策信息有限,进而影响国际矿业战略布局的有效性。提出将获取信息优势的信息联合保障、获取更大影响力和话语权的科技国际合作作为国际矿业战略的重要组成部分,形成矿业投资-科技国际合作-信息联合保障的三元国际矿业战略,并分析了3种要素在三元国际矿业战略体系中的地位和作用,即矿业投资是驱动,信息联合保障是基础,科技国际合作是引领。

关键词：国际矿业战略三元结构科技国际合作信息联合保障

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