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Determination of a astragaloside Ⅳ derivative LS-102 in plasma by ultra-performance liquid chromatography-tandem mass spectrometry in dog plasma and its application in a pharmacokinetic study

Determination of a astragaloside Ⅳ derivative LS-102 in pla...

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首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： wen-xia sun Zhi-Feng Zhang Li-Sheng Ding Lin-Sen Qing Pei Luo Chengdu Institute of Biology Chinese Academy of Sciences Sichuan Industrial Institute of Antibiotics Chengdu University State Key Laboratories for Quality Research in Chinese Medicines Macau University of Science and Technology

Background Astragalosidic acid(LS-102) is a new water-soluble derivative of astragaloside Ⅳ-a major effective component isolated from the Chinese herb Astragali *** previous study showed that LS-102 exhibited potent cardiovascular *** The objective of this study was to investigate the pharmacokinetic properties of LS-102 after single-dose,oral administration in beagle dogs by developing and validating an ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) *** and result The chromatographic separation was performed on a Acquity HSS C18 column(100 mm×2.1 mm, 1.8 μm) by a gradient elution using a mobile phase consisting of water and acetonitrile at a flow rate of 0.35 mL/*** analytes were detected with a triple quadrupole tandem mass spectrometry(MS) in multiple reaction monitoring(MRM) mode and a positive ion electrospray ionization(ESI) of the transitions at m/z821.5→627.5 for *** validation revealed a wide linearity over the range of 2.0-10000 ng/mL together with satisfactory intra-and inter-day precision,accuracy,and *** testing showed that LS-102 spiked into dog plasma was stable for 4 h at room temperature,for up to 2 weeks at-80℃, and during three freeze-thaw *** method was effectively and successfully applied to the pharmacokinetics of LS-102 after oral administration(5,10 and 20 mg/kg) to beagle *** plasma concentrations are attained within approximately 2 h after oral administration with a half-life ranging from 1.55 h to 4.49 *** plasma concentration-time curve of LS-102 after oral administration presents the phenomenon of a double-peak absorption *** peak concentration and area under the concentration-time curve of LS-102 seemed to increase with the increasing doses proportionally,that suggesting linear pharmacokinetics in ***,the doxorubicin(Dox)-injured H9 c2 cell model was prepared by incubating the cells in 1 μM Dox for 24 *** assay and L

关键词： astragalosidic acid astragaloside Ⅳ derivative pharmacokinetics bioavailability UPLC-MS/MS

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二元社会网络与海归企业创新绩效——基于模糊集的定性比较分析

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华东经济管理 2017年第6期31卷 113-118页

作者：赵文李文霞孙国强山西财经大学管理科学与工程学院山西太原030006

海归人才因其特殊的人力资本以及社会资本,已成为推动我国自主创新、促进创新创业的重要力量。文章以深市77家医药制造企业为样本,应用模糊集的定性比较分析方法(fs QCA)探讨了海归企业的国内外社会网络与海归企业创新绩效之间的关系。... 详细信息

海归人才因其特殊的人力资本以及社会资本,已成为推动我国自主创新、促进创新创业的重要力量。文章以深市77家医药制造企业为样本,应用模糊集的定性比较分析方法(fs QCA)探讨了海归企业的国内外社会网络与海归企业创新绩效之间的关系。研究发现:大型海归企业若想以相对较低的研发投入取得高创新绩效,应构建丰富的国外社会网络,同时,应与国内社会网络保持适度的联系;若大型海归企业的国内社会网络较为丰富,则需有较高的研发投入才能取得较高的创新绩效。研究结果进一步理清了二元社会网络与海归企业创新绩效的关系,为相关政策制定提供了理论支撑。

关键词：海归企业二元网络创新模糊集定性比较分析

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang xia Ning Xu wen sun Jianjun Du Jiangli Fan xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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Intermolecular reductive coupling of aliphatic ketones with alkynes and alkenes by BCN photocatalysts

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Science China Chemistry 2025年第1期 181-185页

作者： Yanping xia Luyang sun Jiajia Cheng Sibo Wang Meifang Zheng Xinchen Wang State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University

A photocatalytic process was developed for intermolecular reductive coupling of aliphatic ketones with alkynes/alkenes to furnish tertiary alcohols. Mechanistic studies support that boron carbonitrides(BCN) promote the single electron reduction of unactivated aliphatic ketones to generate ketyl radicals with visible light irradiation, which then react with alkynes and alkenes to afford the allylic and aliphatic alcohols, respectively. The heterogeneous photocatalytic system is compatible with diverse substrates including pharmaceutical-related molecules(43 examples) with reusability and scale-up experiments, verifying the complementary synthetic utility of this method to the homogeneous catalysts.

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu xia wenting Ye Yan sun Jing Cai Fubing Yu Haiping wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang wen-Jie Shi Yu-Xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao xia Li wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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简牍所见秦及西汉初期的未成年“户人”研究

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南都学坛 2025年第1期45卷 13-20页

作者：文霞广东第二师范学院历史与社会发展学院广东广州510303

秦及西汉初期的简牍中出现了一些未成年“户人”,他们均为男性。未成年人成为“户人”的主要影响因素包括性别、尊卑及家庭规模等,年龄不是重要考量因素。未成年男性或担任“户人”,或提前服役,过于繁重的赋役迫使未成年男性作为劳动力... 详细信息

秦及西汉初期的简牍中出现了一些未成年“户人”,他们均为男性。未成年人成为“户人”的主要影响因素包括性别、尊卑及家庭规模等,年龄不是重要考量因素。未成年男性或担任“户人”,或提前服役,过于繁重的赋役迫使未成年男性作为劳动力的价值得到提升。未成年人“户人”被提前成人化,既体现了国家在行政管理上对个人身份信息的漠视,也说明了皇帝和官僚集团极尽可能压榨人民的剩余劳动。

关键词：简牍未成年人户人女户

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Impact time control using biased proportional navigation for missiles with varying velocity

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Chinese Journal of Aeronautics 2020年第3期33卷 956-964页

作者： Guoxin sun Qiuqiu wen Zhiqiang XU Qunli xia School of Aerospace Beijing Institute of TechnologyBeijing 100081China Harbin Jiancheng Industry Company Limited Harbin 150030China

A feasible guidance scheme with impact time constraint is proposed for attacking a stationary target by missiles with time-varying *** main idea is to replace the constant velocity with the future mean velocity;therefore, the existing time-to-go estimation algorithm of the proportional navigation guidance law can be improved to adapt to varying *** order to obtain the prediction of the velocity profile, the velocity differential equation to the downrange is derived, which can be numerically integrated between the current downrange and the target position by the on-board ***, a third-order polynomial is introduced to fit the velocity profile in order to calculate the future mean *** the beginning of each guidance loop, the future mean velocity is predicted and the time-to-go information is updated, based on which a novel biased proportional navigation guidance law is established to achieve the impact time ***,numerical simulation results verified the effectiveness of the time-to-go estimation algorithm and the proposed law.

关键词： Guidance Homing missiles Impact time Proportional navigation guidance Time-varying velocity

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